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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Deoxyribonuclease gamma' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Deoxyribonuclease gamma


(Homo sapiens)
BDBM50206432
PNG
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)
Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12
Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29)
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PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DNase gamma expressed in Rosetta DE3 cells assessed as increase in acidsoluble DNA after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Deoxyribonuclease gamma


(Homo sapiens)
BDBM50206432
PNG
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)
Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12
Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29)
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Nis

Curated by ChEMBL


Assay Description
Inhibition of DNase gamma (unknown origin) transfected in HeLa S3 cells


Citation and Details
More data for this
Ligand-Target Pair
Deoxyribonuclease gamma


(Homo sapiens)
BDBM50333185
PNG
(CHEMBL1644886 | Pontacyl Violet 6R)
Show SMILES Oc1cc(cc2cc(c(N=Nc3cccc4ccccc34)c(O)c12)S(O)(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C20H14N2O8S2/c23-16-10-13(31(25,26)27)8-12-9-17(32(28,29)30)19(20(24)18(12)16)22-21-15-7-3-5-11-4-1-2-6-14(11)15/h1-10,23-24H,(H,25,26,27)(H,28,29,30)
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PubMed
n/an/a 1.61E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DNase gamma expressed in Rosetta DE3 cells assessed as increase in acidsoluble DNA after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Deoxyribonuclease gamma


(Homo sapiens)
BDBM50206432
PNG
(4-(4,6-dichloro-1,3,5-triazin-2-ylamino)-2-(6-hydr...)
Show SMILES OC(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1-c1c2ccc(O)cc2oc2cc(=O)ccc12
Show InChI InChI=1S/C23H12Cl2N4O5/c24-21-27-22(25)29-23(28-21)26-10-1-4-13(20(32)33)16(7-10)19-14-5-2-11(30)8-17(14)34-18-9-12(31)3-6-15(18)19/h1-9,30H,(H,32,33)(H,26,27,28,29)
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PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of DNase gamma-mediated HMGB1 release expressed in human staurosporine-induced HeLaS3 cells treated 1 hr before staurosporine challenge me...


Citation and Details
More data for this
Ligand-Target Pair
Deoxyribonuclease gamma


(Homo sapiens)
BDBM50333186
PNG
((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-...)
Show SMILES OC(=O)[C@@H](CC1CCCCC1)NC(=O)OCC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C24H27NO4/c26-23(27)22(14-16-8-2-1-3-9-16)25-24(28)29-15-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21/h4-7,10-13,16,21-22H,1-3,8-9,14-15H2,(H,25,28)(H,26,27)/t22-/m1/s1
KEGG

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Article
PubMed
n/an/a 3.45E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DNase gamma expressed in Rosetta DE3 cells assessed as increase in acidsoluble DNA after 30 mins


Citation and Details
More data for this
Ligand-Target Pair