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Compile Data Set for Download or QSAR

Found 271 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215446
PNG
(US9296745, 1)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H24F3N5O2/c24-23(25,26)33-17-7-3-5-15(13-17)20-27-18-8-9-19(28-21(18)29-20)31-12-4-6-16(14-31)22(32)30-10-1-2-11-30/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,27,28,29)/t16-/s2
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n/an/a 1.70n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26ClN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27)/t15-/s2
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n/an/a 2.10n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215661
PNG
(US9296745, 199)
Show SMILES C[C@H](c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C20H25ClN8O/c1-13(29-12-15(21)9-23-29)17-24-16-10-22-20(26-18(16)25-17)28-8-4-5-14(11-28)19(30)27-6-2-3-7-27/h9-10,12-14H,2-8,11H2,1H3,(H,22,24,25,26)/t13-,14-/s2
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n/an/a 2.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215447
PNG
(US9296745, 2)
Show SMILES CC(C)Cc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H30N6OS/c1-15(2)12-17-14-31-22(24-17)21-25-18-7-8-19(26-20(18)27-21)29-11-5-6-16(13-29)23(30)28-9-3-4-10-28/h7-8,14-16H,3-6,9-13H2,1-2H3,(H,25,26,27)/t16-/s2
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n/an/a 2.71n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215551
PNG
(US9296745, 108)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H25ClN8O/c22-15-10-24-30(13-15)21(5-6-21)19-25-16-11-23-20(27-17(16)26-19)29-9-3-4-14(12-29)18(31)28-7-1-2-8-28/h10-11,13-14H,1-9,12H2,(H,23,25,26,27)/t14-/s2
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n/an/a 2.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215487
PNG
(US9296745, 42)
Show SMILES CC(C)(C)c1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H30N6OS/c1-23(2,3)17-14-31-21(25-17)20-24-16-8-9-18(26-19(16)27-20)29-12-6-7-15(13-29)22(30)28-10-4-5-11-28/h8-9,14-15H,4-7,10-13H2,1-3H3,(H,24,26,27)/t15-/s2
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n/an/a 3.18n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215599
PNG
(US9296745, 158)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)C1CC1)N1CC=CC1
Show InChI InChI=1/C24H26N6O/c31-24(29-12-1-2-13-29)17-5-4-14-30(15-17)21-11-10-20-23(27-21)28-22(26-20)19-7-3-6-18(25-19)16-8-9-16/h1-3,6-7,10-11,16-17H,4-5,8-9,12-15H2,(H,26,27,28)/t17-/s2
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n/an/a 3.58n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215486
PNG
(US9296745, 154 | US9296745, 41)
Show SMILES Clc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H24ClN5O/c23-17-7-3-5-15(13-17)20-24-18-8-9-19(25-21(18)26-20)28-12-4-6-16(14-28)22(29)27-10-1-2-11-27/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,24,25,26)/t16-/s2
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n/an/a 4.56n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215629
PNG
(US9296745, 196-A | US9296745, 196-B)
Show SMILES C[C@@H](c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C21H26ClN7O/c1-14(29-13-16(22)11-23-29)19-24-17-6-7-18(25-20(17)26-19)28-10-4-5-15(12-28)21(30)27-8-2-3-9-27/h6-7,11,13-15H,2-5,8-10,12H2,1H3,(H,24,25,26)/t14-,15+/s2
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n/an/a 4.60n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215448
PNG
(US9296745, 3)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-n1cccn1)N1CCCC1
Show InChI InChI=1/C25H27N7O/c33-25(30-12-1-2-13-30)19-7-4-14-31(17-19)22-10-9-21-24(28-22)29-23(27-21)18-6-3-8-20(16-18)32-15-5-11-26-32/h3,5-6,8-11,15-16,19H,1-2,4,7,12-14,17H2,(H,27,28,29)/t19-/s2
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n/an/a 4.82n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215568
PNG
(US9296745, 124)
Show SMILES CCOC(=O)C1(CC1)c1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C28H33N5O3/c1-2-36-27(35)28(12-13-28)21-9-5-7-19(17-21)24-29-22-10-11-23(30-25(22)31-24)33-16-6-8-20(18-33)26(34)32-14-3-4-15-32/h5,7,9-11,17,20H,2-4,6,8,12-16,18H2,1H3,(H,29,30,31)/t20-/s2
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n/an/a 5.27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215660
PNG
(US9296745, 197)
Show SMILES C[C@H](c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C21H26ClN7O/c1-14(29-13-16(22)11-23-29)19-24-17-6-7-18(25-20(17)26-19)28-10-4-5-15(12-28)21(30)27-8-2-3-9-27/h6-7,11,13-15H,2-5,8-10,12H2,1H3,(H,24,25,26)/t14-,15-/s2
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Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26ClN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27)/t15-/s2
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n/an/a 5.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215549
PNG
(US9296745, 106)
Show SMILES FC(F)(F)c1ccc(cc1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C26H28F3N5O/c27-26(28,29)19-7-5-18(6-8-19)25(11-12-25)24-30-20-9-10-21(31-22(20)32-24)34-15-3-4-17(16-34)23(35)33-13-1-2-14-33/h5-10,17H,1-4,11-16H2,(H,30,31,32)/t17-/s2
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n/an/a 5.68n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215594
PNG
(US9296745, 153 | US9296745, 182)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)C1CC1)N1CCCC1
Show InChI InChI=1/C24H28N6O/c31-24(29-12-1-2-13-29)17-5-4-14-30(15-17)21-11-10-20-23(27-21)28-22(26-20)19-7-3-6-18(25-19)16-8-9-16/h3,6-7,10-11,16-17H,1-2,4-5,8-9,12-15H2,(H,26,27,28)/t17-/s2
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n/an/a 6.03n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215579
PNG
(US9296745, 136)
Show SMILES Fc1cc2nc([nH]c2nc1N1CCC[C@H](C1)C(=O)N1CCCC1)-c1ccnc(n1)C1CC1
Show InChI InChI=1/C23H26FN7O/c24-16-12-18-21(28-20(27-18)17-7-8-25-19(26-17)14-5-6-14)29-22(16)31-11-3-4-15(13-31)23(32)30-9-1-2-10-30/h7-8,12,14-15H,1-6,9-11,13H2,(H,27,28,29)/t15-/s2
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n/an/a 6.32n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215485
PNG
(US9296745, 40)
Show SMILES CCc1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H26N6OS/c1-2-15-13-29-20(22-15)19-23-16-7-8-17(24-18(16)25-19)27-11-5-6-14(12-27)21(28)26-9-3-4-10-26/h7-8,13-14H,2-6,9-12H2,1H3,(H,23,24,25)/t14-/s2
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n/an/a 6.47n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215449
PNG
(US9296745, 4)
Show SMILES CC(C)c1csc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H28N6OS/c1-14(2)17-13-30-21(24-17)20-23-16-7-8-18(25-19(16)26-20)28-11-5-6-15(12-28)22(29)27-9-3-4-10-27/h7-8,13-15H,3-6,9-12H2,1-2H3,(H,23,25,26)/t15-/s2
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n/an/a 6.64n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215484
PNG
(US9296745, 39)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1coc(n1)-c1ccccc1)N1CCCC1
Show InChI InChI=1/C25H26N6O2/c32-25(30-12-4-5-13-30)18-9-6-14-31(15-18)21-11-10-19-22(28-21)29-23(26-19)20-16-33-24(27-20)17-7-2-1-3-8-17/h1-3,7-8,10-11,16,18H,4-6,9,12-15H2,(H,26,28,29)/t18-/s2
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n/an/a 6.85n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215572
PNG
(US9296745, 128)
Show SMILES CCOC(=O)CCc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C27H33N5O3/c1-2-35-24(33)13-10-19-7-5-8-20(17-19)25-28-22-11-12-23(29-26(22)30-25)32-16-6-9-21(18-32)27(34)31-14-3-4-15-31/h5,7-8,11-12,17,21H,2-4,6,9-10,13-16,18H2,1H3,(H,28,29,30)/t21-/s2
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n/an/a 7.16n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215488
PNG
(US9296745, 155 | US9296745, 43)
Show SMILES FC(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H25F2N5O2/c24-23(25)32-17-7-3-5-15(13-17)20-26-18-8-9-19(27-21(18)28-20)30-12-4-6-16(14-30)22(31)29-10-1-2-11-29/h3,5,7-9,13,16,23H,1-2,4,6,10-12,14H2,(H,26,27,28)/t16-/s2
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n/an/a 7.41n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215631
PNG
(US9296745, 198)
Show SMILES C[C@@H](c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C20H25ClN8O/c1-13(29-12-15(21)9-23-29)17-24-16-10-22-20(26-18(16)25-17)28-8-4-5-14(11-28)19(30)27-6-2-3-7-27/h9-10,12-14H,2-8,11H2,1H3,(H,22,24,25,26)/t13-,14+/s2
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n/an/a 7.80n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215483
PNG
(US9296745, 38)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)N1CCCC1)N1CCCC1
Show InChI InChI=1/C25H31N7O/c33-25(31-14-3-4-15-31)18-7-6-16-32(17-18)22-11-10-20-24(28-22)29-23(27-20)19-8-5-9-21(26-19)30-12-1-2-13-30/h5,8-11,18H,1-4,6-7,12-17H2,(H,27,28,29)/t18-/s2
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n/an/a 7.81n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215517
PNG
(US9296745, 73)
Show SMILES Fc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26FN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27)/t15-/s2
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n/an/a 7.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215450
PNG
(US9296745, 5)
Show SMILES Cc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H27N5O/c1-16-6-4-7-17(14-16)21-24-19-9-10-20(25-22(19)26-21)28-13-5-8-18(15-28)23(29)27-11-2-3-12-27/h4,6-7,9-10,14,18H,2-3,5,8,11-13,15H2,1H3,(H,24,25,26)/t18-/s2
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n/an/a 8.24n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215640
PNG
(US9296745, 209)
Show SMILES Fc1cnn(c1)C1(CC1)c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H25FN8O/c22-15-10-24-30(13-15)21(5-6-21)19-25-16-11-23-20(27-17(16)26-19)29-9-3-4-14(12-29)18(31)28-7-1-2-8-28/h10-11,13-14H,1-9,12H2,(H,23,25,26,27)/t14-/s2
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n/an/a 8.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215589
PNG
(US9296745, 147)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)C1CCC1)N1CCCC1
Show InChI InChI=1/C24H29N7O/c32-24(30-12-1-2-13-30)17-7-4-14-31(15-17)20-9-8-18-23(28-20)29-22(27-18)19-10-11-25-21(26-19)16-5-3-6-16/h8-11,16-17H,1-7,12-15H2,(H,27,28,29)/t17-/s2
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n/an/a 9.21n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215556
PNG
(US9296745, 112)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H23F3N6O/c23-22(24,25)17-7-3-6-15(26-17)19-27-16-8-9-18(28-20(16)29-19)31-12-4-5-14(13-31)21(32)30-10-1-2-11-30/h3,6-9,14H,1-2,4-5,10-13H2,(H,27,28,29)/t14-/s2
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n/an/a 9.23n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215522
PNG
(US9296745, 78)
Show SMILES FC(F)(F)c1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H26F3N7O/c24-23(25,26)16-12-27-33(14-16)22(7-8-22)21-28-17-5-6-18(29-19(17)30-21)32-11-3-4-15(13-32)20(34)31-9-1-2-10-31/h5-6,12,14-15H,1-4,7-11,13H2,(H,28,29,30)/t15-/s2
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n/an/a 9.40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215528
PNG
(US9296745, 84)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1nc(cs1)C1CC1)N1CCCC1
Show InChI InChI=1/C22H26N6OS/c29-22(27-9-1-2-10-27)15-4-3-11-28(12-15)18-8-7-16-19(25-18)26-20(23-16)21-24-17(13-30-21)14-5-6-14/h7-8,13-15H,1-6,9-12H2,(H,23,25,26)/t15-/s2
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n/an/a 9.55n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215623
PNG
(US9296745, 187)
Show SMILES FC(F)(F)c1cccc(n1)-c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H22F3N7O/c22-21(23,24)16-7-3-6-14(26-16)17-27-15-11-25-20(29-18(15)28-17)31-10-4-5-13(12-31)19(32)30-8-1-2-9-30/h3,6-7,11,13H,1-2,4-5,8-10,12H2,(H,25,27,28,29)/t13-/s2
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n/an/a 10.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215492
PNG
(US9296745, 48)
Show SMILES Clc1ccc(OCc2nc3ccc(nc3[nH]2)N2CCC[C@H](C2)C(=O)N2CCCC2)cc1
Show InChI InChI=1/C23H26ClN5O2/c24-17-5-7-18(8-6-17)31-15-20-25-19-9-10-21(27-22(19)26-20)29-13-3-4-16(14-29)23(30)28-11-1-2-12-28/h5-10,16H,1-4,11-15H2,(H,25,26,27)/t16-/s2
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n/an/a 10.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215584
PNG
(US9296745, 141)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCO[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H24ClN7O2/c22-14-11-23-29(12-14)21(5-6-21)20-24-15-3-4-17(25-18(15)26-20)28-9-10-31-16(13-28)19(30)27-7-1-2-8-27/h3-4,11-12,16H,1-2,5-10,13H2,(H,24,25,26)/t16-/s2
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n/an/a 10.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215566
PNG
(US9296745, 122)
Show SMILES FC(F)c1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H24F2N6O/c23-19(24)15-6-3-7-16(25-15)20-26-17-8-9-18(27-21(17)28-20)30-12-4-5-14(13-30)22(31)29-10-1-2-11-29/h3,6-9,14,19H,1-2,4-5,10-13H2,(H,26,27,28)/t14-/s2
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n/an/a 10.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215451
PNG
(US9296745, 6)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-c1cnco1)N1CCCC1
Show InChI InChI=1/C25H26N6O2/c32-25(30-10-1-2-11-30)19-7-4-12-31(15-19)22-9-8-20-24(28-22)29-23(27-20)18-6-3-5-17(13-18)21-14-26-16-33-21/h3,5-6,8-9,13-14,16,19H,1-2,4,7,10-12,15H2,(H,27,28,29)/t19-/s2
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n/an/a 11.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215482
PNG
(US9296745, 37)
Show SMILES COc1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26N6O2/c1-30-19-8-4-7-16(23-19)20-24-17-9-10-18(25-21(17)26-20)28-13-5-6-15(14-28)22(29)27-11-2-3-12-27/h4,7-10,15H,2-3,5-6,11-14H2,1H3,(H,24,25,26)/t15-/s2
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n/an/a 12.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26ClN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27)/t15-/s2
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n/an/a 13.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215565
PNG
(US9296745, 121)
Show SMILES FC(F)Oc1cccc(n1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H24F2N6O2/c23-22(24)32-18-7-3-6-15(25-18)19-26-16-8-9-17(27-20(16)28-19)30-12-4-5-14(13-30)21(31)29-10-1-2-11-29/h3,6-9,14,22H,1-2,4-5,10-13H2,(H,26,27,28)/t14-/s2
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n/an/a 14.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215629
PNG
(US9296745, 196-A | US9296745, 196-B)
Show SMILES C[C@@H](c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C21H26ClN7O/c1-14(29-13-16(22)11-23-29)19-24-17-6-7-18(25-20(17)26-19)28-10-4-5-15(12-28)21(30)27-8-2-3-9-27/h6-7,11,13-15H,2-5,8-10,12H2,1H3,(H,24,25,26)/t14-,15+/s2
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n/an/a 14.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215620
PNG
(US9296745, 184)
Show SMILES FC1(F)CCN(C1)C(=O)[C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(n1)C1CC1
Show InChI InChI=1/C24H26F2N6O/c25-24(26)10-12-32(14-24)23(33)16-3-2-11-31(13-16)20-9-8-19-22(29-20)30-21(28-19)18-5-1-4-17(27-18)15-6-7-15/h1,4-5,8-9,15-16H,2-3,6-7,10-14H2,(H,28,29,30)/t16-/s2
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n/an/a 15.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215526
PNG
(US9296745, 82)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1(CC1)c1ccccn1)N1CCCC1
Show InChI InChI=1/C24H28N6O/c31-22(29-13-3-4-14-29)17-6-5-15-30(16-17)20-9-8-18-21(27-20)28-23(26-18)24(10-11-24)19-7-1-2-12-25-19/h1-2,7-9,12,17H,3-6,10-11,13-16H2,(H,26,27,28)/t17-/s2
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n/an/a 15.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215538
PNG
(US9296745, 95)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)C1CC1)N1CCCC1
Show InChI InChI=1/C23H27N7O/c31-23(29-11-1-2-12-29)16-4-3-13-30(14-16)19-8-7-17-22(27-19)28-21(26-17)18-9-10-24-20(25-18)15-5-6-15/h7-10,15-16H,1-6,11-14H2,(H,26,27,28)/t16-/s2
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n/an/a 15.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215452
PNG
(US9296745, 7)
Show SMILES Clc1cncc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C21H23ClN6O/c22-16-10-15(11-23-12-16)19-24-17-5-6-18(25-20(17)26-19)28-9-3-4-14(13-28)21(29)27-7-1-2-8-27/h5-6,10-12,14H,1-4,7-9,13H2,(H,24,25,26)/t14-/s2
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n/an/a 16.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215538
PNG
(US9296745, 95)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)C1CC1)N1CCCC1
Show InChI InChI=1/C23H27N7O/c31-23(29-11-1-2-12-29)16-4-3-13-30(14-16)19-8-7-17-22(27-19)28-21(26-17)18-9-10-24-20(25-18)15-5-6-15/h7-10,15-16H,1-6,11-14H2,(H,26,27,28)/t16-/s2
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n/an/a 18.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215643
PNG
(US9296745, 212)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CC=CC1
Show InChI InChI=1/C22H24ClN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h1-2,5-6,12,14-15H,3-4,7-11,13H2,(H,25,26,27)/t15-/s2
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n/an/a 18.9n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215661
PNG
(US9296745, 199)
Show SMILES C[C@H](c1nc2cnc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1)n1cc(Cl)cn1
Show InChI InChI=1/C20H25ClN8O/c1-13(29-12-15(21)9-23-29)17-24-16-10-22-20(26-18(16)25-17)28-8-4-5-14(11-28)19(30)27-6-2-3-7-27/h9-10,12-14H,2-8,11H2,1H3,(H,22,24,25,26)/t13-,14-/s2
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215552
PNG
(US9296745, 109-A | US9296745, 109-B | US9296745, 1...)
Show SMILES Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H26ClN7O/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27)/t15-/s2
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215481
PNG
(US9296745, 36)
Show SMILES COc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H27N5O2/c1-30-18-8-4-6-16(14-18)21-24-19-9-10-20(25-22(19)26-21)28-13-5-7-17(15-28)23(29)27-11-2-3-12-27/h4,6,8-10,14,17H,2-3,5,7,11-13,15H2,1H3,(H,24,25,26)/t17-/s2
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215453
PNG
(US9296745, 8)
Show SMILES CNS(=O)(=O)c1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C23H28N6O3S/c1-24-33(31,32)18-8-4-6-16(14-18)21-25-19-9-10-20(26-22(19)27-21)29-13-5-7-17(15-29)23(30)28-11-2-3-12-28/h4,6,8-10,14,17,24H,2-3,5,7,11-13,15H2,1H3,(H,25,26,27)/t17-/s2
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM215480
PNG
(US9296745, 35)
Show SMILES Fc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
Show InChI InChI=1/C22H24FN5O/c23-17-7-3-5-15(13-17)20-24-18-8-9-19(25-21(18)26-20)28-12-4-6-16(14-28)22(29)27-10-1-2-11-27/h3,5,7-9,13,16H,1-2,4,6,10-12,14H2,(H,24,25,26)/t16-/s2
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)

More data for this
Ligand-Target Pair
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