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Compile Data Set for Download or QSAR

Found 57 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50429009
PNG
(CHEMBL2334100)
Show SMILES Cc1c(oc2ccc(cc12)-c1ccccc1)C(=O)Nc1ccc(nc1)N1CCC(COc2cccc(c2)C(O)=O)CC1
Show InChI InChI=1S/C34H31N3O5/c1-22-29-19-25(24-6-3-2-4-7-24)10-12-30(29)42-32(22)33(38)36-27-11-13-31(35-20-27)37-16-14-23(15-17-37)21-41-28-9-5-8-26(18-28)34(39)40/h2-13,18-20,23H,14-17,21H2,1H3,(H,36,38)(H,39,40)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver flag-tagged DGAT2 expressed in baculovirus infected insect cells after 2 hrs by SPA


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50009432
PNG
(CHEMBL3233884)
Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H30N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h1-5,10-15,19-21H,6-9,16-18H2,(H,30,34)(H,32,33)/t20-,21-
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433269
PNG
(CHEMBL2376303)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H17F2N3O4S/c1-3-18(2)17(25)21-14-7-5-11(9-12(14)16(24)22-18)28(26,27)23-15-6-4-10(19)8-13(15)20/h4-9,23H,3H2,1-2H3,(H,21,25)(H,22,24)/t18-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50020045
PNG
(CHEMBL3287865)
Show SMILES C[C@@H]1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C30H32N2O4/c1-20-19-32(30(35)31-26-5-3-2-4-6-26)27-16-15-25(18-28(27)36-20)24-13-11-23(12-14-24)22-9-7-21(8-10-22)17-29(33)34/h2-6,11-16,18,20-22H,7-10,17,19H2,1H3,(H,31,35)(H,33,34)/t20-,21-,22-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50394726
PNG
(CHEMBL2165819)
Show SMILES Nc1c(cnc2ccnn12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C20H22N4O2/c21-20-17(12-22-18-9-10-23-24(18)20)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-19(25)26/h5-10,12-14H,1-4,11,21H2,(H,25,26)/t13-,14-
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 expressed in insect cell membrane using [1-14C]decanoyl-CoA substrate by phospholipid flash plate assay


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50009432
PNG
(CHEMBL3233884)
Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H30N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h1-5,10-15,19-21H,6-9,16-18H2,(H,30,34)(H,32,33)/t20-,21-
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433270
PNG
(CHEMBL2376329)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O5S/c1-4-19(2)18(24)20-16-10-9-14(11-15(16)17(23)21-19)28(25,26)22-12-5-7-13(27-3)8-6-12/h5-11,22H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433271
PNG
(CHEMBL2376327)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-14-9-8-11(10-12(14)16(23)21-18)27(25,26)22-15-7-5-4-6-13(15)19/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433272
PNG
(CHEMBL2376325)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-15-9-8-13(10-14(15)16(23)21-18)27(25,26)22-12-6-4-11(19)5-7-12/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433273
PNG
(CHEMBL2376322)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C18H19N3O4S/c1-3-18(2)17(23)19-15-10-9-13(11-14(15)16(22)20-18)26(24,25)21-12-7-5-4-6-8-12/h4-11,21H,3H2,1-2H3,(H,19,23)(H,20,22)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM27947
PNG
(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human DGAT-2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433274
PNG
(CHEMBL2376321)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC(F)F)cc1
Show InChI InChI=1S/C19H19F2N3O5S/c1-3-19(2)17(26)22-15-9-8-13(10-14(15)16(25)23-19)30(27,28)24-11-4-6-12(7-5-11)29-18(20)21/h4-10,18,24H,3H2,1-2H3,(H,22,26)(H,23,25)/t19-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433275
PNG
(CHEMBL2376320)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O4S/c1-3-18(2)17(27)23-15-9-8-13(10-14(15)16(26)24-18)30(28,29)25-12-6-4-11(5-7-12)19(20,21)22/h4-10,25H,3H2,1-2H3,(H,23,27)(H,24,26)/t18-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433276
PNG
(CHEMBL2376316)
Show SMILES CCC1(CC)CNc2ccc(cc2C(=O)N1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H21F2N3O3S/c1-3-19(4-2)11-22-16-8-6-13(10-14(16)18(25)23-19)28(26,27)24-17-7-5-12(20)9-15(17)21/h5-10,22,24H,3-4,11H2,1-2H3,(H,23,25)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433279
PNG
(CHEMBL2376311)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)N(C)c1ccccc1
Show InChI InChI=1S/C19H21N3O4S/c1-4-19(2)18(24)20-16-11-10-14(12-15(16)17(23)21-19)27(25,26)22(3)13-8-6-5-7-9-13/h5-12H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433278
PNG
(CHEMBL2376312)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2N(C)C1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O4S/c1-4-19(2)18(25)23(3)16-10-9-14(11-15(16)17(24)21-19)28(26,27)22-13-7-5-12(20)6-8-13/h5-11,22H,4H2,1-3H3,(H,21,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50433277
PNG
(CHEMBL2376313)
Show SMILES CCC1(C)N(C)C(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H19F2N3O4S/c1-4-19(2)18(26)22-15-8-6-12(10-13(15)17(25)24(19)3)29(27,28)23-16-7-5-11(20)9-14(16)21/h5-10,23H,4H2,1-3H3,(H,22,26)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT2 using dioleoyl-sn-glycerol and [14C]oleoyl coenzyme A as substrate after 30 mins by liquid scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50362682
PNG
(CHEMBL1939473)
Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3)cc2)n1C)C(O)=O
Show InChI InChI=1S/C19H18N4O3S/c1-12(18(25)26)27-19-22-21-16(23(19)2)13-8-10-15(11-9-13)20-17(24)14-6-4-3-5-7-14/h3-12H,1-2H3,(H,20,24)(H,25,26)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Prosidion Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT2 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50437753
PNG
(CHEMBL2409564)
Show SMILES OC(=O)CC1CCC(CC1)c1ccc(cc1)-c1nc2ccc(NC(=O)c3nc(oc3C(F)(F)F)-c3ccccc3)cc2[nH]1
Show InChI InChI=1S/C32H27F3N4O4/c33-32(34,35)28-27(39-31(43-28)22-4-2-1-3-5-22)30(42)36-23-14-15-24-25(17-23)38-29(37-24)21-12-10-20(11-13-21)19-8-6-18(7-9-19)16-26(40)41/h1-5,10-15,17-19H,6-9,16H2,(H,36,42)(H,37,38)(H,40,41)
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Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human DGAT-2 expressed in Hep3B cell lysate using didecanoyl glycerol and [14C]oleoyl-CoA as substrate after 120 mins by li...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50388918
PNG
(CHEMBL2063278)
Show SMILES CCOC(=O)Nc1ccc2nc([nH]c2c1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H13Cl2N3O2/c1-2-23-16(22)19-9-6-7-12-13(8-9)21-15(20-12)14-10(17)4-3-5-11(14)18/h3-8H,2H2,1H3,(H,19,22)(H,20,21)
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TBA

Assay Description
Inhibition of DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50363956
PNG
(CHEMBL1952025)
Show SMILES Nc1ncnc2CCN(C(=O)c12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
Show InChI InChI=1S/C21H24N4O3/c22-20-19-17(23-12-24-20)9-10-25(21(19)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-18(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
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TBA

Assay Description
Inhibition of human DGAT-2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50438735
PNG
(CHEMBL2414670)
Show SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1
Show InChI InChI=1S/C23H26N6O3/c1-14-27-19(32-28-14)12-15-2-4-16(5-3-15)17-6-8-18(9-7-17)29-10-11-31-22-20(23(29)30)21(24)25-13-26-22/h6-9,13,15-16H,2-5,10-12H2,1H3,(H2,24,25,26)/t15-,16-
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50090510
PNG
(CHEMBL3581716)
Show SMILES CC(=O)Nc1cc(cc2CCN(CCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C24H23F2N3O3S/c1-16(30)27-23-15-20(33(31,32)28-22-8-7-19(25)14-21(22)26)13-18-10-12-29(24(18)23)11-9-17-5-3-2-4-6-17/h2-8,13-15,28H,9-12H2,1H3,(H,27,30)
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Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human DGAT2 transfected in Sf-21 cells using [1-14C]oleoyl-CoA assessed as incorporation of radioactivity into lip...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50355142
PNG
(CHEMBL1835919)
Show SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
Show InChI InChI=1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
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TBA

Assay Description
Inhibition of human DGAT-2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50117659
PNG
(CHEMBL3613703)
Show SMILES COc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)NCCc2cccc(F)c2)c1
Show InChI InChI=1S/C25H25FN2O4S/c1-32-23-7-3-5-19(13-23)14-25(29)28-16-20-8-9-24(15-21(20)17-28)33(30,31)27-11-10-18-4-2-6-22(26)12-18/h2-9,12-13,15,27H,10-11,14,16-17H2,1H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT2 (unknown origin) using [1-14C]decanoyl-CoA and didecanoyl-sn-glycerol substrates incubated for 40 mins


J Med Chem 58: 7164-72 (2015)

More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50009391
PNG
(CHEMBL3233872)
Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2n(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H28N2O3/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-27-25(19-24)16-17-31(27)29(34)30-26-4-2-1-3-5-26/h1-5,10-17,19-21H,6-9,18H2,(H,30,34)(H,32,33)/t20-,21-
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50429008
PNG
(CHEMBL2334082)
Show SMILES OC(=O)c1cccc(OCC2CCN(CC2)c2ccc(NC(=O)c3cccc(Oc4ccccc4)c3)cn2)c1
Show InChI InChI=1S/C31H29N3O5/c35-30(23-6-4-11-28(18-23)39-26-8-2-1-3-9-26)33-25-12-13-29(32-20-25)34-16-14-22(15-17-34)21-38-27-10-5-7-24(19-27)31(36)37/h1-13,18-20,22H,14-17,21H2,(H,33,35)(H,36,37)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50009391
PNG
(CHEMBL3233872)
Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2n(ccc2c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C29H28N2O3/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-27-25(19-24)16-17-31(27)29(34)30-26-4-2-1-3-5-26/h1-5,10-17,19-21H,6-9,18H2,(H,30,34)(H,32,33)/t20-,21-
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT2


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433273
PNG
(CHEMBL2376322)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C18H19N3O4S/c1-3-18(2)17(23)19-15-10-9-13(11-14(15)16(22)20-18)26(24,25)21-12-7-5-4-6-8-12/h4-11,21H,3H2,1-2H3,(H,19,23)(H,20,22)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433272
PNG
(CHEMBL2376325)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-15-9-8-13(10-14(15)16(23)21-18)27(25,26)22-12-6-4-11(19)5-7-12/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433271
PNG
(CHEMBL2376327)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-14-9-8-11(10-12(14)16(23)21-18)27(25,26)22-15-7-5-4-6-13(15)19/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433270
PNG
(CHEMBL2376329)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O5S/c1-4-19(2)18(24)20-16-10-9-14(11-15(16)17(23)21-19)28(25,26)22-12-5-7-13(27-3)8-6-12/h5-11,22H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433269
PNG
(CHEMBL2376303)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H17F2N3O4S/c1-3-18(2)17(25)21-14-7-5-11(9-12(14)16(24)22-18)28(26,27)23-15-6-4-10(19)8-13(15)20/h4-9,23H,3H2,1-2H3,(H,21,25)(H,22,24)/t18-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433279
PNG
(CHEMBL2376311)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)N(C)c1ccccc1
Show InChI InChI=1S/C19H21N3O4S/c1-4-19(2)18(24)20-16-11-10-14(12-15(16)17(23)21-19)27(25,26)22(3)13-8-6-5-7-9-13/h5-12H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433278
PNG
(CHEMBL2376312)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2N(C)C1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O4S/c1-4-19(2)18(25)23(3)16-10-9-14(11-15(16)17(24)21-19)28(26,27)22-13-7-5-12(20)6-8-13/h5-11,22H,4H2,1-3H3,(H,21,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433277
PNG
(CHEMBL2376313)
Show SMILES CCC1(C)N(C)C(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H19F2N3O4S/c1-4-19(2)18(26)22-15-8-6-12(10-13(15)17(25)24(19)3)29(27,28)23-16-7-5-11(20)9-14(16)21/h5-10,23H,4H2,1-3H3,(H,22,26)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433276
PNG
(CHEMBL2376316)
Show SMILES CCC1(CC)CNc2ccc(cc2C(=O)N1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H21F2N3O3S/c1-3-19(4-2)11-22-16-8-6-13(10-14(16)18(25)23-19)28(26,27)24-17-7-5-12(20)9-15(17)21/h5-10,22,24H,3-4,11H2,1-2H3,(H,23,25)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 1


(Homo sapiens)
BDBM50433275
PNG
(CHEMBL2376320)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O4S/c1-3-18(2)17(27)23-15-9-8-13(10-14(15)16(26)24-18)30(28,29)25-12-6-4-11(5-7-12)19(20,21)22/h4-10,25H,3H2,1-2H3,(H,23,27)(H,24,26)/t18-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT1 expressed in insect cell membrane using palmitoleyl alcohol and [14C]stearoyl coenzyme A as substrate after 10 ...


Citation and Details
More data for this
Ligand-Target Pair
Diacyl Glycerolacyltransferase 2 (DGAT-2)


(Homo sapiens (human))
BDBM50117665
PNG
(CHEMBL3613709)
Show SMILES COc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)Nc2cnn(n2)C2CCC2)c1
Show InChI InChI=1S/C23H25N5O4S/c1-32-20-7-2-4-16(10-20)11-23(29)27-14-17-8-9-21(12-18(17)15-27)33(30,31)26-22-13-24-28(25-22)19-5-3-6-19/h2,4,7-10,12-13,19H,3,5-6,11,14-15H2,1H3,(H,25,26)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT2 (unknown origin) using [1-14C]decanoyl-CoA and didecanoyl-sn-glycerol substrates incubated for 40 mins


J Med Chem 58: 7164-72 (2015)

More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433273
PNG
(CHEMBL2376322)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C18H19N3O4S/c1-3-18(2)17(23)19-15-10-9-13(11-14(15)16(22)20-18)26(24,25)21-12-7-5-4-6-8-12/h4-11,21H,3H2,1-2H3,(H,19,23)(H,20,22)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433272
PNG
(CHEMBL2376325)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-15-9-8-13(10-14(15)16(23)21-18)27(25,26)22-12-6-4-11(19)5-7-12/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433271
PNG
(CHEMBL2376327)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C18H18ClN3O4S/c1-3-18(2)17(24)20-14-9-8-11(10-12(14)16(23)21-18)27(25,26)22-15-7-5-4-6-13(15)19/h4-10,22H,3H2,1-2H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433270
PNG
(CHEMBL2376329)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(OC)cc1
Show InChI InChI=1S/C19H21N3O5S/c1-4-19(2)18(24)20-16-10-9-14(11-15(16)17(23)21-19)28(25,26)22-12-5-7-13(27-3)8-6-12/h5-11,22H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433269
PNG
(CHEMBL2376303)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H17F2N3O4S/c1-3-18(2)17(25)21-14-7-5-11(9-12(14)16(24)22-18)28(26,27)23-15-6-4-10(19)8-13(15)20/h4-9,23H,3H2,1-2H3,(H,21,25)(H,22,24)/t18-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433279
PNG
(CHEMBL2376311)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)N(C)c1ccccc1
Show InChI InChI=1S/C19H21N3O4S/c1-4-19(2)18(24)20-16-11-10-14(12-15(16)17(23)21-19)27(25,26)22(3)13-8-6-5-7-9-13/h5-12H,4H2,1-3H3,(H,20,24)(H,21,23)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433278
PNG
(CHEMBL2376312)
Show SMILES CCC1(C)NC(=O)c2cc(ccc2N(C)C1=O)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20ClN3O4S/c1-4-19(2)18(25)23(3)16-10-9-14(11-15(16)17(24)21-19)28(26,27)22-13-7-5-12(20)6-8-13/h5-11,22H,4H2,1-3H3,(H,21,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433277
PNG
(CHEMBL2376313)
Show SMILES CCC1(C)N(C)C(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H19F2N3O4S/c1-4-19(2)18(26)22-15-8-6-12(10-13(15)17(25)24(19)3)29(27,28)23-16-7-5-11(20)9-14(16)21/h5-10,23H,4H2,1-3H3,(H,22,26)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433276
PNG
(CHEMBL2376316)
Show SMILES CCC1(CC)CNc2ccc(cc2C(=O)N1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H21F2N3O3S/c1-3-19(4-2)11-22-16-8-6-13(10-14(16)18(25)23-19)28(26,27)24-17-7-5-12(20)9-15(17)21/h5-10,22,24H,3-4,11H2,1-2H3,(H,23,25)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acyl-CoA wax alcohol acyltransferase 2


(Homo sapiens)
BDBM50433275
PNG
(CHEMBL2376320)
Show SMILES CC[C@]1(C)NC(=O)c2cc(ccc2NC1=O)S(=O)(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N3O4S/c1-3-18(2)17(27)23-15-9-8-13(10-14(15)16(26)24-18)30(28,29)25-12-6-4-11(5-7-12)19(20,21)22/h4-10,25H,3H2,1-2H3,(H,23,27)(H,24,26)/t18-/m0/s1
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant AWAT2 expressed in insect cell membrane using cetyl alcohol and [14C]oleoyl coenzyme A as substrate after 10 to 15 mi...


Citation and Details
More data for this
Ligand-Target Pair
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