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Found 6 hits Enz. Inhib. hit(s) with Target = 'Dickkopf-related protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303038
PNG
(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-a...)
Show SMILES NC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H20N4/c20-17-8-11-23(12-9-17)19-21-10-7-18(22-19)16-6-5-14-3-1-2-4-15(14)13-16/h1-7,10,13,17H,8-9,11-12,20H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303039
PNG
(4-(4-(naphthalen-2-yl)pyrimidin-2-ylamino)benzenes...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C20H16N4O2S/c21-27(25,26)18-9-7-17(8-10-18)23-20-22-12-11-19(24-20)16-6-5-14-3-1-2-4-15(14)13-16/h1-13H,(H2,21,25,26)(H,22,23,24)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303037
PNG
((1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-...)
Show SMILES NCC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2
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n/an/an/an/a 630n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303035
PNG
(4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...)
Show SMILES Cc1ccc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1
Show InChI InChI=1S/C15H14N4O2S2/c1-10-2-7-14(22-10)13-8-9-17-15(19-13)18-11-3-5-12(6-4-11)23(16,20)21/h2-9H,1H3,(H2,16,20,21)(H,17,18,19)
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n/an/an/an/a 7.80E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303036
PNG
(CHEMBL569986 | N-((1-(4-(naphthalen-2-yl)pyrimidin...)
Show SMILES CC(=O)NCC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C22H24N4O/c1-16(27)24-15-17-9-12-26(13-10-17)22-23-11-8-21(25-22)20-7-6-18-4-2-3-5-19(18)14-20/h2-8,11,14,17H,9-10,12-13,15H2,1H3,(H,24,27)
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n/an/an/an/a 1.90E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair
Dickkopf-related protein 1


(Homo sapiens)
BDBM50303040
PNG
(4-(methyl(4-(5-methylthiophen-2-yl)pyrimidin-2-yl)...)
Show SMILES CN(c1ccc(cc1)S(N)(=O)=O)c1nccc(n1)-c1ccc(C)s1
Show InChI InChI=1S/C16H16N4O2S2/c1-11-3-8-15(23-11)14-9-10-18-16(19-14)20(2)12-4-6-13(7-5-12)24(17,21)22/h3-10H,1-2H3,(H2,17,21,22)
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n/an/an/an/a 9.80E+3n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response


Citation and Details
More data for this
Ligand-Target Pair