BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 77 hits Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' AND taxid = 485   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50018474
PNG
(4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dipropyl-...)
Show SMILES CCCc1cc(Cc2cnc(N)nc2N)cc(CCC)c1O
Show InChI InChI=1S/C17H24N4O/c1-3-5-12-7-11(8-13(6-4-2)15(12)22)9-14-10-20-17(19)21-16(14)18/h7-8,10,22H,3-6,9H2,1-2H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421796
PNG
(CHEMBL118480)
Show SMILES Nc1ncc(Cc2cc(I)c(O)c(I)c2)c(N)n1
Show InChI InChI=1S/C11H10I2N4O/c12-7-2-5(3-8(13)9(7)18)1-6-4-16-11(15)17-10(6)14/h2-4,18H,1H2,(H4,14,15,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421814
PNG
(CHEMBL120366 | TCMDC-138050)
Show SMILES COc1c(I)cc(Cc2cnc(N)nc2N)cc1I
Show InChI InChI=1S/C12H12I2N4O/c1-19-10-8(13)3-6(4-9(10)14)2-7-5-17-12(16)18-11(7)15/h3-5H,2H2,1H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421792
PNG
(CHEMBL440946)
Show SMILES CC(C)c1cc(Cc2cnc(N)nc2N)cc(C(C)C)c1O
Show InChI InChI=1S/C17H24N4O/c1-9(2)13-6-11(7-14(10(3)4)15(13)22)5-12-8-20-17(19)21-16(12)18/h6-10,22H,5H2,1-4H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 29n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421797
PNG
(CHEMBL334021)
Show SMILES Nc1ncc(Cc2cc(I)c(OCCCOc3ccccc3)c(I)c2)c(N)n1
Show InChI InChI=1S/C20H20I2N4O2/c21-16-10-13(9-14-12-25-20(24)26-19(14)23)11-17(22)18(16)28-8-4-7-27-15-5-2-1-3-6-15/h1-3,5-6,10-12H,4,7-9H2,(H4,23,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 43n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50406029
PNG
(CHEMBL279455)
Show SMILES CCCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OC
Show InChI InChI=1S/C17H24N4O/c1-4-6-13-8-11(7-12(5-2)15(13)22-3)9-14-10-20-17(19)21-16(14)18/h7-8,10H,4-6,9H2,1-3H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421805
PNG
(CHEMBL432987)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OCCO
Show InChI InChI=1S/C17H24N4O2/c1-3-12-7-11(8-13(4-2)15(12)23-6-5-22)9-14-10-20-17(19)21-16(14)18/h7-8,10,22H,3-6,9H2,1-2H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421785
PNG
(CHEMBL116993)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OCCOCc1ccccc1
Show InChI InChI=1S/C24H30N4O2/c1-3-19-12-18(14-21-15-27-24(26)28-23(21)25)13-20(4-2)22(19)30-11-10-29-16-17-8-6-5-7-9-17/h5-9,12-13,15H,3-4,10-11,14,16H2,1-2H3,(H4,25,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421812
PNG
(CHEMBL25888)
Show SMILES CCCc1cc(Cc2cnc(N)nc2N)cc(CC)c1O
Show InChI InChI=1S/C16H22N4O/c1-3-5-12-7-10(6-11(4-2)14(12)21)8-13-9-19-16(18)20-15(13)17/h6-7,9,21H,3-5,8H2,1-2H3,(H4,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 49n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421803
PNG
(CHEMBL24374)
Show SMILES COc1c(cc(Cc2cnc(N)nc2N)cc1C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C20H30N4O/c1-19(2,3)14-9-12(8-13-11-23-18(22)24-17(13)21)10-15(16(14)25-7)20(4,5)6/h9-11H,8H2,1-7H3,(H4,21,22,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 58n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50018480
PNG
(5-(4-Methoxy-3,5-dipropyl-benzyl)-pyrimidine-2,4-d...)
Show SMILES CCCc1cc(Cc2cnc(N)nc2N)cc(CCC)c1OC
Show InChI InChI=1S/C18H26N4O/c1-4-6-13-8-12(9-14(7-5-2)16(13)23-3)10-15-11-21-18(20)22-17(15)19/h8-9,11H,4-7,10H2,1-3H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421806
PNG
(CHEMBL277176)
Show SMILES CC(C)(C)c1cc(Cc2cnc(N)nc2N)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C19H28N4O/c1-18(2,3)13-8-11(9-14(15(13)24)19(4,5)6)7-12-10-22-17(21)23-16(12)20/h8-10,24H,7H2,1-6H3,(H4,20,21,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 61n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421818
PNG
(CHEMBL280374)
Show SMILES COc1c(cc(Cc2cnc(N)nc2N)cc1C(C)C)C(C)C
Show InChI InChI=1S/C18H26N4O/c1-10(2)14-7-12(8-15(11(3)4)16(14)23-5)6-13-9-21-18(20)22-17(13)19/h7-11H,6H2,1-5H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421804
PNG
(CHEMBL118877)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OCCCOc1ccccc1
Show InChI InChI=1S/C24H30N4O2/c1-3-18-13-17(15-20-16-27-24(26)28-23(20)25)14-19(4-2)22(18)30-12-8-11-29-21-9-6-5-7-10-21/h5-7,9-10,13-14,16H,3-4,8,11-12,15H2,1-2H3,(H4,25,26,27,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 64n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421795
PNG
(CHEMBL418865)
Show SMILES CCC(C)c1cc(Cc2cnc(N)nc2N)cc(CC)c1N
Show InChI InChI=1S/C17H25N5/c1-4-10(3)14-8-11(6-12(5-2)15(14)18)7-13-9-21-17(20)22-16(13)19/h6,8-10H,4-5,7,18H2,1-3H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 75n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421794
PNG
(CHEMBL333424)
Show SMILES Nc1ncc(Cc2cc(Br)c(N)c(Br)c2)c(N)n1
Show InChI InChI=1S/C11H11Br2N5/c12-7-2-5(3-8(13)9(7)14)1-6-4-17-11(16)18-10(6)15/h2-4H,1,14H2,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 93n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421816
PNG
(CHEMBL333696)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1N
Show InChI InChI=1S/C15H21N5/c1-3-10-5-9(6-11(4-2)13(10)16)7-12-8-19-15(18)20-14(12)17/h5-6,8H,3-4,7,16H2,1-2H3,(H4,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 107n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421817
PNG
(CHEMBL25817)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1O
Show InChI InChI=1S/C15H20N4O/c1-3-10-5-9(6-11(4-2)13(10)20)7-12-8-18-15(17)19-14(12)16/h5-6,8,20H,3-4,7H2,1-2H3,(H4,16,17,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421820
PNG
(CHEMBL440334)
Show SMILES CCCCOc1c(CCC)cc(Cc2cnc(N)nc2N)cc1CCC
Show InChI InChI=1S/C21H32N4O/c1-4-7-10-26-19-16(8-5-2)11-15(12-17(19)9-6-3)13-18-14-24-21(23)25-20(18)22/h11-12,14H,4-10,13H2,1-3H3,(H4,22,23,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 132n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421799
PNG
(CHEMBL116650)
Show SMILES CC(C)c1cc(Cc2cnc(N)nc2N)cc(C(C)C)c1N
Show InChI InChI=1S/C17H25N5/c1-9(2)13-6-11(7-14(10(3)4)15(13)18)5-12-8-21-17(20)22-16(12)19/h6-10H,5,18H2,1-4H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 137n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421789
PNG
(CHEMBL23250 | TCMDC-137697)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(CC)c1OC
Show InChI InChI=1S/C16H22N4O/c1-4-11-6-10(7-12(5-2)14(11)21-3)8-13-9-19-16(18)20-15(13)17/h6-7,9H,4-5,8H2,1-3H3,(H4,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 155n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421852
PNG
(CHEMBL57807)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2CC(COC(C)=O)CNc12
Show InChI InChI=1S/C18H23N5O3/c1-10(24)26-9-12-5-13-3-11(6-15(25-2)16(13)21-7-12)4-14-8-22-18(20)23-17(14)19/h3,6,8,12,21H,4-5,7,9H2,1-2H3,(H4,19,20,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421811
PNG
(CHEMBL116183 | TCMDC-137696)
Show SMILES CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1OCC
Show InChI InChI=1S/C17H24N4O3/c1-4-22-13-8-11(7-12-10-20-17(19)21-16(12)18)9-14(23-5-2)15(13)24-6-3/h8-10H,4-7H2,1-3H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421810
PNG
(CHEMBL24155)
Show SMILES COc1c(C)cc(Cc2cnc(N)nc2N)cc1C(C)(C)C
Show InChI InChI=1S/C17H24N4O/c1-10-6-11(7-12-9-20-16(19)21-15(12)18)8-13(14(10)22-5)17(2,3)4/h6,8-9H,7H2,1-5H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 240n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421859
PNG
(CHEMBL60636)
Show SMILES CC1CC(C)c2cc(Cc3cnc(N)nc3N)cc(Cl)c2N1
Show InChI InChI=1S/C16H20ClN5/c1-8-3-9(2)21-14-12(8)5-10(6-13(14)17)4-11-7-20-16(19)22-15(11)18/h5-9,21H,3-4H2,1-2H3,(H4,18,19,20,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421802
PNG
(CHEMBL23384)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C16H22N4O/c1-9-5-10(7-12(13(9)21)16(2,3)4)6-11-8-19-15(18)20-14(11)17/h5,7-8,21H,6H2,1-4H3,(H4,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 259n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421790
PNG
(CHEMBL118237)
Show SMILES CC(C)c1cc(Cc2cnc(N)nc2N)cc(C)c1N
Show InChI InChI=1S/C15H21N5/c1-8(2)12-6-10(4-9(3)13(12)16)5-11-7-19-15(18)20-14(11)17/h4,6-8H,5,16H2,1-3H3,(H4,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421850
PNG
(CHEMBL57458)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc2C(C)CCN(C)c12
Show InChI InChI=1S/C18H25N5/c1-4-13-7-12(8-14-10-21-18(20)22-17(14)19)9-15-11(2)5-6-23(3)16(13)15/h7,9-11H,4-6,8H2,1-3H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421791
PNG
(CHEMBL23447)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(C)c1OC
Show InChI InChI=1S/C15H20N4O/c1-4-11-6-10(5-9(2)13(11)20-3)7-12-8-18-15(17)19-14(12)16/h5-6,8H,4,7H2,1-3H3,(H4,16,17,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421813
PNG
(CHEMBL120807)
Show SMILES Nc1ncc(Cc2cc(Cl)c(N)c(Cl)c2)c(N)n1
Show InChI InChI=1S/C11H11Cl2N5/c12-7-2-5(3-8(13)9(7)14)1-6-4-17-11(16)18-10(6)15/h2-4H,1,14H2,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 318n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421809
PNG
(CHEMBL118367)
Show SMILES CCCCC(CC)COc1c(CC)cc(Cc2cnc(N)nc2N)cc1CC
Show InChI InChI=1S/C23H36N4O/c1-5-9-10-16(6-2)15-28-21-18(7-3)11-17(12-19(21)8-4)13-20-14-26-23(25)27-22(20)24/h11-12,14,16H,5-10,13,15H2,1-4H3,(H4,24,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 319n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50404462
PNG
(4-Hydroxytrimethoprim | CHEMBL1181)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1O
Show InChI InChI=1S/C13H16N4O3/c1-19-9-4-7(5-10(20-2)11(9)18)3-8-6-16-13(15)17-12(8)14/h4-6,18H,3H2,1-2H3,(H4,14,15,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421807
PNG
(CHEMBL24430)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(C)c1O
Show InChI InChI=1S/C14H18N4O/c1-3-10-5-9(4-8(2)12(10)19)6-11-7-17-14(16)18-13(11)15/h4-5,7,19H,3,6H2,1-2H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421800
PNG
(CHEMBL332481)
Show SMILES CCOc1c(CC)cc(Cc2cnc(N)nc2N)cc1CC
Show InChI InChI=1S/C17H24N4O/c1-4-12-7-11(8-13(5-2)15(12)22-6-3)9-14-10-20-17(19)21-16(14)18/h7-8,10H,4-6,9H2,1-3H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 356n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421798
PNG
(CHEMBL120920)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(c1N)C(C)(C)C
Show InChI InChI=1S/C16H23N5/c1-9-5-10(7-12(13(9)17)16(2,3)4)6-11-8-20-15(19)21-14(11)18/h5,7-8H,6,17H2,1-4H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 390n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421854
PNG
(CHEMBL60632)
Show SMILES CC1CCNc2ccc(Cc3cnc(N)nc3N)cc12
Show InChI InChI=1S/C15H19N5/c1-9-4-5-18-13-3-2-10(7-12(9)13)6-11-8-19-15(17)20-14(11)16/h2-3,7-9,18H,4-6H2,1H3,(H4,16,17,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421855
PNG
(CHEMBL293977)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2CC(CO)CNc12
Show InChI InChI=1S/C16H21N5O2/c1-23-13-5-9(3-12-7-20-16(18)21-15(12)17)2-11-4-10(8-22)6-19-14(11)13/h2,5,7,10,19,22H,3-4,6,8H2,1H3,(H4,17,18,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 410n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM18069
PNG
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM18069
PNG
(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
Show InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421819
PNG
(CHEMBL118597)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(C)c1N
Show InChI InChI=1S/C13H17N5/c1-7-3-9(4-8(2)11(7)14)5-10-6-17-13(16)18-12(10)15/h3-4,6H,5,14H2,1-2H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 485n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421786
PNG
(CHEMBL287553)
Show SMILES COc1c(C)cc(Cc2cnc(N)nc2N)cc1C
Show InChI InChI=1S/C14H18N4O/c1-8-4-10(5-9(2)12(8)19-3)6-11-7-17-14(16)18-13(11)15/h4-5,7H,6H2,1-3H3,(H4,15,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421847
PNG
(CHEMBL301628)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2CCCNc12
Show InChI InChI=1S/C15H19N5O/c1-21-12-7-9(5-10-3-2-4-18-13(10)12)6-11-8-19-15(17)20-14(11)16/h5,7-8,18H,2-4,6H2,1H3,(H4,16,17,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 510n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421808
PNG
(CHEMBL417833)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(C)c1O
Show InChI InChI=1S/C13H16N4O/c1-7-3-9(4-8(2)11(7)18)5-10-6-16-13(15)17-12(10)14/h3-4,6,18H,5H2,1-2H3,(H4,14,15,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 526n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50138691
PNG
(5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine | ...)
Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC
Show InChI InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 530n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421846
PNG
(CHEMBL61260)
Show SMILES COCCOc1cc(Cc2cnc(N)nc2N)cc2CCCNc12
Show InChI InChI=1S/C17H23N5O2/c1-23-5-6-24-14-9-11(7-12-3-2-4-20-15(12)14)8-13-10-21-17(19)22-16(13)18/h7,9-10,20H,2-6,8H2,1H3,(H4,18,19,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50138691
PNG
(5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine | ...)
Show SMILES COc1ccc(Cc2cnc(N)nc2N)cc1OC
Show InChI InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Neisseria gonorrhoeae dihydrofolate reductase at 10e8 M


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421787
PNG
(CHEMBL119378)
Show SMILES CCc1cc(Cc2cnc(N)nc2N)cc(C)c1N
Show InChI InChI=1S/C14H19N5/c1-3-10-5-9(4-8(2)12(10)15)6-11-7-18-14(17)19-13(11)16/h4-5,7H,3,6,15H2,1-2H3,(H4,16,17,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421842
PNG
(CHEMBL58074)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2C(C)CCN(CCO)c12
Show InChI InChI=1S/C18H25N5O2/c1-11-3-4-23(5-6-24)16-14(11)8-12(9-15(16)25-2)7-13-10-21-18(20)22-17(13)19/h8-11,24H,3-7H2,1-2H3,(H4,19,20,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 610n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421860
PNG
(CHEMBL292839)
Show SMILES COc1cc(Cc2cnc(N)nc2N)cc2C(C)CCN(CCOC(C)=O)c12
Show InChI InChI=1S/C20H27N5O3/c1-12-4-5-25(6-7-28-13(2)26)18-16(12)9-14(10-17(18)27-3)8-15-11-23-20(22)24-19(15)21/h9-12H,4-8H2,1-3H3,(H4,21,22,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 630n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421858
PNG
(CHEMBL56652)
Show SMILES CCN1CCC(C)c2cc(Cc3cnc(N)nc3N)ccc12
Show InChI InChI=1S/C17H23N5/c1-3-22-7-6-11(2)14-9-12(4-5-15(14)22)8-13-10-20-17(19)21-16(13)18/h4-5,9-11H,3,6-8H2,1-2H3,(H4,18,19,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 690n/an/an/an/an/an/a



Wellcome Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeae


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 77 total )  |  Next  |  Last  >>
Jump to: