BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Dihydroorotase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotase


(Homo sapiens)
BDBM50010599
PNG
(6-Mercaptomethyl-2-oxo-2,3,4,5-tetrahydro-pyrimidi...)
Show SMILES OC(=O)C1CC(NC(=O)N1)C=S
Show InChI InChI=1S/C6H8N2O3S/c9-5(10)4-1-3(2-12)7-6(11)8-4/h2-4H,1H2,(H,9,10)(H2,7,8,11)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
140n/an/an/an/an/an/an/an/a



Mayo Clinic & Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydroorotase (DHO) at pH 7.4 and 8.5


J Med Chem 33: 819-23 (1990)

More data for this
Ligand-Target Pair
Dihydroorotase


(Homo sapiens)
BDBM50020110
PNG
((4S,6R)-6-Mercaptomethyl-2-oxo-hexahydro-pyrimidin...)
Show SMILES OC(=O)[C@@H]1C[C@H](CS)NC(=O)N1
Show InChI InChI=1S/C6H10N2O3S/c9-5(10)4-1-3(2-12)7-6(11)8-4/h3-4,12H,1-2H2,(H,9,10)(H2,7,8,11)/t3-,4+/m1/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
140n/an/an/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Compound ability to inhibit the catalytic activity of hamster Dihydroorotase (DHOase) expressed in E. coli.


Citation and Details
More data for this
Ligand-Target Pair
Dihydroorotase


(Homo sapiens)
BDBM50291969
PNG
((2R,4S)-4-Mercapto-4,6-dioxo-4lambda*5*-[1,4]azaph...)
Show SMILES OC(=O)[C@H]1NC(=O)CP(O)(S)=C1
Show InChI InChI=1S/C5H8NO4PS/c7-4-2-11(10,12)1-3(6-4)5(8)9/h1,3,10,12H,2H2,(H,6,7)(H,8,9)/t3-,11?/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
2.90E+3n/an/an/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Compound ability to inhibit the catalytic activity of hamster Dihydroorotase (DHOase) expressed in E. coli.


Citation and Details
More data for this
Ligand-Target Pair
Dihydroorotase


(Homo sapiens)
BDBM50291969
PNG
((2R,4S)-4-Mercapto-4,6-dioxo-4lambda*5*-[1,4]azaph...)
Show SMILES OC(=O)[C@H]1NC(=O)CP(O)(S)=C1
Show InChI InChI=1S/C5H8NO4PS/c7-4-2-11(10,12)1-3(6-4)5(8)9/h1,3,10,12H,2H2,(H,6,7)(H,8,9)/t3-,11?/m0/s1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
3.10E+3n/an/an/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Compound ability to inhibit the catalytic activity of hamster Dihydroorotase (DHOase) expressed in E. coli.


Citation and Details
More data for this
Ligand-Target Pair
Dihydroorotase


(Homo sapiens)
BDBM50067883
PNG
(4-Hydroxy-4,6-dioxo-4lambda*5*-[1,4]azaphosphinane...)
Show SMILES OC(=O)C1NC(=O)CP(O)(O)=C1
Show InChI InChI=1S/C5H8NO5P/c7-4-2-12(10,11)1-3(6-4)5(8)9/h1,3,10-11H,2H2,(H,6,7)(H,8,9)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
4.00E+3n/an/an/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Compound ability to inhibit the catalytic activity of hamster Dihydroorotase (DHOase) expressed in E. coli.


Citation and Details
More data for this
Ligand-Target Pair
Dihydroorotase


(Homo sapiens)
BDBM50010600
PNG
(CHEMBL168878 | Ethyl-3-borono-2-(carbamylamino)pro...)
Show SMILES CCOC(=O)C(CB(O)O)NC(N)=O
Show InChI InChI=1S/C6H13BN2O5/c1-2-14-5(10)4(3-7(12)13)9-6(8)11/h4,12-13H,2-3H2,1H3,(H3,8,9,11)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
5.07E+3n/an/an/an/an/an/an/an/a



Mayo Clinic & Foundation

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydroorotase (DHO) at pH 6.0


J Med Chem 33: 819-23 (1990)

More data for this
Ligand-Target Pair