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Found 14 hits Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase II' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336818
PNG
(5-(Aminomethyl)-2-benzyl-6-(2,2-dimethylpropyl)-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(Cc2ccccc2)c1C(O)=O
Show InChI InChI=1S/C26H30N2O2/c1-17-10-12-19(13-11-17)23-20(16-27)22(15-26(2,3)4)28-21(24(23)25(29)30)14-18-8-6-5-7-9-18/h5-13H,14-16,27H2,1-4H3,(H,29,30)
KEGG

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n/an/a 250n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336809
PNG
(3-[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(...)
Show SMILES CC(C)Cc1nc(C)c(CCC(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C21H28N2O2/c1-13(2)11-19-18(12-22)21(16-7-5-14(3)6-8-16)17(15(4)23-19)9-10-20(24)25/h5-8,13H,9-12,22H2,1-4H3,(H,24,25)
KEGG

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n/an/a 1.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336817
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CC(C)Cc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C23H32N2O2/c1-14(2)11-18-21(22(26)27)20(16-9-7-15(3)8-10-16)17(13-24)19(25-18)12-23(4,5)6/h7-10,14H,11-13,24H2,1-6H3,(H,26,27)
KEGG

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n/an/a 1.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336816
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-(1-methyl...)
Show SMILES CC(C)c1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-13(2)20-19(21(25)26)18(15-9-7-14(3)8-10-15)16(12-23)17(24-20)11-22(4,5)6/h7-10,13H,11-12,23H2,1-6H3,(H,25,26)
KEGG

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n/an/a 1.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336815
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-4-(4-methyl...)
Show SMILES CCCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-7-17-20(21(25)26)19(15-10-8-14(2)9-11-15)16(13-23)18(24-17)12-22(3,4)5/h8-11H,6-7,12-13,23H2,1-5H3,(H,25,26)
KEGG

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n/an/a 2.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336814
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-ethyl-4-(...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1C(O)=O
Show InChI InChI=1S/C21H28N2O2/c1-6-16-19(20(24)25)18(14-9-7-13(2)8-10-14)15(12-22)17(23-16)11-21(3,4)5/h7-10H,6,11-12,22H2,1-5H3,(H,24,25)
KEGG

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n/an/a 4.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50333184
PNG
(5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-m...)
Show SMILES CC(C)Cc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C19H24N2O2/c1-11(2)9-16-15(10-20)18(14-7-5-12(3)6-8-14)17(19(22)23)13(4)21-16/h5-8,11H,9-10,20H2,1-4H3,(H,22,23)
KEGG

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n/an/a 5.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336813
PNG
(5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-...)
Show SMILES Cc1ccc(cc1)-c1c(CN)c(CC(C)(C)C)nc(C)c1C(O)=O
Show InChI InChI=1S/C20H26N2O2/c1-12-6-8-14(9-7-12)18-15(11-21)16(10-20(3,4)5)22-13(2)17(18)19(23)24/h6-9H,10-11,21H2,1-5H3,(H,23,24)
KEGG

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n/an/a 1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336812
PNG
(5-(Aminomethyl)-6-butyl-2-methyl-4-(4-methylphenyl...)
Show SMILES CCCCc1nc(C)c(C(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C19H24N2O2/c1-4-5-6-16-15(11-20)18(14-9-7-12(2)8-10-14)17(19(22)23)13(3)21-16/h7-10H,4-6,11,20H2,1-3H3,(H,22,23)
KEGG

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n/an/a 1.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336806
PNG
(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Show SMILES CC(C)Cc1nc2ccc(cc2c(-c2ccc(C)cc2)c1CN)N1CC(=O)NCC1=O
Show InChI InChI=1S/C25H28N4O2/c1-15(2)10-22-20(12-26)25(17-6-4-16(3)5-7-17)19-11-18(8-9-21(19)28-22)29-14-23(30)27-13-24(29)31/h4-9,11,15H,10,12-14,26H2,1-3H3,(H,27,30)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney Dipeptidyl peptidase-2 using H-Lys-Ala-pNA.2HCl as substrate after 60 mins by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336808
PNG
(CHEMBL1672115 | [5-(Aminomethyl)-2-methyl-4-(4-met...)
Show SMILES CC(C)Cc1nc(C)c(CC(O)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C20H26N2O2/c1-12(2)9-18-17(11-21)20(15-7-5-13(3)6-8-15)16(10-19(23)24)14(4)22-18/h5-8,12H,9-11,21H2,1-4H3,(H,23,24)
KEGG

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n/an/a 5.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50337787
PNG
((R)-2-(4-(((S)-3-((R)-3-amino-4-(2,4,5-trifluoroph...)
Show SMILES CC(C)[C@@H](Nc1ccc(CNC(=O)[C@@H]2SCCN2C(=O)C[C@H](N)Cc2cc(F)c(F)cc2F)cc1)C(O)=O
Show InChI InChI=1S/C26H31F3N4O4S/c1-14(2)23(26(36)37)32-18-5-3-15(4-6-18)13-31-24(35)25-33(7-8-38-25)22(34)11-17(30)9-16-10-20(28)21(29)12-19(16)27/h3-6,10,12,14,17,23,25,32H,7-9,11,13,30H2,1-2H3,(H,31,35)(H,36,37)/t17-,23-,25+/m1/s1
KEGG

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n/an/a>1.00E+5n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of rat DPP2 expressed in african green monkey COS7 cells after 60 mins by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50333177
PNG
(1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-...)
Show SMILES CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN
Show InChI InChI=1S/C25H34N4O2/c1-15(2)12-21-20(14-26)24(18-9-7-16(3)8-10-18)19(17(4)28-21)13-23(30)29-11-5-6-22(29)25(27)31/h7-10,15,22H,5-6,11-14,26H2,1-4H3,(H2,27,31)/t22-/m0/s1
KEGG

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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DDP2 after 60 mins by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase II


(Rattus norvegicus)
BDBM50336820
PNG
(CHEMBL1672127 | [5-(Aminomethyl)-6-(2,2-dimethylpr...)
Show SMILES CCc1nc(CC(C)(C)C)c(CN)c(-c2ccc(C)cc2)c1CC(O)=O
Show InChI InChI=1S/C22H30N2O2/c1-6-18-16(11-20(25)26)21(15-9-7-14(2)8-10-15)17(13-23)19(24-18)12-22(3,4)5/h7-10H,6,11-13,23H2,1-5H3,(H,25,26)
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Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of rat kidney DPP2 after 60 mins


Citation and Details
More data for this
Ligand-Target Pair