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Found 128 hits Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase IV' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50287059
PNG
((S)-1-(2-Amino-3-methyl-pentanoyl)-pyrrolidine-2-c...)
Show SMILES CCC(C)C(N)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C11H19N3O/c1-3-8(2)10(13)11(15)14-6-4-5-9(14)7-12/h8-10H,3-6,13H2,1-2H3/t8?,9-,10?/m0/s1
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2n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11928
PNG
((1S,3S,5S)-2-{[(2S,4S)-4-[(3-chloro-4-cyanophenyl)...)
Show SMILES Clc1cc(N[C@@H]2CN[C@@H](C2)C(=O)N2[C@H]3C[C@H]3C[C@H]2C#N)ccc1C#N
Show InChI InChI=1S/C18H18ClN5O/c19-15-5-12(2-1-10(15)7-20)23-13-6-16(22-9-13)18(25)24-14(8-21)3-11-4-17(11)24/h1-2,5,11,13-14,16-17,22-23H,3-4,6,9H2/t11-,13+,14+,16+,17+/m1/s1
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3.60 -47.7n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145999
PNG
((1S,5S)-2-(2-Amino-2-cyclopentyl-acetyl)-2-aza-bic...)
Show SMILES NC(C1CCCC1)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C13H19N3O/c14-7-10-5-9-6-11(9)16(10)13(17)12(15)8-3-1-2-4-8/h8-12H,1-6,15H2/t9-,10?,11+,12?/m1/s1
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4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146015
PNG
((1S,5S)-2-[2-Amino-2-(1-methyl-cyclopentyl)-acetyl...)
Show SMILES CC1(CCCC1)C(N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C14H21N3O/c1-14(4-2-3-5-14)12(16)13(18)17-10(8-15)6-9-7-11(9)17/h9-12H,2-7,16H2,1H3/t9-,10?,11+,12?/m1/s1
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7n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146002
PNG
((S)-2-((S)-2-Amino-3-methyl-3-(S)-methyl-butyryl)-...)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C12H19N3O/c1-12(2,3)10(14)11(16)15-8(6-13)4-7-5-9(7)15/h7-10H,4-5,14H2,1-3H3/t7-,8?,9+,10-/m1/s1
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7n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146009
PNG
((1S,5S)-2-[2-Amino-2-(1-methyl-cyclohexyl)-acetyl]...)
Show SMILES CC1(CCCCC1)C(N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C15H23N3O/c1-15(5-3-2-4-6-15)13(17)14(19)18-11(9-16)7-10-8-12(10)18/h10-13H,2-8,17H2,1H3/t10-,11?,12+,13?/m1/s1
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8n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50151003
PNG
((S)-1-((S)-2-Amino-3,3-dimethyl-butyryl)-pyrrolidi...)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C11H19N3O/c1-11(2,3)9(13)10(15)14-6-4-5-8(14)7-12/h8-9H,4-6,13H2,1-3H3/t8-,9+/m0/s1
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8n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146010
PNG
((1S,5S)-2-[2-Amino-2-(1-methyl-cyclobutyl)-acetyl]...)
Show SMILES CC1(CCC1)C(N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C13H19N3O/c1-13(3-2-4-13)11(15)12(17)16-9(7-14)5-8-6-10(8)16/h8-11H,2-6,15H2,1H3/t8-,9?,10+,11?/m1/s1
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11n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146007
PNG
((1R,5S)-3-((S)-2-Amino-3-methyl-butyryl)-3-aza-bic...)
Show SMILES CC(C)[C@H](N)C(=O)N1C[C@H]2C[C@H]2C1C#N
Show InChI InChI=1S/C11H17N3O/c1-6(2)10(13)11(15)14-5-7-3-8(7)9(14)4-12/h6-10H,3,5,13H2,1-2H3/t7-,8-,9?,10+/m1/s1
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12n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145997
PNG
((1S,5S)-2-(2-Amino-2-cyclobutyl-acetyl)-2-aza-bicy...)
Show SMILES NC(C1CCC1)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C12H17N3O/c13-6-9-4-8-5-10(8)15(9)12(16)11(14)7-2-1-3-7/h7-11H,1-5,14H2/t8-,9?,10+,11?/m1/s1
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12n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146013
PNG
((1R,5S)-3-((S)-2-Amino-3,3-dimethyl-butyryl)-3-aza...)
Show SMILES CC(C)(C)[C@H](N)C(=O)N1C[C@H]2C[C@H]2C1C#N
Show InChI InChI=1S/C12H19N3O/c1-12(2,3)10(14)11(16)15-6-7-4-8(7)9(15)5-13/h7-10H,4,6,14H2,1-3H3/t7-,8-,9?,10-/m1/s1
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14n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145996
PNG
((1R,5S)-3-((S)-2-Amino-3-methyl-pentanoyl)-3-aza-b...)
Show SMILES CCC(C)[C@H](N)C(=O)N1C[C@H]2C[C@H]2C1C#N
Show InChI InChI=1S/C12H19N3O/c1-3-7(2)11(14)12(16)15-6-8-4-9(8)10(15)5-13/h7-11H,3-4,6,14H2,1-2H3/t7?,8-,9-,10?,11+/m1/s1
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15n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146005
PNG
((1S,5S)-2-(2-Amino-2-cyclohexyl-acetyl)-2-aza-bicy...)
Show SMILES NC(C1CCCCC1)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C14H21N3O/c15-8-11-6-10-7-12(10)17(11)14(18)13(16)9-4-2-1-3-5-9/h9-13H,1-7,16H2/t10-,11?,12+,13?/m1/s1
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15n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146000
PNG
((1S,5S)-2-((S)-2-Amino-3-methyl-pentanoyl)-2-aza-b...)
Show SMILES CCC(C)[C@H](N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C12H19N3O/c1-3-7(2)11(14)12(16)15-9(6-13)4-8-5-10(8)15/h7-11H,3-5,14H2,1-2H3/t7?,8-,9?,10+,11+/m1/s1
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25n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146004
PNG
((1R,5R)-2-((S)-2-Amino-3-methyl-butyryl)-2-aza-bic...)
Show SMILES CC(C)[C@H](N)C(=O)N1[C@@H]2C[C@@H]2CC1C#N
Show InChI InChI=1S/C11H17N3O/c1-6(2)10(13)11(15)14-8(5-12)3-7-4-9(7)14/h6-10H,3-4,13H2,1-2H3/t7-,8?,9+,10-/m0/s1
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29n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11920
PNG
((1S,3S,5S)-2-{[(2S)-3,3-dimethylpyrrolidin-2-yl]ca...)
Show SMILES CC1(C)CCN[C@@H]1C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C13H19N3O/c1-13(2)3-4-15-11(13)12(17)16-9(7-14)5-8-6-10(8)16/h8-11,15H,3-6H2,1-2H3/t8-,9+,10+,11-/m1/s1
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37 -42.0n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11927
PNG
(4-chloro-N-[(3S,5S)-5-{[(1S,3S,5S)-3-cyano-2-azabi...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C17H19ClN4O3S/c18-11-1-3-14(4-2-11)26(24,25)21-12-7-15(20-9-12)17(23)22-13(8-19)5-10-6-16(10)22/h1-4,10,12-13,15-16,20-21H,5-7,9H2/t10-,12+,13+,15+,16+/m1/s1
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39 -41.9n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50206821
PNG
((R)-3-amino-1-(2-benzoylpiperazin-1-yl)-4-(2,4,5-t...)
Show SMILES N[C@@H](CC(=O)N1CCCCN1C(=O)c1ccccc1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C21H22F3N3O2/c22-17-13-19(24)18(23)11-15(17)10-16(25)12-20(28)26-8-4-5-9-27(26)21(29)14-6-2-1-3-7-14/h1-3,6-7,11,13,16H,4-5,8-10,12,25H2/t16-/m1/s1
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44n/an/an/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney DPP4


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11917
PNG
((1S,3S,5S)-2-[(1S,2S,5R)-3-azabicyclo[3.1.0]hexan-...)
Show SMILES O=C([C@H]1NC[C@@H]2C[C@H]12)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C12H15N3O/c13-4-8-1-6-3-10(6)15(8)12(16)11-9-2-7(9)5-14-11/h6-11,14H,1-3,5H2/t6-,7+,8+,9+,10+,11+/m1/s1
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52 -41.2n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50206820
PNG
((R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4...)
Show SMILES N[C@@H](CC(=O)N1CCCCCN1C(=O)c1ccccc1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H24F3N3O2/c23-18-14-20(25)19(24)12-16(18)11-17(26)13-21(29)27-9-5-2-6-10-28(27)22(30)15-7-3-1-4-8-15/h1,3-4,7-8,12,14,17H,2,5-6,9-11,13,26H2/t17-/m1/s1
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56.2n/an/an/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of pig kidney DPP4


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11925
PNG
(9H-fluoren-9-ylmethyl N-[(3S,5S)-5-{[(1S,3S,5S)-3-...)
Show SMILES O=C(N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N)OCC1c2ccccc2-c2ccccc12
Show InChI InChI=1S/C26H26N4O3/c27-12-17-9-15-10-24(15)30(17)25(31)23-11-16(13-28-23)29-26(32)33-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-8,15-17,22-24,28H,9-11,13-14H2,(H,29,32)/t15-,16+,17+,23+,24+/m1/s1
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57 -40.9n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146006
PNG
((1S,5S)-2-((S)-2-Amino-3-phenyl-propionyl)-2-aza-b...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C15H17N3O/c16-9-12-7-11-8-14(11)18(12)15(19)13(17)6-10-4-2-1-3-5-10/h1-5,11-14H,6-8,17H2/t11-,12?,13+,14+/m1/s1
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65n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146001
PNG
((1S,5S)-2-((S)-1-Amino-pyrrolidine-2-carbonyl)-2-a...)
Show SMILES NN1CCC[C@H]1C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C11H16N4O/c12-6-8-4-7-5-10(7)15(8)11(16)9-2-1-3-14(9)13/h7-10H,1-5,13H2/t7-,8?,9+,10+/m1/s1
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107n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11919
PNG
((1S,3S,5S)-2-{[(2S,3S)-3-methylpyrrolidin-2-yl]car...)
Show SMILES C[C@H]1CCN[C@@H]1C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C12H17N3O/c1-7-2-3-14-11(7)12(16)15-9(6-13)4-8-5-10(8)15/h7-11,14H,2-5H2,1H3/t7-,8+,9-,10-,11-/m0/s1
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126 -39.0n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11926
PNG
(N-[(3S,5S)-5-{[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1...)
Show SMILES CC(C)(C)CC(=O)N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C17H26N4O2/c1-17(2,3)7-15(22)20-11-6-13(19-9-11)16(23)21-12(8-18)4-10-5-14(10)21/h10-14,19H,4-7,9H2,1-3H3,(H,20,22)/t10-,11+,12+,13+,14+/m1/s1
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133 -38.9n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146012
PNG
((1S,5S)-2-((S)-2-Amino-4-methylsulfanyl-butyryl)-2...)
Show SMILES CSCC[C@H](N)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C11H17N3OS/c1-16-3-2-9(13)11(15)14-8(6-12)4-7-5-10(7)14/h7-10H,2-5,13H2,1H3/t7-,8?,9+,10+/m1/s1
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135n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11923
PNG
(substituted diprolyl nitrile 16 | tert-butyl N-[(3...)
Show SMILES CC(C)(C)OC(=O)N[C@@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C16H24N4O3/c1-16(2,3)23-15(22)19-10-6-12(18-8-10)14(21)20-11(7-17)4-9-5-13(9)20/h9-13,18H,4-6,8H2,1-3H3,(H,19,22)/t9-,10+,11+,12+,13+/m1/s1
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140 -38.7n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145998
PNG
((1S,5S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionyl...)
Show SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C17H18N4O/c18-8-12-5-10-7-16(10)21(12)17(22)14(19)6-11-9-20-15-4-2-1-3-13(11)15/h1-4,9-10,12,14,16,20H,5-7,19H2/t10-,12?,14+,16+/m1/s1
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230n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11921
PNG
((1S,3S,5S)-2-{[(2S,3S)-3-ethylpyrrolidin-2-yl]carb...)
Show SMILES CC[C@H]1CCN[C@@H]1C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C13H19N3O/c1-2-8-3-4-15-12(8)13(17)16-10(7-14)5-9-6-11(9)16/h8-12,15H,2-6H2,1H3/t8-,9+,10-,11-,12-/m0/s1
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290 -36.9n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11914
PNG
((1S,3S,5S)-2-[(2S)-pyrrolidin-2-ylcarbonyl]-2-azab...)
Show SMILES O=C([C@@H]1CCCN1)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C11H15N3O/c12-6-8-4-7-5-10(7)14(8)11(15)9-2-1-3-13-9/h7-10,13H,1-5H2/t7-,8+,9+,10+/m1/s1
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305 -36.8n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11924
PNG
(substituted diprolyl nitrile 17 | tert-butyl N-[(3...)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CN[C@@H](C1)C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C16H24N4O3/c1-16(2,3)23-15(22)19-10-6-12(18-8-10)14(21)20-11(7-17)4-9-5-13(9)20/h9-13,18H,4-6,8H2,1-3H3,(H,19,22)/t9-,10-,11+,12+,13+/m1/s1
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492 -35.6n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11922
PNG
((1S,3S,5S)-2-{[(2S,3R)-3-(propan-2-yl)pyrrolidin-2...)
Show SMILES CC(C)[C@H]1CCN[C@@H]1C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C14H21N3O/c1-8(2)11-3-4-16-13(11)14(18)17-10(7-15)5-9-6-12(9)17/h8-13,16H,3-6H2,1-2H3/t9-,10+,11-,12+,13+/m1/s1
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695 -34.8n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145994
PNG
((1R,5R)-2-((S)-2-Amino-3-methyl-pentanoyl)-2-aza-b...)
Show SMILES CCC(C)[C@H](N)C(=O)N1[C@@H]2C[C@@H]2CC1C#N
Show InChI InChI=1S/C12H19N3O/c1-3-7(2)11(14)12(16)15-9(6-13)4-8-5-10(8)15/h7-11H,3-5,14H2,1-2H3/t7?,8-,9?,10+,11-/m0/s1
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1.62E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50145995
PNG
((1S,5S)-2-((S)-3-Methyl-2-methylamino-butyryl)-2-a...)
Show SMILES CN[C@@H](C(C)C)C(=O)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C12H19N3O/c1-7(2)11(14-3)12(16)15-9(6-13)4-8-5-10(8)15/h7-11,14H,4-5H2,1-3H3/t8-,9?,10+,11+/m1/s1
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1.94E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146011
PNG
((1S,5R)-2-((S)-2-Amino-3-methyl-pentanoyl)-2-aza-b...)
Show SMILES CCC(C)[C@H](N)C(=O)N1CC[C@@H]2C[C@]12C#N
Show InChI InChI=1S/C12H19N3O/c1-3-8(2)10(14)11(16)15-5-4-9-6-12(9,15)7-13/h8-10H,3-6,14H2,1-2H3/t8?,9-,10+,12-/m1/s1
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7.50E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50146008
PNG
((1S,5S)-2-(Piperidine-2-carbonyl)-2-aza-bicyclo[3....)
Show SMILES O=C(C1CCCCN1)N1[C@H]2C[C@H]2CC1C#N
Show InChI InChI=1S/C12H17N3O/c13-7-9-5-8-6-11(8)15(9)12(16)10-3-1-2-4-14-10/h8-11,14H,1-6H2/t8-,9?,10?,11+/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase IV.


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11918
PNG
((1S,3S,5S)-2-[(1S,3S,5S)-2-azabicyclo[3.1.0]hexan-...)
Show SMILES O=C([C@@H]1C[C@@H]2C[C@@H]2N1)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C12H15N3O/c13-5-8-1-7-4-11(7)15(8)12(16)10-3-6-2-9(6)14-10/h6-11,14H,1-4H2/t6-,7+,8-,9-,10-,11-/m0/s1
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>1.00E+4>-28.3n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11915
PNG
((1S,3S,5S)-2-[(2R)-pyrrolidin-2-ylcarbonyl]-2-azab...)
Show SMILES O=C([C@H]1CCCN1)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C11H15N3O/c12-6-8-4-7-5-10(7)14(8)11(15)9-2-1-3-13-9/h7-10,13H,1-5H2/t7-,8+,9-,10+/m1/s1
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>1.00E+4>-28.3n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11913
PNG
((1S,3S,5S)-2-[(2S)-piperidin-2-ylcarbonyl]-2-azabi...)
Show SMILES O=C([C@@H]1CCCCN1)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C12H17N3O/c13-7-9-5-8-6-11(8)15(9)12(16)10-3-1-2-4-14-10/h8-11,14H,1-6H2/t8-,9+,10+,11+/m1/s1
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>1.00E+4>-28.3n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM11916
PNG
((1S,3S,5S)-2-[(2S)-azetidin-2-ylcarbonyl]-2-azabic...)
Show SMILES O=C([C@@H]1CCN1)N1[C@H]2C[C@H]2C[C@H]1C#N
Show InChI InChI=1S/C10H13N3O/c11-5-7-3-6-4-9(6)13(7)10(14)8-1-2-12-8/h6-9,12H,1-4H2/t6-,7+,8+,9+/m1/s1
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>1.00E+4>-28.3n/an/an/an/an/a7.422



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437403
PNG
(CHEMBL2408771)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CC2CCCNC2C1
Show InChI InChI=1S/C26H32N6O3/c1-17(2)11-13-31-22-23(28-25(31)30-14-19-10-7-12-27-20(19)15-30)29(3)26(35)32(24(22)34)16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11,19-20,27H,7,10,12-16H2,1-3H3
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n/an/a 0.0500n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437403
PNG
(CHEMBL2408771)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CC2CCCNC2C1
Show InChI InChI=1S/C26H32N6O3/c1-17(2)11-13-31-22-23(28-25(31)30-14-19-10-7-12-27-20(19)15-30)29(3)26(35)32(24(22)34)16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11,19-20,27H,7,10,12-16H2,1-3H3
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n/an/a 0.270n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50228407
PNG
(8-((R)-3-amino-piperidin-1-yl)-3-methyl-7-(3-methy...)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CCC[C@@H](N)C1
Show InChI InChI=1S/C24H30N6O3/c1-16(2)11-13-29-20-21(26-23(29)28-12-7-10-18(25)14-28)27(3)24(33)30(22(20)32)15-19(31)17-8-5-4-6-9-17/h4-6,8-9,11,18H,7,10,12-15,25H2,1-3H3/t18-/m1/s1
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n/an/a 0.730n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CCC2CNCC12
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437404
PNG
(CHEMBL2408655)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CCC2CNCC12
Show InChI InChI=1S/C25H30N6O3/c1-16(2)9-11-30-21-22(27-24(30)29-12-10-18-13-26-14-19(18)29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-9,18-19,26H,10-15H2,1-3H3
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n/an/a 1.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437395
PNG
(CHEMBL2408638)
Show SMILES CC(C)=CCn1c(OCC(C)(C)CN)nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H31N5O4/c1-16(2)11-12-28-19-20(26-22(28)33-15-24(3,4)14-25)27(5)23(32)29(21(19)31)13-18(30)17-9-7-6-8-10-17/h6-11H,12-15,25H2,1-5H3
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n/an/a 6.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437395
PNG
(CHEMBL2408638)
Show SMILES CC(C)=CCn1c(OCC(C)(C)CN)nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H31N5O4/c1-16(2)11-12-28-19-20(26-22(28)33-15-24(3,4)14-25)27(5)23(32)29(21(19)31)13-18(30)17-9-7-6-8-10-17/h6-11H,12-15,25H2,1-5H3
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n/an/a 9n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437396
PNG
(CHEMBL2408651)
Show SMILES CC(C)=CCn1c(OC[C@@H]2CCCN2)nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H29N5O4/c1-16(2)11-13-28-20-21(26-23(28)33-15-18-10-7-12-25-18)27(3)24(32)29(22(20)31)14-19(30)17-8-5-4-6-9-17/h4-6,8-9,11,18,25H,7,10,12-15H2,1-3H3/t18-/m0/s1
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n/an/a 16n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4 using H-Gly-Pro-AMC as substrate by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437402
PNG
(CHEMBL2408774)
Show SMILES CC(C)=CCn1c(nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12)N1CC2CCNC2C1
Show InChI InChI=1S/C25H30N6O3/c1-16(2)10-12-30-21-22(27-24(30)29-13-18-9-11-26-19(18)14-29)28(3)25(34)31(23(21)33)15-20(32)17-7-5-4-6-8-17/h4-8,10,18-19,26H,9,11-15H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4


Citation and Details
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Sus scrofa (pig))
BDBM50437396
PNG
(CHEMBL2408651)
Show SMILES CC(C)=CCn1c(OC[C@@H]2CCCN2)nc2n(C)c(=O)n(CC(=O)c3ccccc3)c(=O)c12
Show InChI InChI=1S/C24H29N5O4/c1-16(2)11-13-28-20-21(26-23(28)33-15-18-10-7-12-25-18)27(3)24(32)29(22(20)31)14-19(30)17-8-5-4-6-9-17/h4-6,8-9,11,18,25H,7,10,12-15H2,1-3H3/t18-/m0/s1
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n/an/a 17n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine DPP4


Citation and Details
More data for this
Ligand-Target Pair
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