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Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with Target = 'Disintegrin and metalloproteinase domain-containing protein 8' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190577
PNG
(CHEMBL3828456)
Show SMILES CC(C)CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](CO)NC1=O
Show InChI InChI=1S/C33H61N11O9/c1-19(2)11-12-24-28(49)39-20(18-45)16-26(46)40-21(8-3-5-13-34)29(50)44-25(17-27(47)48)32(53)42-22(9-4-6-14-35)30(51)41-23(31(52)43-24)10-7-15-38-33(36)37/h19-25,45H,3-18,34-35H2,1-2H3,(H,39,49)(H,40,46)(H,41,51)(H,42,53)(H,43,52)(H,44,50)(H,47,48)(H4,36,37,38)/t20-,21+,22+,23+,24+,25+/m1/s1
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n/an/a 142n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190506
PNG
(CHEMBL3828497)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](CO)NC1=O
Show InChI InChI=1S/C32H59N11O9/c1-18(2)14-23-30(51)38-19(17-44)15-25(45)39-20(8-3-5-11-33)27(48)43-24(16-26(46)47)31(52)41-21(9-4-6-12-34)28(49)40-22(29(50)42-23)10-7-13-37-32(35)36/h18-24,44H,3-17,33-34H2,1-2H3,(H,38,51)(H,39,45)(H,40,49)(H,41,52)(H,42,50)(H,43,48)(H,46,47)(H4,35,36,37)/t19-,20+,21+,22+,23+,24+/m1/s1
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n/an/a 157n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190504
PNG
(CHEMBL3827850)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC1=O
Show InChI InChI=1S/C31H57N11O9/c1-17(2)14-21-28(49)42-23(16-43)30(51)39-19(9-4-6-12-33)26(47)41-22(15-24(44)45)29(50)38-18(8-3-5-11-32)25(46)37-20(27(48)40-21)10-7-13-36-31(34)35/h17-23,43H,3-16,32-33H2,1-2H3,(H,37,46)(H,38,50)(H,39,51)(H,40,48)(H,41,47)(H,42,49)(H,44,45)(H4,34,35,36)/t18-,19-,20-,21-,22-,23+/m0/s1
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n/an/a 182n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedd...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190575
PNG
(CHEMBL3827732)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](CO)NC1=O
Show InChI InChI=1S/C32H58N10O10/c1-18(2)14-23-30(50)37-19(17-43)15-25(44)38-20(8-3-5-11-33)27(47)42-24(16-26(45)46)31(51)40-21(9-4-6-12-34)28(48)39-22(29(49)41-23)10-7-13-36-32(35)52/h18-24,43H,3-17,33-34H2,1-2H3,(H,37,50)(H,38,44)(H,39,48)(H,40,51)(H,41,49)(H,42,47)(H,45,46)(H3,35,36,52)/t19-,20+,21+,22+,23+,24+/m1/s1
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n/an/a 192n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190527
PNG
(CHEMBL3827980)
Show SMILES CC(C)CC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C32H59N11O8/c1-19(2)11-12-23-27(47)37-17-13-25(44)39-20(8-3-5-14-33)28(48)43-24(18-26(45)46)31(51)41-21(9-4-6-15-34)29(49)40-22(30(50)42-23)10-7-16-38-32(35)36/h19-24H,3-18,33-34H2,1-2H3,(H,37,47)(H,39,44)(H,40,49)(H,41,51)(H,42,50)(H,43,48)(H,45,46)(H4,35,36,38)/t20-,21-,22-,23-,24-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190505
PNG
(CHEMBL3827893)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC1=O
Show InChI InChI=1S/C31H57N11O9/c1-17(2)14-21-28(49)42-23(16-43)30(51)39-19(9-4-6-12-33)26(47)41-22(15-24(44)45)29(50)38-18(8-3-5-11-32)25(46)37-20(27(48)40-21)10-7-13-36-31(34)35/h17-23,43H,3-16,32-33H2,1-2H3,(H,37,46)(H,38,50)(H,39,51)(H,40,48)(H,41,47)(H,42,49)(H,44,45)(H4,34,35,36)/t18-,19-,20-,21-,22-,23-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190511
PNG
(CHEMBL3827446)
Show SMILES CC(C)(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C32H59N11O8/c1-32(2,3)18-23-26(47)37-16-12-24(44)39-19(9-4-6-13-33)27(48)42-22(17-25(45)46)30(51)41-20(10-5-7-14-34)28(49)40-21(29(50)43-23)11-8-15-38-31(35)36/h19-23H,4-18,33-34H2,1-3H3,(H,37,47)(H,39,44)(H,40,49)(H,41,51)(H,42,48)(H,43,50)(H,45,46)(H4,35,36,38)/t19-,20-,21-,22-,23-/m0/s1
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n/an/a 256n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190576
PNG
(CHEMBL3827091)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](CO)NC1=O
Show InChI InChI=1S/C33H61N11O9/c1-19(2)15-24-31(52)39-20(18-45)16-26(46)40-21(9-3-6-12-34)28(49)44-25(17-27(47)48)32(53)42-22(10-4-7-13-35)29(50)41-23(30(51)43-24)11-5-8-14-38-33(36)37/h19-25,45H,3-18,34-35H2,1-2H3,(H,39,52)(H,40,46)(H,41,50)(H,42,53)(H,43,51)(H,44,49)(H,47,48)(H4,36,37,38)/t20-,21+,22+,23+,24+,25+/m1/s1
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n/an/a 368n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190538
PNG
(CHEMBL3827647)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C31H57N11O8/c1-2-3-9-19-26(46)36-17-13-24(43)38-20(10-4-6-14-32)27(47)42-23(18-25(44)45)30(50)41-21(11-5-7-15-33)28(48)40-22(29(49)39-19)12-8-16-37-31(34)35/h19-23H,2-18,32-33H2,1H3,(H,36,46)(H,38,43)(H,39,49)(H,40,48)(H,41,50)(H,42,47)(H,44,45)(H4,34,35,37)/t19-,20-,21-,22-,23-/m0/s1
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n/an/a 378n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190508
PNG
(CHEMBL3828432)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](NC1=O)C(O)=O
Show InChI InChI=1S/C32H57N11O10/c1-17(2)14-21-29(50)43-23(31(52)53)15-24(44)38-18(8-3-5-11-33)26(47)42-22(16-25(45)46)30(51)40-19(9-4-6-12-34)27(48)39-20(28(49)41-21)10-7-13-37-32(35)36/h17-23H,3-16,33-34H2,1-2H3,(H,38,44)(H,39,48)(H,40,51)(H,41,49)(H,42,47)(H,43,50)(H,45,46)(H,52,53)(H4,35,36,37)/t18-,19-,20-,21-,22-,23-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190569
PNG
(CHEMBL3827027)
Show SMILES CCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C30H55N11O8/c1-2-8-18-25(45)35-16-12-23(42)37-19(9-3-5-13-31)26(46)41-22(17-24(43)44)29(49)40-20(10-4-6-14-32)27(47)39-21(28(48)38-18)11-7-15-36-30(33)34/h18-22H,2-17,31-32H2,1H3,(H,35,45)(H,37,42)(H,38,48)(H,39,47)(H,40,49)(H,41,46)(H,43,44)(H4,33,34,36)/t18-,19-,20-,21-,22-/m0/s1
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n/an/a 452n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190510
PNG
(CHEMBL3827271)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C31H56N10O9/c1-18(2)16-22-26(45)35-15-11-24(42)37-19(8-3-5-12-32)27(46)41-23(17-25(43)44)30(49)39-20(9-4-6-13-33)28(47)38-21(29(48)40-22)10-7-14-36-31(34)50/h18-23H,3-17,32-33H2,1-2H3,(H,35,45)(H,37,42)(H,38,47)(H,39,49)(H,40,48)(H,41,46)(H,43,44)(H3,34,36,50)/t19-,20-,21-,22-,23-/m0/s1
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n/an/a 890n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50203527
PNG
((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)
Show SMILES COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(=CC1)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of ADAM8


Bioorg Med Chem 16: 8781-94 (2008)


Article DOI: 10.1016/j.bmc.2008.08.058
BindingDB Entry DOI: 10.7270/Q2JD4WM2
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190574
PNG
(CHEMBL3828603)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(=N)N[N+]([O-])=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)C[C@H](CO)NC1=O
Show InChI InChI=1S/C32H58N12O11/c1-18(2)14-23-30(52)37-19(17-45)15-25(46)38-20(8-3-5-11-33)27(49)42-24(16-26(47)48)31(53)40-21(9-4-6-12-34)28(50)39-22(29(51)41-23)10-7-13-36-32(35)43-44(54)55/h18-24,45H,3-17,33-34H2,1-2H3,(H,37,52)(H,38,46)(H,39,50)(H,40,53)(H,41,51)(H,42,49)(H,47,48)(H3,35,36,43)/t19-,20+,21+,22+,23+,24+/m1/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190507
PNG
(CHEMBL3827625)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C31H57N11O8/c1-18(2)16-22-26(46)36-15-11-24(43)38-19(8-3-5-12-32)27(47)42-23(17-25(44)45)30(50)40-20(9-4-6-13-33)28(48)39-21(29(49)41-22)10-7-14-37-31(34)35/h18-23H,3-17,32-33H2,1-2H3,(H,36,46)(H,38,43)(H,39,48)(H,40,50)(H,41,49)(H,42,47)(H,44,45)(H4,34,35,37)/t19-,20-,21-,22-,23-/m0/s1
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Article
PubMed
n/an/a 1.65E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190509
PNG
(CHEMBL3827487)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(=N)N[N+]([O-])=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C31H56N12O10/c1-18(2)16-22-26(47)35-15-11-24(44)37-19(8-3-5-12-32)27(48)41-23(17-25(45)46)30(51)39-20(9-4-6-13-33)28(49)38-21(29(50)40-22)10-7-14-36-31(34)42-43(52)53/h18-23H,3-17,32-33H2,1-2H3,(H,35,47)(H,37,44)(H,38,49)(H,39,51)(H,40,50)(H,41,48)(H,45,46)(H3,34,36,42)/t19-,20-,21-,22-,23-/m0/s1
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PubMed
n/an/a 2.35E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190572
PNG
(CHEMBL3827131)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C30H55N11O8/c1-17(2)15-21-25(45)35-14-10-23(42)37-18(7-3-4-11-31)26(46)41-22(16-24(43)44)29(49)39-19(8-5-12-32)27(47)38-20(28(48)40-21)9-6-13-36-30(33)34/h17-22H,3-16,31-32H2,1-2H3,(H,35,45)(H,37,42)(H,38,47)(H,39,49)(H,40,48)(H,41,46)(H,43,44)(H4,33,34,36)/t18-,19-,20-,21-,22-/m0/s1
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Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190571
PNG
(CHEMBL3828319)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C29H53N11O8/c1-16(2)14-20-24(44)34-13-9-22(41)36-17(6-3-4-10-30)25(45)40-21(15-23(42)43)28(48)38-19(8-11-31)27(47)37-18(26(46)39-20)7-5-12-35-29(32)33/h16-21H,3-15,30-31H2,1-2H3,(H,34,44)(H,36,41)(H,37,47)(H,38,48)(H,39,46)(H,40,45)(H,42,43)(H4,32,33,35)/t17-,18-,19-,20-,21-/m0/s1
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Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190570
PNG
(CHEMBL3827100)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C28H51N11O8/c1-15(2)12-18-23(43)33-11-8-21(40)35-16(6-3-4-9-29)24(44)38-19(13-22(41)42)26(46)39-20(14-30)27(47)36-17(25(45)37-18)7-5-10-34-28(31)32/h15-20H,3-14,29-30H2,1-2H3,(H,33,43)(H,35,40)(H,36,47)(H,37,45)(H,38,44)(H,39,46)(H,41,42)(H4,31,32,34)/t16-,17-,18-,19-,20-/m0/s1
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PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 8


(Homo sapiens)
BDBM50190573
PNG
(CHEMBL3828248)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CCNC1=O
Show InChI InChI=1S/C34H63N11O8/c1-21(2)19-25-29(49)38-17-14-27(46)40-22(11-6-8-15-35)30(50)44-26(20-28(47)48)33(53)42-23(12-7-9-18-45(3,4)5)31(51)41-24(32(52)43-25)13-10-16-39-34(36)37/h21-26H,6-20,35H2,1-5H3,(H10-,36,37,38,39,40,41,42,43,44,46,47,48,49,50,51,52,53)/p+1/t22-,23-,24-,25-,26-/m0/s1
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 ...


Bioorg Med Chem 24: 4032-4037 (2016)


Article DOI: 10.1016/j.bmc.2016.06.042
BindingDB Entry DOI: 10.7270/Q2ST7RS3
More data for this
Ligand-Target Pair