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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'Dopamine D1 receptor' AND taxid = 7957   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D1 receptor


(Carassius auratus)
BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008824
PNG
(1-Aminomethyl-6-bromo-3-phenyl-isochroman-5-ol; hy...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(Br)ccc12)c1ccccc1
Show InChI InChI=1S/C16H16BrNO2/c17-13-7-6-11-12(16(13)19)8-14(20-15(11)9-18)10-4-2-1-3-5-10/h1-7,14-15,19H,8-9,18H2/t14-,15-/m0/s1
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32n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008828
PNG
(1-Aminomethyl-3-phenyl-isochroman-5-ol; hydrochlor...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)cccc12)c1ccccc1
Show InChI InChI=1S/C16H17NO2/c17-10-16-12-7-4-8-14(18)13(12)9-15(19-16)11-5-2-1-3-6-11/h1-8,15-16,18H,9-10,17H2/t15-,16-/m0/s1
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53n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008825
PNG
(1-Aminomethyl-3-cyclohexyl-6-methyl-isochroman-5-o...)
Show SMILES Cc1ccc2[C@H](CN)O[C@@H](Cc2c1O)C1CCCCC1
Show InChI InChI=1S/C17H25NO2/c1-11-7-8-13-14(17(11)19)9-15(20-16(13)10-18)12-5-3-2-4-6-12/h7-8,12,15-16,19H,2-6,9-10,18H2,1H3/t15-,16-/m0/s1
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100n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008831
PNG
(3-Cyclohexyl-6-methyl-1-methylaminomethyl-isochrom...)
Show SMILES CNC[C@@H]1O[C@@H](Cc2c(O)c(C)ccc12)C1CCCCC1
Show InChI InChI=1S/C18H27NO2/c1-12-8-9-14-15(18(12)20)10-16(21-17(14)11-19-2)13-6-4-3-5-7-13/h8-9,13,16-17,19-20H,3-7,10-11H2,1-2H3/t16-,17-/m0/s1
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121n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008827
PNG
(3-Cyclohexyl-1-dimethylaminomethyl-6-methyl-isochr...)
Show SMILES CN(C)C[C@@H]1O[C@@H](Cc2c(O)c(C)ccc12)C1CCCCC1
Show InChI InChI=1S/C19H29NO2/c1-13-9-10-15-16(19(13)21)11-17(14-7-5-4-6-8-14)22-18(15)12-20(2)3/h9-10,14,17-18,21H,4-8,11-12H2,1-3H3/t17-,18-/m0/s1
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125n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008829
PNG
(1-Aminomethyl-6-bromo-3-phenyl-isochroman-5-ol; hy...)
Show SMILES NC[C@H]1O[C@@H](Cc2c(O)c(Br)ccc12)c1ccccc1
Show InChI InChI=1S/C16H16BrNO2/c17-13-7-6-11-12(16(13)19)8-14(20-15(11)9-18)10-4-2-1-3-5-10/h1-7,14-15,19H,8-9,18H2/t14-,15+/m0/s1
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197n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008830
PNG
(1-Aminomethyl-6-methoxy-3-phenyl-isochroman-5-ol; ...)
Show SMILES COc1ccc2[C@H](CN)O[C@@H](Cc2c1O)c1ccccc1
Show InChI InChI=1S/C17H19NO3/c1-20-14-8-7-12-13(17(14)19)9-15(21-16(12)10-18)11-5-3-2-4-6-11/h2-8,15-16,19H,9-10,18H2,1H3/t15-,16-/m0/s1
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247n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50008826
PNG
(3-Cyclohexyl-6-methyl-1-propylaminomethyl-isochrom...)
Show SMILES CCCNC[C@@H]1O[C@@H](Cc2c(O)c(C)ccc12)C1CCCCC1
Show InChI InChI=1S/C20H31NO2/c1-3-11-21-13-19-16-10-9-14(2)20(22)17(16)12-18(23-19)15-7-5-4-6-8-15/h9-10,15,18-19,21-22H,3-8,11-13H2,1-2H3/t18-,19-/m0/s1
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454n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of dopamine stimulated adenylate cyclase


J Med Chem 34: 2946-53 (1991)


Article DOI: 10.1021/jm00114a002
BindingDB Entry DOI: 10.7270/Q2H132MN
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057845
PNG
((5aS,11bS)-2-Butyl-4,5,5a,6,7,11b-hexahydro-1-thia...)
Show SMILES CCCCc1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C19H23NO2S/c1-2-3-4-13-7-12-10-20-15-6-5-11-8-16(21)17(22)9-14(11)18(15)19(12)23-13/h7-9,15,18,20-22H,2-6,10H2,1H3/t15-,18-/m0/s1
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n/an/an/an/a 44n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057846
PNG
((5aS,11bS)-2-Methyl-4,5,5a,6,7,11b-hexahydro-1-thi...)
Show SMILES Cc1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C16H17NO2S/c1-8-4-10-7-17-12-3-2-9-5-13(18)14(19)6-11(9)15(12)16(10)20-8/h4-6,12,15,17-19H,2-3,7H2,1H3/t12-,15-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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n/an/an/an/a 950n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057854
PNG
((5aS,11bR)-2-(3-Methyl-butyl)-4,5,5a,6,7,11b-hexah...)
Show SMILES CC(C)CCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C20H25NO2S/c1-11(2)3-5-13-8-15-19(24-13)10-21-16-6-4-12-7-17(22)18(23)9-14(12)20(15)16/h7-9,11,16,20-23H,3-6,10H2,1-2H3/t16-,20+/m0/s1
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n/an/an/an/a 470n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057839
PNG
((5aS,11bR)-2-Butyl-4,5,5a,6,7,11b-hexahydro-3-thia...)
Show SMILES CCCCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C19H23NO2S/c1-2-3-4-12-8-14-18(23-12)10-20-15-6-5-11-7-16(21)17(22)9-13(11)19(14)15/h7-9,15,19-22H,2-6,10H2,1H3/t15-,19+/m0/s1
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n/an/an/an/a 77n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057843
PNG
((5aS,11bR)-4,5,5a,6,7,11b-Hexahydro-3-thia-5-aza-c...)
Show SMILES Oc1cc2CC[C@@H]3NCc4sccc4[C@H]3c2cc1O
Show InChI InChI=1S/C15H15NO2S/c17-12-5-8-1-2-11-15(10(8)6-13(12)18)9-3-4-19-14(9)7-16-11/h3-6,11,15-18H,1-2,7H2/t11-,15-/m0/s1
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n/an/an/an/a 47n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057847
PNG
((5aS,11bR)-2-m-Tolyl-4,5,5a,6,7,11b-hexahydro-3-th...)
Show SMILES Cc1cccc(c1)-c1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C22H21NO2S/c1-12-3-2-4-14(7-12)20-10-16-21(26-20)11-23-17-6-5-13-8-18(24)19(25)9-15(13)22(16)17/h2-4,7-10,17,22-25H,5-6,11H2,1H3/t17-,22+/m0/s1
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n/an/an/an/a 640n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057837
PNG
((5aS,11bS)-4,5,5a,6,7,11b-Hexahydro-1-thia-5-aza-c...)
Show SMILES Oc1cc2CC[C@@H]3NCc4ccsc4[C@H]3c2cc1O
Show InChI InChI=1S/C15H15NO2S/c17-12-5-8-1-2-11-14(10(8)6-13(12)18)15-9(7-16-11)3-4-19-15/h3-6,11,14,16-18H,1-2,7H2/t11-,14-/m0/s1
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n/an/an/an/a 39n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50010686
PNG
((6aR,12bS)-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydr...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccccc4[C@@H]3c2cc1O
Show InChI InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
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n/an/an/an/a 88n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057857
PNG
((5aS,11bR)-2-Isopropyl-4,5,5a,6,7,11b-hexahydro-3-...)
Show SMILES CC(C)c1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C18H21NO2S/c1-9(2)16-7-12-17(22-16)8-19-13-4-3-10-5-14(20)15(21)6-11(10)18(12)13/h5-7,9,13,18-21H,3-4,8H2,1-2H3/t13-,18+/m0/s1
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n/an/an/an/a 29n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057855
PNG
((5aS,11bR)-2-Isobutyl-4,5,5a,6,7,11b-hexahydro-3-t...)
Show SMILES CC(C)Cc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C19H23NO2S/c1-10(2)5-12-7-14-18(23-12)9-20-15-4-3-11-6-16(21)17(22)8-13(11)19(14)15/h6-8,10,15,19-22H,3-5,9H2,1-2H3/t15-,19+/m0/s1
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n/an/an/an/a 88n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057848
PNG
((5aS,11bR)-2-Chloro-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES Oc1cc2CC[C@@H]3NCc4sc(Cl)cc4[C@H]3c2cc1O
Show InChI InChI=1S/C15H14ClNO2S/c16-14-5-9-13(20-14)6-17-10-2-1-7-3-11(18)12(19)4-8(7)15(9)10/h3-5,10,15,17-19H,1-2,6H2/t10-,15+/m0/s1
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n/an/an/an/a 170n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057841
PNG
((5aS,11bS)-2-Propyl-4,5,5a,6,7,11b-hexahydro-1-thi...)
Show SMILES CCCc1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C18H21NO2S/c1-2-3-12-6-11-9-19-14-5-4-10-7-15(20)16(21)8-13(10)17(14)18(11)22-12/h6-8,14,17,19-21H,2-5,9H2,1H3/t14-,17-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057852
PNG
((5aS,11bS)-2-tert-Butyl-4,5,5a,6,7,11b-hexahydro-1...)
Show SMILES CC(C)(C)c1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C19H23NO2S/c1-19(2,3)16-7-11-9-20-13-5-4-10-6-14(21)15(22)8-12(10)17(13)18(11)23-16/h6-8,13,17,20-22H,4-5,9H2,1-3H3/t13-,17-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057850
PNG
((5aS,11bS)-2-Hexyl-4,5,5a,6,7,11b-hexahydro-1-thia...)
Show SMILES CCCCCCc1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C21H27NO2S/c1-2-3-4-5-6-15-9-14-12-22-17-8-7-13-10-18(23)19(24)11-16(13)20(17)21(14)25-15/h9-11,17,20,22-24H,2-8,12H2,1H3/t17-,20-/m0/s1
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n/an/an/an/a 140n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057833
PNG
((5aS,11bS)-2-Chloro-4,5,5a,6,7,11b-hexahydro-1-thi...)
Show SMILES Oc1cc2CC[C@@H]3NCc4cc(Cl)sc4[C@H]3c2cc1O
Show InChI InChI=1S/C15H14ClNO2S/c16-13-4-8-6-17-10-2-1-7-3-11(18)12(19)5-9(7)14(10)15(8)20-13/h3-5,10,14,17-19H,1-2,6H2/t10-,14-/m0/s1
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n/an/an/an/a 43n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057842
PNG
((5aS,11bS)-2-Ethyl-4,5,5a,6,7,11b-hexahydro-1-thia...)
Show SMILES CCc1cc2CN[C@H]3CCc4cc(O)c(O)cc4[C@@H]3c2s1
Show InChI InChI=1S/C17H19NO2S/c1-2-11-5-10-8-18-13-4-3-9-6-14(19)15(20)7-12(9)16(13)17(10)21-11/h5-7,13,16,18-20H,2-4,8H2,1H3/t13-,16-/m0/s1
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n/an/an/an/a 50n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057853
PNG
((5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-1-thia-5-aza-c...)
Show SMILES Oc1cc2CC[C@H]3NCc4ccsc4[C@H]3c2cc1O
Show InChI InChI=1S/C15H15NO2S/c17-12-5-8-1-2-11-14(10(8)6-13(12)18)15-9(7-16-11)3-4-19-15/h3-6,11,14,16-18H,1-2,7H2/t11-,14+/m1/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057851
PNG
((5aS,11bR)-2-Phenyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES Oc1cc2CC[C@@H]3NCc4sc(cc4[C@H]3c2cc1O)-c1ccccc1
Show InChI InChI=1S/C21H19NO2S/c23-17-8-13-6-7-16-21(14(13)9-18(17)24)15-10-19(25-20(15)11-22-16)12-4-2-1-3-5-12/h1-5,8-10,16,21-24H,6-7,11H2/t16-,21+/m0/s1
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n/an/an/an/a 80n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057858
PNG
((5aR,11bR)-3-Propyl-4,5,5a,6,7,11b-hexahydro-1-thi...)
Show SMILES CCCc1csc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc12
Show InChI InChI=1S/C18H21NO2S/c1-2-3-11-9-22-18-13(11)8-19-14-5-4-10-6-15(20)16(21)7-12(10)17(14)18/h6-7,9,14,17,19-21H,2-5,8H2,1H3/t14-,17-/m1/s1
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n/an/an/an/a 160n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057838
PNG
((5aS,11bR)-2-Pentyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES CCCCCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C20H25NO2S/c1-2-3-4-5-13-9-15-19(24-13)11-21-16-7-6-12-8-17(22)18(23)10-14(12)20(15)16/h8-10,16,20-23H,2-7,11H2,1H3/t16-,20+/m0/s1
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n/an/an/an/a 170n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057856
PNG
((5aR,11bS)-3-Propyl-4,5,5a,6,7,11b-hexahydro-2-thi...)
Show SMILES CCCc1scc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc12
Show InChI InChI=1S/C18H21NO2S/c1-2-3-17-12-8-19-14-5-4-10-6-15(20)16(21)7-11(10)18(14)13(12)9-22-17/h6-7,9,14,18-21H,2-5,8H2,1H3/t14-,18+/m1/s1
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n/an/an/an/a 82n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408141
PNG
(CHEMBL2115372)
Show SMILES Cc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C16H17NO2S/c1-8-4-11-15(20-8)7-17-12-3-2-9-5-13(18)14(19)6-10(9)16(11)12/h4-6,12,16-19H,2-3,7H2,1H3/t12-,16+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408143
PNG
(CHEMBL2115377)
Show SMILES CCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C17H19NO2S/c1-2-10-6-12-16(21-10)8-18-13-4-3-9-5-14(19)15(20)7-11(9)17(12)13/h5-7,13,17-20H,2-4,8H2,1H3/t13-,17+/m0/s1
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n/an/an/an/a 31n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408145
PNG
(CHEMBL2114441)
Show SMILES CC(C)(C)c1cc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C19H23NO2S/c1-19(2,3)17-8-12-16(23-17)9-20-13-5-4-10-6-14(21)15(22)7-11(10)18(12)13/h6-8,13,18,20-22H,4-5,9H2,1-3H3/t13-,18+/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408146
PNG
(CHEMBL2114444)
Show SMILES CCc1cc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C17H19NO2S/c1-2-10-6-12-16(21-10)8-18-13-4-3-9-5-14(19)15(20)7-11(9)17(12)13/h5-7,13,17-20H,2-4,8H2,1H3/t13-,17+/m1/s1
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n/an/an/an/a 22n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408147
PNG
(CHEMBL2114440)
Show SMILES Cc1cc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C16H17NO2S/c1-8-4-11-15(20-8)7-17-12-3-2-9-5-13(18)14(19)6-10(9)16(11)12/h4-6,12,16-19H,2-3,7H2,1H3/t12-,16+/m1/s1
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n/an/an/an/a 33n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50033114
PNG
((5aR,11bS)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES CCCc1cc2[C@H]3[C@@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m1/s1
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n/an/an/an/a 24n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408144
PNG
(CHEMBL2115373)
Show SMILES CC(C)(C)c1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C19H23NO2S/c1-19(2,3)17-8-12-16(23-17)9-20-13-5-4-10-6-14(21)15(22)7-11(10)18(12)13/h6-8,13,18,20-22H,4-5,9H2,1-3H3/t13-,18+/m0/s1
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n/an/an/an/a 1.75E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057840
PNG
((5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-2-thia-5-aza-c...)
Show SMILES Oc1cc2CC[C@H]3NCc4cscc4[C@@H]3c2cc1O
Show InChI InChI=1S/C15H15NO2S/c17-13-3-8-1-2-12-15(10(8)4-14(13)18)11-7-19-6-9(11)5-16-12/h3-4,6-7,12,15-18H,1-2,5H2/t12-,15+/m1/s1
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n/an/an/an/a 240n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057835
PNG
((5aS,11bR)-2-Cyclohexyl-4,5,5a,6,7,11b-hexahydro-3...)
Show SMILES Oc1cc2CC[C@@H]3NCc4sc(cc4[C@H]3c2cc1O)C1CCCCC1
Show InChI InChI=1S/C21H25NO2S/c23-17-8-13-6-7-16-21(14(13)9-18(17)24)15-10-19(25-20(15)11-22-16)12-4-2-1-3-5-12/h8-10,12,16,21-24H,1-7,11H2/t16-,21+/m0/s1
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n/an/an/an/a 94n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057844
PNG
((5aS,11bS)-2-Cyclopentylmethyl-4,5,5a,6,7,11b-hexa...)
Show SMILES Oc1cc2CC[C@@H]3NCc4cc(CC5CCCC5)sc4[C@H]3c2cc1O
Show InChI InChI=1S/C21H25NO2S/c23-18-9-13-5-6-17-20(16(13)10-19(18)24)21-14(11-22-17)8-15(25-21)7-12-3-1-2-4-12/h8-10,12,17,20,22-24H,1-7,11H2/t17-,20-/m0/s1
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n/an/an/an/a 125n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50033116
PNG
((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...)
Show SMILES NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H27NO3/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20/h1-2,11-13,17-18,22-23H,3-10,21H2/t11?,12?,13?,17-,18-,20?/m0/s1
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n/an/an/an/a 8.20n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50057832
PNG
((5aS,11bS)-2-Cyclohexyl-4,5,5a,6,7,11b-hexahydro-1...)
Show SMILES Oc1cc2CC[C@@H]3NCc4cc(sc4[C@H]3c2cc1O)C1CCCCC1
Show InChI InChI=1S/C21H25NO2S/c23-17-8-13-6-7-16-20(15(13)10-18(17)24)21-14(11-22-16)9-19(25-21)12-4-2-1-3-5-12/h8-10,12,16,20,22-24H,1-7,11H2/t16-,20-/m0/s1
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n/an/an/an/a 79n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408144
PNG
(CHEMBL2115373)
Show SMILES CC(C)(C)c1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C19H23NO2S/c1-19(2,3)17-8-12-16(23-17)9-20-13-5-4-10-6-14(21)15(22)7-11(10)18(12)13/h6-8,13,18,20-22H,4-5,9H2,1-3H3/t13-,18+/m0/s1
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n/an/an/an/a 1.75E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408143
PNG
(CHEMBL2115377)
Show SMILES CCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C17H19NO2S/c1-2-10-6-12-16(21-10)8-18-13-4-3-9-5-14(19)15(20)7-11(9)17(12)13/h5-7,13,17-20H,2-4,8H2,1H3/t13-,17+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50033115
PNG
((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES CCCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50408141
PNG
(CHEMBL2115372)
Show SMILES Cc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C16H17NO2S/c1-8-4-11-15(20-8)7-17-12-3-2-9-5-13(18)14(19)6-10(9)16(11)12/h4-6,12,16-19H,2-3,7H2,1H3/t12-,16+/m0/s1
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n/an/an/an/a 87n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Carassius auratus)
BDBM50033115
PNG
((5aS,11bR)-2-Propyl-4,5,5a,6,7,11b-hexahydro-3-thi...)
Show SMILES CCCc1cc2[C@@H]3[C@H](CCc4cc(O)c(O)cc34)NCc2s1
Show InChI InChI=1S/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue


J Med Chem 40: 1585-99 (1997)


Article DOI: 10.1021/jm970038v
BindingDB Entry DOI: 10.7270/Q2Z89D2B
More data for this
Ligand-Target Pair