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Compile Data Set for Download or QSAR

Found 54 hits Enz. Inhib. hit(s) with Target = 'Dopamine beta-hydroxylase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014978
PNG
(1-(3,5-Difluoro-4-hydroxy-benzyl)-1,3-dihydro-imid...)
Show SMILES Oc1c(F)cc(Cn2cc[nH]c2=S)cc1F
Show InChI InChI=1S/C10H8F2N2OS/c11-7-3-6(4-8(12)9(7)15)5-14-2-1-13-10(14)16/h1-4,15H,5H2,(H,13,16)
KEGG

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n/an/a 74.1n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025811
PNG
(1-(3,5-Dichloro-4-hydroxy-benzyl)-1,3-dihydro-imid...)
Show SMILES Oc1c(Cl)cc(Cn2cc[nH]c2=S)cc1Cl
Show InChI InChI=1S/C10H8Cl2N2OS/c11-7-3-6(4-8(12)9(7)15)5-14-2-1-13-10(14)16/h1-4,15H,5H2,(H,13,16)
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n/an/a 676n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50000439
PNG
(5-Butyl-pyridine-2-carboxylic acid | 5-Butyl-pyrid...)
Show SMILES CCCCc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13)
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 0.4-1.1


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014983
PNG
(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Fc1cc(F)cc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H8F2N2S/c11-8-3-7(4-9(12)5-8)6-14-2-1-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.1-1.4


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014983
PNG
(1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Fc1cc(F)cc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H8F2N2S/c11-8-3-7(4-9(12)5-8)6-14-2-1-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025795
PNG
(1-(3-Fluoro-4-hydroxy-benzyl)-1,3-dihydro-imidazol...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1F
Show InChI InChI=1S/C10H9FN2OS/c11-8-5-7(1-2-9(8)14)6-13-4-3-12-10(13)15/h1-5,14H,6H2,(H,12,15)
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n/an/a 1.51E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025806
PNG
(1-(3-Chloro-4-hydroxy-benzyl)-1,3-dihydro-imidazol...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1Cl
Show InChI InChI=1S/C10H9ClN2OS/c11-8-5-7(1-2-9(8)14)6-13-4-3-12-10(13)15/h1-5,14H,6H2,(H,12,15)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025803
PNG
(1-(3,4-Dihydroxy-benzyl)-1,3-dihydro-imidazole-2-t...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1O
Show InChI InChI=1S/C10H10N2O2S/c13-8-2-1-7(5-9(8)14)6-12-4-3-11-10(12)15/h1-5,13-14H,6H2,(H,11,15)
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n/an/a 2.19E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025793
PNG
(1-(3,5-Dichloro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Clc1cc(Cl)cc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H8Cl2N2S/c11-8-3-7(4-9(12)5-8)6-14-2-1-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014968
PNG
(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)
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n/an/a 2.57E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014968
PNG
(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)
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n/an/a 2.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.3-4.6


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014969
PNG
(1-(3-Fluoro-benzyl)-1,3-dihydro-imidazole-2-thione...)
Show SMILES Fc1cccc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H9FN2S/c11-9-3-1-2-8(6-9)7-13-5-4-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 5.62E+3n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014960
PNG
(1-Benzyl-1,3-dihydro-imidazole-2-thione | 1-Benzyl...)
Show SMILES S=c1[nH]ccn1Cc1ccccc1
Show InChI InChI=1S/C10H10N2S/c13-10-11-6-7-12(10)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,11,13)
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n/an/a 1.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value range from 8.9-13


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025789
PNG
(1-(3-Chloro-benzyl)-1,3-dihydro-imidazole-2-thione...)
Show SMILES Clc1cccc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H9ClN2S/c11-9-3-1-2-8(6-9)7-13-5-4-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025810
PNG
(1-(3-Bromo-4-hydroxy-benzyl)-1,3-dihydro-imidazole...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1Br
Show InChI InChI=1S/C10H9BrN2OS/c11-8-5-7(1-2-9(8)14)6-13-4-3-12-10(13)15/h1-5,14H,6H2,(H,12,15)
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025791
PNG
(1-(2,4-Dichloro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Clc1ccc(Cn2cc[nH]c2=S)c(Cl)c1
Show InChI InChI=1S/C10H8Cl2N2S/c11-8-2-1-7(9(12)5-8)6-14-4-3-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50024476
PNG
(1-(5-Hydroxy-pyridin-2-ylmethyl)-1,3-dihydro-imida...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)nc1
Show InChI InChI=1S/C9H9N3OS/c13-8-2-1-7(11-5-8)6-12-4-3-10-9(12)14/h1-5,13H,6H2,(H,10,14)
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n/an/a 2.70E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 21-35


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025797
PNG
(1-(3,4-Dichloro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Clc1ccc(Cn2cc[nH]c2=S)cc1Cl
Show InChI InChI=1S/C10H8Cl2N2S/c11-8-2-1-7(5-9(8)12)6-14-4-3-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 2.82E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025785
PNG
(1-(4-Hydroxy-3-nitro-benzyl)-1,3-dihydro-imidazole...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1[N+]([O-])=O
Show InChI InChI=1S/C10H9N3O3S/c14-9-2-1-7(5-8(9)13(15)16)6-12-4-3-11-10(12)17/h1-5,14H,6H2,(H,11,17)
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n/an/a 3.09E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50014960
PNG
(1-Benzyl-1,3-dihydro-imidazole-2-thione | 1-Benzyl...)
Show SMILES S=c1[nH]ccn1Cc1ccccc1
Show InChI InChI=1S/C10H10N2S/c13-10-11-6-7-12(10)8-9-4-2-1-3-5-9/h1-7H,8H2,(H,11,13)
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n/an/a 3.31E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025790
PNG
(1-(3,5-Difluoro-4-methoxy-benzyl)-1,3-dihydro-imid...)
Show SMILES COc1c(F)cc(Cn2cc[nH]c2=S)cc1F
Show InChI InChI=1S/C11H10F2N2OS/c1-16-10-8(12)4-7(5-9(10)13)6-15-3-2-14-11(15)17/h2-5H,6H2,1H3,(H,14,17)
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n/an/a 3.63E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025799
PNG
(1-(3,5-Dichloro-4-methoxy-benzyl)-1,3-dihydro-imid...)
Show SMILES COc1c(Cl)cc(Cn2cc[nH]c2=S)cc1Cl
Show InChI InChI=1S/C11H10Cl2N2OS/c1-16-10-8(12)4-7(5-9(10)13)6-15-3-2-14-11(15)17/h2-5H,6H2,1H3,(H,14,17)
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n/an/a 4.68E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025802
PNG
(1-(4-Fluoro-benzyl)-1,3-dihydro-imidazole-2-thione...)
Show SMILES Fc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H9FN2S/c11-9-3-1-8(2-4-9)7-13-6-5-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 4.68E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025804
PNG
(1-(4-Hydroxy-3-methyl-benzyl)-1,3-dihydro-imidazol...)
Show SMILES Cc1cc(Cn2cc[nH]c2=S)ccc1O
Show InChI InChI=1S/C11H12N2OS/c1-8-6-9(2-3-10(8)14)7-13-5-4-12-11(13)15/h2-6,14H,7H2,1H3,(H,12,15)
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025787
PNG
(1-(2,3-Dichloro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Clc1cccc(Cn2cc[nH]c2=S)c1Cl
Show InChI InChI=1S/C10H8Cl2N2S/c11-8-3-1-2-7(9(8)12)6-14-5-4-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 5.25E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025807
PNG
(1-(4-Nitro-benzyl)-1,3-dihydro-imidazole-2-thione ...)
Show SMILES [O-][N+](=O)c1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H9N3O2S/c14-13(15)9-3-1-8(2-4-9)7-12-6-5-11-10(12)16/h1-6H,7H2,(H,11,16)
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n/an/a 5.25E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025808
PNG
(1-(2,3,5,6-Tetrafluoro-4-hydroxy-benzyl)-1,3-dihyd...)
Show SMILES Oc1c(F)c(F)c(Cn2cc[nH]c2=S)c(F)c1F
Show InChI InChI=1S/C10H6F4N2OS/c11-5-4(3-16-2-1-15-10(16)18)6(12)8(14)9(17)7(5)13/h1-2,17H,3H2,(H,15,18)
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n/an/a 6.17E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406071
PNG
(CHEMBL63619)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1C
Show InChI InChI=1S/C12H14N2OS/c1-9-7-10(3-4-11(9)15-2)8-14-6-5-13-12(14)16/h3-7H,8H2,1-2H3,(H,13,16)
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n/an/a 6.92E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406074
PNG
(CHEMBL302341)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1F
Show InChI InChI=1S/C11H11FN2OS/c1-15-10-3-2-8(6-9(10)12)7-14-5-4-13-11(14)16/h2-6H,7H2,1H3,(H,13,16)
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n/an/a 7.41E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406081
PNG
(CHEMBL294549)
Show SMILES COc1ccccc1Cn1cc[nH]c1=S
Show InChI InChI=1S/C11H12N2OS/c1-14-10-5-3-2-4-9(10)8-13-7-6-12-11(13)15/h2-7H,8H2,1H3,(H,12,15)
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n/an/a 7.41E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025805
PNG
(1-(2,6-Dichloro-4-hydroxy-benzyl)-1,3-dihydro-imid...)
Show SMILES Oc1cc(Cl)c(Cn2cc[nH]c2=S)c(Cl)c1
Show InChI InChI=1S/C10H8Cl2N2OS/c11-8-3-6(15)4-9(12)7(8)5-14-2-1-13-10(14)16/h1-4,15H,5H2,(H,13,16)
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n/an/a 7.59E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406079
PNG
(CHEMBL441985)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1Br
Show InChI InChI=1S/C11H11BrN2OS/c1-15-10-3-2-8(6-9(10)12)7-14-5-4-13-11(14)16/h2-6H,7H2,1H3,(H,13,16)
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n/an/a 8.32E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025788
PNG
(1-(4-Chloro-benzyl)-1,3-dihydro-imidazole-2-thione...)
Show SMILES Clc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H9ClN2S/c11-9-3-1-8(2-4-9)7-13-6-5-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 9.55E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025801
PNG
(1-(2,5-Dichloro-benzyl)-1,3-dihydro-imidazole-2-th...)
Show SMILES Clc1ccc(Cl)c(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H8Cl2N2S/c11-8-1-2-9(12)7(5-8)6-14-4-3-13-10(14)15/h1-5H,6H2,(H,13,15)
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n/an/a 9.77E+4n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025796
PNG
(1-(2,4,6-Trichloro-benzyl)-1,3-dihydro-imidazole-2...)
Show SMILES Clc1cc(Cl)c(Cn2cc[nH]c2=S)c(Cl)c1
Show InChI InChI=1S/C10H7Cl3N2S/c11-6-3-8(12)7(9(13)4-6)5-15-2-1-14-10(15)16/h1-4H,5H2,(H,14,16)
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n/an/a 1.02E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50024478
PNG
(1-Pyridin-3-ylmethyl-1,3-dihydro-imidazole-2-thion...)
Show SMILES S=c1[nH]ccn1Cc1cccnc1
Show InChI InChI=1S/C9H9N3S/c13-9-11-4-5-12(9)7-8-2-1-3-10-6-8/h1-6H,7H2,(H,11,13)
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n/an/a 1.04E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 89-121


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406073
PNG
(CHEMBL63701)
Show SMILES Brc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C10H9BrN2S/c11-9-3-1-8(2-4-9)7-13-6-5-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 1.15E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025786
PNG
(1-(4-Hydroxy-3-trifluoromethyl-benzyl)-1,3-dihydro...)
Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1C(F)(F)F
Show InChI InChI=1S/C11H9F3N2OS/c12-11(13,14)8-5-7(1-2-9(8)17)6-16-4-3-15-10(16)18/h1-5,17H,6H2,(H,15,18)
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n/an/a 1.20E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50024477
PNG
(1-Pyridin-2-ylmethyl-1,3-dihydro-imidazole-2-thion...)
Show SMILES S=c1[nH]ccn1Cc1ccccn1
Show InChI InChI=1S/C9H9N3S/c13-9-11-5-6-12(9)7-8-3-1-2-4-10-8/h1-6H,7H2,(H,11,13)
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n/an/a 1.31E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 76-220


J Med Chem 30: 1309-13 (1987)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025794
PNG
(1-(3-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES Oc1cccc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-2-8(6-9)7-12-5-4-11-10(12)14/h1-6,13H,7H2,(H,11,14)
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n/an/a 1.48E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406072
PNG
(CHEMBL65265)
Show SMILES Cc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C11H12N2S/c1-9-2-4-10(5-3-9)8-13-7-6-12-11(13)14/h2-7H,8H2,1H3,(H,12,14)
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n/an/a 1.48E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406077
PNG
(CHEMBL63667)
Show SMILES COc1cc(Cl)c(Cn2cc[nH]c2=S)c(Cl)c1
Show InChI InChI=1S/C11H10Cl2N2OS/c1-16-7-4-9(12)8(10(13)5-7)6-15-3-2-14-11(15)17/h2-5H,6H2,1H3,(H,14,17)
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n/an/a 1.55E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025809
PNG
(1-(3-Methoxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES COc1cccc(Cn2cc[nH]c2=S)c1
Show InChI InChI=1S/C11H12N2OS/c1-14-10-4-2-3-9(7-10)8-13-6-5-12-11(13)15/h2-7H,8H2,1H3,(H,12,15)
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n/an/a 1.58E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406084
PNG
(CHEMBL67213)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1C(F)(F)F
Show InChI InChI=1S/C12H11F3N2OS/c1-18-10-3-2-8(6-9(10)12(13,14)15)7-17-5-4-16-11(17)19/h2-6H,7H2,1H3,(H,16,19)
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n/an/a 1.74E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406075
PNG
(CHEMBL64938)
Show SMILES FC(F)(F)c1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C11H9F3N2S/c12-11(13,14)9-3-1-8(2-4-9)7-16-6-5-15-10(16)17/h1-6H,7H2,(H,15,17)
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n/an/a 2.00E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025486
PNG
(1-(4-Methoxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1
Show InChI InChI=1S/C11H12N2OS/c1-14-10-4-2-9(3-5-10)8-13-7-6-12-11(13)15/h2-7H,8H2,1H3,(H,12,15)
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n/an/a 2.04E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406080
PNG
(CHEMBL65169)
Show SMILES Cc1ccccc1Cn1cc[nH]c1=S
Show InChI InChI=1S/C11H12N2S/c1-9-4-2-3-5-10(9)8-13-7-6-12-11(13)14/h2-7H,8H2,1H3,(H,12,14)
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n/an/a 3.39E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406085
PNG
(CHEMBL308667)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1OC
Show InChI InChI=1S/C12H14N2O2S/c1-15-10-4-3-9(7-11(10)16-2)8-14-6-5-13-12(14)17/h3-7H,8H2,1-2H3,(H,13,17)
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n/an/a 3.39E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50406083
PNG
(CHEMBL304123)
Show SMILES Clc1ccccc1Cn1cc[nH]c1=S
Show InChI InChI=1S/C10H9ClN2S/c11-9-4-2-1-3-8(9)7-13-6-5-12-10(13)14/h1-6H,7H2,(H,12,14)
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n/an/a 3.55E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
Dopamine beta-hydroxylase


(Rattus norvegicus)
BDBM50025784
PNG
(1-(4-Methoxy-3-nitro-benzyl)-1,3-dihydro-imidazole...)
Show SMILES COc1ccc(Cn2cc[nH]c2=S)cc1[N+]([O-])=O
Show InChI InChI=1S/C11H11N3O3S/c1-17-10-3-2-8(6-9(10)14(15)16)7-13-5-4-12-11(13)18/h2-6H,7H2,1H3,(H,12,18)
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n/an/a 3.55E+5n/an/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally


J Med Chem 33: 274-81 (1990)

More data for this
Ligand-Target Pair
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