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Compile Data Set for Download or QSAR

Found 451 hits Enz. Inhib. hit(s) with Target = 'Dopamine receptor' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor


(Bos taurus)
BDBM50060601
PNG
((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)NCC(N)=O
Show InChI InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1
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0.0400n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p (Pre treated with 1 uM) calculated for the high affinity components of the [3H]spiroperidol b...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060602
PNG
(2-[3-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]p...)
Show SMILES NC(=O)CN1CCC(N2CC(=O)N3CCC[C@H]3C2=O)C1=O
Show InChI InChI=1S/C13H18N4O4/c14-10(18)6-15-5-3-9(12(15)20)17-7-11(19)16-4-1-2-8(16)13(17)21/h8-9H,1-7H2,(H2,14,18)/t8-,9?/m0/s1
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0.0500n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p (Pre treated with 1 nM) calculated for the high affinity components of the [3H]spiroperidol b...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060603
PNG
((3S,7aR)-6-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1...)
Show SMILES NC(=O)[C@H]1CS[C@@H]2CC(N3CC(=O)N4CCC[C@H]4C3=O)C(=O)N12
Show InChI InChI=1S/C14H18N4O4S/c15-12(20)9-6-23-11-4-8(14(22)18(9)11)17-5-10(19)16-3-1-2-7(16)13(17)21/h7-9,11H,1-6H2,(H2,15,20)/t7-,8?,9+,11+/m0/s1
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0.0660n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Percentage of receptor in the low affinity form for the compound to Dopamine receptor D2 in absence of Gpp(NH)p (pre treated with 100 nM)


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060603
PNG
((3S,7aR)-6-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1...)
Show SMILES NC(=O)[C@H]1CS[C@@H]2CC(N3CC(=O)N4CCC[C@H]4C3=O)C(=O)N12
Show InChI InChI=1S/C14H18N4O4S/c15-12(20)9-6-23-11-4-8(14(22)18(9)11)17-5-10(19)16-3-1-2-7(16)13(17)21/h7-9,11H,1-6H2,(H2,15,20)/t7-,8?,9+,11+/m0/s1
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0.0670n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p (Pre treated with 100 nM) calculated for the high affinity components of the [3H]spiroperidol...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060600
PNG
((S)-2-((S)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]pyraz...)
Show SMILES CC(C)C[C@H](N1CC(=O)N2CCC[C@H]2C1=O)C(=O)NCC(N)=O
Show InChI InChI=1S/C15H24N4O4/c1-9(2)6-11(14(22)17-7-12(16)20)19-8-13(21)18-5-3-4-10(18)15(19)23/h9-11H,3-8H2,1-2H3,(H2,16,20)(H,17,22)/t10-,11-/m0/s1
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0.0680n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Percentage of receptor in the high affinity form for the compound to Dopamine receptor D2 in presence of Gpp(NH)p (pretreated with 100 nM)


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060600
PNG
((S)-2-((S)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]pyraz...)
Show SMILES CC(C)C[C@H](N1CC(=O)N2CCC[C@H]2C1=O)C(=O)NCC(N)=O
Show InChI InChI=1S/C15H24N4O4/c1-9(2)6-11(14(22)17-7-12(16)20)19-8-13(21)18-5-3-4-10(18)15(19)23/h9-11H,3-8H2,1-2H3,(H2,16,20)(H,17,22)/t10-,11-/m0/s1
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0.0800n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p (Pre treated with 100 nM) calculated for the high affinity components of the [3H]spiroperidol...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060602
PNG
(2-[3-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]p...)
Show SMILES NC(=O)CN1CCC(N2CC(=O)N3CCC[C@H]3C2=O)C1=O
Show InChI InChI=1S/C13H18N4O4/c14-10(18)6-15-5-3-9(12(15)20)17-7-11(19)16-4-1-2-8(16)13(17)21/h8-9H,1-7H2,(H2,14,18)/t8-,9?/m0/s1
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0.0800n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in absence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recept...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060600
PNG
((S)-2-((S)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]pyraz...)
Show SMILES CC(C)C[C@H](N1CC(=O)N2CCC[C@H]2C1=O)C(=O)NCC(N)=O
Show InChI InChI=1S/C15H24N4O4/c1-9(2)6-11(14(22)17-7-12(16)20)19-8-13(21)18-5-3-4-10(18)15(19)23/h9-11H,3-8H2,1-2H3,(H2,16,20)(H,17,22)/t10-,11-/m0/s1
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0.0800n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in absence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recept...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060601
PNG
((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)NCC(N)=O
Show InChI InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1
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0.0900n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in absence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recept...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060603
PNG
((3S,7aR)-6-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1...)
Show SMILES NC(=O)[C@H]1CS[C@@H]2CC(N3CC(=O)N4CCC[C@H]4C3=O)C(=O)N12
Show InChI InChI=1S/C14H18N4O4S/c15-12(20)9-6-23-11-4-8(14(22)18(9)11)17-5-10(19)16-3-1-2-7(16)13(17)21/h7-9,11H,1-6H2,(H2,15,20)/t7-,8?,9+,11+/m0/s1
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0.0980n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in absence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recept...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060600
PNG
((S)-2-((S)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]pyraz...)
Show SMILES CC(C)C[C@H](N1CC(=O)N2CCC[C@H]2C1=O)C(=O)NCC(N)=O
Show InChI InChI=1S/C15H24N4O4/c1-9(2)6-11(14(22)17-7-12(16)20)19-8-13(21)18-5-3-4-10(18)15(19)23/h9-11H,3-8H2,1-2H3,(H2,16,20)(H,17,22)/t10-,11-/m0/s1
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0.120n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recep...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060601
PNG
((E)-6-(3-oxo-3-phenylprop-1-enyl)pyrimidine-2,4(1H...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)NCC(N)=O
Show InChI InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recep...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060603
PNG
((3S,7aR)-6-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1...)
Show SMILES NC(=O)[C@H]1CS[C@@H]2CC(N3CC(=O)N4CCC[C@H]4C3=O)C(=O)N12
Show InChI InChI=1S/C14H18N4O4S/c15-12(20)9-6-23-11-4-8(14(22)18(9)11)17-5-10(19)16-3-1-2-7(16)13(17)21/h7-9,11H,1-6H2,(H2,15,20)/t7-,8?,9+,11+/m0/s1
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0.140n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recep...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50060602
PNG
(2-[3-((2R,8aS)-1,4-Dioxo-hexahydro-pyrrolo[1,2-a]p...)
Show SMILES NC(=O)CN1CCC(N2CC(=O)N3CCC[C@H]3C2=O)C1=O
Show InChI InChI=1S/C13H18N4O4/c14-10(18)6-15-5-3-9(12(15)20)17-7-11(19)16-4-1-2-8(16)13(17)21/h8-9H,1-7H2,(H2,14,18)/t8-,9?/m0/s1
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0.190n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibitory constant of compound in presence of Gpp(NH)p calculated for the high affinity components of the [3H]spiroperidol binding to Dopamine recep...


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.300n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Evaluated for binding towards Dopamine receptor D2 using [3H]-spiperone as radioligand, in cloned mammalian receptors expressed in CHO-K1 cells


J Med Chem 36: 3188-96 (1993)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50264513
PNG
(4-Bromo-6-{2-[4-(2-methoxyphenyl)piperazin-1-yl]-e...)
Show SMILES COc1ccccc1N1CCN(CCc2cc(Br)c3nc[nH]c3c2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-26-19-5-3-2-4-18(19)25-10-8-24(9-11-25)7-6-15-12-16(21)20-17(13-15)22-14-23-20/h2-5,12-14H,6-11H2,1H3,(H,22,23)
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0.560n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50334150
PNG
(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Show SMILES Fc1ccc(cc1)C(CCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(F)cc1
Show InChI InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
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0.600n/an/an/an/an/an/an/an/a



Cooperation Pharmaceutique Fran�aise

Curated by ChEMBL


Assay Description
Binding affinity of compound towards Dopamine receptor D2 using [3H]raclopride (1.2 nM) ligand in striatum bovine was determined


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.700n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]-U-86,170


J Med Chem 36: 3188-96 (1993)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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1.80n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Binding Affinity on high Affinity Site of Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]pramipexole was tested


J Med Chem 43: 756-62 (2000)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50123627
PNG
((S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Show SMILES CCCN(CCC)[C@H]1CCc2c(C1)ccc(O)c2O
Show InChI InChI=1S/C16H25NO2/c1-3-9-17(10-4-2)13-6-7-14-12(11-13)5-8-15(18)16(14)19/h5,8,13,18-19H,3-4,6-7,9-11H2,1-2H3/t13-/m0/s1
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2n/an/an/an/an/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50017466
PNG
(2-Methylsulfanylmethyl-4-propyl-1,2,3,4,4a,5,6,10b...)
Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1CCc1cc(O)c(O)cc21
Show InChI InChI=1S/C18H27NO2S/c1-3-6-19-10-12(11-22-2)7-15-14-9-18(21)17(20)8-13(14)4-5-16(15)19/h8-9,12,15-16,20-21H,3-7,10-11H2,1-2H3/t12-,15-,16-/m1/s1
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2n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
High binding affinity of the compound for dopamine D-2 receptor from bovine anterior pitutary membrane, using radioligand [3H]-spiroperidol


J Med Chem 32: 961-8 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50007170
PNG
(Adamantane-1-carboxylic acid {4-[4-(2-methoxy-phen...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1
Show InChI InChI=1S/C26H39N3O2/c1-31-24-7-3-2-6-23(24)29-12-10-28(11-13-29)9-5-4-8-27-25(30)26-17-20-14-21(18-26)16-22(15-20)19-26/h2-3,6-7,20-22H,4-5,8-19H2,1H3,(H,27,30)/t20-,21+,22-,26?
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2.70n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards D2-dopaminergic receptor using [3H]-NMSP as radioligand


J Med Chem 34: 2633-8 (1991)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50122735
PNG
(3-(4-Methyl-cyclohexyl)-1-propyl-piperidine; hydro...)
Show SMILES CCCN1CCCC(C1)C1CCC(C)CC1
Show InChI InChI=1S/C15H29N/c1-3-10-16-11-4-5-15(12-16)14-8-6-13(2)7-9-14/h13-15H,3-12H2,1-2H3
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4n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity)


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50017469
PNG
((9-Hydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydro-b...)
Show SMILES CCCN1C[C@H](CC#N)C[C@H]2[C@H]1CCc1ccc(O)cc21
Show InChI InChI=1S/C18H24N2O/c1-2-9-20-12-13(7-8-19)10-17-16-11-15(21)5-3-14(16)4-6-18(17)20/h3,5,11,13,17-18,21H,2,4,6-7,9-10,12H2,1H3/t13-,17-,18-/m1/s1
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4n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
High binding affinity of the compound for dopamine D-2 receptor from bovine anterior pitutary membrane, using radioligand [3H]-spiroperidol in bovine...


J Med Chem 32: 961-8 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50122737
PNG
(3-Cyclohexyl-1-propyl-piperidine; hydrochloride | ...)
Show SMILES CCCN1CCCC(C1)C1CCCCC1
Show InChI InChI=1S/C14H27N/c1-2-10-15-11-6-9-14(12-15)13-7-4-3-5-8-13/h13-14H,2-12H2,1H3
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4n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity)


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50054067
PNG
((2R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen...)
Show SMILES CCCN(CCC)[C@@H]1CCc2ccc(O)cc2C1
Show InChI InChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3/t15-/m1/s1
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5n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]-Pramipexole from high affinity binding sites of bovine cloned D2 receptors stably expressed in CHO cells.


Bioorg Med Chem Lett 11: 2863-6 (2001)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50122736
PNG
(3-(3-Methyl-cyclohexyl)-1-propyl-piperidine; hydro...)
Show SMILES CCCN1CCCC(C1)C1CCCC(C)C1
Show InChI InChI=1S/C15H29N/c1-3-9-16-10-5-8-15(12-16)14-7-4-6-13(2)11-14/h13-15H,3-12H2,1-2H3
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5n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity)


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50264478
PNG
(4-Chloro-6-{2-[4-(2-methoxyphenyl)piperazin-1-yl]-...)
Show SMILES COc1ccccc1N1CCN(CCc2cc(Cl)c3nc[nH]c3c2)CC1
Show InChI InChI=1S/C20H23ClN4O/c1-26-19-5-3-2-4-18(19)25-10-8-24(9-11-25)7-6-15-12-16(21)20-17(13-15)22-14-23-20/h2-5,12-14H,6-11H2,1H3,(H,22,23)
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5.49n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50088844
PNG
(4-{4-[4-(4-Phenyl-piperazin-1-yl)-butyl]-phenyl}-t...)
Show SMILES Nc1nc(cs1)-c1ccc(CCCCN2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C23H28N4S/c24-23-25-22(18-28-23)20-11-9-19(10-12-20)6-4-5-13-26-14-16-27(17-15-26)21-7-2-1-3-8-21/h1-3,7-12,18H,4-6,13-17H2,(H2,24,25)
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5.5n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Dopamine receptor D2


Bioorg Med Chem Lett 10: 875-9 (2000)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50264541
PNG
(4-Bromo-6-(2-{4-[3-(trifluoromethyl)phenyl]piperaz...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCc2cc(Br)c3nc[nH]c3c2)CC1
Show InChI InChI=1S/C20H20BrF3N4/c21-17-10-14(11-18-19(17)26-13-25-18)4-5-27-6-8-28(9-7-27)16-3-1-2-15(12-16)20(22,23)24/h1-3,10-13H,4-9H2,(H,25,26)
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5.77n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50017464
PNG
((8,9-Dihydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahyd...)
Show SMILES CCCN1C[C@H](CC#N)C[C@H]2[C@H]1CCc1cc(O)c(O)cc21
Show InChI InChI=1S/C18H24N2O2/c1-2-7-20-11-12(5-6-19)8-15-14-10-18(22)17(21)9-13(14)3-4-16(15)20/h9-10,12,15-16,21-22H,2-5,7-8,11H2,1H3/t12-,15-,16-/m1/s1
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6n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
High binding affinity of the compound for dopamine D-2 receptor from bovine anterior pitutary membrane, using radioligand [3H]-spiroperidol


J Med Chem 32: 961-8 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50123625
PNG
((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Show SMILES CCCN(CCc1cccs1)[C@H]1CCc2c(C1)ccc(O)c2O
Show InChI InChI=1S/C19H25NO2S/c1-2-10-20(11-9-16-4-3-12-23-16)15-6-7-17-14(13-15)5-8-18(21)19(17)22/h3-5,8,12,15,21-22H,2,6-7,9-11,13H2,1H3/t15-/m0/s1
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6n/an/an/an/an/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50019719
PNG
(5-Fluoro-1-[1-(5-methyl-2,3-dihydro-benzo[1,4]diox...)
Show SMILES Cc1cccc2OC(CN3CCC(CC3)n3c4ccc(F)cc4[nH]c3=O)COc12
Show InChI InChI=1S/C22H24FN3O3/c1-14-3-2-4-20-21(14)28-13-17(29-20)12-25-9-7-16(8-10-25)26-19-6-5-15(23)11-18(19)24-22(26)27/h2-6,11,16-17H,7-10,12-13H2,1H3,(H,24,27)
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8n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiroperidol from bovine caudate nucleus membrane Dopamine receptor D2


J Med Chem 30: 814-9 (1987)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50017462
PNG
(2-Methyl-4-propyl-1,2,3,4,4a,5,6,10b-octahydro-ben...)
Show SMILES CCCN1C[C@H](C)C[C@H]2[C@H]1CCc1ccc(O)cc21
Show InChI InChI=1S/C17H25NO/c1-3-8-18-11-12(2)9-16-15-10-14(19)6-4-13(15)5-7-17(16)18/h4,6,10,12,16-17,19H,3,5,7-9,11H2,1-2H3/t12-,16-,17-/m1/s1
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8n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
High binding affinity of the compound for dopamine D-2 receptor from bovine anterior pitutary membrane, using radioligand [3H]-spiroperidol


J Med Chem 32: 961-8 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM81924
PNG
((R)-3-(1-Propyl-piperidin-3-yl)-phenol | 3PPP(+/-)...)
Show SMILES CCCN1CCCC(C1)c1cccc(O)c1
Show InChI InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3
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8.5n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]-U-86,170


J Med Chem 36: 3188-96 (1993)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50116767
PNG
(CHEMBL310867 | Dipropyl-(S)-1,2,3,4-tetrahydro-pyr...)
Show SMILES CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1
Show InChI InChI=1S/C17H25N3/c1-3-10-19(11-4-2)14-8-9-16-15(13-14)17-7-5-6-12-20(17)18-16/h5-7,12,14H,3-4,8-11,13H2,1-2H3/t14-/m0/s1
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8.60n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Binding affinity of compound against Dopamine receptor D2 was measured using [3H]-pramipexole in Bovine striatal membranes


Bioorg Med Chem Lett 12: 2377-80 (2002)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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11n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Binding Affinity was tested on high Affinity Site of Bovine Dopamine D2 Receptor. Tested for ability to displace the radioligand [3H]spiperone was te...


J Med Chem 43: 756-62 (2000)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50041961
PNG
(((1S,2R)-5-Methoxy-1-methyl-1,2,3,4-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C
Show InChI InChI=1S/C18H29NO/c1-5-12-19(13-6-2)17-11-10-16-15(14(17)3)8-7-9-18(16)20-4/h7-9,14,17H,5-6,10-13H2,1-4H3/t14-,17+/m0/s1
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13n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]-U-86,170


J Med Chem 36: 3188-96 (1993)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50264544
PNG
(6-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-1H-...)
Show SMILES COc1ccccc1N1CCN(CCc2ccc3nc[nH]c3c2)CC1
Show InChI InChI=1S/C20H24N4O/c1-25-20-5-3-2-4-19(20)24-12-10-23(11-13-24)9-8-16-6-7-17-18(14-16)22-15-21-17/h2-7,14-15H,8-13H2,1H3,(H,21,22)
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13.1n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50017461
PNG
(2-Methylsulfanylmethyl-4-propyl-1,2,3,4,4a,5,6,10b...)
Show SMILES CCCN1C[C@H](CSC)C[C@H]2[C@H]1CCc1ccc(O)cc21
Show InChI InChI=1S/C18H27NOS/c1-3-8-19-11-13(12-21-2)9-17-16-10-15(20)6-4-14(16)5-7-18(17)19/h4,6,10,13,17-18,20H,3,5,7-9,11-12H2,1-2H3/t13-,17-,18-/m1/s1
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14n/an/an/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
High binding affinity of the compound for dopamine D-2 receptor from bovine anterior pitutary membrane, using radioligand [3H]-spiroperidol in bovine...


J Med Chem 32: 961-8 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50085331
PNG
((4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine | 4-eth...)
Show SMILES CCCN(CCC)C1CCC(=CC1)C#C
Show InChI InChI=1S/C14H23N/c1-4-11-15(12-5-2)14-9-7-13(6-3)8-10-14/h3,7,14H,4-5,8-12H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
Binding Affinity was tested on high Affinity Site of Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]pramipexole


J Med Chem 43: 756-62 (2000)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM55121
PNG
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Show SMILES NCCc1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
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15n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity site


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50123626
PNG
((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Show SMILES CCCN(CCc1cccs1)[C@H]1CCc2c(O)cccc2C1
Show InChI InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
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15n/an/an/an/an/an/an/an/a



University Centre for Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50041961
PNG
(((1S,2R)-5-Methoxy-1-methyl-1,2,3,4-tetrahydro-nap...)
Show SMILES CCCN(CCC)[C@@H]1CCc2c(OC)cccc2[C@@H]1C
Show InChI InChI=1S/C18H29NO/c1-5-12-19(13-6-2)17-11-10-16-15(14(17)3)8-7-9-18(16)20-4/h7-9,14,17H,5-6,10-13H2,1-4H3/t14-,17+/m0/s1
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18n/an/an/an/an/an/an/an/a



University of Göteborg

Curated by ChEMBL


Assay Description
Evaluated for binding towards Dopamine receptor D2 using [3H]-spiperone as radioligand, in cloned mammalian receptors expressed in CHO-K1 cells


J Med Chem 36: 3188-96 (1993)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50068422
PNG
(3-(3,4-Dimethyl-phenyl)-1-propyl-piperidine | CHEM...)
Show SMILES CCCN1CCCC(C1)c1ccc(C)c(C)c1
Show InChI InChI=1S/C16H25N/c1-4-9-17-10-5-6-16(12-17)15-8-7-13(2)14(3)11-15/h7-8,11,16H,4-6,9-10,12H2,1-3H3
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19n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity site


Citation and Details
More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50264509
PNG
(4-Chloro-6-{2-[4-(2-chlorophenyl)piperazin-1-yl]et...)
Show SMILES Clc1ccccc1N1CCN(CCc2cc(Cl)c3nc[nH]c3c2)CC1
Show InChI InChI=1S/C19H20Cl2N4/c20-15-3-1-2-4-18(15)25-9-7-24(8-10-25)6-5-14-11-16(21)19-17(12-14)22-13-23-19/h1-4,11-13H,5-10H2,(H,22,23)
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19.1n/an/an/an/an/an/an/an/a



University of Belgrade

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from dopamine D2 receptor in bovine caudate nuclei synaptosomal membrane by liquid scintillation spectrometry


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More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 was determined by displacement of [3H]-spiroperidol from bovine nucleus caudate membranes.


J Med Chem 30: 814-9 (1987)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50105731
PNG
((S)-7-Dipropylamino-5,6,7,8-tetrahydro-indolizine-...)
Show SMILES CCCN(CCC)[C@H]1CCn2c(C1)ccc2C=O
Show InChI InChI=1S/C15H24N2O/c1-3-8-16(9-4-2)13-7-10-17-14(11-13)5-6-15(17)12-18/h5-6,12-13H,3-4,7-11H2,1-2H3/t13-/m0/s1
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21n/an/an/an/an/an/an/an/a



Friedrich-Alexander University

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]-Pramipexole from high affinity binding sites of bovine cloned D2 receptors stably expressed in CHO cells.


Bioorg Med Chem Lett 11: 2863-6 (2001)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50019721
PNG
(1-[1-(6,7-Dimethyl-2,3-dihydro-benzo[1,4]dioxin-2-...)
Show SMILES Cc1cc2OCC(CN3CCC(CC3)n3c4ccc(F)cc4[nH]c3=O)Oc2cc1C
Show InChI InChI=1S/C23H26FN3O3/c1-14-9-21-22(10-15(14)2)30-18(13-29-21)12-26-7-5-17(6-8-26)27-20-4-3-16(24)11-19(20)25-23(27)28/h3-4,9-11,17-18H,5-8,12-13H2,1-2H3,(H,25,28)
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25n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiroperidol from bovine caudate nucleus membrane Dopamine receptor D2


J Med Chem 30: 814-9 (1987)

More data for this
Ligand-Target Pair
Dopamine receptor


(Bos taurus)
BDBM50058225
PNG
(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Show SMILES Cc1cccc(c1)C(=O)NCN1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C20H22N4O/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21/h2-8,13H,9-12,15H2,1H3,(H,22,25)
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25n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity)


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Ligand-Target Pair
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