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Found 6 hits Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase; MEK1/2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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PC sid
PDB
UniChem

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AffyNet 
Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of MEK


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.78E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.96E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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GoogleScholar
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PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens-Homo sapiens (human))
BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
KEGG

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


Citation and Details
More data for this
Ligand-Target Pair