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Compile Data Set for Download or QSAR

Found 877 hits Enz. Inhib. hit(s) with Target = 'Dual specificity phosphatase Cdc25B' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM41999
PNG
(3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic ...)
Show SMILES OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Show InChI InChI=1S/C16H12O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-2,4-5,17,21-22H,3,6H2,(H,19,20)
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80n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50106497
PNG
(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Show SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12
Show InChI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-4,20-21H,5-9H2
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95n/an/an/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)-$l^{5}-stibanyl]phenyl}p...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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369n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129580
PNG
(3-[4,6-Dichloro-7-(3-methyl-but-2-enyl)-1H-indol-3...)
Show SMILES CC(C)=CCc1c(Cl)cc(Cl)c2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H15Cl2NO4/c1-8(2)3-4-9-11(20)5-12(21)15-10(7-22-17(9)15)16-18(25)13(23)6-14(24)19(16)26/h3,5,7,16,22H,4,6H2,1-2H3
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430n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129574
PNG
(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Show SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H17NO4/c1-10(2)6-7-11-4-3-5-12-13(9-20-17(11)12)16-18(23)14(21)8-15(22)19(16)24/h3-6,9,16,20H,7-8H2,1-2H3
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640n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50084504
PNG
(CHEMBL3426991)
Show SMILES Nc1cccc(c1)-c1ccc2c(cc(Nc3ccccc3)[nH]c2=O)c1
Show InChI InChI=1S/C21H17N3O/c22-17-6-4-5-14(12-17)15-9-10-19-16(11-15)13-20(24-21(19)25)23-18-7-2-1-3-8-18/h1-13H,22H2,(H2,23,24,25)
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1.90E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50096680
PNG
((E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-...)
Show SMILES CCCc1sc(NS(=O)(=O)\C=C\c2ccccc2Cl)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2O2S2/c1-2-5-18-19(15-8-10-16(21)11-9-15)23-20(27-18)24-28(25,26)13-12-14-6-3-4-7-17(14)22/h3-4,6-13H,2,5H2,1H3,(H,23,24)/b13-12+
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4.60E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibitory activity against human recombinant Cdc25B phosphatase enzyme


Bioorg Med Chem Lett 11: 313-7 (2001)

More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50388723
PNG
(CHEMBL2057662)
Show SMILES OC(=O)CCc1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H9O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-5H,6-7H2,(H,10,11);2*1H2;;/q;;;;+2/p-2
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4.70E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM26617
PNG
(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)
Show SMILES OC(=O)c1ccccc1C(=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C16H10O7/c17-13(9-3-1-2-4-10(9)14(18)19)8-5-6-11(15(20)21)12(7-8)16(22)23/h1-7H,(H,18,19)(H,20,21)(H,22,23)
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5.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129575
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-[1,4]benzoquinone ...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C14H9NO4/c16-10-5-11(17)14(19)12(13(10)18)8-6-15-9-4-2-1-3-7(8)9/h1-4,6,12,15H,5H2
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1.30E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cdc25B phosphatase was determined using mFP as a substrate


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50096693
PNG
((E)-2-Naphthalen-2-yl-ethenesulfonic acid (4,5-dip...)
Show SMILES O=S(=O)(Nc1nc(c(s1)-c1ccccc1)-c1ccccc1)\C=C\c1ccc2ccccc2c1
Show InChI InChI=1S/C27H20N2O2S2/c30-33(31,18-17-20-15-16-21-9-7-8-14-24(21)19-20)29-27-28-25(22-10-3-1-4-11-22)26(32-27)23-12-5-2-6-13-23/h1-19H,(H,28,29)/b18-17+
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3.60E+4n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibitory activity against human recombinant Cdc25B phosphatase enzyme


Bioorg Med Chem Lett 11: 313-7 (2001)

More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50388538
PNG
(CHEMBL507159)
Show SMILES COc1ccc(Cc2ccc3[nH]c(=O)cc(C)c3c2)cc1S(O)(=O)=O
Show InChI InChI=1S/C18H17NO5S/c1-11-7-18(20)19-15-5-3-12(9-14(11)15)8-13-4-6-16(24-2)17(10-13)25(21,22)23/h3-7,9-10H,8H2,1-2H3,(H,19,20)(H,21,22,23)
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8.40E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50328823
PNG
(5,5'-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)dif...)
Show SMILES OS(=O)(=O)c1ccc(o1)-c1nnc(nc1-c1ccc(o1)S(O)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C16H10N4O8S2/c21-29(22,23)12-6-4-10(27-12)14-15(11-5-7-13(28-11)30(24,25)26)19-20-16(18-14)9-3-1-2-8-17-9/h1-8H,(H,21,22,23)(H,24,25,26)
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1.59E+5n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50391109
PNG
(CHEMBL179166 | Vanadates)
Show SMILES [O-][V]([O-])([O-])=O
Show InChI InChI=1S/4O.V/q;3*-1;
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n/an/a 0.930n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057655
PNG
(CHEMBL3322829)
Show SMILES COc1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H16N4O5S/c1-30-17-8-2-14(3-9-17)20(27)23-22-25-24-21(32-22)15-4-10-18(11-5-15)31-19-12-6-16(7-13-19)26(28)29/h2-13H,1H3,(H,23,25,27)
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n/an/a 1.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057664
PNG
(CHEMBL3322846)
Show SMILES Cc1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O6S/c1-13-2-4-14(5-3-13)20(28)23-22-25-24-21(34-22)15-6-9-17(10-7-15)33-19-11-8-16(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 1.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057670
PNG
(CHEMBL3322855)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H12N6O8S/c28-19(13-2-1-3-14(10-13)25(29)30)22-21-24-23-20(36-21)12-4-7-16(8-5-12)35-18-9-6-15(26(31)32)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 1.30n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057672
PNG
(CHEMBL3322857)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3ccccc3)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H15N5O6S/c28-20(12-14-4-2-1-3-5-14)23-22-25-24-21(34-22)15-6-9-17(10-7-15)33-19-11-8-16(26(29)30)13-18(19)27(31)32/h1-11,13H,12H2,(H,23,25,28)
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n/an/a 1.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057666
PNG
(CHEMBL3322850)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C24H19N5O9S/c1-35-19-10-14(11-20(36-2)21(19)37-3)22(30)25-24-27-26-23(39-24)13-4-7-16(8-5-13)38-18-9-6-15(28(31)32)12-17(18)29(33)34/h4-12H,1-3H3,(H,25,27,30)
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n/an/a 2.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057667
PNG
(CHEMBL3322852)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccc(Cl)cc3)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12ClN5O6S/c22-14-5-1-12(2-6-14)19(28)23-21-25-24-20(34-21)13-3-8-16(9-4-13)33-18-10-7-15(26(29)30)11-17(18)27(31)32/h1-11H,(H,23,25,28)
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n/an/a 2.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057662
PNG
(CHEMBL3322844)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3cccc4ccccc34)s2)cc1
Show InChI InChI=1S/C26H18N4O4S/c31-24(16-19-6-3-5-17-4-1-2-7-23(17)19)27-26-29-28-25(35-26)18-8-12-21(13-9-18)34-22-14-10-20(11-15-22)30(32)33/h1-15H,16H2,(H,27,29,31)
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n/an/a 2.5n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057668
PNG
(CHEMBL3322853)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3F)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12FN5O6S/c22-16-4-2-1-3-15(16)19(28)23-21-25-24-20(34-21)12-5-8-14(9-6-12)33-18-10-7-13(26(29)30)11-17(18)27(31)32/h1-11H,(H,23,25,28)
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n/an/a 2.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057659
PNG
(CHEMBL3322841)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccco3)s2)cc1
Show InChI InChI=1S/C19H12N4O5S/c24-17(16-2-1-11-27-16)20-19-22-21-18(29-19)12-3-7-14(8-4-12)28-15-9-5-13(6-10-15)23(25)26/h1-11H,(H,20,22,24)
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n/an/a 2.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057673
PNG
(CHEMBL3322858)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3cccc4ccccc34)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C26H17N5O6S/c32-24(14-18-6-3-5-16-4-1-2-7-21(16)18)27-26-29-28-25(38-26)17-8-11-20(12-9-17)37-23-13-10-19(30(33)34)15-22(23)31(35)36/h1-13,15H,14H2,(H,27,29,32)
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n/an/a 3n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057663
PNG
(CHEMBL3322845)
Show SMILES Cc1ccccc1C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O6S/c1-13-4-2-3-5-17(13)20(28)23-22-25-24-21(34-22)14-6-9-16(10-7-14)33-19-11-8-15(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 3.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057653
PNG
(CHEMBL3322833)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3)s2)cc1
Show InChI InChI=1S/C21H14N4O4S/c26-19(14-4-2-1-3-5-14)22-21-24-23-20(30-21)15-6-10-17(11-7-15)29-18-12-8-16(9-13-18)25(27)28/h1-13H,(H,22,24,26)
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n/an/a 3.30n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057661
PNG
(CHEMBL3322842)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3cccnc3)s2)cc1
Show InChI InChI=1S/C20H13N5O4S/c26-18(14-2-1-11-21-12-14)22-20-24-23-19(30-20)13-3-7-16(8-4-13)29-17-9-5-15(6-10-17)25(27)28/h1-12H,(H,22,24,26)
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n/an/a 3.40n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057658
PNG
(CHEMBL3322840)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccc(cc3)[N+]([O-])=O)s2)cc1
Show InChI InChI=1S/C21H13N5O6S/c27-19(13-1-5-15(6-2-13)25(28)29)22-21-24-23-20(33-21)14-3-9-17(10-4-14)32-18-11-7-16(8-12-18)26(30)31/h1-12H,(H,22,24,27)
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n/an/a 4n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057665
PNG
(CHEMBL3322848)
Show SMILES COc1cccc(c1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O7S/c1-33-17-4-2-3-14(11-17)20(28)23-22-25-24-21(35-22)13-5-8-16(9-6-13)34-19-10-7-15(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 4.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057654
PNG
(CHEMBL3322830)
Show SMILES Cc1ccccc1C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H16N4O4S/c1-14-4-2-3-5-19(14)20(27)23-22-25-24-21(31-22)15-6-10-17(11-7-15)30-18-12-8-16(9-13-18)26(28)29/h2-13H,1H3,(H,23,25,27)
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n/an/a 4.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057656
PNG
(CHEMBL3322835)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3F)s2)cc1
Show InChI InChI=1S/C21H13FN4O4S/c22-18-4-2-1-3-17(18)19(27)23-21-25-24-20(31-21)13-5-9-15(10-6-13)30-16-11-7-14(8-12-16)26(28)29/h1-12H,(H,23,25,27)
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n/an/a 4.5n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057657
PNG
(CHEMBL3322836)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3cccc(F)c3)s2)cc1
Show InChI InChI=1S/C21H13FN4O4S/c22-15-3-1-2-14(12-15)19(27)23-21-25-24-20(31-21)13-4-8-17(9-5-13)30-18-10-6-16(7-11-18)26(28)29/h1-12H,(H,23,25,27)
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n/an/a 4.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057671
PNG
(CHEMBL3322856)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H12N6O8S/c28-19(12-1-5-14(6-2-12)25(29)30)22-21-24-23-20(36-21)13-3-8-16(9-4-13)35-18-10-7-15(26(31)32)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 4.80n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057669
PNG
(CHEMBL3322854)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3[N+]([O-])=O)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12N6O8S/c28-19(15-3-1-2-4-16(15)26(31)32)22-21-24-23-20(36-21)12-5-8-14(9-6-12)35-18-10-7-13(25(29)30)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 8n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDC25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Virginia Polytechnic Institute and State University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged full length human Cdc25B expressed in Escherichia coli


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50208827
PNG
(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
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n/an/a 100n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of GST tagged Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM41999
PNG
(3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic ...)
Show SMILES OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Show InChI InChI=1S/C16H12O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-2,4-5,17,21-22H,3,6H2,(H,19,20)
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n/an/a 100n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrof...


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Virginia Polytechnic Institute and State University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50177318
PNG
(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C36H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-15-17-29(18-16-27)36(40)32-24-23-31-33(32)25-42-37-35(31)28-19-21-30(22-20-28)41-26-34(38)39/h15-25H,2-14,26H2,1H3,(H,38,39)
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n/an/a 120n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against cdc25B phosphatase


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50317356
PNG
(3-(3-stearoyl-1H-pyrazole-5-carboxamido)thiophene-...)
Show SMILES CCCCCCCCCCCCCCCCCC(=O)c1cc([nH]n1)C(=O)Nc1ccsc1C(O)=O
Show InChI InChI=1S/C27H41N3O4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-24(31)22-20-23(30-29-22)26(32)28-21-18-19-35-25(21)27(33)34/h18-20H,2-17H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 120n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of CDC25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50208827
PNG
(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
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n/an/a 125n/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50317355
PNG
(2-(3-stearoyl-1H-pyrazole-5-carboxamido)benzoic ac...)
Show SMILES CCCCCCCCCCCCCCCCCC(=O)c1cc([nH]n1)C(=O)Nc1ccccc1C(O)=O
Show InChI InChI=1S/C29H43N3O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-21-27(33)25-22-26(32-31-25)28(34)30-24-20-18-17-19-23(24)29(35)36/h17-20,22H,2-16,21H2,1H3,(H,30,34)(H,31,32)(H,35,36)
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n/an/a 160n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of CDC25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50317365
PNG
(5-(4-chlorophenyl)-3-stearoylpyrrolo[3,4-c]pyrazol...)
Show SMILES CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2C(=O)N(C(=O)c12)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H40ClN3O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-24(34)26-25-27(32-31-26)29(36)33(28(25)35)23-20-18-22(30)19-21-23/h18-21H,2-17H2,1H3,(H,31,32)
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n/an/a 170n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of CDC25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50297586
PNG
(CHEMBL557129 | N-(1-benzyl-3-cyano-1H-pyrrolo[3,2-...)
Show SMILES O=S(=O)(Nc1c(C#N)c2nc3ccccc3nc2n1Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H17N5O2S/c25-15-19-22-24(27-21-14-8-7-13-20(21)26-22)29(16-17-9-3-1-4-10-17)23(19)28-32(30,31)18-11-5-2-6-12-18/h1-14,28H,16H2
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n/an/a 200n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM124256
PNG
((3S,3aR,4S,7aS)-4-acetyl-7-dodecyl-3-methyl-1-oxo-...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@]12[C@H]([C@H](C)OC1=O)[C@H](C(C)=O)C(=CC2CCCCCCCCCCCC)C(O)=O
Show InChI InChI=1S/C39H66O5/c1-5-7-9-11-13-15-17-18-19-21-23-25-27-29-39-33(28-26-24-22-20-16-14-12-10-8-6-2)30-34(37(41)42)35(31(3)40)36(39)32(4)44-38(39)43/h27,29-30,32-33,35-36H,5-26,28H2,1-4H3,(H,41,42)/b29-27+/t32-,33?,35+,36+,39-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Lanzhou University





Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50106497
PNG
(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Show SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12
Show InChI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-4,20-21H,5-9H2
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n/an/a 210n/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human cell division cycle 25B


J Med Chem 44: 4042-9 (2001)

More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50297585
PNG
(CHEMBL557673 | N-(1-benzyl-1H-pyrrolo[3,2-b]quinox...)
Show SMILES O=S(=O)(Nc1cc2nc3ccccc3nc2n1Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H18N4O2S/c28-30(29,18-11-5-2-6-12-18)26-22-15-21-23(25-20-14-8-7-13-19(20)24-21)27(22)16-17-9-3-1-4-10-17/h1-15,26H,16H2
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n/an/a 210n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of GST-fused Cdc25B


Citation and Details
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM124255
PNG
((3S,3aR,4S,7R,7aS)-4-acetyl-7-dodecyl-3-methyl-1-o...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@]12[C@H]([C@H](C)OC1=O)[C@H](C(C)=O)C(=C[C@H]2CCCCCCCCCCCC)C(O)=O
Show InChI InChI=1S/C39H66O5/c1-5-7-9-11-13-15-17-18-19-21-23-25-27-29-39-33(28-26-24-22-20-16-14-12-10-8-6-2)30-34(37(41)42)35(31(3)40)36(39)32(4)44-38(39)43/h27,29-30,32-33,35-36H,5-26,28H2,1-4H3,(H,41,42)/b29-27+/t32-,33+,35+,36+,39-/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Lanzhou University





Citation and Details
More data for this
Ligand-Target Pair
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