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Compile Data Set for Download or QSAR

Found 886 hits Enz. Inhib. hit(s) with Target = 'Dual specificity phosphatase Cdc25B' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM41999
PNG
(3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic ...)
Show SMILES OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Show InChI InChI=1S/C16H12O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-2,4-5,17,21-22H,3,6H2,(H,19,20)
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80n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50106497
PNG
(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Show SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12
Show InChI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-4,20-21H,5-9H2
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95n/an/an/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25B


Bioorg Med Chem 19: 2145-55 (2011)


Article DOI: 10.1016/j.bmc.2011.02.047
BindingDB Entry DOI: 10.7270/Q2BR8SHK
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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369n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...


Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
BindingDB Entry DOI: 10.7270/Q2RB75N4
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129580
PNG
(3-[4,6-Dichloro-7-(3-methyl-but-2-enyl)-1H-indol-3...)
Show SMILES CC(C)=CCc1c(Cl)cc(Cl)c2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H15Cl2NO4/c1-8(2)3-4-9-11(20)5-12(21)15-10(7-22-17(9)15)16-18(25)13(23)6-14(24)19(16)26/h3,5,7,16,22H,4,6H2,1-2H3
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430n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate


J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129574
PNG
(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Show SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O
Show InChI InChI=1S/C19H17NO4/c1-10(2)6-7-11-4-3-5-12-13(9-20-17(11)12)16-18(23)14(21)8-15(22)19(16)24/h3-6,9,16,20H,7-8H2,1-2H3
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640n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate


J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50084504
PNG
(CHEMBL3426991)
Show SMILES Nc1cccc(c1)-c1ccc2c(cc(Nc3ccccc3)[nH]c2=O)c1
Show InChI InChI=1S/C21H17N3O/c22-17-6-4-5-14(12-17)15-9-10-19-16(11-15)13-20(24-21(19)25)23-18-7-2-1-3-8-18/h1-13H,22H2,(H2,23,24,25)
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1.90E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...


Bioorg Med Chem 23: 2810-8 (2015)


Article DOI: 10.1016/j.bmc.2015.01.043
BindingDB Entry DOI: 10.7270/Q2CJ8G62
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50096680
PNG
((E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-...)
Show SMILES CCCc1sc(NS(=O)(=O)\C=C\c2ccccc2Cl)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2O2S2/c1-2-5-18-19(15-8-10-16(21)11-9-15)23-20(27-18)24-28(25,26)13-12-14-6-3-4-7-17(14)22/h3-4,6-13H,2,5H2,1H3,(H,23,24)/b13-12+
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4.60E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human recombinant Cdc25B phosphatase enzyme


Bioorg Med Chem Lett 11: 313-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00658-2
BindingDB Entry DOI: 10.7270/Q2DR2TRG
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50388723
PNG
(CHEMBL2057662)
Show SMILES OC(=O)CCc1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H9O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-5H,6-7H2,(H,10,11);2*1H2;;/q;;;;+2/p-2
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4.70E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...


Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
BindingDB Entry DOI: 10.7270/Q2RB75N4
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM26617
PNG
(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)
Show SMILES OC(=O)c1ccccc1C(=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C16H10O7/c17-13(9-3-1-2-4-10(9)14(18)19)8-5-6-11(15(20)21)12(7-8)16(22)23/h1-7H,(H,18,19)(H,20,21)(H,22,23)
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5.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50129575
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-[1,4]benzoquinone ...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C14H9NO4/c16-10-5-11(17)14(19)12(13(10)18)8-6-15-9-4-2-1-3-7(8)9/h1-4,6,12,15H,5H2
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1.30E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cdc25B phosphatase was determined using mFP as a substrate


J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50096693
PNG
((E)-2-Naphthalen-2-yl-ethenesulfonic acid (4,5-dip...)
Show SMILES O=S(=O)(Nc1nc(c(s1)-c1ccccc1)-c1ccccc1)\C=C\c1ccc2ccccc2c1
Show InChI InChI=1S/C27H20N2O2S2/c30-33(31,18-17-20-15-16-21-9-7-8-14-24(21)19-20)29-27-28-25(22-10-3-1-4-11-22)26(32-27)23-12-5-2-6-13-23/h1-19H,(H,28,29)/b18-17+
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3.60E+4n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibitory activity against human recombinant Cdc25B phosphatase enzyme


Bioorg Med Chem Lett 11: 313-7 (2001)


Article DOI: 10.1016/s0960-894x(00)00658-2
BindingDB Entry DOI: 10.7270/Q2DR2TRG
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50388538
PNG
(CHEMBL507159)
Show SMILES COc1ccc(Cc2ccc3[nH]c(=O)cc(C)c3c2)cc1S(O)(=O)=O
Show InChI InChI=1S/C18H17NO5S/c1-11-7-18(20)19-15-5-3-12(9-14(11)15)8-13-4-6-16(24-2)17(10-13)25(21,22)23/h3-7,9-10H,8H2,1-2H3,(H,19,20)(H,21,22,23)
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8.40E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50328823
PNG
(5,5'-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)dif...)
Show SMILES OS(=O)(=O)c1ccc(o1)-c1nnc(nc1-c1ccc(o1)S(O)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C16H10N4O8S2/c21-29(22,23)12-6-4-10(27-12)14-15(11-5-7-13(28-11)30(24,25)26)19-20-16(18-14)9-3-1-2-8-17-9/h1-8H,(H,21,22,23)(H,24,25,26)
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1.59E+5n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50391109
PNG
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Show SMILES [O-][V]([O-])([O-])=O
Show InChI InChI=1S/4O.V/q;3*-1;
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n/an/a 0.910n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50391109
PNG
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Show SMILES [O-][V]([O-])([O-])=O
Show InChI InChI=1S/4O.V/q;3*-1;
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n/an/a 0.930n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057655
PNG
(CHEMBL3322829)
Show SMILES COc1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H16N4O5S/c1-30-17-8-2-14(3-9-17)20(27)23-22-25-24-21(32-22)15-4-10-18(11-5-15)31-19-12-6-16(7-13-19)26(28)29/h2-13H,1H3,(H,23,25,27)
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n/an/a 1.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057664
PNG
(CHEMBL3322846)
Show SMILES Cc1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O6S/c1-13-2-4-14(5-3-13)20(28)23-22-25-24-21(34-22)15-6-9-17(10-7-15)33-19-11-8-16(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 1.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057670
PNG
(CHEMBL3322855)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H12N6O8S/c28-19(13-2-1-3-14(10-13)25(29)30)22-21-24-23-20(36-21)12-4-7-16(8-5-12)35-18-9-6-15(26(31)32)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 1.30n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057672
PNG
(CHEMBL3322857)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3ccccc3)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H15N5O6S/c28-20(12-14-4-2-1-3-5-14)23-22-25-24-21(34-22)15-6-9-17(10-7-15)33-19-11-8-16(26(29)30)13-18(19)27(31)32/h1-11,13H,12H2,(H,23,25,28)
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n/an/a 1.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201805
PNG
(CHEMBL3903987)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N/c3ccccc3)N(C2=O)c2ccccc2)c1C
Show InChI InChI=1S/C25H23N3O3S/c1-4-31-24(30)22-16(2)20(26-17(22)3)15-21-23(29)28(19-13-9-6-10-14-19)25(32-21)27-18-11-7-5-8-12-18/h5-15,26H,4H2,1-3H3/b21-15-,27-25-
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n/an/a 1.70n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057666
PNG
(CHEMBL3322850)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C24H19N5O9S/c1-35-19-10-14(11-20(36-2)21(19)37-3)22(30)25-24-27-26-23(39-24)13-4-7-16(8-5-13)38-18-9-6-15(28(31)32)12-17(18)29(33)34/h4-12H,1-3H3,(H,25,27,30)
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n/an/a 2.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057667
PNG
(CHEMBL3322852)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccc(Cl)cc3)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12ClN5O6S/c22-14-5-1-12(2-6-14)19(28)23-21-25-24-20(34-21)13-3-8-16(9-4-13)33-18-10-7-15(26(29)30)11-17(18)27(31)32/h1-11H,(H,23,25,28)
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n/an/a 2.20n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201807
PNG
(CHEMBL3934071)
Show SMILES CC(C)N1\C(S\C(=C/c2ccc(OCCN(C)c3ccccn3)cc2)C1=O)=N\O
Show InChI InChI=1S/C21H24N4O3S/c1-15(2)25-20(26)18(29-21(25)23-27)14-16-7-9-17(10-8-16)28-13-12-24(3)19-6-4-5-11-22-19/h4-11,14-15,27H,12-13H2,1-3H3/b18-14-,23-21-
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n/an/a 2.5n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057662
PNG
(CHEMBL3322844)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3cccc4ccccc34)s2)cc1
Show InChI InChI=1S/C26H18N4O4S/c31-24(16-19-6-3-5-17-4-1-2-7-23(17)19)27-26-29-28-25(35-26)18-8-12-21(13-9-18)34-22-14-10-20(11-15-22)30(32)33/h1-15H,16H2,(H,27,29,31)
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n/an/a 2.5n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057659
PNG
(CHEMBL3322841)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccco3)s2)cc1
Show InChI InChI=1S/C19H12N4O5S/c24-17(16-2-1-11-27-16)20-19-22-21-18(29-19)12-3-7-14(8-4-12)28-15-9-5-13(6-10-15)23(25)26/h1-11H,(H,20,22,24)
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n/an/a 2.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057668
PNG
(CHEMBL3322853)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3F)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12FN5O6S/c22-16-4-2-1-3-15(16)19(28)23-21-25-24-20(34-21)12-5-8-14(9-6-12)33-18-10-7-13(26(29)30)11-17(18)27(31)32/h1-11H,(H,23,25,28)
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n/an/a 2.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201802
PNG
(CHEMBL3981128)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N/c3ccc(OC)cc3)N(C2=O)c2ccc(OC)cc2)c1C
Show InChI InChI=1S/C27H27N3O5S/c1-6-35-26(32)24-16(2)22(28-17(24)3)15-23-25(31)30(19-9-13-21(34-5)14-10-19)27(36-23)29-18-7-11-20(33-4)12-8-18/h7-15,28H,6H2,1-5H3/b23-15-,29-27-
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n/an/a 2.70n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201801
PNG
(CHEMBL3942806)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N/c3ccc(F)cc3)N(C2=O)c2ccc(F)cc2)c1C
Show InChI InChI=1S/C25H21F2N3O3S/c1-4-33-24(32)22-14(2)20(28-15(22)3)13-21-23(31)30(19-11-7-17(27)8-12-19)25(34-21)29-18-9-5-16(26)6-10-18/h5-13,28H,4H2,1-3H3/b21-13-,29-25-
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n/an/a 2.90n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057673
PNG
(CHEMBL3322858)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)Cc3cccc4ccccc34)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C26H17N5O6S/c32-24(14-18-6-3-5-16-4-1-2-7-21(16)18)27-26-29-28-25(38-26)17-8-11-20(12-9-17)37-23-13-10-19(30(33)34)15-22(23)31(35)36/h1-13,15H,14H2,(H,27,29,32)
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n/an/a 3n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057663
PNG
(CHEMBL3322845)
Show SMILES Cc1ccccc1C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O6S/c1-13-4-2-3-5-17(13)20(28)23-22-25-24-21(34-22)14-6-9-16(10-7-14)33-19-11-8-15(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 3.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057653
PNG
(CHEMBL3322833)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3)s2)cc1
Show InChI InChI=1S/C21H14N4O4S/c26-19(14-4-2-1-3-5-14)22-21-24-23-20(30-21)15-6-10-17(11-7-15)29-18-12-8-16(9-13-18)25(27)28/h1-13H,(H,22,24,26)
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n/an/a 3.30n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201798
PNG
(CHEMBL3944187)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N/c3cccc(F)c3)N(C2=O)c2cccc(F)c2)c1C
Show InChI InChI=1S/C25H21F2N3O3S/c1-4-33-24(32)22-14(2)20(28-15(22)3)13-21-23(31)30(19-10-6-8-17(27)12-19)25(34-21)29-18-9-5-7-16(26)11-18/h5-13,28H,4H2,1-3H3/b21-13-,29-25-
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n/an/a 3.40n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057661
PNG
(CHEMBL3322842)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3cccnc3)s2)cc1
Show InChI InChI=1S/C20H13N5O4S/c26-18(14-2-1-11-21-12-14)22-20-24-23-19(30-20)13-3-7-16(8-4-13)29-17-9-5-15(6-10-17)25(27)28/h1-12H,(H,22,24,26)
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n/an/a 3.40n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201804
PNG
(CHEMBL3952328)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N/c3ccccc3F)N(C2=O)c2ccccc2F)c1C
Show InChI InChI=1S/C25H21F2N3O3S/c1-4-33-24(32)22-14(2)19(28-15(22)3)13-21-23(31)30(20-12-8-6-10-17(20)27)25(34-21)29-18-11-7-5-9-16(18)26/h5-13,28H,4H2,1-3H3/b21-13-,29-25-
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n/an/a 3.70n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057658
PNG
(CHEMBL3322840)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccc(cc3)[N+]([O-])=O)s2)cc1
Show InChI InChI=1S/C21H13N5O6S/c27-19(13-1-5-15(6-2-13)25(28)29)22-21-24-23-20(33-21)14-3-9-17(10-4-14)32-18-11-7-16(8-12-18)26(30)31/h1-12H,(H,22,24,27)
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n/an/a 4n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057654
PNG
(CHEMBL3322830)
Show SMILES Cc1ccccc1C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H16N4O4S/c1-14-4-2-3-5-19(14)20(27)23-22-25-24-21(31-22)15-6-10-17(11-7-15)30-18-12-8-16(9-13-18)26(28)29/h2-13H,1H3,(H,23,25,27)
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n/an/a 4.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057665
PNG
(CHEMBL3322848)
Show SMILES COc1cccc(c1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C22H15N5O7S/c1-33-17-4-2-3-14(11-17)20(28)23-22-25-24-21(35-22)13-5-8-16(9-6-13)34-19-10-7-15(26(29)30)12-18(19)27(31)32/h2-12H,1H3,(H,23,25,28)
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n/an/a 4.10n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057656
PNG
(CHEMBL3322835)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3F)s2)cc1
Show InChI InChI=1S/C21H13FN4O4S/c22-18-4-2-1-3-17(18)19(27)23-21-25-24-20(31-21)13-5-9-15(10-6-13)30-16-11-7-14(8-12-16)26(28)29/h1-12H,(H,23,25,27)
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n/an/a 4.5n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057657
PNG
(CHEMBL3322836)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3cccc(F)c3)s2)cc1
Show InChI InChI=1S/C21H13FN4O4S/c22-15-3-1-2-14(12-15)19(27)23-21-25-24-20(31-21)13-4-8-17(9-5-13)30-18-10-6-16(7-11-18)26(28)29/h1-12H,(H,23,25,27)
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n/an/a 4.60n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057671
PNG
(CHEMBL3322856)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1nnc(s1)-c1ccc(Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C21H12N6O8S/c28-19(12-1-5-14(6-2-12)25(29)30)22-21-24-23-20(36-21)13-3-8-16(9-4-13)35-18-10-7-15(26(31)32)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 4.80n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50201803
PNG
(CHEMBL3908947)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/S\C(=N\O)N(C(C)C)C2=O)c1C
Show InChI InChI=1S/C16H21N3O4S/c1-6-23-15(21)13-9(4)11(17-10(13)5)7-12-14(20)19(8(2)3)16(18-22)24-12/h7-8,17,22H,6H2,1-5H3/b12-7-,18-16+
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n/an/a 5.80n/an/an/an/an/an/a



Xi'an Jiaotong University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-tagged CDC25B assessed as reduction in dephosphorylation of florigenic phosphatase substrate preincubated for 1 h...


Eur J Med Chem 122: 756-769 (2016)


Article DOI: 10.1016/j.ejmech.2016.05.060
BindingDB Entry DOI: 10.7270/Q25Q4Z2D
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50057669
PNG
(CHEMBL3322854)
Show SMILES [O-][N+](=O)c1ccc(Oc2ccc(cc2)-c2nnc(NC(=O)c3ccccc3[N+]([O-])=O)s2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H12N6O8S/c28-19(15-3-1-2-4-16(15)26(31)32)22-21-24-23-20(36-21)12-5-8-14(9-6-12)35-18-10-7-13(25(29)30)11-17(18)27(33)34/h1-11H,(H,22,24,28)
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n/an/a 8n/an/an/an/an/an/a



Liaoning Normal University

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B (unknown origin)


Bioorg Med Chem Lett 24: 4125-8 (2014)


Article DOI: 10.1016/j.bmcl.2014.07.055
BindingDB Entry DOI: 10.7270/Q2MP54XR
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of Cdc25B


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Universit£ Paris Descartes

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDC25B


Bioorg Med Chem 16: 9040-9 (2008)


Article DOI: 10.1016/j.bmc.2008.08.009
BindingDB Entry DOI: 10.7270/Q2833SZB
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Virginia Polytechnic Institute and State University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged full length human Cdc25B expressed in Escherichia coli


Bioorg Med Chem 17: 2276-81 (2009)


Article DOI: 10.1016/j.bmc.2008.10.090
BindingDB Entry DOI: 10.7270/Q21J99MN
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50208827
PNG
(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Show SMILES OCCSC1=C(SCCO)C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
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n/an/a 100n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of GST tagged Cdc25B


Bioorg Med Chem Lett 17: 2351-4 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.046
BindingDB Entry DOI: 10.7270/Q2DF6QWF
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM41999
PNG
(3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic ...)
Show SMILES OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Show InChI InChI=1S/C16H12O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-2,4-5,17,21-22H,3,6H2,(H,19,20)
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n/an/a 100n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrof...


J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50267086
PNG
(Adociaquinone B | CHEMBL476648)
Show SMILES C[C@@]12CCCc3coc(c13)C(=O)c1cc3C(=O)C4=NCCS(=O)(=O)C4C(=O)c3cc21
Show InChI InChI=1S/C22H17NO6S/c1-22-4-2-3-10-9-29-20(15(10)22)18(25)13-7-11-12(8-14(13)22)19(26)21-16(17(11)24)23-5-6-30(21,27)28/h7-9,21H,2-6H2,1H3/t21?,22-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Virginia Polytechnic Institute and State University

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coli


Bioorg Med Chem 17: 2276-81 (2009)


Article DOI: 10.1016/j.bmc.2008.10.090
BindingDB Entry DOI: 10.7270/Q21J99MN
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50317356
PNG
(3-(3-stearoyl-1H-pyrazole-5-carboxamido)thiophene-...)
Show SMILES CCCCCCCCCCCCCCCCCC(=O)c1cc([nH]n1)C(=O)Nc1ccsc1C(O)=O
Show InChI InChI=1S/C27H41N3O4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-24(31)22-20-23(30-29-22)26(32)28-21-18-19-35-25(21)27(33)34/h18-20H,2-17H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 120n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of CDC25B


Bioorg Med Chem Lett 20: 2876-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.03.040
BindingDB Entry DOI: 10.7270/Q2W959CB
More data for this
Ligand-Target Pair
Dual specificity phosphatase Cdc25B


(Homo sapiens (Human))
BDBM50177318
PNG
(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C36H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-15-17-29(18-16-27)36(40)32-24-23-31-33(32)25-42-37-35(31)28-19-21-30(22-20-28)41-26-34(38)39/h15-25H,2-14,26H2,1H3,(H,38,39)
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n/an/a 120n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against cdc25B phosphatase


Bioorg Med Chem Lett 16: 499-502 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.062
BindingDB Entry DOI: 10.7270/Q2319VFG
More data for this
Ligand-Target Pair
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