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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Dynamin-2' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-2


(Rattus norvegicus)
BDBM50423883
PNG
(CHEMBL2312430)
Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of rat full length His6-tagged dyn2 using phosphotidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTP


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More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055861
PNG
(CHEMBL3329968)
Show SMILES OC(=O)c1ccc(NC2=CC(=O)C(Nc3ccc(cc3)C(O)=O)=CC2=O)cc1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-7-3-12(4-8-14)20(27)28)18(24)9-15(17)21-13-5-1-11(2-6-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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n/an/a 9.10E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055860
PNG
(CHEMBL3329967)
Show SMILES OC(=O)c1cccc(NC2=CC(=O)C(Nc3cccc(c3)C(O)=O)=CC2=O)c1
Show InChI InChI=1S/C20H14N2O6/c23-17-10-16(22-14-6-2-4-12(8-14)20(27)28)18(24)9-15(17)21-13-5-1-3-11(7-13)19(25)26/h1-10,21-22H,(H,25,26)(H,27,28)
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n/an/a 1.47E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50268295
PNG
(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N
Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+
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n/an/a 1.60E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of rat full length His6-tagged dyn2 using phosphotidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTP


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055859
PNG
(CHEMBL3329966)
Show SMILES Oc1ccc(NC2=CC(=O)C(Nc3ccc(O)cc3)=CC2=O)cc1
Show InChI InChI=1S/C18H14N2O4/c21-13-5-1-11(2-6-13)19-15-9-18(24)16(10-17(15)23)20-12-3-7-14(22)8-4-12/h1-10,19-22H
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n/an/a 2.36E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50055862
PNG
(CHEMBL3329969)
Show SMILES Oc1cccc(NC2=CC(=O)C(Nc3cccc(O)c3)=CC2=O)c1
Show InChI InChI=1S/C18H14N2O4/c21-13-5-1-3-11(7-13)19-15-9-18(24)16(10-17(15)23)20-12-4-2-6-14(22)8-12/h1-10,19-22H
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n/an/a 4.37E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of phosphatidylserine-stimulated GTPase activity of recombinant rat Dynamin 2 expressed in Sf21 cells assessed as inhibition of orthophosp...


Citation and Details
More data for this
Ligand-Target Pair