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Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with Target = 'Dynamin-2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-2


(Homo sapiens)
BDBM50316543
PNG
(CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...)
Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O
Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)
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n/an/a 290n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316542
PNG
(CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...)
Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O
Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)
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n/an/a 390n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316539
PNG
(CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihy...)
Show SMILES Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O
Show InChI InChI=1S/C22H18N4O8/c23-19-11(7-9-1-3-13(27)15(29)17(9)33-19)21(31)25-5-6-26-22(32)12-8-10-2-4-14(28)16(30)18(10)34-20(12)24/h1-4,7-8,23-24,27-30H,5-6H2,(H,25,31)(H,26,32)
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n/an/a 440n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423883
PNG
(CHEMBL2312430)
Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423885
PNG
(CHEMBL2312431)
Show SMILES CCCCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C26H45N3/c1-4-5-6-7-8-9-10-11-12-15-19-27-22-24-23-29(21-16-20-28(2)3)26-18-14-13-17-25(24)26/h13-14,17-18,23,27H,4-12,15-16,19-22H2,1-3H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423888
PNG
(CHEMBL2312414)
Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CC(O)CN(C)C)c2ccccc12)\C#N
Show InChI InChI=1S/C25H36N4O2/c1-4-5-6-7-8-11-14-27-25(31)20(16-26)15-21-17-29(19-22(30)18-28(2)3)24-13-10-9-12-23(21)24/h9-10,12-13,15,17,22,30H,4-8,11,14,18-19H2,1-3H3,(H,27,31)/b20-15+
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n/an/a 3.50E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423886
PNG
(CHEMBL2312428)
Show SMILES CCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C22H37N3/c1-4-5-6-7-8-11-15-23-18-20-19-25(17-12-16-24(2)3)22-14-10-9-13-21(20)22/h9-10,13-14,19,23H,4-8,11-12,15-18H2,1-3H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423887
PNG
(CHEMBL2312415)
Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CC(O)CN2CCCC2)c2ccccc12)\C#N
Show InChI InChI=1S/C28H40N4O2/c1-3-4-5-6-7-10-15-30-28(34)23(19-29)18-26-22(2)32(27-14-9-8-13-25(26)27)21-24(33)20-31-16-11-12-17-31/h8-9,13-14,18,24,33H,3-7,10-12,15-17,20-21H2,1-2H3,(H,30,34)/b23-18+
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n/an/a 4.50E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50268295
PNG
(2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...)
Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N
Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+
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n/an/a 5.00E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50423884
PNG
(CHEMBL2312432)
Show SMILES CCCCCCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C28H49N3/c1-4-5-6-7-8-9-10-11-12-13-14-17-21-29-24-26-25-31(23-18-22-30(2)3)28-20-16-15-19-27(26)28/h15-16,19-20,25,29H,4-14,17-18,21-24H2,1-3H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316542
PNG
(CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...)
Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O
Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)
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n/an/a 1.07E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316541
PNG
(CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydro...)
Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1
Show InChI InChI=1S/C23H20N4O6/c24-20-16(8-12-2-4-14(28)10-18(12)32-20)22(30)26-6-1-7-27-23(31)17-9-13-3-5-15(29)11-19(13)33-21(17)25/h2-5,8-11,24-25,28-29H,1,6-7H2,(H,26,30)(H,27,31)
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n/an/a 1.67E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316540
PNG
(CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...)
Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12
Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)
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n/an/a 3.48E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318676
PNG
(4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2...)
Show SMILES OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O
Show InChI InChI=1S/C23H15ClN2O6/c24-14-4-8-17(23(31)32)19(10-14)25-20(28)13-3-7-16-18(9-13)22(30)26(21(16)29)15-5-1-12(11-27)2-6-15/h1-10,27H,11H2,(H,25,28)(H,31,32)
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n/an/a 4.00E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316540
PNG
(CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...)
Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12
Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)
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n/an/a 4.82E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318675
PNG
(4-Chloro-2-{[2-(3-nitrophenyl)-1,3-dioxo-2,3-dihyd...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H12ClN3O7/c23-12-5-7-16(22(30)31)18(9-12)24-19(27)11-4-6-15-17(8-11)21(29)25(20(15)28)13-2-1-3-14(10-13)26(32)33/h1-10H,(H,24,27)(H,30,31)
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n/an/a 6.30E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318674
PNG
(4-Chloro-2-{[2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dih...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1O
Show InChI InChI=1S/C22H13ClN2O6/c23-12-6-8-14(22(30)31)16(10-12)24-19(27)11-5-7-13-15(9-11)21(29)25(20(13)28)17-3-1-2-4-18(17)26/h1-10,26H,(H,24,27)(H,30,31)
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n/an/a 7.10E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316543
PNG
(CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...)
Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O
Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)
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n/an/a 7.46E+4n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50318677
PNG
(4-Chloro-2-{[2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dih...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(O)cc1
Show InChI InChI=1S/C22H13ClN2O6/c23-12-2-8-16(22(30)31)18(10-12)24-19(27)11-1-7-15-17(9-11)21(29)25(20(15)28)13-3-5-14(26)6-4-13/h1-10,26H,(H,24,27)(H,30,31)
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n/an/a 1.14E+5n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method


Citation and Details
More data for this
Ligand-Target Pair
Dynamin-2


(Homo sapiens)
BDBM50316539
PNG
(CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihy...)
Show SMILES Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O
Show InChI InChI=1S/C22H18N4O8/c23-19-11(7-9-1-3-13(27)15(29)17(9)33-19)21(31)25-5-6-26-22(32)12-8-10-2-4-14(28)16(30)18(10)34-20(12)24/h1-4,7-8,23-24,27-30H,5-6H2,(H,25,31)(H,26,32)
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n/an/a 1.30E+6n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...


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