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Compile Data Set for Download or QSAR

Found 12 hits Enz. Inhib. hit(s) with Target = 'ELAV-like protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ELAV-like protein 1


(Homo sapiens)
BDBM50326009
PNG
(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Show SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12
Show InChI InChI=1S/C13H10O4/c1-6-11-7(5-17-6)4-8-9(14)2-3-10(15)12(8)13(11)16/h2-3,5,14-15H,4H2,1H3
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n/an/an/a 0.100n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein dimerization with TMR-labeled A/U-rich element of TNFalpha by confocal fluctuation...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326010
PNG
(CHEMBL1242196 | Dehydromutactin)
Show SMILES Cc1cc(O)c2c(O)cccc2c1-c1cc(O)cc(=O)o1
Show InChI InChI=1S/C16H12O5/c1-8-5-12(19)16-10(3-2-4-11(16)18)15(8)13-6-9(17)7-14(20)21-13/h2-7,17-19H,1H3
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n/an/an/a 9n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length HuR assessed as protein interaction with TMR-labeled A/U-rich element of COX2 by confocal fluctuation spectrosc...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326011
PNG
(CHEMBL1240971 | Okicenone)
Show SMILES Cc1cc(O)cc2cc3C(O)CCC(=O)c3c(O)c12
Show InChI InChI=1S/C15H14O4/c1-7-4-9(16)5-8-6-10-11(17)2-3-12(18)14(10)15(19)13(7)8/h4-6,11,16-17,19H,2-3H2,1H3
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n/an/an/a 85n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Binding affinity to recombinant full length HuR assessed as protein dimerization with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation sp...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326011
PNG
(CHEMBL1240971 | Okicenone)
Show SMILES Cc1cc(O)cc2cc3C(O)CCC(=O)c3c(O)c12
Show InChI InChI=1S/C15H14O4/c1-7-4-9(16)5-8-6-10-11(17)2-3-12(18)14(10)15(19)13(7)8/h4-6,11,16-17,19H,2-3H2,1H3
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n/an/an/a 90n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Binding affinity to HuR after 24 hrs by microdialysis method


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326009
PNG
(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Show SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12
Show InChI InChI=1S/C13H10O4/c1-6-11-7(5-17-6)4-8-9(14)2-3-10(15)12(8)13(11)16/h2-3,5,14-15H,4H2,1H3
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n/an/an/a 14n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein interaction with TMR-labeled A/U-rich element of TNFalpha by confocal fluctuation ...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326009
PNG
(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Show SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12
Show InChI InChI=1S/C13H10O4/c1-6-11-7(5-17-6)4-8-9(14)2-3-10(15)12(8)13(11)16/h2-3,5,14-15H,4H2,1H3
PDB
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n/an/an/a 420n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Binding affinity recombinant HuR RRM1/RRM2 domain by confocal fluctuation spectroscopy


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326009
PNG
(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Show SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12
Show InChI InChI=1S/C13H10O4/c1-6-11-7(5-17-6)4-8-9(14)2-3-10(15)12(8)13(11)16/h2-3,5,14-15H,4H2,1H3
PDB
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PubMed
n/an/an/a 0.100n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein dimerization with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spe...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326010
PNG
(CHEMBL1242196 | Dehydromutactin)
Show SMILES Cc1cc(O)c2c(O)cccc2c1-c1cc(O)cc(=O)o1
Show InChI InChI=1S/C16H12O5/c1-8-5-12(19)16-10(3-2-4-11(16)18)15(8)13-6-9(17)7-14(20)21-13/h2-7,17-19H,1H3
PDB
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n/an/an/a 0.100n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length HuR assessed as protein dimerization with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spectros...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326010
PNG
(CHEMBL1242196 | Dehydromutactin)
Show SMILES Cc1cc(O)c2c(O)cccc2c1-c1cc(O)cc(=O)o1
Show InChI InChI=1S/C16H12O5/c1-8-5-12(19)16-10(3-2-4-11(16)18)15(8)13-6-9(17)7-14(20)21-13/h2-7,17-19H,1H3
PDB
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n/an/an/a 9n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length HuR assessed as protein interaction with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spectrosc...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326010
PNG
(CHEMBL1242196 | Dehydromutactin)
Show SMILES Cc1cc(O)c2c(O)cccc2c1-c1cc(O)cc(=O)o1
Show InChI InChI=1S/C16H12O5/c1-8-5-12(19)16-10(3-2-4-11(16)18)15(8)13-6-9(17)7-14(20)21-13/h2-7,17-19H,1H3
PDB
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PubMed
n/an/an/a 6n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Binding affinity to recombinant full length HuR assessed as protein dimerization with TMR-labeled A/U-rich element of COX2 by confocal fluctuation sp...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326009
PNG
(5,8-dihydroxy-3-methylnaphtho[2,3-c]furan-4(9H)-on...)
Show SMILES Cc1occ2Cc3c(O)ccc(O)c3C(=O)c12
Show InChI InChI=1S/C13H10O4/c1-6-11-7(5-17-6)4-8-9(14)2-3-10(15)12(8)13(11)16/h2-3,5,14-15H,4H2,1H3
PDB
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n/an/an/a 230n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant HuR RRM1/RRM2 domain assessed as protein interaction with TMR-labeled A/U-rich element of IL-2 by confocal fluctuation spec...


Citation and Details
More data for this
Ligand-Target Pair
ELAV-like protein 1


(Homo sapiens)
BDBM50326010
PNG
(CHEMBL1242196 | Dehydromutactin)
Show SMILES Cc1cc(O)c2c(O)cccc2c1-c1cc(O)cc(=O)o1
Show InChI InChI=1S/C16H12O5/c1-8-5-12(19)16-10(3-2-4-11(16)18)15(8)13-6-9(17)7-14(20)21-13/h2-7,17-19H,1H3
PDB
MMDB

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Article
PubMed
n/an/an/a 0.0100n/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length HuR assessed as protein dimerization with TMR-labeled A/U-rich element of COX2 by confocal fluctuation spectros...


Citation and Details
More data for this
Ligand-Target Pair