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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Elongation factor 1-alpha 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Elongation factor 1-alpha 1


(Homo sapiens)
BDBM50347601
PNG
(CHEMBL1802814)
Show SMILES COc1ccc(Nc2nc3cc4c(cc3n2[C@H](C)C2CCCCC2)oc(cc4=O)-c2ccc(cc2)C(=O)N[C@@H](CC(C)C)C(N)=O)cc1
Show InChI InChI=1S/C38H43N5O5/c1-22(2)18-31(36(39)45)41-37(46)26-12-10-25(11-13-26)34-21-33(44)29-19-30-32(20-35(29)48-34)43(23(3)24-8-6-5-7-9-24)38(42-30)40-27-14-16-28(47-4)17-15-27/h10-17,19-24,31H,5-9,18H2,1-4H3,(H2,39,45)(H,40,42)(H,41,46)/t23-,31+/m1/s1
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n/an/an/a 3.74n/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Binding affinity to eEF1A1 expressed in human MDA-MB-231 cells using 1 uM biotinylated compound immobilized on streptavidin sensor chip by surface pl...


J Med Chem 54: 4339-49 (2011)

More data for this
Ligand-Target Pair
Elongation factor 1-alpha 1


(Homo sapiens)
BDBM50347603
PNG
(CHEMBL1802973)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(cc1)-c1cc(=O)c2cc(c(N[C@H](C)C3CCCCC3)cc2o1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C30H36N4O6/c1-17(2)13-24(29(31)36)33-30(37)21-11-9-20(10-12-21)27-16-26(35)22-14-25(34(38)39)23(15-28(22)40-27)32-18(3)19-7-5-4-6-8-19/h9-12,14-19,24,32H,4-8,13H2,1-3H3,(H2,31,36)(H,33,37)/t18-,24+/m1/s1
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n/an/an/a 57.2n/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Binding affinity to eEF1A1 expressed in human MDA-MB-231 cells using 1 uM biotinylated compound immobilized on streptavidin sensor chip by surface pl...


J Med Chem 54: 4339-49 (2011)

More data for this
Ligand-Target Pair
Elongation factor 1-alpha 1


(Homo sapiens)
BDBM50347602
PNG
(CHEMBL1802815)
Show SMILES CC(C)CNc1nc2cc3c(cc2n1Cc1ccccc1)oc(cc3=O)-c1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C37H35N5O4/c1-23(2)21-39-37-41-29-18-28-32(43)20-33(46-34(28)19-31(29)42(37)22-25-11-7-4-8-12-25)26-13-15-27(16-14-26)36(45)40-30(35(38)44)17-24-9-5-3-6-10-24/h3-16,18-20,23,30H,17,21-22H2,1-2H3,(H2,38,44)(H,39,41)(H,40,45)/t30-/m0/s1
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n/an/an/a 8.15n/an/an/an/an/a



University of California Davis

Curated by ChEMBL


Assay Description
Binding affinity to eEF1A1 expressed in human MDA-MB-231 cells using 1 uM biotinylated compound immobilized on streptavidin sensor chip by surface pl...


J Med Chem 54: 4339-49 (2011)

More data for this
Ligand-Target Pair