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Compile Data Set for Download or QSAR

Found 15 hits Enz. Inhib. hit(s) with Target = 'Endo-beta-N-acetylglucosaminidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50304533
PNG
(2-((5R,6S,7R,8S)-8-acetamido-6,7-dihydroxy-5-methy...)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)n2cc(CC(O)=O)nc12
Show InChI InChI=1/C12H17N3O6/c1-5(17)13-9-11(21)10(20)7(4-16)15-3-6(2-8(18)19)14-12(9)15/h3,7,9-11,16,20-21H,2,4H2,1H3,(H,13,17)(H,18,19)/t7-,9-,10+,11-/s2
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0.925n/an/an/an/an/an/an/an/a



Okayama University

Curated by ChEMBL


Assay Description
Competitive inhibition of human placenta beta-N-acetylglucosaminidase by pNP-GlcNAc substrate hydrolysis assay


Bioorg Med Chem 17: 7248-53 (2009)


Article DOI: 10.1016/j.bmc.2009.08.052
BindingDB Entry DOI: 10.7270/Q20865D3
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50304532
PNG
((1R*, 3S*, 5S*, 6S*, 7R*, 7a S*)-5-acetamidomethyl...)
Show SMILES CC(=O)NC[C@H]1[C@H](O)[C@H](O)[C@@H]2[C@H](O)C[C@@H](CO)N12
Show InChI InChI=1/C11H20N2O5/c1-5(15)12-3-7-10(17)11(18)9-8(16)2-6(4-14)13(7)9/h6-11,14,16-18H,2-4H2,1H3,(H,12,15)/t6-,7-,8+,9-,10-,11+/s2
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1.25n/an/an/an/an/an/an/an/a



Okayama University

Curated by ChEMBL


Assay Description
Mixed type inhibition of human placenta beta-N-acetylglucosaminidase by pNP-GlcNAc substrate hydrolysis assay


Bioorg Med Chem 17: 7248-53 (2009)


Article DOI: 10.1016/j.bmc.2009.08.052
BindingDB Entry DOI: 10.7270/Q20865D3
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50304533
PNG
(2-((5R,6S,7R,8S)-8-acetamido-6,7-dihydroxy-5-methy...)
Show SMILES CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)n2cc(CC(O)=O)nc12
Show InChI InChI=1/C12H17N3O6/c1-5(17)13-9-11(21)10(20)7(4-16)15-3-6(2-8(18)19)14-12(9)15/h3,7,9-11,16,20-21H,2,4H2,1H3,(H,13,17)(H,18,19)/t7-,9-,10+,11-/s2
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n/an/a 1.83n/an/an/an/an/an/a



Okayama University

Curated by ChEMBL


Assay Description
Inhibition of human placenta beta-N-acetylglucosaminidase by pNP-GlcNAc substrate hydrolysis assay


Bioorg Med Chem 17: 7248-53 (2009)


Article DOI: 10.1016/j.bmc.2009.08.052
BindingDB Entry DOI: 10.7270/Q20865D3
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50304532
PNG
((1R*, 3S*, 5S*, 6S*, 7R*, 7a S*)-5-acetamidomethyl...)
Show SMILES CC(=O)NC[C@H]1[C@H](O)[C@H](O)[C@@H]2[C@H](O)C[C@@H](CO)N12
Show InChI InChI=1/C11H20N2O5/c1-5(15)12-3-7-10(17)11(18)9-8(16)2-6(4-14)13(7)9/h6-11,14,16-18H,2-4H2,1H3,(H,12,15)/t6-,7-,8+,9-,10-,11+/s2
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n/an/a 2.39n/an/an/an/an/an/a



Okayama University

Curated by ChEMBL


Assay Description
Inhibition of human placenta beta-N-acetylglucosaminidase by pNP-GlcNAc substrate hydrolysis assay


Bioorg Med Chem 17: 7248-53 (2009)


Article DOI: 10.1016/j.bmc.2009.08.052
BindingDB Entry DOI: 10.7270/Q20865D3
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Arthrobacter protophormiae)
BDBM50373151
PNG
(CHEMBL259756)
Show SMILES CC1=N[C@H]2[C@@H](O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H](CO[C@H]5O[C@H](CO[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)[C@@H]5O)[C@@H]4O)[C@@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@@H]2O)S1
Show InChI InChI=1S/C62H103NO49S/c1-12-63-23-33(80)47(19(8-70)106-62(23)113-12)107-59-46(93)50(110-60-52(39(86)28(75)16(5-67)101-60)112-61-51(38(85)27(74)17(6-68)102-61)111-57-43(90)36(83)26(73)15(4-66)99-57)32(79)22(105-59)11-96-55-44(91)49(109-58-45(92)48(30(77)18(7-69)100-58)108-56-42(89)35(82)25(72)14(3-65)98-56)31(78)21(104-55)10-95-54-41(88)37(84)29(76)20(103-54)9-94-53-40(87)34(81)24(71)13(2-64)97-53/h13-62,64-93H,2-11H2,1H3/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47-,48+,49+,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+/m1/s1
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n/an/a 220n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase after 5 mins by HPAEC-PED method


Bioorg Med Chem 16: 4670-5 (2008)


Article DOI: 10.1016/j.bmc.2008.02.032
BindingDB Entry DOI: 10.7270/Q2QJ7J55
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50373151
PNG
(CHEMBL259756)
Show SMILES CC1=N[C@H]2[C@@H](O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H](CO[C@H]5O[C@H](CO[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)[C@@H]5O)[C@@H]4O)[C@@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@@H]2O)S1
Show InChI InChI=1S/C62H103NO49S/c1-12-63-23-33(80)47(19(8-70)106-62(23)113-12)107-59-46(93)50(110-60-52(39(86)28(75)16(5-67)101-60)112-61-51(38(85)27(74)17(6-68)102-61)111-57-43(90)36(83)26(73)15(4-66)99-57)32(79)22(105-59)11-96-55-44(91)49(109-58-45(92)48(30(77)18(7-69)100-58)108-56-42(89)35(82)25(72)14(3-65)98-56)31(78)21(104-55)10-95-54-41(88)37(84)29(76)20(103-54)9-94-53-40(87)34(81)24(71)13(2-64)97-53/h13-62,64-93H,2-11H2,1H3/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47-,48+,49+,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of human endo-beta-N-acetylglucosaminidase expressed in Hek293 cells after 3 mins


Bioorg Med Chem 16: 4670-5 (2008)


Article DOI: 10.1016/j.bmc.2008.02.032
BindingDB Entry DOI: 10.7270/Q2QJ7J55
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50070209
PNG
(Aciphex | CHEBI:8768 | LY-307640 | RABEPRAZOLE | R...)
Show SMILES COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C
Show InChI InChI=1/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
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n/an/a 4.47E+3n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...


Bioorg Med Chem Lett 27: 2962-2966 (2017)

More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Arthrobacter protophormiae)
BDBM50373153
PNG
(CHEMBL261523)
Show SMILES CC1=N[C@H]2[C@@H](O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@@H]2O)S1
Show InChI InChI=1S/C26H43NO19S/c1-6-27-11-15(34)21(9(4-30)44-26(11)47-6)45-25-20(39)22(46-24-19(38)17(36)13(32)8(3-29)42-24)14(33)10(43-25)5-40-23-18(37)16(35)12(31)7(2-28)41-23/h7-26,28-39H,2-5H2,1H3/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16+,17+,18+,19+,20+,21-,22+,23+,24+,25+,26+/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase after 5 mins by HPAEC-PED method


Bioorg Med Chem 16: 4670-5 (2008)


Article DOI: 10.1016/j.bmc.2008.02.032
BindingDB Entry DOI: 10.7270/Q2QJ7J55
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50402289
PNG
(TENATOPRAZOLE)
Show SMILES COc1ccc2[nH]c(nc2n1)S(=O)Cc1ncc(C)c(OC)c1C
Show InChI InChI=1/C16H18N4O3S/c1-9-7-17-12(10(2)14(9)23-4)8-24(21)16-18-11-5-6-13(22-3)19-15(11)20-16/h5-7H,8H2,1-4H3,(H,18,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...


Bioorg Med Chem Lett 27: 2962-2966 (2017)

More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50070208
PNG
(A-65006 | AG-1749 | CHEBI:6375 | LANSOPRAZOLE | La...)
Show SMILES Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1
Show InChI InChI=1/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
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n/an/a 2.44E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...


Bioorg Med Chem Lett 27: 2962-2966 (2017)

More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50247930
PNG
(DEXLANSOPRAZOLE | Dexilant | Dexilant solutab | De...)
Show SMILES Cc1c(OCC(F)(F)F)ccnc1C[S@@+]([O-])c1nc2ccccc2[nH]1
Show InChI InChI=1/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)/t25-/s2
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...


Bioorg Med Chem Lett 27: 2962-2966 (2017)

More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50103597
PNG
(Antra | CHEBI:77260 | H 168/68 | H-168/68 | Losec ...)
Show SMILES COc1ccc2[nH]c(nc2c1)[S+]([O-])Cc1ncc(C)c(OC)c1C
Show InChI InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-MYC/DDK-tagged ENGase expressed in HEK293T cells using heat inactivated bovine ribonuclease B as substrate pretreat...


Bioorg Med Chem Lett 27: 2962-2966 (2017)

More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Arthrobacter protophormiae)
BDBM50373152
PNG
(CHEMBL260584)
Show SMILES CC1=N[C@H]2[C@@H](O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H]2O)S1
Show InChI InChI=1S/C14H23NO9S/c1-4-15-7-9(19)12(6(3-17)23-14(7)25-4)24-13-11(21)10(20)8(18)5(2-16)22-13/h5-14,16-21H,2-3H2,1H3/t5-,6-,7-,8-,9-,10+,11+,12-,13+,14+/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase after 5 mins by HPAEC-PED method


Bioorg Med Chem 16: 4670-5 (2008)


Article DOI: 10.1016/j.bmc.2008.02.032
BindingDB Entry DOI: 10.7270/Q2QJ7J55
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50235890
PNG
((2S,3S)-3-Hydroxybaikiain | (2S,3S)-3-hydroxy-1,2,...)
Show SMILES O[C@H]1C=CCN[C@@H]1C(O)=O
Show InChI InChI=1/C6H9NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-2,4-5,7-8H,3H2,(H,9,10)/t4-,5-/s2
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n/an/a 7.50E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human placenta beta-N-acetylglucosaminidase


Bioorg Med Chem Lett 18: 1810-3 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.028
BindingDB Entry DOI: 10.7270/Q2MW2GWC
More data for this
Ligand-Target Pair
Endo-beta-N-acetylglucosaminidase


(Homo sapiens (Human))
BDBM50235890
PNG
((2S,3S)-3-Hydroxybaikiain | (2S,3S)-3-hydroxy-1,2,...)
Show SMILES O[C@H]1C=CCN[C@@H]1C(O)=O
Show InChI InChI=1/C6H9NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-2,4-5,7-8H,3H2,(H,9,10)/t4-,5-/s2
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n/an/a 7.50E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of human Placental beta-N-acetylglucosaminidase


Bioorg Med Chem 16: 8273-86 (2008)


Article DOI: 10.1016/j.bmc.2008.06.016
BindingDB Entry DOI: 10.7270/Q2F47P0Z
More data for this
Ligand-Target Pair