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Found 12 hits Enz. Inhib. hit(s) with Target = 'Endothelin-converting enzyme 1' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282593
PNG
(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-naphthale...)
Show SMILES CC(C)C[C@H](NC(CCc1cccc2ccccc12)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C30H36N3O6P/c1-19(2)16-26(29(34)33-27(30(35)36)17-22-18-31-25-13-6-5-12-24(22)25)32-28(40(37,38)39)15-14-21-10-7-9-20-8-3-4-11-23(20)21/h3-13,18-19,26-28,31-32H,14-17H2,1-2H3,(H,33,34)(H,35,36)(H2,37,38,39)/t26-,27-,28?/m0/s1
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Article
n/an/a 260n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282595
PNG
(CHEMBL281562 | PO3 2-Leu-Trp-O-3K)
Show SMILES CC(C)C[C@H](NP([O-])([O-])=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Show InChI InChI=1S/C17H24N3O6P/c1-10(2)7-14(20-27(24,25)26)16(21)19-15(17(22)23)8-11-9-18-13-6-4-3-5-12(11)13/h3-6,9-10,14-15,18H,7-8H2,1-2H3,(H,19,21)(H,22,23)(H3,20,24,25,26)/p-3/t14-,15-/m0/s1
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Article
n/an/a 960n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282588
PNG
(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-phenyl-1-...)
Show SMILES CC(C)C[C@H](NC(CCc1ccccc1)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H34N3O6P/c1-17(2)14-22(28-24(36(33,34)35)13-12-18-8-4-3-5-9-18)25(30)29-23(26(31)32)15-19-16-27-21-11-7-6-10-20(19)21/h3-11,16-17,22-24,27-28H,12-15H2,1-2H3,(H,29,30)(H,31,32)(H2,33,34,35)/t22-,23-,24?/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282585
PNG
(CHEMBL22509 | PO3 2-Nle-Trp-O-3K)
Show SMILES CCCC[C@H](NP([O-])([O-])=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Show InChI InChI=1S/C17H24N3O6P/c1-2-3-7-14(20-27(24,25)26)16(21)19-15(17(22)23)9-11-10-18-13-8-5-4-6-12(11)13/h4-6,8,10,14-15,18H,2-3,7,9H2,1H3,(H,19,21)(H,22,23)(H3,20,24,25,26)/p-3/t14-,15-/m0/s1
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Article
n/an/a 1.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282587
PNG
(3-(S)-1H-Indol-3-yl-2-{(S)-2-[3-(1H-indol-3-yl)-1-...)
Show SMILES CC(C)C[C@H](NC(CCc1c[nH]c2ccccc12)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C28H35N4O6P/c1-17(2)13-24(27(33)32-25(28(34)35)14-19-16-30-23-10-6-4-8-21(19)23)31-26(39(36,37)38)12-11-18-15-29-22-9-5-3-7-20(18)22/h3-10,15-17,24-26,29-31H,11-14H2,1-2H3,(H,32,33)(H,34,35)(H2,36,37,38)/t24-,25-,26?/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282591
PNG
(CHEMBL281785 | PO3 2-Ile-Trp-O-3K)
Show SMILES CC[C@@H](C)[C@H](NP([O-])([O-])=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C([O-])=O
Show InChI InChI=1S/C17H24N3O6P/c1-3-10(2)15(20-27(24,25)26)16(21)19-14(17(22)23)8-11-9-18-13-7-5-4-6-12(11)13/h4-7,9-10,14-15,18H,3,8H2,1-2H3,(H,19,21)(H,22,23)(H3,20,24,25,26)/p-3/t10-,14+,15+/m1/s1
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Article
n/an/a 2.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282589
PNG
(2-{(S)-2-[3-(4-Hydroxy-phenyl)-1-phosphono-propyla...)
Show SMILES CC(C)C[C@H](NC(CCc1ccc(O)cc1)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C26H34N3O7P/c1-16(2)13-22(28-24(37(34,35)36)12-9-17-7-10-19(30)11-8-17)25(31)29-23(26(32)33)14-18-15-27-21-6-4-3-5-20(18)21/h3-8,10-11,15-16,22-24,27-28,30H,9,12-14H2,1-2H3,(H,29,31)(H,32,33)(H2,34,35,36)/t22-,23-,24?/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50251742
PNG
((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Show SMILES CC(C)C[C@H](NP(O)(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C23H34N3O10P/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34)/t12-,16-,17-,18-,19+,20+,23-/m0/s1
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Article
n/an/a 3.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282586
PNG
(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(phosphonome...)
Show SMILES CC(C)C[C@H](NCP(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C18H26N3O6P/c1-11(2)7-15(20-10-28(25,26)27)17(22)21-16(18(23)24)8-12-9-19-14-6-4-3-5-13(12)14/h3-6,9,11,15-16,19-20H,7-8,10H2,1-2H3,(H,21,22)(H,23,24)(H2,25,26,27)/t15-,16-/m0/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282590
PNG
(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(4-phenyl-1-...)
Show SMILES CC(C)C[C@H](NC(CCCc1ccccc1)P(O)(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C27H36N3O6P/c1-18(2)15-23(29-25(37(34,35)36)14-8-11-19-9-4-3-5-10-19)26(31)30-24(27(32)33)16-20-17-28-22-13-7-6-12-21(20)22/h3-7,9-10,12-13,17-18,23-25,28-29H,8,11,14-16H2,1-2H3,(H,30,31)(H,32,33)(H2,34,35,36)/t23-,24-,25?/m0/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282594
PNG
(CHEMBL280917 | PO3 2-Leu-Nal-O-3K)
Show SMILES CC(C)C[C@H](NP([O-])([O-])=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C([O-])=O
Show InChI InChI=1S/C19H25N2O6P/c1-12(2)10-16(21-28(25,26)27)18(22)20-17(19(23)24)11-14-8-5-7-13-6-3-4-9-15(13)14/h3-9,12,16-17H,10-11H2,1-2H3,(H,20,22)(H,23,24)(H3,21,25,26,27)/p-3/t16-,17-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Endothelin-converting enzyme 1


(Bos taurus)
BDBM50282592
PNG
(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(1-phosphono...)
Show SMILES CCCC(N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)P(O)(O)=O
Show InChI InChI=1S/C21H32N3O6P/c1-4-7-19(31(28,29)30)23-17(10-13(2)3)20(25)24-18(21(26)27)11-14-12-22-16-9-6-5-8-15(14)16/h5-6,8-9,12-13,17-19,22-23H,4,7,10-11H2,1-3H3,(H,24,25)(H,26,27)(H2,28,29,30)/t17-,18-,19?/m0/s1
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Article
n/an/a 1.50E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cells


Citation and Details
More data for this
Ligand-Target Pair