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Compile Data Set for Download or QSAR

Found 164 hits Enz. Inhib. hit(s) with Target = 'Ephrin type-B receptor 3 (EPHB3)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205472
PNG
((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Show SMILES O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)
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>2.00E+3n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of EphB3


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205477
PNG
((Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinol...)
Show SMILES O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C22H17N3OS/c26-21-20(12-14-8-9-18-16(11-14)7-4-10-23-18)27-22(25-21)24-19-13-17(19)15-5-2-1-3-6-15/h1-12,17,19H,13H2,(H,24,25,26)/t17-,19+/m0/s1
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205472
PNG
((5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-y...)
Show SMILES O=C1N=C(NCc2cccs2)SC1=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50205468
PNG
((Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H...)
Show SMILES NC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1
Show InChI InChI=1S/C13H9N3OS/c14-13-16-12(17)11(18-13)7-8-3-4-10-9(6-8)2-1-5-15-10/h1-7H,(H2,14,16,17)
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>2.00E+3n/an/an/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50299218
PNG
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)
Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C
Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30)
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n/an/a 15n/an/an/an/an/an/a



University of Zurich

Curated by ChEMBL


Assay Description
Inhibition of EphB3 by [gamma33-P]ATP based assay


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311312
PNG
(CHEMBL1078739 | N-(2-chlorophenyl)-6-phenylimidazo...)
Show SMILES Clc1ccccc1NC(=O)c1cnc2ccc(cn12)-c1ccccc1
Show InChI InChI=1S/C20H14ClN3O/c21-16-8-4-5-9-17(16)23-20(25)18-12-22-19-11-10-15(13-24(18)19)14-6-2-1-3-7-14/h1-13H,(H,23,25)
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n/an/a 60n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311306
PNG
(CHEMBL1078214 | N-(2-chlorophenyl)-5-(piperidin-1-...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(cc12)N1CCCCC1
Show InChI InChI=1S/C19H19ClN4O/c20-16-6-2-3-7-17(16)22-19(25)15-13-21-24-11-8-14(12-18(15)24)23-9-4-1-5-10-23/h2-3,6-8,11-13H,1,4-5,9-10H2,(H,22,25)
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n/an/a 63n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311302
PNG
(CHEMBL1078107 | N-(2-chlorophenyl)-5-phenylpyrazol...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C20H14ClN3O/c21-17-8-4-5-9-18(17)23-20(25)16-13-22-24-11-10-15(12-19(16)24)14-6-2-1-3-7-14/h1-13H,(H,23,25)
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n/an/a 66n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311303
PNG
(CHEMBL1077571 | N-(2-chlorophenyl)-5-(dimethylamin...)
Show SMILES CN(C)c1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H15ClN4O/c1-20(2)11-7-8-21-15(9-11)12(10-18-21)16(22)19-14-6-4-3-5-13(14)17/h3-10H,1-2H3,(H,19,22)
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n/an/a 77n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311316
PNG
(CHEMBL1077739 | LDN-211904 | N-(2-chlorophenyl)-6-...)
Show SMILES Clc1ccccc1NC(=O)c1cnc2ccc(cn12)C1CCNCC1
Show InChI InChI=1S/C19H19ClN4O/c20-15-3-1-2-4-16(15)23-19(25)17-11-22-18-6-5-14(12-24(17)18)13-7-9-21-10-8-13/h1-6,11-13,21H,7-10H2,(H,23,25)
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n/an/a 79n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311313
PNG
(CHEMBL1078840 | N-(2-chlorophenyl)-6-(piperidin-1-...)
Show SMILES Clc1ccccc1NC(=O)c1cnc2ccc(cn12)N1CCCCC1
Show InChI InChI=1S/C19H19ClN4O/c20-15-6-2-3-7-16(15)22-19(25)17-12-21-18-9-8-14(13-24(17)18)23-10-4-1-5-11-23/h2-3,6-9,12-13H,1,4-5,10-11H2,(H,22,25)
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n/an/a 87n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311318
PNG
(6-bromo-N-(2-chlorophenyl)-2-methylimidazo[1,2-a]p...)
Show SMILES Cc1nc2ccc(Br)cn2c1C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C15H11BrClN3O/c1-9-14(20-8-10(16)6-7-13(20)18-9)15(21)19-12-5-3-2-4-11(12)17/h2-8H,1H3,(H,19,21)
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n/an/a 173n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311301
PNG
(CHEMBL1080959 | N-(2-chlorophenyl)-5-methoxypyrazo...)
Show SMILES COc1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1
Show InChI InChI=1S/C15H12ClN3O2/c1-21-10-6-7-19-14(8-10)11(9-17-19)15(20)18-13-5-3-2-4-12(13)16/h2-9H,1H3,(H,18,20)
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n/an/a 190n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311304
PNG
(CHEMBL1078108 | N-(2-chlorophenyl)-5-(1H-pyrrol-1-...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(cc12)-n1cccc1
Show InChI InChI=1S/C18H13ClN4O/c19-15-5-1-2-6-16(15)21-18(24)14-12-20-23-10-7-13(11-17(14)23)22-8-3-4-9-22/h1-12H,(H,21,24)
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n/an/a 200n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311317
PNG
(CHEMBL1077740 | N-(2-chlorophenyl)-6-(4-hydroxypip...)
Show SMILES OC1(CCNCC1)c1ccc2ncc(C(=O)Nc3ccccc3Cl)n2c1
Show InChI InChI=1S/C19H19ClN4O2/c20-14-3-1-2-4-15(14)23-18(25)16-11-22-17-6-5-13(12-24(16)17)19(26)7-9-21-10-8-19/h1-6,11-12,21,26H,7-10H2,(H,23,25)
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n/an/a 228n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311305
PNG
(CHEMBL1078109 | N-(2-chlorophenyl)-5-morpholinopyr...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(cc12)N1CCOCC1
Show InChI InChI=1S/C18H17ClN4O2/c19-15-3-1-2-4-16(15)21-18(24)14-12-20-23-6-5-13(11-17(14)23)22-7-9-25-10-8-22/h1-6,11-12H,7-10H2,(H,21,24)
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n/an/a 240n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311296
PNG
(CHEMBL1081498 | N-(2-chlorophenyl)-5-methylpyrazol...)
Show SMILES Cc1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1
Show InChI InChI=1S/C15H12ClN3O/c1-10-6-7-19-14(8-10)11(9-17-19)15(20)18-13-5-3-2-4-12(13)16/h2-9H,1H3,(H,18,20)
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n/an/a 260n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50357333
PNG
(CHEMBL1916891)
Show SMILES CN(C)C\C=C\C(=O)N(C)c1cc2c(cc1F)nc(Nc1ccccc1C)c1cncn21
Show InChI InChI=1S/C24H25FN6O/c1-16-8-5-6-9-18(16)27-24-22-14-26-15-31(22)21-13-20(17(25)12-19(21)28-24)30(4)23(32)10-7-11-29(2)3/h5-10,12-15H,11H2,1-4H3,(H,27,28)/b10-7+
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n/an/a 350n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of EPHB3 relative to control


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311311
PNG
(CHEMBL1078738 | N-(2-chlorophenyl)imidazo[1,2-a]py...)
Show SMILES Clc1ccccc1NC(=O)c1cnc2ccccn12
Show InChI InChI=1S/C14H10ClN3O/c15-10-5-1-2-6-11(10)17-14(19)12-9-16-13-7-3-4-8-18(12)13/h1-9H,(H,17,19)
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n/an/a 460n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311288
PNG
(CHEMBL1078785 | N-(2-chlorophenyl)pyrazolo[1,5-a]p...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccccc12
Show InChI InChI=1S/C14H10ClN3O/c15-11-5-1-2-6-12(11)17-14(19)10-9-16-18-8-4-3-7-13(10)18/h1-9H,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50363957
PNG
(CHEMBL1952210)
Show SMILES COc1ccc(cc1)N1Cc2cnc(Nc3ccccc3)nc2N([C@@H]2CC[C@@H](O)C2)C1=O
Show InChI InChI=1S/C24H25N5O3/c1-32-21-11-8-18(9-12-21)28-15-16-14-25-23(26-17-5-3-2-4-6-17)27-22(16)29(24(28)31)19-7-10-20(30)13-19/h2-6,8-9,11-12,14,19-20,30H,7,10,13,15H2,1H3,(H,25,26,27)/t19-,20-/m1/s1
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n/an/a 1.09E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50182212
PNG
(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Show SMILES COc1ccc(cc1)N1Cc2cnc(Nc3ccc(F)cc3)nc2N(C2CC[C@@H](O)C2)C1=O
Show InChI InChI=1S/C24H24FN5O3/c1-33-21-10-7-18(8-11-21)29-14-15-13-26-23(27-17-4-2-16(25)3-5-17)28-22(15)30(24(29)32)19-6-9-20(31)12-19/h2-5,7-8,10-11,13,19-20,31H,6,9,12,14H2,1H3,(H,26,27,28)/t19?,20-/m1/s1
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n/an/a 1.25E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against EphB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311299
PNG
(5-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Show SMILES Clc1ccn2ncc(C(=O)Nc3ccccc3Cl)c2c1
Show InChI InChI=1S/C14H9Cl2N3O/c15-9-5-6-19-13(7-9)10(8-17-19)14(20)18-12-4-2-1-3-11(12)16/h1-8H,(H,18,20)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50428059
PNG
(CHEMBL2322989)
Show SMILES C[C@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C35H50N2O4/c1-21(8-13-32(39)37-31(33(40)41)18-22-20-36-30-7-5-4-6-25(22)30)27-11-12-28-26-10-9-23-19-24(38)14-16-34(23,2)29(26)15-17-35(27,28)3/h4-7,20-21,23-24,26-29,31,36,38H,8-19H2,1-3H3,(H,37,39)(H,40,41)/t21-,23-,24-,26+,27-,28+,29+,31+,34+,35-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Displacement of ephrin-B1-Fc from EphB3 receptor Fc ectodomain (unknown origin) after 1 hr by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/a 9.40E+3n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311310
PNG
(CHEMBL1077850 | N-(2-chlorophenyl)pyrazolo[1,5-a]p...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccncc12
Show InChI InChI=1S/C13H9ClN4O/c14-10-3-1-2-4-11(10)17-13(19)9-7-16-18-6-5-15-8-12(9)18/h1-8H,(H,17,19)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311295
PNG
(CHEMBL1080223 | N-(2-chlorophenyl)-4-methylpyrazol...)
Show SMILES Cc1cccn2ncc(C(=O)Nc3ccccc3Cl)c12
Show InChI InChI=1S/C15H12ClN3O/c1-10-5-4-8-19-14(10)11(9-17-19)15(20)18-13-7-3-2-6-12(13)16/h2-9H,1H3,(H,18,20)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311297
PNG
(CHEMBL1081499 | N-(2-chlorophenyl)-6-methylpyrazol...)
Show SMILES Cc1ccc2c(cnn2c1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C15H12ClN3O/c1-10-6-7-14-11(8-17-19(14)9-10)15(20)18-13-5-3-2-4-12(13)16/h2-9H,1H3,(H,18,20)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311309
PNG
(CHEMBL1078239 | N-(2-chlorophenyl)-[1,2,3]triazolo...)
Show SMILES Clc1ccccc1NC(=O)c1nnn2ccccc12
Show InChI InChI=1S/C13H9ClN4O/c14-9-5-1-2-6-10(9)15-13(19)12-11-7-3-4-8-18(11)17-16-12/h1-8H,(H,15,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311294
PNG
(2-chloro-N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)anil...)
Show SMILES Clc1ccccc1NCc1cnn2ccccc12
Show InChI InChI=1S/C14H12ClN3/c15-12-5-1-2-6-13(12)16-9-11-10-17-18-8-4-3-7-14(11)18/h1-8,10,16H,9H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311293
PNG
(2-chloro-N-(pyrazolo[1,5-a]pyridin-3-yl)benzamide ...)
Show SMILES Clc1ccccc1C(=O)Nc1cnn2ccccc12
Show InChI InChI=1S/C14H10ClN3O/c15-11-6-2-1-5-10(11)14(19)17-12-9-16-18-8-4-3-7-13(12)18/h1-9H,(H,17,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311292
PNG
(CHEMBL1077512 | N-(2-cyanophenyl)pyrazolo[1,5-a]py...)
Show SMILES O=C(Nc1ccccc1C#N)c1cnn2ccccc12
Show InChI InChI=1S/C15H10N4O/c16-9-11-5-1-2-6-13(11)18-15(20)12-10-17-19-8-4-3-7-14(12)19/h1-8,10H,(H,18,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311291
PNG
(CHEMBL1078902 | N-(2-(trifluoromethyl)phenyl)pyraz...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)c1cnn2ccccc12
Show InChI InChI=1S/C15H10F3N3O/c16-15(17,18)11-5-1-2-6-12(11)20-14(22)10-9-19-21-8-4-3-7-13(10)21/h1-9H,(H,20,22)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311308
PNG
(CHEMBL1078238 | N-(2-chlorophenyl)-1H-indazole-3-c...)
Show SMILES Clc1ccccc1NC(=O)c1n[nH]c2ccccc12
Show InChI InChI=1S/C14H10ClN3O/c15-10-6-2-4-8-12(10)16-14(19)13-9-5-1-3-7-11(9)17-18-13/h1-8H,(H,16,19)(H,17,18)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311307
PNG
(5-(benzyloxy)-N-(2-chlorophenyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C21H16ClN3O2/c22-18-8-4-5-9-19(18)24-21(26)17-13-23-25-11-10-16(12-20(17)25)27-14-15-6-2-1-3-7-15/h1-13H,14H2,(H,24,26)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311314
PNG
(CHEMBL1078542 | N-(2-methoxyphenyl)-6-phenylimidaz...)
Show SMILES COc1ccccc1NC(=O)c1cnc2ccc(cn12)-c1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-26-19-10-6-5-9-17(19)23-21(25)18-13-22-20-12-11-16(14-24(18)20)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311315
PNG
(CHEMBL1077738 | N-(2-chlorophenyl)-2-methyl-6-phen...)
Show SMILES Cc1nc2ccc(cn2c1C(=O)Nc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C21H16ClN3O/c1-14-20(21(26)24-18-10-6-5-9-17(18)22)25-13-16(11-12-19(25)23-14)15-7-3-2-4-8-15/h2-13H,1H3,(H,24,26)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311300
PNG
(6-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Show SMILES Clc1ccc2c(cnn2c1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C14H9Cl2N3O/c15-9-5-6-13-10(7-17-19(13)8-9)14(20)18-12-4-2-1-3-11(12)16/h1-8H,(H,18,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311298
PNG
(4-chloro-N-(2-chlorophenyl)pyrazolo[1,5-a]pyridine...)
Show SMILES Clc1ccccc1NC(=O)c1cnn2cccc(Cl)c12
Show InChI InChI=1S/C14H9Cl2N3O/c15-10-4-1-2-6-12(10)18-14(20)9-8-17-19-7-3-5-11(16)13(9)19/h1-8H,(H,18,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311289
PNG
(CHEMBL1078965 | N-(2-fluorophenyl)pyrazolo[1,5-a]p...)
Show SMILES Fc1ccccc1NC(=O)c1cnn2ccccc12
Show InChI InChI=1S/C14H10FN3O/c15-11-5-1-2-6-12(11)17-14(19)10-9-16-18-8-4-3-7-13(10)18/h1-9H,(H,17,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50311290
PNG
(CHEMBL1079075 | N-(2,3-dichlorophenyl)pyrazolo[1,5...)
Show SMILES Clc1cccc(NC(=O)c2cnn3ccccc23)c1Cl
Show InChI InChI=1S/C14H9Cl2N3O/c15-10-4-3-5-11(13(10)16)18-14(20)9-8-17-19-7-2-1-6-12(9)19/h1-8H,(H,18,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EphB3 kinase-mediated BTK-peptide phosphorylation assessed as 33P incorporation after 30 mins by scintillation counti...


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM50359359
PNG
(CHEMBL1929238)
Show SMILES CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C
Show InChI InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM93228
PNG
(Kinase inhibitor, D1)
Show SMILES CC(C)(C)Nc1c([nH]c2ncnn12)C1CC1
Show InChI InChI=1S/C11H17N5/c1-11(2,3)15-9-8(7-4-5-7)14-10-12-6-13-16(9)10/h6-7,15H,4-5H2,1-3H3,(H,12,13,14)
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n/an/a 1.58E+5n/an/an/an/an/an/a



University of Dundee



Assay Description
Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...


Citation and Details
More data for this
Ligand-Target Pair
Tyrosine Kinase EPHB3


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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PCBioAssay
n/an/an/a 1.40E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Tyrosine Kinase EPHB3


(Homo sapiens (Human))
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/an/a 6.90E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Tyrosine Kinase EPHB3


(Homo sapiens (Human))
BDBM31093
PNG
(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
Show InChI InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)
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n/an/an/a 3.50E+6n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM26145
PNG
(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-5-6-14(24)10-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/an/a 81n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to human EPHB3


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/an/a 1.40E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EPHB3 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM24773
PNG
(AMG 706 | AMG-706 | Motesanib | N-(3,3-dimethyl-1,...)
Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
Show InChI InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EPHB3 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Ephrin type-B receptor 3 (EPHB3)


(Homo sapiens (Human))
BDBM31085
PNG
(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EPHB3 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
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