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Found 27 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor(L858R, T790M)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM50399676
PNG
(CHEMBL2178352 | US9096601, 8-26)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1
Show InChI InChI=1S/C27H32N8/c1-33-15-17-34(18-16-33)22-13-11-21(12-14-22)29-26-28-19-24-25(32-26)35(23-9-5-6-10-23)27(31-24)30-20-7-3-2-4-8-20/h2-4,7-8,11-14,19,23H,5-6,9-10,15-18H2,1H3,(H,30,31)(H,28,29,32)
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n/an/a 1n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173428
PNG
(US9096601, 8-2)
Show SMILES CC(C)n1c(Nc2ccc(F)c(Cl)c2)nc2cnc(Nc3ccc(cc3)C(=O)NN3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H29ClFN9O/c1-16(2)37-23-22(32-26(37)31-19-8-9-21(28)20(27)14-19)15-29-25(33-23)30-18-6-4-17(5-7-18)24(38)34-36-12-10-35(3)11-13-36/h4-9,14-16H,10-13H2,1-3H3,(H,31,32)(H,34,38)(H,29,30,33)
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n/an/a 1n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173438
PNG
(US9096601, 8-12)
Show SMILES CC(C)n1c(Nc2cccc(c2)C#C)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C27H30N8/c1-5-20-7-6-8-22(17-20)30-27-31-24-18-28-26(32-25(24)35(27)19(2)3)29-21-9-11-23(12-10-21)34-15-13-33(4)14-16-34/h1,6-12,17-19H,13-16H2,2-4H3,(H,30,31)(H,28,29,32)
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n/an/a 3n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173445
PNG
(US9096601, 8-19)
Show SMILES CC(C)n1c(Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C32H34ClFN8O/c1-21(2)42-30-28(19-35-31(39-30)36-24-7-10-26(11-8-24)41-15-13-40(3)14-16-41)38-32(42)37-25-9-12-29(27(33)18-25)43-20-22-5-4-6-23(34)17-22/h4-12,17-19,21H,13-16,20H2,1-3H3,(H,37,38)(H,35,36,39)
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n/an/a 4n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173443
PNG
(US9096601, 8-17)
Show SMILES COc1cccc(Nc2nc3cnc(Nc4ccc(cc4)N4CCN(C)CC4)nc3n2C(C)C)c1
Show InChI InChI=1S/C26H32N8O/c1-18(2)34-24-23(30-26(34)29-20-6-5-7-22(16-20)35-4)17-27-25(31-24)28-19-8-10-21(11-9-19)33-14-12-32(3)13-15-33/h5-11,16-18H,12-15H2,1-4H3,(H,29,30)(H,27,28,31)
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n/an/a 4n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173447
PNG
(US9096601, 8-21)
Show SMILES CC(C)n1c(Nc2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C32H34ClFN10O/c1-20(2)44-29-28(19-35-30(41-29)36-21-8-11-25(12-9-21)43-16-14-42(3)15-17-43)40-31(44)37-22-4-6-23(7-5-22)38-32(45)39-24-10-13-27(34)26(33)18-24/h4-13,18-20H,14-17H2,1-3H3,(H,37,40)(H,35,36,41)(H2,38,39,45)
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n/an/a 5n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173437
PNG
(US9096601, 8-11)
Show SMILES CC(C)n1c(Nc2cccc(Br)c2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C25H29BrN8/c1-17(2)34-23-22(30-25(34)29-20-6-4-5-18(26)15-20)16-27-24(31-23)28-19-7-9-21(10-8-19)33-13-11-32(3)12-14-33/h4-10,15-17H,11-14H2,1-3H3,(H,29,30)(H,27,28,31)
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n/an/a 5n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173435
PNG
(US9096601, 8-9)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)nc12
Show InChI InChI=1S/C27H32N8O/c1-18(2)35-24-23(32-27(35)31-20-7-5-4-6-8-20)17-28-26(33-24)30-21-11-9-19(10-12-21)25(36)29-22-13-15-34(3)16-14-22/h4-12,17-18,22H,13-16H2,1-3H3,(H,29,36)(H,31,32)(H,28,30,33)
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n/an/a 6n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173431
PNG
(US9096601, 8-5)
Show SMILES CC(C)n1c(Nc2ccc(F)c(Cl)c2)nc2cnc(Nc3ccc(cc3F)C(=O)NN3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H28ClF2N9O/c1-15(2)38-23-22(33-26(38)31-17-5-6-19(28)18(27)13-17)14-30-25(34-23)32-21-7-4-16(12-20(21)29)24(39)35-37-10-8-36(3)9-11-37/h4-7,12-15H,8-11H2,1-3H3,(H,31,33)(H,35,39)(H,30,32,34)
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n/an/a 6n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173439
PNG
(US9096601, 8-13)
Show SMILES CC(C)n1c(Nc2ccc(F)c(Cl)c2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C25H28ClFN8/c1-16(2)35-23-22(31-25(35)30-18-6-9-21(27)20(26)14-18)15-28-24(32-23)29-17-4-7-19(8-5-17)34-12-10-33(3)11-13-34/h4-9,14-16H,10-13H2,1-3H3,(H,30,31)(H,28,29,32)
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n/an/a 9n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173442
PNG
(US9096601, 8-16)
Show SMILES CC(C)n1c(Nc2cccc(c2)C(F)(F)F)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H29F3N8/c1-17(2)37-23-22(33-25(37)32-20-6-4-5-18(15-20)26(27,28)29)16-30-24(34-23)31-19-7-9-21(10-8-19)36-13-11-35(3)12-14-36/h4-10,15-17H,11-14H2,1-3H3,(H,32,33)(H,30,31,34)
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n/an/a 12n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173441
PNG
(US9096601, 8-15)
Show SMILES CC(C)n1c(Nc2ccc(Br)cc2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C25H29BrN8/c1-17(2)34-23-22(30-25(34)29-20-6-4-18(26)5-7-20)16-27-24(31-23)28-19-8-10-21(11-9-19)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,29,30)(H,27,28,31)
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n/an/a 15n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173430
PNG
(US9096601, 8-4 | US9096601, 8-6)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3ccc(cc3F)C(=O)NN3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H30FN9O/c1-17(2)36-23-22(31-26(36)29-19-7-5-4-6-8-19)16-28-25(32-23)30-21-10-9-18(15-20(21)27)24(37)33-35-13-11-34(3)12-14-35/h4-10,15-17H,11-14H2,1-3H3,(H,29,31)(H,33,37)(H,28,30,32)
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n/an/a 18n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173463
PNG
(US9096601, 8-38)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3cccc(NC(=O)C=C)c3)nc12
Show InChI InChI=1S/C23H23N7O/c1-4-20(31)25-17-11-8-12-18(13-17)26-22-24-14-19-21(29-22)30(15(2)3)23(28-19)27-16-9-6-5-7-10-16/h4-15H,1H2,2-3H3,(H,25,31)(H,27,28)(H,24,26,29)
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n/an/a 37n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173449
PNG
(US9096601, 8-23)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CC4)c3n2)cc1
Show InChI InChI=1S/C25H28N8/c1-31-13-15-32(16-14-31)20-9-7-19(8-10-20)27-24-26-17-22-23(30-24)33(21-11-12-21)25(29-22)28-18-5-3-2-4-6-18/h2-10,17,21H,11-16H2,1H3,(H,28,29)(H,26,27,30)
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n/an/a 41n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173436
PNG
(US9096601, 8-10)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C25H30N8/c1-18(2)33-23-22(29-25(33)28-19-7-5-4-6-8-19)17-26-24(30-23)27-20-9-11-21(12-10-20)32-15-13-31(3)14-16-32/h4-12,17-18H,13-16H2,1-3H3,(H,28,29)(H,26,27,30)
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n/an/a 46n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173430
PNG
(US9096601, 8-4 | US9096601, 8-6)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3ccc(cc3F)C(=O)NN3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H30FN9O/c1-17(2)36-23-22(31-26(36)29-19-7-5-4-6-8-19)16-28-25(32-23)30-21-10-9-18(15-20(21)27)24(37)33-35-13-11-34(3)12-14-35/h4-10,15-17H,11-14H2,1-3H3,(H,29,31)(H,33,37)(H,28,30,32)
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n/an/a 46n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173452
PNG
(US9096601, 8-27)
Show SMILES CC(C)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C26H29F3N8/c1-17(2)37-23-22(33-25(37)32-20-6-4-18(5-7-20)26(27,28)29)16-30-24(34-23)31-19-8-10-21(11-9-19)36-14-12-35(3)13-15-36/h4-11,16-17H,12-15H2,1-3H3,(H,32,33)(H,30,31,34)
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n/an/a 54n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173444
PNG
(US9096601, 8-18)
Show SMILES COc1ccc(Nc2nc3cnc(Nc4ccc(cc4)N4CCN(C)CC4)nc3n2C(C)C)cc1
Show InChI InChI=1S/C26H32N8O/c1-18(2)34-24-23(30-26(34)29-20-7-11-22(35-4)12-8-20)17-27-25(31-24)28-19-5-9-21(10-6-19)33-15-13-32(3)14-16-33/h5-12,17-18H,13-16H2,1-4H3,(H,29,30)(H,27,28,31)
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n/an/a 57n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173454
PNG
(US9096601, 8-29)
Show SMILES CC(C)n1c(Nc2cccnc2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C24H29N9/c1-17(2)33-22-21(29-24(33)28-19-5-4-10-25-15-19)16-26-23(30-22)27-18-6-8-20(9-7-18)32-13-11-31(3)12-14-32/h4-10,15-17H,11-14H2,1-3H3,(H,28,29)(H,26,27,30)
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n/an/a 64n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173448
PNG
(US9096601, 8-22)
Show SMILES CC(C)n1c(Nc2ccc(cc2)C(=O)Nc2cccc(F)c2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C32H34FN9O/c1-21(2)42-29-28(20-34-31(39-29)36-24-11-13-27(14-12-24)41-17-15-40(3)16-18-41)38-32(42)37-25-9-7-22(8-10-25)30(43)35-26-6-4-5-23(33)19-26/h4-14,19-21H,15-18H2,1-3H3,(H,35,43)(H,37,38)(H,34,36,39)
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n/an/a 87n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173427
PNG
(US9096601, 8-1)
Show SMILES CC(C)n1c(Nc2ccccc2)nc2cnc(Nc3ccc(cc3)C(=O)N[N]3=CCN(C)CC3)nc12
Show InChI InChI=1S/C26H30N9O/c1-18(2)35-23-22(30-26(35)29-20-7-5-4-6-8-20)17-27-25(31-23)28-21-11-9-19(10-12-21)24(36)32-34-15-13-33(3)14-16-34/h4-12,15,17-18H,13-14,16H2,1-3H3,(H,29,30)(H,32,36)(H,27,28,31)
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n/an/a 90n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173433
PNG
(US9096601, 8-7)
Show SMILES COc1cc(ccc1Nc1ncc2nc(Nc3ccccc3)n(C(C)C)c2n1)C(=O)NN1CCN(C)CC1
Show InChI InChI=1S/C27H33N9O2/c1-18(2)36-24-22(31-27(36)29-20-8-6-5-7-9-20)17-28-26(32-24)30-21-11-10-19(16-23(21)38-4)25(37)33-35-14-12-34(3)13-15-35/h5-11,16-18H,12-15H2,1-4H3,(H,29,31)(H,33,37)(H,28,30,32)
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n/an/a 128n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173455
PNG
(US9096601, 8-30)
Show SMILES CC(C)n1c(NC2CCCCC2)nc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C25H36N8/c1-18(2)33-23-22(29-25(33)28-19-7-5-4-6-8-19)17-26-24(30-23)27-20-9-11-21(12-10-20)32-15-13-31(3)14-16-32/h9-12,17-19H,4-8,13-16H2,1-3H3,(H,28,29)(H,26,27,30)
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n/an/a 228n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173429
PNG
(US9096601, 8-3)
Show SMILES CC(C)n1c(Nc2cccc(NC(C)=O)c2)nc2cnc(Nc3ccc(cc3F)C(=O)N[N]3=CCN(C)CC3)nc12
Show InChI InChI=1S/C28H32FN10O2/c1-17(2)39-25-24(34-28(39)32-21-7-5-6-20(15-21)31-18(3)40)16-30-27(35-25)33-23-9-8-19(14-22(23)29)26(41)36-38-12-10-37(4)11-13-38/h5-9,12,14-17H,10-11,13H2,1-4H3,(H,31,40)(H,32,34)(H,36,41)(H,30,33,35)
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n/an/a 245n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173451
PNG
(US9096601, 8-25)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)[nH]c3n2)cc1
Show InChI InChI=1S/C22H24N8/c1-29-11-13-30(14-12-29)18-9-7-17(8-10-18)24-21-23-15-19-20(27-21)28-22(26-19)25-16-5-3-2-4-6-16/h2-10,15H,11-14H2,1H3,(H3,23,24,25,26,27,28)
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n/an/a 458n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M)


(Homo sapiens)
BDBM173450
PNG
(US9096601, 8-24)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C)c3n2)cc1
Show InChI InChI=1S/C23H26N8/c1-29-12-14-31(15-13-29)19-10-8-18(9-11-19)25-22-24-16-20-21(28-22)30(2)23(27-20)26-17-6-4-3-5-7-17/h3-11,16H,12-15H2,1-2H3,(H,26,27)(H,24,25,28)
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n/an/a 522n/an/an/an/an/an/a



CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; Sichuan University

US Patent


Assay Description
The object of this assay was to test the inventive compounds for the kinase inhibitory activity in vitro. In this assay, an isotopic labeling method ...


US Patent US9096601 (2015)

More data for this
Ligand-Target Pair