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Compile Data Set for Download or QSAR

Found 41 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor (EGFR) (T790M/L858R)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202371
PNG
(US9238629, I-3)
Show SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C22H20F3N5O3/c1-4-19(31)27-13-6-5-7-14(10-13)28-20-16(22(23,24)25)12-26-21(30-20)29-17-9-8-15(32-2)11-18(17)33-3/h4-12H,1H2,2-3H3,(H,27,31)(H2,26,28,29,30)
PDB

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n/an/a<1n/an/an/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202376
PNG
(US9238629, I-8)
Show SMILES COc1ccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H21BrN4O5/c1-5-18(28)25-13-7-6-8-14(11-13)32-21-15(23)12-24-22(27-21)26-16-9-10-17(29-2)20(31-4)19(16)30-3/h5-12H,1H2,2-4H3,(H,25,28)(H,24,26,27)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202380
PNG
(US9238629, I-12)
Show SMILES COc1ccccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1
Show InChI InChI=1S/C20H17ClN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202378
PNG
(US9238629, I-10)
Show SMILES COc1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1OC
Show InChI InChI=1S/C23H21F3N4O5/c1-5-18(31)28-13-7-6-8-14(11-13)35-21-15(23(24,25)26)12-27-22(30-21)29-16-9-10-17(32-2)20(34-4)19(16)33-3/h5-12H,1H2,2-4H3,(H,28,31)(H,27,29,30)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202379
PNG
(US9238629, I-11)
Show SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1OC
Show InChI InChI=1S/C23H22F3N5O4/c1-5-18(32)28-13-7-6-8-14(11-13)29-21-15(23(24,25)26)12-27-22(31-21)30-16-9-10-17(33-2)20(35-4)19(16)34-3/h5-12H,1H2,2-4H3,(H,28,32)(H2,27,29,30,31)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202373
PNG
(US9238629, I-5)
Show SMILES COc1ccc(Nc2ncc(Br)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H22BrN5O4/c1-5-18(29)25-13-7-6-8-14(11-13)26-21-15(23)12-24-22(28-21)27-16-9-10-17(30-2)20(32-4)19(16)31-3/h5-12H,1H2,2-4H3,(H,25,29)(H2,24,26,27,28)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202377
PNG
(US9238629, I-9)
Show SMILES COc1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C22H19F3N4O4/c1-4-19(30)27-13-6-5-7-15(10-13)33-20-16(22(23,24)25)12-26-21(29-20)28-17-9-8-14(31-2)11-18(17)32-3/h4-12H,1H2,2-3H3,(H,27,30)(H,26,28,29)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202375
PNG
(US9238629, I-7)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H21ClN4O5/c1-5-18(28)25-13-7-6-8-14(11-13)32-21-15(23)12-24-22(27-21)26-16-9-10-17(29-2)20(31-4)19(16)30-3/h5-12H,1H2,2-4H3,(H,25,28)(H,24,26,27)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202372
PNG
(US9238629, I-4)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H22ClN5O4/c1-5-18(29)25-13-7-6-8-14(11-13)26-21-15(23)12-24-22(28-21)27-16-9-10-17(30-2)20(32-4)19(16)31-3/h5-12H,1H2,2-4H3,(H,25,29)(H2,24,26,27,28)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202370
PNG
(US9238629, I-2)
Show SMILES COc1ccccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O3/c1-3-18(29)26-13-7-6-8-14(11-13)31-19-15(21(22,23)24)12-25-20(28-19)27-16-9-4-5-10-17(16)30-2/h3-12H,1H2,2H3,(H,26,29)(H,25,27,28)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202369
PNG
(US9238629, I-1)
Show SMILES COc1ccccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O2/c1-3-18(30)26-13-7-6-8-14(11-13)27-19-15(21(22,23)24)12-25-20(29-19)28-16-9-4-5-10-17(16)31-2/h3-12H,1H2,2H3,(H,26,30)(H2,25,27,28,29)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202390
PNG
(US9238629, I-22)
Show SMILES COc1ccccc1Nc1ncc(Br)c(Nc2cccc(NC(=O)C=C)c2)n1
Show InChI InChI=1S/C20H18BrN5O2/c1-3-18(27)23-13-7-6-8-14(11-13)24-19-15(21)12-22-20(26-19)25-16-9-4-5-10-17(16)28-2/h3-12H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202389
PNG
(US9238629, I-21)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H20ClN5O3/c1-4-19(28)24-13-6-5-7-14(10-13)25-20-16(22)12-23-21(27-20)26-17-9-8-15(29-2)11-18(17)30-3/h4-12H,1H2,2-3H3,(H,24,28)(H2,23,25,26,27)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202388
PNG
(US9238629, I-20)
Show SMILES COc1ccc(Nc2ncc(Br)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H20BrN5O3/c1-4-19(28)24-13-6-5-7-14(10-13)25-20-16(22)12-23-21(27-20)26-17-9-8-15(29-2)11-18(17)30-3/h4-12H,1H2,2-3H3,(H,24,28)(H2,23,25,26,27)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202384
PNG
(US9238629, I-16)
Show SMILES COc1cccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c1OC
Show InChI InChI=1S/C22H20F3N5O3/c1-4-18(31)27-13-7-5-8-14(11-13)28-20-15(22(23,24)25)12-26-21(30-20)29-16-9-6-10-17(32-2)19(16)33-3/h4-12H,1H2,2-3H3,(H,27,31)(H2,26,28,29,30)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202383
PNG
(US9238629, I-15)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H19ClN4O4/c1-4-19(27)24-13-6-5-7-15(10-13)30-20-16(22)12-23-21(26-20)25-17-9-8-14(28-2)11-18(17)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202374
PNG
(US9238629, I-14 | US9238629, I-6)
Show SMILES COc1cccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c1OC
Show InChI InChI=1S/C21H19BrN4O4/c1-4-18(27)24-13-7-5-8-14(11-13)30-20-15(22)12-23-21(26-20)25-16-9-6-10-17(28-2)19(16)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202381
PNG
(US9238629, I-13)
Show SMILES COc1ccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H19BrN4O4/c1-4-19(27)24-13-6-5-7-15(10-13)30-20-16(22)12-23-21(26-20)25-17-9-8-14(28-2)11-18(17)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202374
PNG
(US9238629, I-14 | US9238629, I-6)
Show SMILES COc1cccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c1OC
Show InChI InChI=1S/C21H19BrN4O4/c1-4-18(27)24-13-7-5-8-14(11-13)30-20-15(22)12-23-21(26-20)25-16-9-6-10-17(28-2)19(16)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
PDB

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n/an/a 20n/an/an/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202386
PNG
(US9238629, I-18)
Show SMILES COc1ccccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1
Show InChI InChI=1S/C20H18ClN5O2/c1-3-18(27)23-13-7-6-8-14(11-13)24-19-15(21)12-22-20(26-19)25-16-9-4-5-10-17(16)28-2/h3-12H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202387
PNG
(US9238629, I-19)
Show SMILES COc1ccccc1Nc1ncc(F)c(Oc2cccc(NC(=O)C=C)c2)n1
Show InChI InChI=1S/C20H17FN4O3/c1-3-18(26)23-13-7-6-8-14(11-13)28-19-15(21)12-22-20(25-19)24-16-9-4-5-10-17(16)27-2/h3-12H,1H2,2H3,(H,23,26)(H,22,24,25)
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n/an/a 20n/an/an/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202391
PNG
(US9238629, I-23)
Show SMILES COc1cccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c1OC
Show InChI InChI=1S/C22H19F3N4O4/c1-4-18(30)27-13-7-5-8-14(11-13)33-20-15(22(23,24)25)12-26-21(29-20)28-16-9-6-10-17(31-2)19(16)32-3/h4-12H,1H2,2-3H3,(H,27,30)(H,26,28,29)
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n/an/a 20n/an/an/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202385
PNG
(US9238629, I-17)
Show SMILES COc1cccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C=C)c3)n2)c1OC
Show InChI InChI=1S/C21H20ClN5O3/c1-4-18(28)24-13-7-5-8-14(11-13)25-20-15(22)12-23-21(27-20)26-16-9-6-10-17(29-2)19(16)30-3/h4-12H,1H2,2-3H3,(H,24,28)(H2,23,25,26,27)
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n/an/a 55n/an/an/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202372
PNG
(US9238629, I-4)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H22ClN5O4/c1-5-18(29)25-13-7-6-8-14(11-13)26-21-15(23)12-24-22(28-21)27-16-9-10-17(30-2)20(32-4)19(16)31-3/h5-12H,1H2,2-4H3,(H,25,29)(H2,24,26,27,28)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202373
PNG
(US9238629, I-5)
Show SMILES COc1ccc(Nc2ncc(Br)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H22BrN5O4/c1-5-18(29)25-13-7-6-8-14(11-13)26-21-15(23)12-24-22(28-21)27-16-9-10-17(30-2)20(32-4)19(16)31-3/h5-12H,1H2,2-4H3,(H,25,29)(H2,24,26,27,28)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202374
PNG
(US9238629, I-14 | US9238629, I-6)
Show SMILES COc1cccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c1OC
Show InChI InChI=1S/C21H19BrN4O4/c1-4-18(27)24-13-7-5-8-14(11-13)30-20-15(22)12-23-21(26-20)25-16-9-6-10-17(28-2)19(16)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202376
PNG
(US9238629, I-8)
Show SMILES COc1ccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H21BrN4O5/c1-5-18(28)25-13-7-6-8-14(11-13)32-21-15(23)12-24-22(27-21)26-16-9-10-17(29-2)20(31-4)19(16)30-3/h5-12H,1H2,2-4H3,(H,25,28)(H,24,26,27)
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n/an/an/an/a 300n/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202377
PNG
(US9238629, I-9)
Show SMILES COc1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C22H19F3N4O4/c1-4-19(30)27-13-6-5-7-15(10-13)33-20-16(22(23,24)25)12-26-21(29-20)28-17-9-8-14(31-2)11-18(17)32-3/h4-12H,1H2,2-3H3,(H,27,30)(H,26,28,29)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202378
PNG
(US9238629, I-10)
Show SMILES COc1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1OC
Show InChI InChI=1S/C23H21F3N4O5/c1-5-18(31)28-13-7-6-8-14(11-13)35-21-15(23(24,25)26)12-27-22(30-21)29-16-9-10-17(32-2)20(34-4)19(16)33-3/h5-12H,1H2,2-4H3,(H,28,31)(H,27,29,30)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202384
PNG
(US9238629, I-16)
Show SMILES COc1cccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c1OC
Show InChI InChI=1S/C22H20F3N5O3/c1-4-18(31)27-13-7-5-8-14(11-13)28-20-15(22(23,24)25)12-26-21(30-20)29-16-9-6-10-17(32-2)19(16)33-3/h4-12H,1H2,2-3H3,(H,27,31)(H2,26,28,29,30)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202383
PNG
(US9238629, I-15)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H19ClN4O4/c1-4-19(27)24-13-6-5-7-15(10-13)30-20-16(22)12-23-21(26-20)25-17-9-8-14(28-2)11-18(17)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202381
PNG
(US9238629, I-13)
Show SMILES COc1ccc(Nc2ncc(Br)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H19BrN4O4/c1-4-19(27)24-13-6-5-7-15(10-13)30-20-16(22)12-23-21(26-20)25-17-9-8-14(28-2)11-18(17)29-3/h4-12H,1H2,2-3H3,(H,24,27)(H,23,25,26)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202379
PNG
(US9238629, I-11)
Show SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1OC
Show InChI InChI=1S/C23H22F3N5O4/c1-5-18(32)28-13-7-6-8-14(11-13)29-21-15(23(24,25)26)12-27-22(31-21)30-16-9-10-17(33-2)20(35-4)19(16)34-3/h5-12H,1H2,2-4H3,(H,28,32)(H2,27,29,30,31)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202369
PNG
(US9238629, I-1)
Show SMILES COc1ccccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O2/c1-3-18(30)26-13-7-6-8-14(11-13)27-19-15(21(22,23)24)12-25-20(29-19)28-16-9-4-5-10-17(16)31-2/h3-12H,1H2,2H3,(H,26,30)(H2,25,27,28,29)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202391
PNG
(US9238629, I-23)
Show SMILES COc1cccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c1OC
Show InChI InChI=1S/C22H19F3N4O4/c1-4-18(30)27-13-7-5-8-14(11-13)33-20-15(22(23,24)25)12-26-21(29-20)28-16-9-6-10-17(31-2)19(16)32-3/h4-12H,1H2,2-3H3,(H,27,30)(H,26,28,29)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202371
PNG
(US9238629, I-3)
Show SMILES COc1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C22H20F3N5O3/c1-4-19(31)27-13-6-5-7-14(10-13)28-20-16(22(23,24)25)12-26-21(30-20)29-17-9-8-15(32-2)11-18(17)33-3/h4-12H,1H2,2-3H3,(H,27,31)(H2,26,28,29,30)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202370
PNG
(US9238629, I-2)
Show SMILES COc1ccccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O3/c1-3-18(29)26-13-7-6-8-14(11-13)31-19-15(21(22,23)24)12-25-20(28-19)27-16-9-4-5-10-17(16)30-2/h3-12H,1H2,2H3,(H,26,29)(H,25,27,28)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202390
PNG
(US9238629, I-22)
Show SMILES COc1ccccc1Nc1ncc(Br)c(Nc2cccc(NC(=O)C=C)c2)n1
Show InChI InChI=1S/C20H18BrN5O2/c1-3-18(27)23-13-7-6-8-14(11-13)24-19-15(21)12-22-20(26-19)25-16-9-4-5-10-17(16)28-2/h3-12H,1H2,2H3,(H,23,27)(H2,22,24,25,26)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202389
PNG
(US9238629, I-21)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H20ClN5O3/c1-4-19(28)24-13-6-5-7-14(10-13)25-20-16(22)12-23-21(27-20)26-17-9-8-15(29-2)11-18(17)30-3/h4-12H,1H2,2-3H3,(H,24,28)(H2,23,25,26,27)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202388
PNG
(US9238629, I-20)
Show SMILES COc1ccc(Nc2ncc(Br)c(Nc3cccc(NC(=O)C=C)c3)n2)c(OC)c1
Show InChI InChI=1S/C21H20BrN5O3/c1-4-19(28)24-13-6-5-7-14(10-13)25-20-16(22)12-23-21(27-20)26-17-9-8-15(29-2)11-18(17)30-3/h4-12H,1H2,2-3H3,(H,24,28)(H2,23,25,26,27)
PDB

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n/an/an/an/a 300n/an/an/an/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor (EGFR) (T790M/L858R)


(Homo sapiens (Human))
BDBM202375
PNG
(US9238629, I-7)
Show SMILES COc1ccc(Nc2ncc(Cl)c(Oc3cccc(NC(=O)C=C)c3)n2)c(OC)c1OC
Show InChI InChI=1S/C22H21ClN4O5/c1-5-18(28)25-13-7-6-8-14(11-13)32-21-15(23)12-24-22(27-21)26-16-9-10-17(29-2)20(31-4)19(16)30-3/h5-12H,1H2,2-4H3,(H,25,28)(H,24,26,27)
PDB

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Celgene Avilomics Research, Inc.

US Patent


Assay Description
To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...


US Patent US9238629 (2016)

More data for this
Ligand-Target Pair