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Compile Data Set for Download or QSAR

Found 1007 hits Enz. Inhib. hit(s) with Target = 'Epithelial discoidin domain-containing receptor 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1b (unknown origin) assessed as reduction in collagen-induced DDR1b activation


J Med Chem 58: 3287-301 (2015)


Article DOI: 10.1021/jm5012319
BindingDB Entry DOI: 10.7270/Q2DV1MMV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185584
PNG
(US9156852, 1)
Show SMILES Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-2-7-16-15(8-9-26-22(16)29-14-5-3-13(24)4-6-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
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n/an/a 2n/an/an/an/an/an/a



HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223090
PNG
(2-Morpholinoethyl 4-(6-((5-((2-chloro-6-methylphen...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCCN1CCOCC1
Show InChI InChI=1S/C27H33ClN8O4S/c1-18-4-3-5-20(28)24(18)33-25(37)21-17-29-26(41-21)32-22-16-23(31-19(2)30-22)35-6-8-36(9-7-35)27(38)40-15-12-34-10-13-39-14-11-34/h3-5,16-17H,6-15H2,1-2H3,(H,33,37)(H,29,30,31,32)
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n/an/a 2.26n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430865
PNG
(CHEMBL2336037)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C22H15ClN4O/c1-15-5-7-18(22(28)26-20-4-2-3-19(23)12-20)11-17(15)8-6-16-13-24-21-9-10-25-27(21)14-16/h2-5,7,9-14H,1H3,(H,26,28)
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n/an/a 2.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223091
PNG
(2-(Dimethylamino)ethyl 4-(6-((5-((2-chloro-6-methy...)
Show SMILES CN(C)CCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H31ClN8O3S/c1-16-6-5-7-18(26)22(16)31-23(35)19-15-27-24(38-19)30-20-14-21(29-17(2)28-20)33-8-10-34(11-9-33)25(36)37-13-12-32(3)4/h5-7,14-15H,8-13H2,1-4H3,(H,31,35)(H,27,28,29,30)
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n/an/a 2.56n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223082
PNG
(Ethyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES CCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C23H26ClN7O3S/c1-4-34-23(33)31-10-8-30(9-11-31)19-12-18(26-15(3)27-19)28-22-25-13-17(35-22)21(32)29-20-14(2)6-5-7-16(20)24/h5-7,12-13H,4,8-11H2,1-3H3,(H,29,32)(H,25,26,27,28)
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n/an/a 3.15n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223085
PNG
(Butyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES CCCCOC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H30ClN7O3S/c1-4-5-13-36-25(35)33-11-9-32(10-12-33)21-14-20(28-17(3)29-21)30-24-27-15-19(37-24)23(34)31-22-16(2)7-6-8-18(22)26/h6-8,14-15H,4-5,9-13H2,1-3H3,(H,31,34)(H,27,28,29,30)
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n/an/a 3.20n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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n/an/a 3.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISA


Bioorg Med Chem 18: 6977-86 (2010)


Article DOI: 10.1016/j.bmc.2010.08.026
BindingDB Entry DOI: 10.7270/Q2930TC9
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430862
PNG
(CHEMBL2336040)
Show SMILES COc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O2/c1-16-6-8-19(23(28)26-20-4-3-5-21(13-20)29-2)12-18(16)9-7-17-14-24-22-10-11-25-27(22)15-17/h3-6,8,10-15H,1-2H3,(H,26,28)
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n/an/a 4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223089
PNG
(2-Chloroethyl 4-(6-((5-((2-chloro-6-methylphenyl)c...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCCCl
Show InChI InChI=1S/C23H25Cl2N7O3S/c1-14-4-3-5-16(25)20(14)30-21(33)17-13-26-22(36-17)29-18-12-19(28-15(2)27-18)31-7-9-32(10-8-31)23(34)35-11-6-24/h3-5,12-13H,6-11H2,1-2H3,(H,30,33)(H,26,27,28,29)
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n/an/a 4.21n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223093
PNG
((E)-2-((6-(4-(but-2-enoyl)piperazin-1-yl)-2-methyl...)
Show SMILES C\C=C\C(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C24H26ClN7O2S/c1-4-6-21(33)32-11-9-31(10-12-32)20-13-19(27-16(3)28-20)29-24-26-14-18(35-24)23(34)30-22-15(2)7-5-8-17(22)25/h4-8,13-14H,9-12H2,1-3H3,(H,30,34)(H,26,27,28,29)/b6-4+
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n/an/a 4.25n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223081
PNG
(Methyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES COC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H24ClN7O3S/c1-13-5-4-6-15(23)19(13)28-20(31)16-12-24-21(34-16)27-17-11-18(26-14(2)25-17)29-7-9-30(10-8-29)22(32)33-3/h4-6,11-12H,7-10H2,1-3H3,(H,28,31)(H,24,25,26,27)
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n/an/a 4.32n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223092
PNG
(2-((6-(4-Acryloylpiperazin-1-yl)-2-methylpyrimidin...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H24ClN7O2S/c1-4-20(32)31-10-8-30(9-11-31)19-12-18(26-15(3)27-19)28-23-25-13-17(34-23)22(33)29-21-14(2)6-5-7-16(21)24/h4-7,12-13H,1,8-11H2,2-3H3,(H,29,33)(H,25,26,27,28)
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n/an/a 4.54n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88314
PNG
(US9695118, 202)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](CNC)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-5-4-18(25)8-17(22)12-31-23(33)16-9-20(24(27,28)29)19(21(26)10-16)14-32-7-6-15(13-32)11-30-2/h4-5,8-10,15,30H,3,6-7,11-14H2,1-2H3,(H,31,33)/t15-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/a 4.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM185589
PNG
(US9156852, 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
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n/an/a 5n/an/an/an/an/an/a



HANMI PHARM. CO., LTD

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against FMS, DDR1 and DDR2 kinases using Kinase Screening and Profiling Servic...


US Patent US9156852 (2015)


BindingDB Entry DOI: 10.7270/Q24T6H4D
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223094
PNG
(Methyl 3-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES COC(=O)N1CCC(C1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C22H23ClN6O3S/c1-12-5-4-6-15(23)19(12)28-20(30)17-10-24-21(33-17)27-18-9-16(25-13(2)26-18)14-7-8-29(11-14)22(31)32-3/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,28,30)(H,24,25,26,27)
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n/an/a 5.23n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223083
PNG
(Isopropyl 4-(6-((5-((2-chloro-6-methylphenyl)carba...)
Show SMILES CC(C)OC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C24H28ClN7O3S/c1-14(2)35-24(34)32-10-8-31(9-11-32)20-12-19(27-16(4)28-20)29-23-26-13-18(36-23)22(33)30-21-15(3)6-5-7-17(21)25/h5-7,12-14H,8-11H2,1-4H3,(H,30,33)(H,26,27,28,29)
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n/an/a 5.99n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50112618
PNG
(CHEMBL3608787)
Show SMILES C[C@H](NC(=O)Nc1ccccc1)c1ccc(C)c(NC(=O)c2cnc3ccccn23)c1
Show InChI InChI=1S/C24H23N5O2/c1-16-11-12-18(17(2)26-24(31)27-19-8-4-3-5-9-19)14-20(16)28-23(30)21-15-25-22-10-6-7-13-29(21)22/h3-15,17H,1-2H3,(H,28,30)(H2,26,27,31)/t17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Astex Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) after 1 hr by time resolved fluorescence method


ACS Med Chem Lett 6: 798-803 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00143
BindingDB Entry DOI: 10.7270/Q2SQ925G
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430868
PNG
(CHEMBL2331602)
Show SMILES Cc1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C23H18N4O/c1-16-4-3-5-21(12-16)26-23(28)20-8-6-17(2)19(13-20)9-7-18-14-24-22-10-11-25-27(22)15-18/h3-6,8,10-15H,1-2H3,(H,26,28)
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n/an/a 6n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430857
PNG
(CHEMBL2336021)
Show SMILES Cc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H15F3N4O/c1-15-5-7-18(22(31)29-20-4-2-3-19(12-20)23(24,25)26)11-17(15)8-6-16-13-27-21-9-10-28-30(21)14-16/h2-5,7,9-14H,1H3,(H,29,31)
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n/an/a 6.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430850
PNG
(CHEMBL2336006)
Show SMILES Cc1cc(C)cc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C24H20N4O/c1-16-10-17(2)12-22(11-16)27-24(29)21-6-4-18(3)20(13-21)7-5-19-14-25-23-8-9-26-28(23)15-19/h4,6,8-15H,1-3H3,(H,27,29)
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n/an/a 6.30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77638
PNG
(US9695118, 161)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCC[C@H](N)C2)c(OC(F)(F)F)c1
Show InChI InChI=1S/C23H27ClF3N3O4S/c1-2-35(32,33)21-8-7-18(24)10-17(21)12-29-22(31)15-5-6-16(20(11-15)34-23(25,26)27)13-30-9-3-4-19(28)14-30/h5-8,10-11,19H,2-4,9,12-14,28H2,1H3,(H,29,31)/t19-/m0/s1
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n/an/a 6.5n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223084
PNG
(Allyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CC1)C(=O)OCC=C
Show InChI InChI=1S/C24H26ClN7O3S/c1-4-12-35-24(34)32-10-8-31(9-11-32)20-13-19(27-16(3)28-20)29-23-26-14-18(36-23)22(33)30-21-15(2)6-5-7-17(21)25/h4-7,13-14H,1,8-12H2,2-3H3,(H,30,33)(H,26,27,28,29)
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n/an/a 6.69n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88312
PNG
(US9695118, 200)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430847
PNG
(CHEMBL2336009)
Show SMILES CN1CCN(Cc2cc(C)cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)c2)CC1
Show InChI InChI=1S/C29H30N6O/c1-21-14-24(19-34-12-10-33(3)11-13-34)16-27(15-21)32-29(36)26-6-4-22(2)25(17-26)7-5-23-18-30-28-8-9-31-35(28)20-23/h4,6,8-9,14-18,20H,10-13,19H2,1-3H3,(H,32,36)
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n/an/a 6.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223086
PNG
(Isobutyl 4-(6-((5-((2-chloro-6-methylphenyl)carbam...)
Show SMILES CC(C)COC(=O)N1CCN(CC1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C25H30ClN7O3S/c1-15(2)14-36-25(35)33-10-8-32(9-11-33)21-12-20(28-17(4)29-21)30-24-27-13-19(37-24)23(34)31-22-16(3)6-5-7-18(22)26/h5-7,12-13,15H,8-11,14H2,1-4H3,(H,31,34)(H,27,28,29,30)
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n/an/a 6.75n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430839
PNG
(CHEMBL2336015)
Show SMILES CCc1ccc(cc1C#Cc1cnc2ccnn2c1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O/c1-3-23-6-7-25(16-24(23)5-4-21-18-34-28-8-9-35-39(28)20-21)29(40)36-27-15-22(14-26(17-27)30(31,32)33)19-38-12-10-37(2)11-13-38/h6-9,14-18,20H,3,10-13,19H2,1-2H3,(H,36,40)
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n/an/a 6.80n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430840
PNG
(CHEMBL2336017)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3cccc(c3)C#Cc3cnc4ccnn4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C28H25F3N6O/c1-35-9-11-36(12-10-35)18-22-14-24(28(29,30)31)16-25(15-22)34-27(38)23-4-2-3-20(13-23)5-6-21-17-32-26-7-8-33-37(26)19-21/h2-4,7-8,13-17,19H,9-12,18H2,1H3,(H,34,38)
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n/an/a 7n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223087
PNG
(Phenyl 4-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cc(nc(C)n2)N2CCN(CC2)C(=O)Oc2ccccc2)s1
Show InChI InChI=1S/C27H26ClN7O3S/c1-17-7-6-10-20(28)24(17)33-25(36)21-16-29-26(39-21)32-22-15-23(31-18(2)30-22)34-11-13-35(14-12-34)27(37)38-19-8-4-3-5-9-19/h3-10,15-16H,11-14H2,1-2H3,(H,33,36)(H,29,30,31,32)
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n/an/a 7.14n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223104
PNG
(2-((6-((1-Acryloylpyrrolidin-3-yl)amino)-2-methylp...)
Show SMILES Cc1nc(NC2CCN(C2)C(=O)C=C)cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)n1
Show InChI InChI=1S/C23H24ClN7O2S/c1-4-20(32)31-9-8-15(12-31)28-18-10-19(27-14(3)26-18)29-23-25-11-17(34-23)22(33)30-21-13(2)6-5-7-16(21)24/h4-7,10-11,15H,1,8-9,12H2,2-3H3,(H,30,33)(H2,25,26,27,28,29)
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n/an/a 7.31n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88311
PNG
(US9695118, 199)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223100
PNG
(Phenyl 3-(6-((5-((2-chloro-6-methylphenyl)carbamoy...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)C1CCN(C1)C(=O)Oc1ccccc1
Show InChI InChI=1S/C27H25ClN6O3S/c1-16-7-6-10-20(28)24(16)33-25(35)22-14-29-26(38-22)32-23-13-21(30-17(2)31-23)18-11-12-34(15-18)27(36)37-19-8-4-3-5-9-19/h3-10,13-14,18H,11-12,15H2,1-2H3,(H,33,35)(H,29,30,31,32)
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n/an/a 7.51n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM286684
PNG
(7-((R)-3-Amino-pyrrolidin-1-ylmethyl)-3-(5-chloro-...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
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n/an/a 7.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430848
PNG
(CHEMBL2336008)
Show SMILES CN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4ccnn4c3)cc(c2)C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-3-5-24(15-23(20)6-4-21-17-33-27-7-8-34-38(27)19-21)28(39)35-26-14-22(13-25(16-26)29(30,31)32)18-37-11-9-36(2)10-12-37/h3,5,7-8,13-17,19H,9-12,18H2,1-2H3,(H,35,39)
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n/an/a 8.90n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM104010
PNG
(DDR1-IN-2)
Show SMILES CCN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(NCc3cnc4[nH]ccc4c3OC)c2)CC1
Show InChI InChI=1S/C31H35F3N6O2/c1-4-39-11-13-40(14-12-39)19-22-7-6-21(15-26(22)31(32,33)34)30(41)38-24-8-5-20(2)27(16-24)36-17-23-18-37-29-25(9-10-35-29)28(23)42-3/h5-10,15-16,18,36H,4,11-14,17,19H2,1-3H3,(H,35,37)(H,38,41)
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n/an/a 9n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human DDR1 in doxycycline-stimulated human U2OS cells assessed as inhibition of collagen-1-induced autophosphorylation incubated for 1 ...


J Med Chem 58: 3287-301 (2015)


Article DOI: 10.1021/jm5012319
BindingDB Entry DOI: 10.7270/Q2DV1MMV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77182
PNG
(US9695118, 22)
Show SMILES CCSc1ccc(F)cc1NNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H14F4N2OS/c1-2-24-14-7-6-12(17)9-13(14)21-22-15(23)10-4-3-5-11(8-10)16(18,19)20/h3-9,21H,2H2,1H3,(H,22,23)
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n/an/a 9n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88242
PNG
(US9695118, 633)
Show SMILES CCS(=O)(=O)c1c(C)cc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30Cl2F3N3O3S/c1-4-37(35,36)23-15(2)8-18(26)9-17(23)12-32-24(34)16-10-21(25(28,29)30)20(22(27)11-16)14-33-7-5-6-19(13-33)31-3/h8-11,19,31H,4-7,12-14H2,1-3H3,(H,32,34)/t19-/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223096
PNG
(Isopropyl 3-(6-((5-((2-chloro-6-methylphenyl)carba...)
Show SMILES CC(C)OC(=O)N1CCC(C1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C24H27ClN6O3S/c1-13(2)34-24(33)31-9-8-16(12-31)18-10-20(28-15(4)27-18)29-23-26-11-19(35-23)22(32)30-21-14(3)6-5-7-17(21)25/h5-7,10-11,13,16H,8-9,12H2,1-4H3,(H,30,32)(H,26,27,28,29)
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n/an/a 9.14n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88316
PNG
(US9695118, 222)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Br)c(CN2CCC[C@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26BrClF3N3O3S/c1-2-35(33,34)21-6-5-16(25)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(24)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM223095
PNG
(Ethyl 3-(6-((5-((2-chloro-6-methylphenyl)carbamoyl...)
Show SMILES CCOC(=O)N1CCC(C1)c1cc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)nc(C)n1
Show InChI InChI=1S/C23H25ClN6O3S/c1-4-33-23(32)30-9-8-15(12-30)17-10-19(27-14(3)26-17)28-22-25-11-18(34-22)21(31)29-20-13(2)6-5-7-16(20)24/h5-7,10-11,15H,4,8-9,12H2,1-3H3,(H,29,31)(H,25,26,27,28)
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n/an/a 9.60n/an/an/an/an/an/a



Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences



Assay Description
The effects of compounds on the kinases DDR1 and DDR2 were assessed by using a LanthaScreen Eu kinase activity assay technology (Invitrogen, Carlsbad...


Chem Biol Drug Des 89: 420-427 (2017)


Article DOI: 10.1111/cbdd.12863
BindingDB Entry DOI: 10.7270/Q29C6W98
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50430854
PNG
(CHEMBL2336024)
Show SMILES CN(C)c1cccc(NC(=O)c2ccc(C)c(c2)C#Cc2cnc3ccnn3c2)c1
Show InChI InChI=1S/C24H21N5O/c1-17-7-9-20(24(30)27-21-5-4-6-22(14-21)28(2)3)13-19(17)10-8-18-15-25-23-11-12-26-29(23)16-18/h4-7,9,11-16H,1-3H3,(H,27,30)
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n/an/a 9.70n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of DDR1 (unknown origin) using fluorescein-labeled poly GAT as substrate incubated for 1 hr prior to substrate addition measured after 1 h...


J Med Chem 56: 3281-95 (2013)


Article DOI: 10.1021/jm301824k
BindingDB Entry DOI: 10.7270/Q22V2HHJ
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM50080409
PNG
(CHEMBL3422020 | US9695118, 43)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H27ClF3N3O3S/c1-3-34(32,33)21-7-6-19(24)12-18(21)14-28-22(31)16-4-5-17(20(13-16)23(25,26)27)15-30-10-8-29(2)9-11-30/h4-7,12-13H,3,8-11,14-15H2,1-2H3,(H,28,31)
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n/an/a 9.70n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM286640
PNG
(7-((R)-3-Amino-pyrrolidin-1-ylmethyl)-8-bromo-3-(5...)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2c(Br)c(CN3CC[C@@H](N)C3)c(cc2c1=O)C(F)(F)F
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n/an/a 9.80n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured using the LanthaScreen(Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporatio...


US Patent US9567304 (2017)

More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88309
PNG
(US9695118, 197)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H26Cl2F3N3O3S/c1-2-35(33,34)21-6-5-16(24)8-15(21)11-30-22(32)14-9-19(23(26,27)28)18(20(25)10-14)13-31-7-3-4-17(29)12-31/h5-6,8-10,17H,2-4,7,11-13,29H2,1H3,(H,30,32)/t17-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77664
PNG
(US9695118, 192)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@H](C2)N(C)C)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-4-36(34,35)22-6-5-17(25)9-16(22)12-30-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-7-18(13-32)31(2)3/h5-6,9-11,18H,4,7-8,12-14H2,1-3H3,(H,30,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88310
PNG
(US9695118, 198)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCC[C@H](C2)NC)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H28Cl2F3N3O3S/c1-3-36(34,35)22-7-6-17(25)9-16(22)12-31-23(33)15-10-20(24(27,28)29)19(21(26)11-15)14-32-8-4-5-18(13-32)30-2/h6-7,9-11,18,30H,3-5,8,12-14H2,1-2H3,(H,31,33)/t18-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88267
PNG
(US9695118, 683)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCOC3(CNC3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H26Cl2F3N3O4S/c1-2-37(34,35)21-4-3-17(25)7-16(21)10-31-22(33)15-8-19(24(27,28)29)18(20(26)9-15)11-32-5-6-36-23(14-32)12-30-13-23/h3-4,7-9,30H,2,5-6,10-14H2,1H3,(H,31,33)
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM88276
PNG
(US9695118, 707)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CCCC3(CCCCN3)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H32Cl2F3N3O3S/c1-2-39(37,38)24-7-6-20(28)12-19(24)15-33-25(36)18-13-22(27(30,31)32)21(23(29)14-18)16-35-11-5-9-26(17-35)8-3-4-10-34-26/h6-7,12-14,34H,2-5,8-11,15-17H2,1H3,(H,33,36)
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens)
BDBM77663
PNG
(US9695118, 191)
Show SMILES CCS(=O)(=O)c1ccc(Cl)cc1CNC(=O)c1cc(Cl)c(CN2CC[C@@H](N)C2)c(c1)C(F)(F)F
Show InChI InChI=1S/C22H24Cl2F3N3O3S/c1-2-34(32,33)20-4-3-15(23)7-14(20)10-29-21(31)13-8-18(22(25,26)27)17(19(24)9-13)12-30-6-5-16(28)11-30/h3-4,7-9,16H,2,5-6,10-12,28H2,1H3,(H,29,31)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha

US Patent


Assay Description
DDR1 binding activity was measured by the LanthaScreen (Registered trademark) Eu Kinase Binding Assay (manufactured by Life Technologies Corporation)...


US Patent US9695118 (2017)


BindingDB Entry DOI: 10.7270/Q2736P1T
More data for this
Ligand-Target Pair
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