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Found 255 hits Enz. Inhib. hit(s) with Target = 'Epoxide hydrolase 2' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50066843
PNG
(CHEMBL3401636)
Show SMILES O=C(N[C@H]1[C@@H]([C@@H]1c1ccccc1)c1ccccc1)N1CCCCC1
Show InChI InChI=1/C21H24N2O/c24-21(23-14-8-3-9-15-23)22-20-18(16-10-4-1-5-11-16)19(20)17-12-6-2-7-13-17/h1-2,4-7,10-13,18-20H,3,8-9,14-15H2,(H,22,24)/t18-,19+,20+
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n/an/a 0.200n/an/an/an/an/an/a



Sumitomo Dainippon Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50066840
PNG
(CHEMBL3401639)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N[C@@H]1CCCN(C1)C(=O)N[C@H]1[C@@H]([C@@H]1c1ccccc1)c1ccccc1
Show InChI InChI=1/C27H28FN3O3S/c28-21-13-15-23(16-14-21)35(33,34)30-22-12-7-17-31(18-22)27(32)29-26-24(19-8-3-1-4-9-19)25(26)20-10-5-2-6-11-20/h1-6,8-11,13-16,22,24-26,30H,7,12,17-18H2,(H,29,32)/t22-,24-,25+,26+/s2
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n/an/a 0.200n/an/an/an/an/an/a



Sumitomo Dainippon Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50066841
PNG
(CHEMBL3401638)
Show SMILES CS(=O)(=O)N[C@@H]1CCCN(C1)C(=O)N[C@H]1[C@@H]([C@@H]1c1ccccc1)c1ccccc1
Show InChI InChI=1/C22H27N3O3S/c1-29(27,28)24-18-13-8-14-25(15-18)22(26)23-21-19(16-9-4-2-5-10-16)20(21)17-11-6-3-7-12-17/h2-7,9-12,18-21,24H,8,13-15H2,1H3,(H,23,26)/t18-,19-,20+,21+/s2
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n/an/a 0.800n/an/an/an/an/an/a



Sumitomo Dainippon Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50100519
PNG
(CHEMBL3327067)
Show SMILES CC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C18H24F3N3O2/c1-3-12(2)16(25)24-10-8-15(9-11-24)23-17(26)22-14-6-4-13(5-7-14)18(19,20)21/h4-7,12,15H,3,8-11H2,1-2H3,(H2,22,23,26)/t12-/s2
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n/an/a<1.30n/an/an/an/an/an/a



Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis , One Shields Avenue, Davis, California 95616, United States.

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50417987
PNG
(CHEMBL1672132)
Show SMILES O=C(N[C@H]1C[C@@H]1c1ccccc1)NC1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c25-21(23-20-15-19(20)16-7-3-1-4-8-16)22-17-11-13-24(14-12-17)18-9-5-2-6-10-18/h1-10,17,19-20H,11-15H2,(H2,22,23,25)/t19-,20+/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase in cell free system


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50100518
PNG
(CHEMBL3327064)
Show SMILES CC(C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H22F3N3O2/c1-11(2)15(24)23-9-7-14(8-10-23)22-16(25)21-13-5-3-12(4-6-13)17(18,19)20/h3-6,11,14H,7-10H2,1-2H3,(H2,21,22,25)
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n/an/a 1.80n/an/an/an/an/an/a



Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis , One Shields Avenue, Davis, California 95616, United States.

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50435764
PNG
(CHEMBL2392692)
Show SMILES CNc1nc(C)nc(n1)N1CCC(CC1)C(=O)NCc1ccc(Br)cc1OC(F)(F)F
Show InChI InChI=1S/C19H22BrF3N6O2/c1-11-26-17(24-2)28-18(27-11)29-7-5-12(6-8-29)16(30)25-10-13-3-4-14(20)9-15(13)31-19(21,22)23/h3-4,9,12H,5-8,10H2,1-2H3,(H,25,30)(H,24,26,27,28)
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase using PHOME as substrate assessed as formation of 6-methoxy-2-naphthaldehyde incubated for 10 mins prior ...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310794
PNG
(CHEMBL1080973 | N-(2,4-dichlorobenzyl)-3-methyl-3-...)
Show SMILES CC1(CCCN(C1)C(=O)NCc1ccc(Cl)cc1Cl)c1ccccc1
Show InChI InChI=1S/C20H22Cl2N2O/c1-20(16-6-3-2-4-7-16)10-5-11-24(14-20)19(25)23-13-15-8-9-17(21)12-18(15)22/h2-4,6-9,12H,5,10-11,13-14H2,1H3,(H,23,25)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310797
PNG
(3-methyl-3-phenyl-N-(4-(pyridin-2-yl)benzyl)piperi...)
Show SMILES CC1(CCCN(C1)C(=O)NCc1ccc(cc1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C25H27N3O/c1-25(22-8-3-2-4-9-22)15-7-17-28(19-25)24(29)27-18-20-11-13-21(14-12-20)23-10-5-6-16-26-23/h2-6,8-14,16H,7,15,17-19H2,1H3,(H,27,29)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310822
PNG
(CHEMBL1078754 | methyl 3-(1-(4-chlorophenylcarbamo...)
Show SMILES COC(=O)CCC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C22H25ClN2O3/c1-28-20(26)12-14-22(17-6-3-2-4-7-17)13-5-15-25(16-22)21(27)24-19-10-8-18(23)9-11-19/h2-4,6-11H,5,12-16H2,1H3,(H,24,27)
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n/an/a 3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50417983
PNG
(CHEMBL1672128)
Show SMILES COc1cccc2CCC(Cc12)C(=O)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C21H23NO2/c1-24-20-9-5-8-15-10-11-16(12-18(15)20)21(23)22-19-13-17(19)14-6-3-2-4-7-14/h2-9,16-17,19H,10-13H2,1H3,(H,22,23)/t16?,17-,19+/m1/s1
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n/an/a 3.02n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase in cell free system


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446768
PNG
(CHEMBL3114595)
Show SMILES FC(F)(F)c1ccccc1OC1CCN(CC1)C(=O)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C22H23F3N2O2/c23-22(24,25)18-8-4-5-9-20(18)29-16-10-12-27(13-11-16)21(28)26-19-14-17(19)15-6-2-1-3-7-15/h1-9,16-17,19H,10-14H2,(H,26,28)/t17-,19+/m1/s1
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n/an/a 3.20n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50066844
PNG
(CHEMBL3401635)
Show SMILES OC(=O)CCc1ccc(OC2CCN(CC2)C(=O)N[C@H]2[C@@H]([C@@H]2c2ccc(F)cc2)c2ccc(F)cc2)cc1
Show InChI InChI=1/C30H30F2N2O4/c31-22-8-4-20(5-9-22)27-28(21-6-10-23(32)11-7-21)29(27)33-30(37)34-17-15-25(16-18-34)38-24-12-1-19(2-13-24)3-14-26(35)36/h1-2,4-13,25,27-29H,3,14-18H2,(H,33,37)(H,35,36)/t27-,28+,29+
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n/an/a 3.20n/an/an/an/an/an/a



Sumitomo Dainippon Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50445769
PNG
(CHEMBL3104615)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C24H24F5N3O3/c25-18-3-1-4-19(26)20(18)21(33)31-13-10-23(11-14-31)9-2-12-32(15-23)22(34)30-16-5-7-17(8-6-16)35-24(27,28)29/h1,3-8H,2,9-15H2,(H,30,34)
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n/an/a 3.30n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant sEH expressed in baculovirus infected insect Sf9 cells using cyano(6-methoxynaphthalen-2-yl)methyl trans-[(3-phenyloxir...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446774
PNG
(CHEMBL3114618)
Show SMILES Clc1ccccc1OC1CCN(CC1)C(=O)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C21H23ClN2O2/c22-18-8-4-5-9-20(18)26-16-10-12-24(13-11-16)21(25)23-19-14-17(19)15-6-2-1-3-7-15/h1-9,16-17,19H,10-14H2,(H,23,25)/t17-,19+/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50066845
PNG
(CHEMBL3401634)
Show SMILES OC(=O)CCc1ccc(OC2CCN(CC2)C(=O)N[C@H]2[C@@H]([C@@H]2c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1/C30H32N2O4/c33-26(34)16-13-21-11-14-24(15-12-21)36-25-17-19-32(20-18-25)30(35)31-29-27(22-7-3-1-4-8-22)28(29)23-9-5-2-6-10-23/h1-12,14-15,25,27-29H,13,16-20H2,(H,31,35)(H,33,34)/t27-,28+,29+
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n/an/a 3.90n/an/an/an/an/an/a



Sumitomo Dainippon Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50268440
PNG
(2-(2,4-dichlorophenyl)-1-(6-(methylsulfonyl)spiro[...)
Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)Cc3ccc(Cl)cc3Cl)CCc2c1
Show InChI InChI=1S/C22H23Cl2NO4S/c1-30(27,28)18-4-5-20-16(12-18)6-7-22(29-20)8-10-25(11-9-22)21(26)13-15-2-3-17(23)14-19(15)24/h2-5,12,14H,6-11,13H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310818
PNG
(3-methyl-3-phenyl-N-((1S,2R)-2-phenylcyclopropyl)p...)
Show SMILES CC1(CCCN(C1)C(=O)N[C@H]1C[C@@H]1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H26N2O/c1-22(18-11-6-3-7-12-18)13-8-14-24(16-22)21(25)23-20-15-19(20)17-9-4-2-5-10-17/h2-7,9-12,19-20H,8,13-16H2,1H3,(H,23,25)/t19-,20+,22?/m1/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50302475
PNG
(CHEMBL567491 | N-(3,3-diphenylpropyl)-1-(2-ethoxye...)
Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H28N2O3/c1-2-30-18-17-27-19-22(13-14-24(27)28)25(29)26-16-15-23(20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-14,19,23H,2,15-18H2,1H3,(H,26,29)
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n/an/a 4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441467
PNG
(CHEMBL2436573)
Show SMILES Oc1ccc(F)c(c1)C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C23H23F4N3O4/c24-19-6-3-16(31)13-18(19)20(32)29-10-7-22(8-11-29)9-12-30(14-22)21(33)28-15-1-4-17(5-2-15)34-23(25,26)27/h1-6,13,31H,7-12,14H2,(H,28,33)
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n/an/a 4.10n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446754
PNG
(CHEMBL3114609)
Show SMILES OC(=O)c1ccc(OC2CCN(CC2)C(=O)N[C@H]2C[C@@H]2c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C22H23ClN2O4/c23-18-12-15(21(26)27)6-7-20(18)29-16-8-10-25(11-9-16)22(28)24-19-13-17(19)14-4-2-1-3-5-14/h1-7,12,16-17,19H,8-11,13H2,(H,24,28)(H,26,27)/t17-,19+/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446771
PNG
(CHEMBL3114592)
Show SMILES Cc1ccccc1OC1CCN(CC1)C(=O)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c1-16-7-5-6-10-21(16)26-18-11-13-24(14-12-18)22(25)23-20-15-19(20)17-8-3-2-4-9-17/h2-10,18-20H,11-15H2,1H3,(H,23,25)/t19-,20+/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50302461
PNG
(CHEMBL567703 | N-((4'-(methylsulfonyl)biphenyl-4-y...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(CNC(=O)c2ccc(OCCC(F)(F)F)nc2)cc1
Show InChI InChI=1S/C23H21F3N2O4S/c1-33(30,31)20-9-6-18(7-10-20)17-4-2-16(3-5-17)14-28-22(29)19-8-11-21(27-15-19)32-13-12-23(24,25)26/h2-11,15H,12-14H2,1H3,(H,28,29)
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n/an/a 4.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441468
PNG
(CHEMBL2436564)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C23H22F5N3O3/c24-17-2-1-3-18(25)19(17)20(32)30-11-8-22(9-12-30)10-13-31(14-22)21(33)29-15-4-6-16(7-5-15)34-23(26,27)28/h1-7H,8-14H2,(H,29,33)
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n/an/a 4.5n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441469
PNG
(CHEMBL2436586)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)C2(CC2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H23F6N3O3/c22-20(23,24)19(5-6-19)16(31)29-10-7-18(8-11-29)9-12-30(13-18)17(32)28-14-1-3-15(4-2-14)33-21(25,26)27/h1-4H,5-13H2,(H,28,32)
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n/an/a 4.70n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50297413
PNG
(CHEMBL560537 | N-(3,3-diphenyl-propyl)-nicotinamid...)
Show SMILES O=C(NCCC(c1ccccc1)c1ccccc1)c1cccnc1
Show InChI InChI=1S/C21H20N2O/c24-21(19-12-7-14-22-16-19)23-15-13-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-12,14,16,20H,13,15H2,(H,23,24)
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n/an/a 4.80n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM25738
PNG
(1-adamantan-1-yl-3-{5-[2-(2-ethoxyethoxy)ethoxy]pe...)
Show SMILES CCOCCOCCOCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H40N2O4/c1-2-26-8-9-28-11-10-27-7-5-3-4-6-23-21(25)24-22-15-18-12-19(16-22)14-20(13-18)17-22/h18-20H,2-17H2,1H3,(H2,23,24,25)
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n/an/a 5n/an/an/an/an/an/a



University of California-Davis

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase by fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM25737
PNG
(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)
Show SMILES OC(=O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310787
PNG
(CHEMBL1079360 | N-(4-chlorophenyl)-3-methyl-3-phen...)
Show SMILES CC1(CCCN(C1)C(=O)Nc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C19H21ClN2O/c1-19(15-6-3-2-4-7-15)12-5-13-22(14-19)18(23)21-17-10-8-16(20)9-11-17/h2-4,6-11H,5,12-14H2,1H3,(H,21,23)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310799
PNG
(CHEMBL1078265 | N-(4-chlorophenethyl)-3-methyl-3-p...)
Show SMILES CC1(CCCN(C1)C(=O)NCCc1ccc(Cl)cc1)c1ccccc1
Show InChI InChI=1S/C21H25ClN2O/c1-21(18-6-3-2-4-7-18)13-5-15-24(16-21)20(25)23-14-12-17-8-10-19(22)11-9-17/h2-4,6-11H,5,12-16H2,1H3,(H,23,25)
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n/an/a 5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446763
PNG
(CHEMBL3114600)
Show SMILES COc1ccc(OC2CCN(CC2)C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C22H26N2O3/c1-26-17-7-9-18(10-8-17)27-19-11-13-24(14-12-19)22(25)23-21-15-20(21)16-5-3-2-4-6-16/h2-10,19-21H,11-15H2,1H3,(H,23,25)/t20-,21+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446764
PNG
(CHEMBL3114599)
Show SMILES COc1cccc(OC2CCN(CC2)C(=O)N[C@H]2C[C@@H]2c2ccccc2)c1
Show InChI InChI=1S/C22H26N2O3/c1-26-18-8-5-9-19(14-18)27-17-10-12-24(13-11-17)22(25)23-21-15-20(21)16-6-3-2-4-7-16/h2-9,14,17,20-21H,10-13,15H2,1H3,(H,23,25)/t20-,21+/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441470
PNG
(CHEMBL2436574)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C23H23ClF3N3O3/c24-19-4-2-1-3-18(19)20(31)29-12-9-22(10-13-29)11-14-30(15-22)21(32)28-16-5-7-17(8-6-16)33-23(25,26)27/h1-8H,9-15H2,(H,28,32)
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n/an/a 5.20n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446775
PNG
(CHEMBL3114617)
Show SMILES O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(CC1)OC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H30N2O2/c31-28(29-26-20-25(26)21-10-4-1-5-11-21)30-18-16-24(17-19-30)32-27(22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-15,24-27H,16-20H2,(H,29,31)/t25-,26+/m1/s1
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n/an/a 5.20n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50305643
PNG
(4-(1-(2,4-dichlorobenzylcarbamoyl)piperidin-4-ylox...)
Show SMILES OC(=O)c1ccc(OC2CCN(CC2)C(=O)NCc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C20H20Cl2N2O4/c21-15-4-1-14(18(22)11-15)12-23-20(27)24-9-7-17(8-10-24)28-16-5-2-13(3-6-16)19(25)26/h1-6,11,17H,7-10,12H2,(H,23,27)(H,25,26)
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n/an/a 5.30n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441471
PNG
(CHEMBL2436572)
Show SMILES Fc1ccccc1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C23H23F4N3O3/c24-19-4-2-1-3-18(19)20(31)29-12-9-22(10-13-29)11-14-30(15-22)21(32)28-16-5-7-17(8-6-16)33-23(25,26)27/h1-8H,9-15H2,(H,28,32)
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n/an/a 5.30n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441472
PNG
(CHEMBL2436578)
Show SMILES Cc1cc(no1)C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Show InChI InChI=1S/C21H23F3N4O4/c1-14-12-17(26-32-14)18(29)27-9-6-20(7-10-27)8-11-28(13-20)19(30)25-15-2-4-16(5-3-15)31-21(22,23)24/h2-5,12H,6-11,13H2,1H3,(H,25,30)
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n/an/a 5.30n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50446761
PNG
(CHEMBL3114602)
Show SMILES O=C(N[C@H]1C[C@@H]1c1ccccc1)N1CCC(CC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H28N2O2/c30-27(28-26-19-25(26)21-10-5-2-6-11-21)29-16-14-23(15-17-29)31-24-13-7-12-22(18-24)20-8-3-1-4-9-20/h1-13,18,23,25-26H,14-17,19H2,(H,28,30)/t25-,26+/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



Dainippon Sumitomo Pharma Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310790
PNG
(CHEMBL1080076 | N-(biphenyl-4-yl)-3-methyl-3-pheny...)
Show SMILES CC1(CCCN(C1)C(=O)Nc1ccc(cc1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H26N2O/c1-25(22-11-6-3-7-12-22)17-8-18-27(19-25)24(28)26-23-15-13-21(14-16-23)20-9-4-2-5-10-20/h2-7,9-16H,8,17-19H2,1H3,(H,26,28)
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50302464
PNG
(CHEMBL567110 | N-(2-(trifluoromethoxy)benzyl)-6-(3...)
Show SMILES FC(F)(F)CCOc1ccc(cn1)C(=O)NCc1ccccc1OC(F)(F)F
Show InChI InChI=1S/C17H14F6N2O3/c18-16(19,20)7-8-27-14-6-5-12(10-24-14)15(26)25-9-11-3-1-2-4-13(11)28-17(21,22)23/h1-6,10H,7-9H2,(H,25,26)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50295540
PNG
(CHEMBL561788 | N-(2-phenylcyclopropyl)-4-(3-(2-(tr...)
Show SMILES FC(F)(F)c1ccccc1-c1noc(n1)C1CCN(CC1)C(=O)NC1CC1c1ccccc1
Show InChI InChI=1S/C24H23F3N4O2/c25-24(26,27)19-9-5-4-8-17(19)21-29-22(33-30-21)16-10-12-31(13-11-16)23(32)28-20-14-18(20)15-6-2-1-3-7-15/h1-9,16,18,20H,10-14H2,(H,28,32)
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50191854
PNG
(CHEMBL436774 | N-(1-acetyl-piperidin-4-yl)-N'-(ada...)
Show SMILES CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C18H29N3O2/c1-12(22)21-4-2-16(3-5-21)19-17(23)20-18-9-13-6-14(10-18)8-15(7-13)11-18/h13-16H,2-11H2,1H3,(H2,19,20,23)
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n/an/a 6n/an/an/an/an/an/a



University of California-Davis

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant soluble epoxide hydrolase by fluorescent assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310800
PNG
(3-methyl-3-phenyl-N-(3-(pyridin-3-yl)propyl)piperi...)
Show SMILES CC1(CCCN(C1)C(=O)NCCCc1cccnc1)c1ccccc1
Show InChI InChI=1S/C21H27N3O/c1-21(19-10-3-2-4-11-19)12-7-15-24(17-21)20(25)23-14-6-9-18-8-5-13-22-16-18/h2-5,8,10-11,13,16H,6-7,9,12,14-15,17H2,1H3,(H,23,25)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


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More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50310798
PNG
(CHEMBL1078264 | N-(4-(1H-indol-5-yl)benzyl)-3-meth...)
Show SMILES CC1(CCCN(C1)C(=O)NCc1ccc(cc1)-c1ccc2[nH]ccc2c1)c1ccccc1
Show InChI InChI=1S/C28H29N3O/c1-28(25-6-3-2-4-7-25)15-5-17-31(20-28)27(32)30-19-21-8-10-22(11-9-21)23-12-13-26-24(18-23)14-16-29-26/h2-4,6-14,16,18,29H,5,15,17,19-20H2,1H3,(H,30,32)
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n/an/a 6n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat soluble epoxide hydrolase


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50302476
PNG
(CHEMBL567283 | N-(2,4-dichlorobenzyl)-1-(2-ethoxye...)
Show SMILES CCOCCn1cc(ccc1=O)C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H18Cl2N2O3/c1-2-24-8-7-21-11-13(4-6-16(21)22)17(23)20-10-12-3-5-14(18)9-15(12)19/h3-6,9,11H,2,7-8,10H2,1H3,(H,20,23)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of rat sEH


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50297400
PNG
((S)-4-Cyano-N-[3-(4-fluorophenyl)-3-(4-methanesulf...)
Show SMILES CS(=O)(=O)c1ccc(cc1)[C@@H](CCNC(=O)c1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C24H21FN2O3S/c1-31(29,30)22-12-8-19(9-13-22)23(18-6-10-21(25)11-7-18)14-15-27-24(28)20-4-2-17(16-26)3-5-20/h2-13,23H,14-15H2,1H3,(H,27,28)/t23-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50297414
PNG
(CHEMBL556234 | N-[3-(4-Fluorophenyl)-3-(4-methanes...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(CCNC(=O)c1ccc(OCC(F)(F)F)nc1)c1ccc(F)cc1
Show InChI InChI=1S/C24H22F4N2O4S/c1-35(32,33)20-9-4-17(5-10-20)21(16-2-7-19(25)8-3-16)12-13-29-23(31)18-6-11-22(30-14-18)34-15-24(26,27)28/h2-11,14,21H,12-13,15H2,1H3,(H,29,31)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50297412
PNG
(CHEMBL560740 | N-[3,3-Bis-(4-fluorophenyl)-propyl]...)
Show SMILES Fc1ccc(cc1)C(CCNC(=O)c1ccc(OCC(F)(F)F)nc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H19F5N2O2/c24-18-6-1-15(2-7-18)20(16-3-8-19(25)9-4-16)11-12-29-22(31)17-5-10-21(30-13-17)32-14-23(26,27)28/h1-10,13,20H,11-12,14H2,(H,29,31)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of rhodamine-labeled probe from rat soluble epoxide hydrolase by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441474
PNG
(CHEMBL2436563)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC2(CCN(C2)C(=O)Nc2ccc(cc2)C(F)(F)F)CC1
Show InChI InChI=1S/C23H22F5N3O2/c24-17-2-1-3-18(25)19(17)20(32)30-11-8-22(9-12-30)10-13-31(14-22)21(33)29-16-6-4-15(5-7-16)23(26,27)28/h1-7H,8-14H2,(H,29,33)
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n/an/a 6.10n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
Epoxide hydrolase 2


(Rattus norvegicus)
BDBM50441475
PNG
(CHEMBL2436589)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)N2CCC3(C2)CCN(CC3)C(=O)CC2CC2)cc1
Show InChI InChI=1S/C21H26F3N3O3/c22-21(23,24)30-17-5-3-16(4-6-17)25-19(29)27-12-9-20(14-27)7-10-26(11-8-20)18(28)13-15-1-2-15/h3-6,15H,1-2,7-14H2,(H,25,29)
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n/an/a 6.40n/an/an/an/an/an/a



Toray Industries Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat sEH expressed in Sf9 insect cells using cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl]carbonate after 2...


Citation and Details
More data for this
Ligand-Target Pair
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