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Compile Data Set for Download or QSAR

Found 111 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 2-alpha kinase 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414894
PNG
(CHEMBL573760)
Show SMILES COc1cc2C(=O)c3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H15Cl2N3O3/c1-26-14-6-9-10(7-15(14)27-2)18(25)16-17(9)23-24-19(16)22-8-11-12(20)4-3-5-13(11)21/h3-7H,8H2,1-2H3,(H2,22,23,24)
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n/an/a 6.31n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414893
PNG
(CHEMBL578426)
Show SMILES COc1cc2Cc3c(NCc4c(C)cccc4C)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C21H23N3O2/c1-12-6-5-7-13(2)17(12)11-22-21-16-8-14-9-18(25-3)19(26-4)10-15(14)20(16)23-24-21/h5-7,9-10H,8,11H2,1-4H3,(H2,22,23,24)
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n/an/a 7.94n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414892
PNG
(CHEMBL576168)
Show SMILES COc1cc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H20ClN3O2/c1-11-5-4-6-16(21)15(11)10-22-20-14-7-12-8-17(25-2)18(26-3)9-13(12)19(14)23-24-20/h4-6,8-9H,7,10H2,1-3H3,(H2,22,23,24)
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n/an/a 19.9n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414891
PNG
(CHEMBL574005)
Show SMILES COc1cc-2c(Cc3c(NCc4c(Cl)cccc4Cl)[nH]nc-23)cc1OCC(O)CO
Show InChI InChI=1S/C21H21Cl2N3O4/c1-29-18-7-13-11(6-19(18)30-10-12(28)9-27)5-14-20(13)25-26-21(14)24-8-15-16(22)3-2-4-17(15)23/h2-4,6-7,12,27-28H,5,8-10H2,1H3,(H2,24,25,26)
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n/an/a 31.6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442162
PNG
(CHEMBL2441342)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2F)C(=O)Cc2cccc(n2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H18F4N6O/c1-32-10-15(19-21(28)29-11-30-22(19)32)13-5-6-16-14(20(13)24)7-8-33(16)18(34)9-12-3-2-4-17(31-12)23(25,26)27/h2-6,10-11H,7-9H2,1H3,(H2,28,29,30)
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n/an/a 37n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414895
PNG
(CHEMBL578836)
Show SMILES COc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C19H18ClN3O/c1-11-4-3-5-17(20)16(11)10-21-19-15-8-12-6-7-13(24-2)9-14(12)18(15)22-23-19/h3-7,9H,8,10H2,1-2H3,(H2,21,22,23)
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n/an/a 50.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442163
PNG
(CHEMBL2441346)
Show SMILES Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C22H22FN7O/c1-12-8-13(2)30(27-12)10-18(31)29-7-6-15-17(29)5-4-14(20(15)23)16-9-28(3)22-19(16)21(24)25-11-26-22/h4-5,8-9,11H,6-7,10H2,1-3H3,(H2,24,25,26)
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n/an/a 61n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414890
PNG
(CHEMBL565272)
Show SMILES COc1cc2oc3c(NCc4c(Cl)cccc4Cl)[nH]nc3c2cc1OC
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n/an/a 63.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414889
PNG
(CHEMBL574443)
Show SMILES COc1cc2Cc3c(NCc4ccccc4C)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H21N3O2/c1-12-6-4-5-7-13(12)11-21-20-16-8-14-9-17(24-2)18(25-3)10-15(14)19(16)22-23-20/h4-7,9-10H,8,11H2,1-3H3,(H2,21,22,23)
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n/an/a 63.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414888
PNG
(CHEMBL583635)
Show SMILES COc1cc2-c3n[nH]c(NCc4c(Cl)cccc4Cl)c3S(=O)(=O)c2cc1OC
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-26-13-6-9-15(7-14(13)27-2)28(24,25)17-16(9)22-23-18(17)21-8-10-11(19)4-3-5-12(10)20/h3-7H,8H2,1-2H3,(H2,21,22,23)
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n/an/a 79.4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414887
PNG
(CHEMBL574209)
Show SMILES COc1cc-2c(Cc3c(NCc4c(C)cccc4Cl)[nH]nc-23)c(OC)c1
Show InChI InChI=1S/C20H20ClN3O2/c1-11-5-4-6-17(21)16(11)10-22-20-15-9-13-14(19(15)23-24-20)7-12(25-2)8-18(13)26-3/h4-8H,9-10H2,1-3H3,(H2,22,23,24)
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n/an/a 126n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414886
PNG
(CHEMBL573763)
Show SMILES COc1cc2Cc3c(NCc4ccccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-14-18(13(12)9-17(16)25-2)22-23-19(14)21-10-11-5-3-4-6-15(11)20/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396536
PNG
(CHEMBL2171122)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc12
Show InChI InChI=1S/C23H20ClN5O/c1-28-12-18(21-22(25)26-13-27-23(21)28)15-5-6-19-16(11-15)7-8-29(19)20(30)10-14-3-2-4-17(24)9-14/h2-6,9,11-13H,7-8,10H2,1H3,(H2,25,26,27)
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n/an/a 214n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414884
PNG
(CHEMBL573770)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1cc3OCOc3cc-21
Show InChI InChI=1S/C19H16ClN3O2/c1-10-3-2-4-15(20)14(10)8-21-19-13-5-11-6-16-17(25-9-24-16)7-12(11)18(13)22-23-19/h2-4,6-7H,5,8-9H2,1H3,(H2,21,22,23)
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n/an/a 251n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414885
PNG
(CHEMBL574009)
Show SMILES CN(C)c1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C20H21ClN4/c1-12-5-4-6-18(21)17(12)11-22-20-16-9-13-7-8-14(25(2)3)10-15(13)19(16)23-24-20/h4-8,10H,9,11H2,1-3H3,(H2,22,23,24)
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n/an/a 251n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414883
PNG
(CHEMBL576948)
Show SMILES CCc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C20H20ClN3/c1-3-13-7-8-14-10-16-19(15(14)9-13)23-24-20(16)22-11-17-12(2)5-4-6-18(17)21/h4-9H,3,10-11H2,1-2H3,(H2,22,23,24)
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n/an/a 316n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396534
PNG
(CHEMBL2171124)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
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n/an/a 420n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442166
PNG
(CHEMBL2441340)
Show SMILES Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
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TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414881
PNG
(CHEMBL575913)
Show SMILES COc1ccc-2c(Cc3c(NCc4c(C)cccc4Cl)[nH]nc-23)c1
Show InChI InChI=1S/C19H18ClN3O/c1-11-4-3-5-17(20)16(11)10-21-19-15-9-12-8-13(24-2)6-7-14(12)18(15)22-23-19/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
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n/an/a 501n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414882
PNG
(CHEMBL582642)
Show SMILES COc1cc2sc3c(NCc4c(C)cccc4Cl)[nH]nc3c2cc1OC
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n/an/a 501n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414880
PNG
(CHEMBL574208)
Show SMILES COc1cc2Cc3c(NCc4ccccc4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H19N3O2/c1-23-16-9-13-8-15-18(14(13)10-17(16)24-2)21-22-19(15)20-11-12-6-4-3-5-7-12/h3-7,9-10H,8,11H2,1-2H3,(H2,20,21,22)
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n/an/a 631n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414879
PNG
(CHEMBL573280)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1ccc(Br)cc-21
Show InChI InChI=1S/C18H15BrClN3/c1-10-3-2-4-16(20)15(10)9-21-18-14-7-11-5-6-12(19)8-13(11)17(14)22-23-18/h2-6,8H,7,9H2,1H3,(H2,21,22,23)
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n/an/a 794n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414878
PNG
(CHEMBL575914)
Show SMILES COc1cccc-2c1Cc1c(NCc3c(C)cccc3Cl)[nH]nc-21
Show InChI InChI=1S/C19H18ClN3O/c1-11-5-3-7-16(20)15(11)10-21-19-14-9-13-12(18(14)22-23-19)6-4-8-17(13)24-2/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
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n/an/a 794n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414877
PNG
(CHEMBL574006)
Show SMILES COc1cc2Cc3c(NCc4cccc(Cl)c4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-15-18(14(12)9-17(16)25-2)22-23-19(15)21-10-11-4-3-5-13(20)6-11/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414876
PNG
(CHEMBL575078)
Show SMILES CSc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C19H18ClN3S/c1-11-4-3-5-17(20)16(11)10-21-19-15-8-12-6-7-13(24-2)9-14(12)18(15)22-23-19/h3-7,9H,8,10H2,1-2H3,(H2,21,22,23)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414875
PNG
(CHEMBL575915)
Show SMILES COc1cc2Cc3c(NCc4ccc(Cl)cc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H17Cl2N3O2/c1-25-16-6-11-5-14-18(13(11)8-17(16)26-2)23-24-19(14)22-9-10-3-4-12(20)7-15(10)21/h3-4,6-8H,5,9H2,1-2H3,(H2,22,23,24)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414874
PNG
(CHEMBL583189)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1ccccc-21
Show InChI InChI=1S/C18H16ClN3/c1-11-5-4-8-16(19)15(11)10-20-18-14-9-12-6-2-3-7-13(12)17(14)21-22-18/h2-8H,9-10H2,1H3,(H2,20,21,22)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396531
PNG
(CHEMBL2171132)
Show SMILES Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc2N(CCc2c1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C27H23N5OS/c1-31-15-20(13-30-31)21-14-29-27(28)25-22(16-34-26(21)25)18-7-8-23-19(12-18)9-10-32(23)24(33)11-17-5-3-2-4-6-17/h2-8,12-16H,9-11H2,1H3,(H2,28,29)
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n/an/a 1.86E+3n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414872
PNG
(CHEMBL574010)
Show SMILES COc1cc2Cc3c(NCc4ccc(Cl)cc4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-15-18(14(12)9-17(16)25-2)22-23-19(15)21-10-11-3-5-13(20)6-4-11/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414873
PNG
(CHEMBL578663)
Show SMILES COc1cc2Cc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H17Cl2N3O2/c1-25-16-7-10-6-12-18(11(10)8-17(16)26-2)23-24-19(12)22-9-13-14(20)4-3-5-15(13)21/h3-5,7-8H,6,9H2,1-2H3,(H2,22,23,24)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414871
PNG
(CHEMBL577153)
Show SMILES COc1ccccc1CNc1[nH]nc-2c1Cc1cc(OC)c(OC)cc-21
Show InChI InChI=1S/C20H21N3O3/c1-24-16-7-5-4-6-12(16)11-21-20-15-8-13-9-17(25-2)18(26-3)10-14(13)19(15)22-23-20/h4-7,9-10H,8,11H2,1-3H3,(H2,21,22,23)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50401152
PNG
(CHEMBL2205766)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a<1.00E+4n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of EIF2AK1


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414868
PNG
(CHEMBL574630)
Show SMILES COc1cccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c12
Show InChI InChI=1S/C19H18ClN3O/c1-11-5-3-7-15(20)14(11)10-21-19-13-9-12-6-4-8-16(24-2)17(12)18(13)22-23-19/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414869
PNG
(CHEMBL566755)
Show SMILES COc1cc2CCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-17-8-11-6-7-12-19(13(11)9-18(17)27-2)24-25-20(12)23-10-14-15(21)4-3-5-16(14)22/h3-5,8-9H,6-7,10H2,1-2H3,(H2,23,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414870
PNG
(CHEMBL566756)
Show SMILES COc1cc2CCCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C21H21Cl2N3O2/c1-27-18-9-12-5-3-6-13-20(14(12)10-19(18)28-2)25-26-21(13)24-11-15-16(22)7-4-8-17(15)23/h4,7-10H,3,5-6,11H2,1-2H3,(H2,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50072074
PNG
(CHEMBL3407847)
Show SMILES CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N
Show InChI InChI=1S/C25H22F3N5O2/c1-13-4-7-17(23(34)32-16-6-9-20(35-3)18(11-16)25(26,27)28)22(29)21(13)14-5-8-19-15(10-14)12-31-24(30-2)33-19/h4-12H,29H2,1-3H3,(H,32,34)(H,30,31,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HRI (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50072073
PNG
(CHEMBL3407848)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C33H27N5O5/c1-37-31(21-10-6-4-7-11-21)30(33(40)38(37)22-12-8-5-9-13-22)32(39)36-29-15-14-23(20-35-29)43-26-16-17-34-25-19-28(42-3)27(41-2)18-24(25)26/h4-20H,1-3H3,(H,35,36,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HRI (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396528
PNG
(CHEMBL2171128)
Show SMILES Nc1ncc(-c2cccnc2)c2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12
Show InChI InChI=1S/C28H22N4OS/c29-28-26-23(17-34-27(26)22(16-31-28)21-7-4-11-30-15-21)19-8-9-24-20(14-19)10-12-32(24)25(33)13-18-5-2-1-3-6-18/h1-9,11,14-17H,10,12-13H2,(H2,29,31)
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n/an/a 1.21E+4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396530
PNG
(CHEMBL2171133)
Show SMILES Nc1nccc2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12
Show InChI InChI=1S/C23H19N3OS/c24-23-22-18(14-28-20(22)8-10-25-23)16-6-7-19-17(13-16)9-11-26(19)21(27)12-15-4-2-1-3-5-15/h1-8,10,13-14H,9,11-12H2,(H2,24,25)
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n/an/a 1.70E+4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM26474
PNG
(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50355497
PNG
(AZD-6244 | CHEMBL1614701)
Show SMILES Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO
Show InChI InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50355504
PNG
(CHEMBL1908393)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/an/a 980n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50355496
PNG
(CHEMBL1908397)
Show SMILES O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1
Show InChI InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50308060
PNG
(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Show SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50326053
PNG
(CHEMBL608533 | NA | PKC-412)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM13535
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
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