BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 111 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 2-alpha kinase 1' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414894
PNG
(CHEMBL573760)
Show SMILES COc1cc2C(=O)c3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H15Cl2N3O3/c1-26-14-6-9-10(7-15(14)27-2)18(25)16-17(9)23-24-19(16)22-8-11-12(20)4-3-5-13(11)21/h3-7H,8H2,1-2H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.31n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414893
PNG
(CHEMBL578426)
Show SMILES COc1cc2Cc3c(NCc4c(C)cccc4C)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C21H23N3O2/c1-12-6-5-7-13(2)17(12)11-22-21-16-8-14-9-18(25-3)19(26-4)10-15(14)20(16)23-24-21/h5-7,9-10H,8,11H2,1-4H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.94n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414892
PNG
(CHEMBL576168)
Show SMILES COc1cc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H20ClN3O2/c1-11-5-4-6-16(21)15(11)10-22-20-14-7-12-8-17(25-2)18(26-3)9-13(12)19(14)23-24-20/h4-6,8-9H,7,10H2,1-3H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19.9n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414891
PNG
(CHEMBL574005)
Show SMILES COc1cc-2c(Cc3c(NCc4c(Cl)cccc4Cl)[nH]nc-23)cc1OCC(O)CO
Show InChI InChI=1S/C21H21Cl2N3O4/c1-29-18-7-13-11(6-19(18)30-10-12(28)9-27)5-14-20(13)25-26-21(14)24-8-15-16(22)3-2-4-17(15)23/h2-4,6-7,12,27-28H,5,8-10H2,1H3,(H2,24,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31.6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442162
PNG
(CHEMBL2441342)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2F)C(=O)Cc2cccc(n2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H18F4N6O/c1-32-10-15(19-21(28)29-11-30-22(19)32)13-5-6-16-14(20(13)24)7-8-33(16)18(34)9-12-3-2-4-17(31-12)23(25,26)27/h2-6,10-11H,7-9H2,1H3,(H2,28,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 37n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details

Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414895
PNG
(CHEMBL578836)
Show SMILES COc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C19H18ClN3O/c1-11-4-3-5-17(20)16(11)10-21-19-15-8-12-6-7-13(24-2)9-14(12)18(15)22-23-19/h3-7,9H,8,10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442163
PNG
(CHEMBL2441346)
Show SMILES Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C22H22FN7O/c1-12-8-13(2)30(27-12)10-18(31)29-7-6-15-17(29)5-4-14(20(15)23)16-9-28(3)22-19(16)21(24)25-11-26-22/h4-5,8-9,11H,6-7,10H2,1-3H3,(H2,24,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details

Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414889
PNG
(CHEMBL574443)
Show SMILES COc1cc2Cc3c(NCc4ccccc4C)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H21N3O2/c1-12-6-4-5-7-13(12)11-21-20-16-8-14-9-17(24-2)18(25-3)10-15(14)19(16)22-23-20/h4-7,9-10H,8,11H2,1-3H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 63.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414890
PNG
(CHEMBL565272)
Show SMILES COc1cc2oc3c(NCc4c(Cl)cccc4Cl)[nH]nc3c2cc1OC
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 63.1n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414888
PNG
(CHEMBL583635)
Show SMILES COc1cc2-c3n[nH]c(NCc4c(Cl)cccc4Cl)c3S(=O)(=O)c2cc1OC
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-26-13-6-9-15(7-14(13)27-2)28(24,25)17-16(9)22-23-18(17)21-8-10-11(19)4-3-5-12(10)20/h3-7H,8H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 79.4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414887
PNG
(CHEMBL574209)
Show SMILES COc1cc-2c(Cc3c(NCc4c(C)cccc4Cl)[nH]nc-23)c(OC)c1
Show InChI InChI=1S/C20H20ClN3O2/c1-11-5-4-6-17(21)16(11)10-22-20-15-9-13-14(19(15)23-24-20)7-12(25-2)8-18(13)26-3/h4-8H,9-10H2,1-3H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 126n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414886
PNG
(CHEMBL573763)
Show SMILES COc1cc2Cc3c(NCc4ccccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-14-18(13(12)9-17(16)25-2)22-23-19(14)21-10-11-5-3-4-6-15(11)20/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396536
PNG
(CHEMBL2171122)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc12
Show InChI InChI=1S/C23H20ClN5O/c1-28-12-18(21-22(25)26-13-27-23(21)28)15-5-6-19-16(11-15)7-8-29(19)20(30)10-14-3-2-4-17(24)9-14/h2-6,9,11-13H,7-8,10H2,1H3,(H2,25,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 214n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414884
PNG
(CHEMBL573770)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1cc3OCOc3cc-21
Show InChI InChI=1S/C19H16ClN3O2/c1-10-3-2-4-15(20)14(10)8-21-19-13-5-11-6-16-17(25-9-24-16)7-12(11)18(13)22-23-19/h2-4,6-7H,5,8-9H2,1H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 251n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414885
PNG
(CHEMBL574009)
Show SMILES CN(C)c1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C20H21ClN4/c1-12-5-4-6-18(21)17(12)11-22-20-16-9-13-7-8-14(25(2)3)10-15(13)19(16)23-24-20/h4-8,10H,9,11H2,1-3H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 251n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414883
PNG
(CHEMBL576948)
Show SMILES CCc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C20H20ClN3/c1-3-13-7-8-14-10-16-19(15(14)9-13)23-24-20(16)22-11-17-12(2)5-4-6-18(17)21/h4-9H,3,10-11H2,1-2H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 316n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396534
PNG
(CHEMBL2171124)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 420n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50442166
PNG
(CHEMBL2441340)
Show SMILES Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 460n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of HRI (unknown origin) assessed as EIF2AK1 phosphorylation


Citation and Details

Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414882
PNG
(CHEMBL582642)
Show SMILES COc1cc2sc3c(NCc4c(C)cccc4Cl)[nH]nc3c2cc1OC
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 501n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414881
PNG
(CHEMBL575913)
Show SMILES COc1ccc-2c(Cc3c(NCc4c(C)cccc4Cl)[nH]nc-23)c1
Show InChI InChI=1S/C19H18ClN3O/c1-11-4-3-5-17(20)16(11)10-21-19-15-9-12-8-13(24-2)6-7-14(12)18(15)22-23-19/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 501n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414880
PNG
(CHEMBL574208)
Show SMILES COc1cc2Cc3c(NCc4ccccc4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H19N3O2/c1-23-16-9-13-8-15-18(14(13)10-17(16)24-2)21-22-19(15)20-11-12-6-4-3-5-7-12/h3-7,9-10H,8,11H2,1-2H3,(H2,20,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 631n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414878
PNG
(CHEMBL575914)
Show SMILES COc1cccc-2c1Cc1c(NCc3c(C)cccc3Cl)[nH]nc-21
Show InChI InChI=1S/C19H18ClN3O/c1-11-5-3-7-16(20)15(11)10-21-19-14-9-13-12(18(14)22-23-19)6-4-8-17(13)24-2/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 794n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414879
PNG
(CHEMBL573280)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1ccc(Br)cc-21
Show InChI InChI=1S/C18H15BrClN3/c1-10-3-2-4-16(20)15(10)9-21-18-14-7-11-5-6-12(19)8-13(11)17(14)22-23-18/h2-6,8H,7,9H2,1H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 794n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414877
PNG
(CHEMBL574006)
Show SMILES COc1cc2Cc3c(NCc4cccc(Cl)c4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-15-18(14(12)9-17(16)25-2)22-23-19(15)21-10-11-4-3-5-13(20)6-11/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414876
PNG
(CHEMBL575078)
Show SMILES CSc1ccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c2c1
Show InChI InChI=1S/C19H18ClN3S/c1-11-4-3-5-17(20)16(11)10-21-19-15-8-12-6-7-13(24-2)9-14(12)18(15)22-23-19/h3-7,9H,8,10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414875
PNG
(CHEMBL575915)
Show SMILES COc1cc2Cc3c(NCc4ccc(Cl)cc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H17Cl2N3O2/c1-25-16-6-11-5-14-18(13(11)8-17(16)26-2)23-24-19(14)22-9-10-3-4-12(20)7-15(10)21/h3-4,6-8H,5,9H2,1-2H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.26E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414874
PNG
(CHEMBL583189)
Show SMILES Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1ccccc-21
Show InChI InChI=1S/C18H16ClN3/c1-11-5-4-8-16(19)15(11)10-20-18-14-9-12-6-2-3-7-13(12)17(14)21-22-18/h2-8H,9-10H2,1H3,(H2,20,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.58E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396531
PNG
(CHEMBL2171132)
Show SMILES Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc2N(CCc2c1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C27H23N5OS/c1-31-15-20(13-30-31)21-14-29-27(28)25-22(16-34-26(21)25)18-7-8-23-19(12-18)9-10-32(23)24(33)11-17-5-3-2-4-6-17/h2-8,12-16H,9-11H2,1H3,(H2,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.86E+3n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414872
PNG
(CHEMBL574010)
Show SMILES COc1cc2Cc3c(NCc4ccc(Cl)cc4)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H18ClN3O2/c1-24-16-8-12-7-15-18(14(12)9-17(16)25-2)22-23-19(15)21-10-11-3-5-13(20)6-4-11/h3-6,8-9H,7,10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414873
PNG
(CHEMBL578663)
Show SMILES COc1cc2Cc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C19H17Cl2N3O2/c1-25-16-7-10-6-12-18(11(10)8-17(16)26-2)23-24-19(12)22-9-13-14(20)4-3-5-15(13)21/h3-5,7-8H,6,9H2,1-2H3,(H2,22,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414871
PNG
(CHEMBL577153)
Show SMILES COc1ccccc1CNc1[nH]nc-2c1Cc1cc(OC)c(OC)cc-21
Show InChI InChI=1S/C20H21N3O3/c1-24-16-7-5-4-6-12(16)11-21-20-15-8-13-9-17(25-2)18(26-3)10-14(13)19(15)22-23-20/h4-7,9-10H,8,11H2,1-3H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.16E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50401152
PNG
(CHEMBL2205766)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<1.00E+4n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of EIF2AK1


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414869
PNG
(CHEMBL566755)
Show SMILES COc1cc2CCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C20H19Cl2N3O2/c1-26-17-8-11-6-7-12-19(13(11)9-18(17)27-2)24-25-20(12)23-10-14-15(21)4-3-5-16(14)22/h3-5,8-9H,6-7,10H2,1-2H3,(H2,23,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414870
PNG
(CHEMBL566756)
Show SMILES COc1cc2CCCc3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC
Show InChI InChI=1S/C21H21Cl2N3O2/c1-27-18-9-12-5-3-6-13-20(14(12)10-19(18)28-2)25-26-21(13)24-11-15-16(22)7-4-8-17(15)23/h4,7-10H,3,5-6,11H2,1-2H3,(H2,24,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50414868
PNG
(CHEMBL574630)
Show SMILES COc1cccc2Cc3c(NCc4c(C)cccc4Cl)[nH]nc3-c12
Show InChI InChI=1S/C19H18ClN3O/c1-11-5-3-7-15(20)14(11)10-21-19-13-9-12-6-4-8-16(24-2)17(12)18(13)22-23-19/h3-8H,9-10H2,1-2H3,(H2,21,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HRI kinase


Bioorg Med Chem Lett 19: 6548-51 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.033
BindingDB Entry DOI: 10.7270/Q26Q1ZGZ
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50072074
PNG
(CHEMBL3407847)
Show SMILES CNc1ncc2cc(ccc2n1)-c1c(C)ccc(C(=O)Nc2ccc(OC)c(c2)C(F)(F)F)c1N
Show InChI InChI=1S/C25H22F3N5O2/c1-13-4-7-17(23(34)32-16-6-9-20(35-3)18(11-16)25(26,27)28)22(29)21(13)14-5-8-19-15(10-14)12-31-24(30-2)33-19/h4-12H,29H2,1-3H3,(H,32,34)(H,30,31,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HRI (unknown origin)


J Med Chem 58: 1426-41 (2015)


Article DOI: 10.1021/jm5017494
BindingDB Entry DOI: 10.7270/Q27W6DWN
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50072073
PNG
(CHEMBL3407848)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C33H27N5O5/c1-37-31(21-10-6-4-7-11-21)30(33(40)38(37)22-12-8-5-9-13-22)32(39)36-29-15-14-23(20-35-29)43-26-16-17-34-25-19-28(42-3)27(41-2)18-24(25)26/h4-20H,1-3H3,(H,35,36,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HRI (unknown origin)


J Med Chem 58: 1426-41 (2015)


Article DOI: 10.1021/jm5017494
BindingDB Entry DOI: 10.7270/Q27W6DWN
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396528
PNG
(CHEMBL2171128)
Show SMILES Nc1ncc(-c2cccnc2)c2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12
Show InChI InChI=1S/C28H22N4OS/c29-28-26-23(17-34-27(26)22(16-31-28)21-7-4-11-30-15-21)19-8-9-24-20(14-19)10-12-32(24)25(33)13-18-5-2-1-3-6-18/h1-9,11,14-17H,10,12-13H2,(H2,29,31)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.21E+4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50396530
PNG
(CHEMBL2171133)
Show SMILES Nc1nccc2scc(-c3ccc4N(CCc4c3)C(=O)Cc3ccccc3)c12
Show InChI InChI=1S/C23H19N3OS/c24-23-22-18(14-28-20(22)8-10-25-23)16-6-7-19-17(13-16)9-11-26(19)21(27)12-15-4-2-1-3-5-15/h1-8,10,13-14H,9,11-12H2,(H2,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of HRI assessed as EIF2AK1 phosphorylation


J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | Vargatef)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem
Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50308060
PNG
(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Show SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50326053
PNG
(CHEMBL608533 | PKC-412)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM25045
PNG
(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM60589
PNG
(6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM50332294
PNG
(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Show SMILES Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
n/an/an/a 1.00E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 1


(Homo sapiens)
BDBM5446
PNG
(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
Show InChI InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for EIF2AK1 kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 111 total )  |  Next  |  Last  >>
Jump to: