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Found 58 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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4.10E+3n/an/an/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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1.21E+4n/an/an/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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1.71E+4n/an/an/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110843
PNG
(CHEMBL3604542)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32+;;;;/s2
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110843
PNG
(CHEMBL3604542)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32+;;;;/s2
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50386762
PNG
(CHEMBL2046906)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Br)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H21BrN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1
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n/an/a 700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...


J Med Chem 55: 3837-51 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110892
PNG
(CHEMBL3604537)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31-;;;;/s2
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n/an/a 1.19E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110895
PNG
(CHEMBL3604540)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32+;;;;/s2
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n/an/a 1.24E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110892
PNG
(CHEMBL3604537)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31-;;;;/s2
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n/an/a 1.28E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110844
PNG
(CHEMBL3604543)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32-;;;;/s2
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294223
PNG
(2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-{[({[(pho...)
Show SMILES C[n+]1cn(C2OC(COP([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O13P3S/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33)/p-4
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n/an/a 1.44E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110844
PNG
(CHEMBL3604543)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32-;;;;/s2
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n/an/a 1.44E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110895
PNG
(CHEMBL3604540)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32+;;;;/s2
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n/an/a 1.49E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50386768
PNG
(CHEMBL2046908)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(cc3)C#N)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H21N6O9P/c20-7-10-1-3-11(4-2-10)32-6-5-24-9-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)8-33-35(29,30)31/h1-4,9,12,14-15,18,26-27H,5-6,8H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...


J Med Chem 55: 3837-51 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50386766
PNG
(CHEMBL2046905)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H21ClN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...


J Med Chem 55: 3837-51 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50316302
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1
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n/an/a 2.36E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110894
PNG
(CHEMBL3604539)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O
Show InChI InChI=1/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33-;;;;/s2
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n/an/a 2.55E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110896
PNG
(CHEMBL3604541)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32-;;;;/s2
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n/an/a 2.61E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365099
PNG
(CHEMBL1951197)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)NP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H31N11O20P4/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)10(33)6(50-19)2-47-53(39,40)29-54(41,42)51-56(45,46)52-55(43,44)48-3-7-11(34)12(35)18(49-7)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H10-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44,45,46)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 2.62E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50386769
PNG
(CHEMBL2046910)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Cl)c(F)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H20ClFN5O9P/c19-9-2-1-8(5-10(9)20)32-4-3-24-7-25(15-12(24)16(28)23-18(21)22-15)17-14(27)13(26)11(34-17)6-33-35(29,30)31/h1-2,5,7,11,13-14,17,26-27H,3-4,6H2,(H4-,21,22,23,28,29,30,31)/t11-,13-,14-,17-/m1/s1
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n/an/a 2.65E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...


J Med Chem 55: 3837-51 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110893
PNG
(CHEMBL3604538)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O
Show InChI InChI=1/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33+;;;;/s2
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n/an/a 3.22E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110894
PNG
(CHEMBL3604539)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O
Show InChI InChI=1/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33-;;;;/s2
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n/an/a 3.26E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110891
PNG
(CHEMBL3604536)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31+;;;;/s2
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n/an/a 3.26E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365100
PNG
(CHEMBL1951195)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)NP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H31N11O20P4/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)11(34)7(50-19)3-48-55(43,44)52-56(45,46)51-54(41,42)29-53(39,40)47-2-6-10(33)12(35)18(49-6)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H10-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44,45,46)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 3.52E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365099
PNG
(CHEMBL1951197)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)NP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H31N11O20P4/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)10(33)6(50-19)2-47-53(39,40)29-54(41,42)51-56(45,46)52-55(43,44)48-3-7-11(34)12(35)18(49-7)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H10-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44,45,46)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 3.58E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110896
PNG
(CHEMBL3604541)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12
Show InChI InChI=1/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32-;;;;/s2
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n/an/a 3.68E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365101
PNG
(CHEMBL1951193)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)NP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N11O17P3/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)10(33)6(48-19)2-45-50(39,40)29-51(41,42)49-52(43,44)46-3-7-11(34)12(35)18(47-7)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H9-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 3.74E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294221
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O17P3S/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(46-19)3-44-51(42,52)48-50(40,41)47-49(38,39)43-2-6-10(32)12(34)18(45-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,52)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-,51+/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365101
PNG
(CHEMBL1951193)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)NP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N11O17P3/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)10(33)6(48-19)2-45-50(39,40)29-51(41,42)49-52(43,44)46-3-7-11(34)12(35)18(47-7)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H9-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 3.97E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110891
PNG
(CHEMBL3604536)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O
Show InChI InChI=1/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31+;;;;/s2
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n/an/a 4.12E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50386771
PNG
(CHEMBL2046912)
Show SMILES Nc1nc2n(c[n+](Cc3cc4cc(Cl)ccc4o3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H19ClN5O9P/c20-9-1-2-11-8(3-9)4-10(33-11)5-24-7-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)6-32-35(29,30)31/h1-4,7,12,14-15,18,26-27H,5-6H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of eIF4E in rabbit reticulocyte cell lysate assessed as inhibition of cap-dependent translation after 90 mins by luciferase reporter gene ...


J Med Chem 55: 3837-51 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
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n/an/a 4.39E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of rabbit beta-glo...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110893
PNG
(CHEMBL3604538)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O
Show InChI InChI=1/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33+;;;;/s2
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n/an/a 4.47E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365103
PNG
(CHEMBL1951189)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N10O21P4/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(49-19)3-47-54(40,41)51-56(44,45)52-55(42,43)50-53(38,39)46-2-6-10(32)12(34)18(48-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H9-,22,23,25,26,27,28,36,37,38,39,40,41,42,43,44,45)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50316302
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1
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n/an/a 5.72E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365102
PNG
(CHEMBL1951191)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N11O17P3/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)11(34)7(48-19)3-46-52(43,44)49-51(41,42)29-50(39,40)45-2-6-10(33)12(35)18(47-6)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H9-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 5.97E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294222
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-puri...)
Show SMILES C[n+]1cn(C2OC(COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)C(O)C2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-4
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n/an/a 8.00E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eukaryotic initiation factor 4E in micrococcal nuclease-pretreated rabbit reticulocyte lysate assessed as inhibition of m7,3'-O-GpppG-c...


Bioorg Med Chem Lett 19: 1921-5 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50110845
PNG
(CHEMBL3351000)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12
Show InChI InChI=1/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/t6-,7-,10-,11-,12-,13-,18-,19-/s2
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n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...


Bioorg Med Chem 23: 5369-81 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50294220
PNG
(2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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PubMed
n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365102
PNG
(CHEMBL1951191)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N11O17P3/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)11(34)7(48-19)3-46-52(43,44)49-51(41,42)29-50(39,40)45-2-6-10(33)12(35)18(47-6)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H9-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44)/p-3/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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PubMed
n/an/a 8.49E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate by luciferase reporter gene assay


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365100
PNG
(CHEMBL1951195)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)NP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H31N11O20P4/c1-30-5-32(15-9(30)17(38)28-21(23)26-15)19-13(36)11(34)7(50-19)3-48-55(43,44)52-56(45,46)51-54(41,42)29-53(39,40)47-2-6-10(33)12(35)18(49-6)31-4-24-8-14(31)25-20(22)27-16(8)37/h4-7,10-13,18-19,33-36H,2-3H2,1H3,(H10-,22,23,25,26,27,28,29,37,38,39,40,41,42,43,44,45,46)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)
BDBM50365103
PNG
(CHEMBL1951189)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[n-]c(=O)c12
Show InChI InChI=1S/C21H30N10O21P4/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(49-19)3-47-54(40,41)51-56(44,45)52-55(42,43)50-53(38,39)46-2-6-10(32)12(34)18(48-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H9-,22,23,25,26,27,28,36,37,38,39,40,41,42,43,44,45)/p-4/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated mRNA translation in rabbit reticulocyte lysate pre-incubated for 60 mins prior to mRNA addition by luciferase reporter g...


Bioorg Med Chem 20: 1699-710 (2012)

More data for this
Ligand-Target Pair
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