BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 239 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E (eIF4E)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50316302
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
Article
PubMed
28n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386777
PNG
(CHEMBL2046918)
Show SMILES CNc1nc2nc(-c3ccc(cc3)C(F)(F)P(O)(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1
Show InChI InChI=1S/C21H19ClF2N5O5P/c1-25-20-27-17-16(19(30)28-20)29(10-11-34-15-8-6-14(22)7-9-15)18(26-17)12-2-4-13(5-3-12)21(23,24)35(31,32)33/h2-9H,10-11H2,1H3,(H2,31,32,33)(H2,25,27,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386762
PNG
(CHEMBL2046906)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Br)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H21BrN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386774
PNG
(CHEMBL2046915)
Show SMILES CC1(C)O[C@@H]2[C@@H](COP(O)([O-])=O)O[C@H]([C@@H]2O1)n1c[n+](CCOc2ccc(Cl)cc2)c2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C21H25ClN5O9P/c1-21(2)35-15-13(9-33-37(29,30)31)34-19(16(15)36-21)27-10-26(14-17(27)24-20(23)25-18(14)28)7-8-32-12-5-3-11(22)4-6-12/h3-6,10,13,15-16,19H,7-9H2,1-2H3,(H4-,23,24,25,28,29,30,31)/t13-,15-,16-,19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386769
PNG
(CHEMBL2046910)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Cl)c(F)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H20ClFN5O9P/c19-9-2-1-8(5-10(9)20)32-4-3-24-7-25(15-12(24)16(28)23-18(21)22-15)17-14(27)13(26)11(34-17)6-33-35(29,30)31/h1-2,5,7,11,13-14,17,26-27H,3-4,6H2,(H4-,21,22,23,28,29,30,31)/t11-,13-,14-,17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386766
PNG
(CHEMBL2046905)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H21ClN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386775
PNG
(CHEMBL2046916)
Show SMILES CNc1nc2nc(-c3ccc(cc3)P(O)(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1
Show InChI InChI=1S/C20H19ClN5O5P/c1-22-20-24-17-16(19(27)25-20)26(10-11-31-14-6-4-13(21)5-7-14)18(23-17)12-2-8-15(9-3-12)32(28,29)30/h2-9H,10-11H2,1H3,(H2,28,29,30)(H2,22,24,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PDB
Article
PubMed
n/an/a 95n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386771
PNG
(CHEMBL2046912)
Show SMILES Nc1nc2n(c[n+](Cc3cc4cc(Cl)ccc4o3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H19ClN5O9P/c20-9-1-2-11-8(3-9)4-10(33-11)5-24-7-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)6-32-35(29,30)31/h1-4,7,12,14-15,18,26-27H,5-6H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 117n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386768
PNG
(CHEMBL2046908)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(cc3)C#N)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C19H21N6O9P/c20-7-10-1-3-11(4-2-10)32-6-5-24-9-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)8-33-35(29,30)31/h1-4,9,12,14-15,18,26-27H,5-6,8H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 125n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386776
PNG
(CHEMBL2046917)
Show SMILES CNc1nc2nc(-c3ccc(CP(O)(O)=O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1
Show InChI InChI=1S/C21H21ClN5O5P/c1-23-21-25-18-17(20(28)26-21)27(10-11-32-16-8-6-15(22)7-9-16)19(24-18)14-4-2-13(3-5-14)12-33(29,30)31/h2-9H,10-12H2,1H3,(H2,29,30,31)(H2,23,25,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167266
PNG
(US9073881, 15 | US9073881, 16)
Show SMILES OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H12Cl2N2O4S/c23-17-8-6-12(10-18(17)24)19-11-31-21(25-19)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 500n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167338
PNG
(US9073881, 88)
Show SMILES OC(=O)c1cc(ccc1-c1cc(OC(F)(F)F)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3F3NO3S/c24-17-6-3-13(33-23(27,28)29)9-15(17)14-4-1-12(7-16(14)22(31)32)21-30-20(10-34-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 600n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167388
PNG
(US9073881, 140)
Show SMILES Cc1ccc(Cl)c(c1F)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H13Cl3FNO2S/c1-11-2-6-17(25)20(21(11)27)14-5-3-13(8-15(14)23(29)30)22-28-19(10-31-22)12-4-7-16(24)18(26)9-12/h2-10H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 700n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167372
PNG
(US9073881, 124)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(F)cc1C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl2F4NO2S/c24-18-6-2-11(8-19(18)25)20-10-33-21(30-20)12-1-4-14(16(7-12)22(31)32)15-5-3-13(26)9-17(15)23(27,28)29/h1-10H,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 800n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167330
PNG
(US9073881, 80)
Show SMILES CC(NC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1/C31H22Cl2N2O3S/c1-18(19-5-3-2-4-6-19)34-29(36)21-9-7-20(8-10-21)24-13-11-23(15-25(24)31(37)38)30-35-28(17-39-30)22-12-14-26(32)27(33)16-22/h2-18H,1H3,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 970n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167376
PNG
(US9073881, 128)
Show SMILES OC(=O)c1cc(ccc1-c1cc(ccc1Cl)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3F3NO2S/c24-17-6-3-13(23(27,28)29)9-15(17)14-4-1-12(7-16(14)22(31)32)21-30-20(10-33-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167392
PNG
(US9073881, 144)
Show SMILES Cc1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H14Cl3NO2S/c1-12-2-6-18(24)16(8-12)15-5-3-14(9-17(15)23(28)29)22-27-21(11-30-22)13-4-7-19(25)20(26)10-13/h2-11H,1H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167334
PNG
(US9073881, 84)
Show SMILES OC(=O)c1cc(ccc1-c1cnc(O)nc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H11Cl2N3O3S/c21-15-4-2-10(6-16(15)22)17-9-29-18(25-17)11-1-3-13(14(5-11)19(26)27)12-7-23-20(28)24-8-12/h1-9H,(H,26,27)(H,23,24,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167337
PNG
(US9073881, 87)
Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H14Cl2F3NO3S/c1-33-14-4-6-16(18(10-14)24(27,28)29)15-5-2-13(8-17(15)23(31)32)22-30-21(11-34-22)12-3-7-19(25)20(26)9-12/h2-11H,1H3,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167316
PNG
(US9073881, 65)
Show SMILES COc1cccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C31H22Cl2N2O4S/c1-39-23-4-2-3-18(13-23)16-34-29(36)20-7-5-19(6-8-20)24-11-9-22(14-25(24)31(37)38)30-35-28(17-40-30)21-10-12-26(32)27(33)15-21/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167328
PNG
(US9073881, 77)
Show SMILES NC(=O)c1ncccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H13Cl2N3O3S/c23-16-6-4-11(9-17(16)24)18-10-31-21(27-18)12-3-5-13(15(8-12)22(29)30)14-2-1-7-26-19(14)20(25)28/h1-10H,(H2,25,28)(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167265
PNG
(US9073881, 14)
Show SMILES OC(=O)c1cc(ccc1-c1cc(Cl)ccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl3N2O4S/c23-13-3-6-20(27(30)31)15(9-13)14-4-1-12(7-16(14)22(28)29)21-26-19(10-32-21)11-2-5-17(24)18(25)8-11/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167355
PNG
(US9073881, 105)
Show SMILES Cc1cc(ccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)C#N
Show InChI InChI=1S/C24H14Cl2N2O2S/c1-13-8-14(11-27)2-5-17(13)18-6-3-16(9-19(18)24(29)30)23-28-22(12-31-23)15-4-7-20(25)21(26)10-15/h2-10,12H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.30E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386779
PNG
(CHEMBL2046920)
Show SMILES CCOP(O)(=O)c1ccc(cc1)-c1nc2nc(NC)[nH]c(=O)c2n1CCOc1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN5O5P/c1-3-33-34(30,31)17-10-4-14(5-11-17)20-25-19-18(21(29)27-22(24-2)26-19)28(20)12-13-32-16-8-6-15(23)7-9-16/h4-11H,3,12-13H2,1-2H3,(H,30,31)(H2,24,26,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.35E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167382
PNG
(US9073881, 134)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(F)cc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl3FNO2S/c23-17-6-2-11(8-19(17)25)20-10-30-21(27-20)12-1-4-14(16(7-12)22(28)29)15-5-3-13(26)9-18(15)24/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167398
PNG
(US9073881, 150)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(Cl)cc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl4NO2S/c23-13-3-5-15(18(25)9-13)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-6-17(24)19(26)8-11/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167344
PNG
(US9073881, 94)
Show SMILES COc1ccc(c(Cl)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H14Cl3NO3S/c1-30-14-4-6-16(19(25)10-14)15-5-2-13(8-17(15)23(28)29)22-27-21(11-31-22)12-3-7-18(24)20(26)9-12/h2-11H,1H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167323
PNG
(US9073881, 72)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1ccc(F)cc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C30H19Cl2FN2O3S/c31-25-12-8-20(14-26(25)32)27-16-39-29(35-27)21-7-11-23(24(13-21)30(37)38)18-3-5-19(6-4-18)28(36)34-15-17-1-9-22(33)10-2-17/h1-14,16H,15H2,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167366
PNG
(US9073881, 118)
Show SMILES CC(=O)c1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H14Cl3NO3S/c1-12(29)13-3-6-19(25)17(8-13)16-5-2-15(9-18(16)24(30)31)23-28-22(11-32-23)14-4-7-20(26)21(27)10-14/h2-11H,1H3,(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM50386767
PNG
(CHEMBL2046907)
Show SMILES Nc1nc2n(c[n+](CCOc3ccc(F)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H21FN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of [3H]m7-GTP binding to human FLAG-His6 tagged eIF4E expressed in Escherichia coli by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167381
PNG
(US9073881, 133)
Show SMILES OC(=O)c1cc(ccc1-c1cc(F)cc(F)c1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H10Cl2F3NO2S/c23-16-4-2-10(6-17(16)24)19-9-31-21(28-19)11-1-3-13(15(5-11)22(29)30)14-7-12(25)8-18(26)20(14)27/h1-9H,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167387
PNG
(US9073881, 139)
Show SMILES Cc1ccc(F)c(c1Cl)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H13Cl3FNO2S/c1-11-2-7-18(27)20(21(11)26)14-5-3-13(8-15(14)23(29)30)22-28-19(10-31-22)12-4-6-16(24)17(25)9-12/h2-10H,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167375
PNG
(US9073881, 127)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(cc1Cl)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3F3NO2S/c24-17-6-2-11(8-19(17)26)20-10-33-21(30-20)12-1-4-14(16(7-12)22(31)32)15-5-3-13(9-18(15)25)23(27,28)29/h1-10H,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.60E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167394
PNG
(US9073881, 146)
Show SMILES OC(=O)c1cc(ccc1-c1sccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H10Cl3NO2S2/c21-14-4-2-10(8-16(14)23)17-9-28-19(24-17)11-1-3-12(13(7-11)20(25)26)18-15(22)5-6-27-18/h1-9H,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167395
PNG
(US9073881, 147)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(Cl)cc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H12Cl3NO2S/c23-15-5-1-12(2-6-15)16-7-3-14(9-17(16)22(27)28)21-26-20(11-29-21)13-4-8-18(24)19(25)10-13/h1-11H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167362
PNG
(US9073881, 114)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(C#N)c(Cl)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3N2O2S/c24-18-6-4-13(9-20(18)26)21-11-31-22(28-21)14-3-5-16(17(7-14)23(29)30)12-1-2-15(10-27)19(25)8-12/h1-9,11H,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167396
PNG
(US9073881, 148)
Show SMILES OC(=O)c1cc(ccc1-c1cc(Cl)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl4NO2S/c23-13-3-6-17(24)15(9-13)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167359
PNG
(US9073881, 110)
Show SMILES OC(=O)c1cc(ccc1-c1cc(Cl)ccc1C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3N2O2S/c24-15-4-1-14(10-27)17(9-15)16-5-2-13(7-18(16)23(29)30)22-28-21(11-31-22)12-3-6-19(25)20(26)8-12/h1-9,11H,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167321
PNG
(US9073881, 70)
Show SMILES Cc1cccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C31H22Cl2N2O3S/c1-18-3-2-4-19(13-18)16-34-29(36)21-7-5-20(6-8-21)24-11-9-23(14-25(24)31(37)38)30-35-28(17-39-30)22-10-12-26(32)27(33)15-22/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.70E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167340
PNG
(US9073881, 90)
Show SMILES COc1cccc(Cl)c1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H14Cl3NO3S/c1-30-20-4-2-3-17(25)21(20)14-7-5-13(9-15(14)23(28)29)22-27-19(11-31-22)12-6-8-16(24)18(26)10-12/h2-11H,1H3,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167379
PNG
(US9073881, 131)
Show SMILES OC(=O)c1cc(ccc1-c1cc(F)ccc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl2F2NO2S/c23-17-5-2-11(8-18(17)24)20-10-30-21(27-20)12-1-4-14(16(7-12)22(28)29)15-9-13(25)3-6-19(15)26/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.80E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167363
PNG
(US9073881, 115)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(Cl)c(c1)C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl3N2O2S/c24-18-5-2-12(7-15(18)10-27)16-4-1-14(8-17(16)23(29)30)22-28-21(11-31-22)13-3-6-19(25)20(26)9-13/h1-9,11H,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167386
PNG
(US9073881, 138)
Show SMILES OC(=O)c1cc(ccc1-c1cccc(F)c1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl2F2NO2S/c23-16-7-5-11(9-17(16)24)19-10-30-21(27-19)12-4-6-13(15(8-12)22(28)29)14-2-1-3-18(25)20(14)26/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167329
PNG
(US9073881, 78 | US9073881, 79)
Show SMILES Cc1cc(ccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H15Cl2NO4S/c1-12-8-15(23(28)29)3-5-16(12)17-6-2-14(9-18(17)24(30)31)22-27-21(11-32-22)13-4-7-19(25)20(26)10-13/h2-11H,1H3,(H,28,29)(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.90E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167315
PNG
(US9073881, 64)
Show SMILES COc1ccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C31H22Cl2N2O4S/c1-39-23-10-2-18(3-11-23)16-34-29(36)20-6-4-19(5-7-20)24-12-8-22(14-25(24)31(37)38)30-35-28(17-40-30)21-9-13-26(32)27(33)15-21/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167339
PNG
(US9073881, 89)
Show SMILES CCOc1ccc(c(Cl)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16Cl3NO3S/c1-2-31-15-5-7-17(20(26)11-15)16-6-3-14(9-18(16)24(29)30)23-28-22(12-32-23)13-4-8-19(25)21(27)10-13/h3-12H,2H2,1H3,(H,29,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167255
PNG
(US9073881, 4)
Show SMILES OC(=O)c1cc(ccc1-c1cc(ccc1[N+]([O-])=O)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H11Cl2F3N2O4S/c24-17-5-2-11(8-18(17)25)19-10-35-21(29-19)12-1-4-14(16(7-12)22(31)32)15-9-13(23(26,27)28)3-6-20(15)30(33)34/h1-10H,(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167400
PNG
(US9073881, 152)
Show SMILES OC(=O)c1cc(ccc1-c1cccc(Cl)c1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H11Cl4NO2S/c23-16-7-5-11(9-18(16)25)19-10-30-21(27-19)12-4-6-13(15(8-12)22(28)29)14-2-1-3-17(24)20(14)26/h1-10H,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167324
PNG
(US9073881, 73)
Show SMILES OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1cccc(F)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C30H19Cl2FN2O3S/c31-25-11-9-20(14-26(25)32)27-16-39-29(35-27)21-8-10-23(24(13-21)30(37)38)18-4-6-19(7-5-18)28(36)34-15-17-2-1-3-22(33)12-17/h1-14,16H,15H2,(H,34,36)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E (eIF4E)


(Homo sapiens (Human))
BDBM167393
PNG
(US9073881, 145)
Show SMILES OC(=O)c1cc(ccc1-c1ccsc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H10Cl3NO2S2/c21-15-4-2-10(8-16(15)22)17-9-28-19(24-17)11-1-3-12(14(7-11)20(25)26)13-5-6-27-18(13)23/h1-9H,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2.20E+3n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human eIF4E (aa 28-217) with a C-terminal His tag (HH-eIF4E) was expressed in E. coli in inclusion bodies. The protein was solubilized with 8 M urea ...


US Patent US9073881 (2015)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 239 total )  |  Next  |  Last  >>
Jump to: