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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102484
PNG
(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N[C@@](O)(CC(O)=O)C(O)=O
Show InChI InChI=1S/C8H14N2O7/c1-3(11)5(9)6(14)10-8(17,7(15)16)2-4(12)13/h3,5,11,17H,2,9H2,1H3,(H,10,14)(H,12,13)(H,15,16)/t3-,5+,8-/m1/s1
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600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid.


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102484
PNG
(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N[C@@](O)(CC(O)=O)C(O)=O
Show InChI InChI=1S/C8H14N2O7/c1-3(11)5(9)6(14)10-8(17,7(15)16)2-4(12)13/h3,5,11,17H,2,9H2,1H3,(H,10,14)(H,12,13)(H,15,16)/t3-,5+,8-/m1/s1
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
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PubMed
4.90E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acid


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102486
PNG
(2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid...)
Show SMILES OC(=O)[C@H]1OC(=N[C@@H]1C(O)=O)c1ccccc1
Show InChI InChI=1S/C11H9NO5/c13-10(14)7-8(11(15)16)17-9(12-7)6-4-2-1-3-5-6/h1-5,7-8H,(H,13,14)(H,15,16)/t7-,8-/m0/s1
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PC cid
PC sid
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1.40E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid in mammalian cells


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102486
PNG
(2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid...)
Show SMILES OC(=O)[C@H]1OC(=N[C@@H]1C(O)=O)c1ccccc1
Show InChI InChI=1S/C11H9NO5/c13-10(14)7-8(11(15)16)17-9(12-7)6-4-2-1-3-5-6/h1-5,7-8H,(H,13,14)(H,15,16)/t7-,8-/m0/s1
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
4.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acid in mammalian cells


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102487
PNG
(2-Phenyl-oxazole-4,5-dicarboxylic acid | CHEMBL841...)
Show SMILES OC(=O)c1nc(oc1C(O)=O)-c1ccccc1
Show InChI InChI=1S/C11H7NO5/c13-10(14)7-8(11(15)16)17-9(12-7)6-4-2-1-3-5-6/h1-5H,(H,13,14)(H,15,16)
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CHEMBL
PC cid
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UniChem
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PubMed
7.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid.


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Rattus norvegicus)
BDBM50102487
PNG
(2-Phenyl-oxazole-4,5-dicarboxylic acid | CHEMBL841...)
Show SMILES OC(=O)c1nc(oc1C(O)=O)-c1ccccc1
Show InChI InChI=1S/C11H7NO5/c13-10(14)7-8(11(15)16)17-9(12-7)6-4-2-1-3-5-6/h1-5H,(H,13,14)(H,15,16)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
5.30E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acid.


J Med Chem 44: 2507-10 (2001)

More data for this
Ligand-Target Pair