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Compile Data Set for Download or QSAR

Found 154 hits Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 3


(HUMAN)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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PubMed
51n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252046
PNG
((2S,4S)-2-amino-4-(benzyloxymethyl)pentanedioic ac...)
Show SMILES N[C@@H](C[C@@H](COCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H17NO5/c14-11(13(17)18)6-10(12(15)16)8-19-7-9-4-2-1-3-5-9/h1-5,10-11H,6-8,14H2,(H,15,16)(H,17,18)/t10-,11-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86711
PNG
(3-[3-Methyl-4-(4-chlorophenyl)benzoylamino]alanine...)
Show SMILES Cc1cc(ccc1-c1ccc(Cl)cc1)C(=O)NC[C@H](N)C(O)=O
Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-12(16(21)20-9-15(19)17(22)23)4-7-14(10)11-2-5-13(18)6-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1
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1.45E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Mol Pharmacol 68: 974-82 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86714
PNG
(WAY 212922 | WAY-212922)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1
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1.84E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Mol Pharmacol 68: 974-82 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252050
PNG
((2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioi...)
Show SMILES N[C@@H](C[C@@H](CCC(N)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H14N2O5/c9-5(8(14)15)3-4(7(12)13)1-2-6(10)11/h4-5H,1-3,9H2,(H2,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252047
PNG
((2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid | (2...)
Show SMILES N[C@@H](C[C@@H](CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO6/c8-4(7(13)14)1-3(6(11)12)2-5(9)10/h3-4H,1-2,8H2,(H,9,10)(H,11,12)(H,13,14)/t3-,4-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252049
PNG
((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Show SMILES N[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO6/c9-5(8(14)15)3-4(7(12)13)1-2-6(10)11/h4-5H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251893
PNG
((2S,4R)-2-amino-4-(3-(benzylamino)-3-oxopropyl)pen...)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252662
PNG
((2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid...)
Show SMILES CCCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H20N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h7-8H,2-6,12H2,1H3,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252048
PNG
((2S,4R)-2-amino-4-(3-methoxy-3-oxopropyl)pentanedi...)
Show SMILES COC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO6/c1-16-7(11)3-2-5(8(12)13)4-6(10)9(14)15/h5-6H,2-4,10H2,1H3,(H,12,13)(H,14,15)/t5-,6+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251894
PNG
((2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glut...)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C22H26N2O5/c23-19(22(28)29)13-17(21(26)27)11-12-20(25)24-14-18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-19H,11-14,23H2,(H,24,25)(H,26,27)(H,28,29)/t17-,19+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


J Med Chem 51: 4085-92 (2008)

Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86712
PNG
(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Show SMILES N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O
Show InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1
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3.79E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Mol Pharmacol 68: 974-82 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86713
PNG
(WAY 213394 | WAY-213394)
Show SMILES Cc1ccccc1-c1ccc(NC(=O)C[C@H](N)C(O)=O)cc1
Show InChI InChI=1S/C17H18N2O3/c1-11-4-2-3-5-14(11)12-6-8-13(9-7-12)19-16(20)10-15(18)17(21)22/h2-9,15H,10,18H2,1H3,(H,19,20)(H,21,22)/t15-/m0/s1
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6.56E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Mol Pharmacol 68: 974-82 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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6.60E+3n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86316
PNG
(WAY-855)
Show SMILES N[C@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Br J Pharmacol 140: 839-46 (2003)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50088230
PNG
((2S,4R)-4-propylglutamic acid | 2-Amino-4-propyl-p...)
Show SMILES CCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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3.20E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178684
PNG
((2S,4R)-4-ethylglutamic acid | CHEMBL372124)
Show SMILES CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H13NO4/c1-2-4(6(9)10)3-5(8)7(11)12/h4-5H,2-3,8H2,1H3,(H,9,10)(H,11,12)/t4-,5+/m1/s1
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3.80E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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4.60E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197104
PNG
((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4-,5+/m1/s1
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4.90E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178683
PNG
((2S,4S)-4-isopropylglutamic acid | CHEMBL199564)
Show SMILES CC(C)[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-4(2)5(7(10)11)3-6(9)8(12)13/h4-6H,3,9H2,1-2H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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5.10E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197105
PNG
((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5-/m0/s1
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5.20E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


J Med Chem 49: 6532-8 (2006)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178688
PNG
((2S,4R)-4-benzylglutamic acid | CHEMBL198618)
Show SMILES N[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H15NO4/c13-10(12(16)17)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,13H2,(H,14,15)(H,16,17)/t9-,10+/m1/s1
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6.60E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178685
PNG
((2S,4R)-4-butylglutamic acid | CHEMBL381004)
Show SMILES CCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H17NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h6-7H,2-5,10H2,1H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178686
PNG
((2S,4R)-4-isopentylglutamic acid | CHEMBL197176)
Show SMILES CC(C)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h6-8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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8.10E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50088220
PNG
((2S,4R)-4-pentylglutamic acid | 2-Amino-4-pentyl-p...)
Show SMILES CCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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9.80E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178687
PNG
((2S,4R)-4-isobutylglutamic acid | CHEMBL199617)
Show SMILES CC(C)C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H17NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h5-7H,3-4,10H2,1-2H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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3.00E+5n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


J Med Chem 48: 7980-92 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50180146
PNG
((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Show SMILES OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c10-7(11)5-2-3-1-4(5)6(9-3)8(12)13/h3-6,9H,1-2H2,(H,10,11)(H,12,13)/t3?,4?,5-,6-/m0/s1
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>4.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


J Med Chem 49: 172-8 (2006)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410463
PNG
(CHEMBL2113115)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(F)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15FN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410457
PNG
(CHEMBL2113112)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-13(23-16(24)9-15(22)17(25)26)5-6-14(10)11-3-2-4-12(8-11)18(19,20)21/h2-8,15H,9,22H2,1H3,(H,23,24)(H,25,26)/t15-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410455
PNG
(CHEMBL2113116)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Cl)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15ClN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410464
PNG
(CHEMBL2113111)
Show SMILES CCc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H18ClFN2O3/c1-2-10-7-11(12-3-5-14(20)13(19)8-12)4-6-16(10)22-17(23)9-15(21)18(24)25/h3-8,15H,2,9,21H2,1H3,(H,22,23)(H,24,25)/t15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50327884
PNG
((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


J Med Chem 53: 7236-50 (2010)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410451
PNG
(CHEMBL1628570)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H16N2O3/c18-15(17(21)22)9-16(20)19-12-5-6-14-11(8-12)7-10-3-1-2-4-13(10)14/h1-6,8,15H,7,9,18H2,(H,19,20)(H,21,22)/t15-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410450
PNG
(CHEMBL2113118)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3c-2cc(Cl)cc3Cl)c1)C(O)=O
Show InChI InChI=1S/C17H14Cl2N2O3/c18-9-5-12-11-2-1-10(21-16(22)7-15(20)17(23)24)3-8(11)4-13(12)14(19)6-9/h1-3,5-6,15H,4,7,20H2,(H,21,22)(H,23,24)/t15-/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410456
PNG
(CHEMBL2113122)
Show SMILES N[C@@H](CC(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H15F3N2O3/c18-17(19,20)12-3-1-2-11(8-12)10-4-6-13(7-5-10)22-15(23)9-14(21)16(24)25/h1-8,14H,9,21H2,(H,22,23)(H,24,25)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173936
PNG
(2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...)
Show SMILES Cc1cc(ccc1NC(=O)CC(N)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C17H18N2O3/c1-11-9-13(12-5-3-2-4-6-12)7-8-15(11)19-16(20)10-14(18)17(21)22/h2-9,14H,10,18H2,1H3,(H,19,20)(H,21,22)
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410465
PNG
(CHEMBL2113113)
Show SMILES N[C@@H](CC(=O)Nc1ccc(-c2ccc(F)c(Cl)c2)c(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H13ClF4N2O3/c18-12-5-8(1-4-13(12)19)10-3-2-9(6-11(10)17(20,21)22)24-15(25)7-14(23)16(26)27/h1-6,14H,7,23H2,(H,24,25)(H,26,27)/t14-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410458
PNG
(CHEMBL2113123)
Show SMILES Cc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-12(11-3-2-4-13(8-11)18(19,20)21)5-6-15(10)23-16(24)9-14(22)17(25)26/h2-8,14H,9,22H2,1H3,(H,23,24)(H,25,26)/t14-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410459
PNG
(CHEMBL2113117)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Br)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15BrN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410461
PNG
(CHEMBL2113126)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-6-11(21-16(22)8-15(20)17(23)24)3-4-12(9)10-2-5-13(18)14(19)7-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)/t15-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173935
PNG
(2-Amino-N-biphenyl-4-yl-succinamic acid | CHEMBL19...)
Show SMILES NC(CC(=O)Nc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H16N2O3/c17-14(16(20)21)10-15(19)18-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14H,10,17H2,(H,18,19)(H,20,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173914
PNG
(2-Amino-N-(3'-chloro-4'-fluoro-6-methyl-biphenyl-3...)
Show SMILES Cc1ccc(NC(=O)CC(N)C(O)=O)cc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H16ClFN2O3/c1-9-2-4-11(21-16(22)8-15(20)17(23)24)7-12(9)10-3-5-14(19)13(18)6-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173917
PNG
(2-Amino-N-(10-ethyl-10H-phenoxazin-2-yl)-succinami...)
Show SMILES CCN1c2ccccc2Oc2ccc(NC(=O)CC(N)C(O)=O)cc12
Show InChI InChI=1S/C18H19N3O4/c1-2-21-13-5-3-4-6-15(13)25-16-8-7-11(9-14(16)21)20-17(22)10-12(19)18(23)24/h3-9,12H,2,10,19H2,1H3,(H,20,22)(H,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410452
PNG
(CHEMBL2113125)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-13(20-16(21)9-15(19)17(22)23)6-7-14(10)11-2-4-12(18)5-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410448
PNG
(CHEMBL2113120)
Show SMILES N[C@@H](CC(=O)Nc1ccc2oc3cc(F)c(F)cc3c2c1)C(O)=O
Show InChI InChI=1S/C16H12F2N2O4/c17-10-4-9-8-3-7(20-15(21)6-12(19)16(22)23)1-2-13(8)24-14(9)5-11(10)18/h1-5,12H,6,19H2,(H,20,21)(H,22,23)/t12-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410447
PNG
(CHEMBL2113130)
Show SMILES N[C@@H](CC(=O)Nc1ccc2-c3ccccc3C(=O)c2c1)C(O)=O
Show InChI InChI=1S/C17H14N2O4/c18-14(17(22)23)8-15(20)19-9-5-6-11-10-3-1-2-4-12(10)16(21)13(11)7-9/h1-7,14H,8,18H2,(H,19,20)(H,22,23)/t14-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86714
PNG
(WAY 212922 | WAY-212922)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Bioorg Med Chem Lett 15: 4985-8 (2005)

More data for this
Ligand-Target Pair
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