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Compile Data Set for Download or QSAR

Found 154 hits Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 3


(HUMAN)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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PubMed
51n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252046
PNG
((2S,4S)-2-amino-4-(benzyloxymethyl)pentanedioic ac...)
Show SMILES N[C@@H](C[C@@H](COCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C13H17NO5/c14-11(13(17)18)6-10(12(15)16)8-19-7-9-4-2-1-3-5-9/h1-5,10-11H,6-8,14H2,(H,15,16)(H,17,18)/t10-,11-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86711
PNG
(3-[3-Methyl-4-(4-chlorophenyl)benzoylamino]alanine...)
Show SMILES Cc1cc(ccc1-c1ccc(Cl)cc1)C(=O)NC[C@H](N)C(O)=O
Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-12(16(21)20-9-15(19)17(22)23)4-7-14(10)11-2-5-13(18)6-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1
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1.45E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86714
PNG
(WAY 212922 | WAY-212922)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1
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1.84E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252050
PNG
((2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioi...)
Show SMILES N[C@@H](C[C@@H](CCC(N)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H14N2O5/c9-5(8(14)15)3-4(7(12)13)1-2-6(10)11/h4-5H,1-3,9H2,(H2,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251951
PNG
((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CO)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO5/c7-4(6(11)12)1-3(2-8)5(9)10/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252047
PNG
((2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid | (2...)
Show SMILES N[C@@H](C[C@@H](CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO6/c8-4(7(13)14)1-3(6(11)12)2-5(9)10/h3-4H,1-2,8H2,(H,9,10)(H,11,12)(H,13,14)/t3-,4-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252049
PNG
((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Show SMILES N[C@@H](C[C@@H](CCC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO6/c9-5(8(14)15)3-4(7(12)13)1-2-6(10)11/h4-5H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251893
PNG
((2S,4R)-2-amino-4-(3-(benzylamino)-3-oxopropyl)pen...)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H20N2O5/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252662
PNG
((2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid...)
Show SMILES CCCNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H20N2O5/c1-2-5-13-9(14)4-3-7(10(15)16)6-8(12)11(17)18/h7-8H,2-6,12H2,1H3,(H,13,14)(H,15,16)(H,17,18)/t7-,8+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252051
PNG
((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Show SMILES CNC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H16N2O5/c1-11-7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6H,2-4,10H2,1H3,(H,11,12)(H,13,14)(H,15,16)/t5-,6+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50252048
PNG
((2S,4R)-2-amino-4-(3-methoxy-3-oxopropyl)pentanedi...)
Show SMILES COC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO6/c1-16-7(11)3-2-5(8(12)13)4-6(10)9(14)15/h5-6H,2-4,10H2,1H3,(H,12,13)(H,14,15)/t5-,6+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50251894
PNG
((2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glut...)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C22H26N2O5/c23-19(22(28)29)13-17(21(26)27)11-12-20(25)24-14-18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-19H,11-14,23H2,(H,24,25)(H,26,27)(H,28,29)/t17-,19+/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universite Blaise Pascal

Curated by ChEMBL


Assay Description
Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86712
PNG
(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Show SMILES N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O
Show InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1
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3.79E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86713
PNG
(WAY 213394 | WAY-213394)
Show SMILES Cc1ccccc1-c1ccc(NC(=O)C[C@H](N)C(O)=O)cc1
Show InChI InChI=1S/C17H18N2O3/c1-11-4-2-3-5-14(11)12-6-8-13(9-7-12)19-16(20)10-15(18)17(21)22/h2-9,15H,10,18H2,1H3,(H,19,20)(H,21,22)/t15-/m0/s1
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6.56E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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6.60E+3n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197103
PNG
((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86316
PNG
(WAY-855)
Show SMILES N[C@]1([C@H]2C3C[C@@H]1C[C@@H]23)C(O)=O
Show InChI InChI=1S/C8H11NO2/c9-8(7(10)11)3-1-4-5(2-3)6(4)8/h3-6H,1-2,9H2,(H,10,11)/t3-,4+,5?,6+,8+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50088230
PNG
((2S,4R)-4-propylglutamic acid | 2-Amino-4-propyl-p...)
Show SMILES CCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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3.20E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178684
PNG
((2S,4R)-4-ethylglutamic acid | CHEMBL372124)
Show SMILES CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H13NO4/c1-2-4(6(9)10)3-5(8)7(11)12/h4-5H,2-3,8H2,1H3,(H,9,10)(H,11,12)/t4-,5+/m1/s1
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3.80E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50180145
PNG
((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Show SMILES OC(=O)[C@H]1CC[C@H]2CN[C@@H]([C@@H]12)C(O)=O
Show InChI InChI=1S/C9H13NO4/c11-8(12)5-2-1-4-3-10-7(6(4)5)9(13)14/h4-7,10H,1-3H2,(H,11,12)(H,13,14)/t4-,5-,6+,7-/m0/s1
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4.60E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197104
PNG
((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4-,5+/m1/s1
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4.90E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178683
PNG
((2S,4S)-4-isopropylglutamic acid | CHEMBL199564)
Show SMILES CC(C)[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-4(2)5(7(10)11)3-6(9)8(12)13/h4-6H,3,9H2,1-2H3,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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PubMed
5.10E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50197105
PNG
((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Show SMILES N[C@@H]([C@H]1CC[C@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5-/m0/s1
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5.20E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178688
PNG
((2S,4R)-4-benzylglutamic acid | CHEMBL198618)
Show SMILES N[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C12H15NO4/c13-10(12(16)17)7-9(11(14)15)6-8-4-2-1-3-5-8/h1-5,9-10H,6-7,13H2,(H,14,15)(H,16,17)/t9-,10+/m1/s1
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6.60E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178685
PNG
((2S,4R)-4-butylglutamic acid | CHEMBL381004)
Show SMILES CCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H17NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h6-7H,2-5,10H2,1H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178686
PNG
((2S,4R)-4-isopentylglutamic acid | CHEMBL197176)
Show SMILES CC(C)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h6-8H,3-5,11H2,1-2H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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8.10E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50088220
PNG
((2S,4R)-4-pentylglutamic acid | 2-Amino-4-pentyl-p...)
Show SMILES CCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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9.80E+4n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50178687
PNG
((2S,4R)-4-isobutylglutamic acid | CHEMBL199617)
Show SMILES CC(C)C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H17NO4/c1-5(2)3-6(8(11)12)4-7(10)9(13)14/h5-7H,3-4,10H2,1-2H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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3.00E+5n/an/an/an/an/an/an/an/a



Université Blaise Pascal

Curated by ChEMBL


Assay Description
Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50180146
PNG
((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Show SMILES OC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c10-7(11)5-2-3-1-4(5)6(9-3)8(12)13/h3-6,9H,1-2H2,(H,10,11)(H,12,13)/t3?,4?,5-,6-/m0/s1
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>4.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Activity against human EAAT3 transfected in HEK293 cells


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410463
PNG
(CHEMBL2113115)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(F)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15FN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410457
PNG
(CHEMBL2113112)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-13(23-16(24)9-15(22)17(25)26)5-6-14(10)11-3-2-4-12(8-11)18(19,20)21/h2-8,15H,9,22H2,1H3,(H,23,24)(H,25,26)/t15-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410455
PNG
(CHEMBL2113116)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Cl)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15ClN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410464
PNG
(CHEMBL2113111)
Show SMILES CCc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H18ClFN2O3/c1-2-10-7-11(12-3-5-14(20)13(19)8-12)4-6-16(10)22-17(23)9-15(21)18(24)25/h3-8,15H,2,9,21H2,1H3,(H,22,23)(H,24,25)/t15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50327884
PNG
((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Show SMILES N[C@@H]([C@H](OCc1cccc(NC(=O)c2ccc(cc2)C(F)(F)F)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C19H17F3N2O6/c20-19(21,22)12-6-4-11(5-7-12)16(25)24-13-3-1-2-10(8-13)9-30-15(18(28)29)14(23)17(26)27/h1-8,14-15H,9,23H2,(H,24,25)(H,26,27)(H,28,29)/t14-,15-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



University of Berne

Curated by ChEMBL


Assay Description
Inhibition of human EAAC1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410451
PNG
(CHEMBL1628570)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H16N2O3/c18-15(17(21)22)9-16(20)19-12-5-6-14-11(8-12)7-10-3-1-2-4-13(10)14/h1-6,8,15H,7,9,18H2,(H,19,20)(H,21,22)/t15-/m0/s1
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n/an/a 420n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410450
PNG
(CHEMBL2113118)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3c-2cc(Cl)cc3Cl)c1)C(O)=O
Show InChI InChI=1S/C17H14Cl2N2O3/c18-9-5-12-11-2-1-10(21-16(22)7-15(20)17(23)24)3-8(11)4-13(12)14(19)6-9/h1-3,5-6,15H,4,7,20H2,(H,21,22)(H,23,24)/t15-/m0/s1
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n/an/a 450n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410456
PNG
(CHEMBL2113122)
Show SMILES N[C@@H](CC(=O)Nc1ccc(cc1)-c1cccc(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H15F3N2O3/c18-17(19,20)12-3-1-2-11(8-12)10-4-6-13(7-5-10)22-15(23)9-14(21)16(24)25/h1-8,14H,9,21H2,(H,22,23)(H,24,25)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173936
PNG
(2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...)
Show SMILES Cc1cc(ccc1NC(=O)CC(N)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C17H18N2O3/c1-11-9-13(12-5-3-2-4-6-12)7-8-15(11)19-16(20)10-14(18)17(21)22/h2-9,14H,10,18H2,1H3,(H,19,20)(H,21,22)
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410465
PNG
(CHEMBL2113113)
Show SMILES N[C@@H](CC(=O)Nc1ccc(-c2ccc(F)c(Cl)c2)c(c1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C17H13ClF4N2O3/c18-12-5-8(1-4-13(12)19)10-3-2-9(6-11(10)17(20,21)22)24-15(25)7-14(23)16(26)27/h1-6,14H,7,23H2,(H,24,25)(H,26,27)/t14-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410458
PNG
(CHEMBL2113123)
Show SMILES Cc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O3/c1-10-7-12(11-3-2-4-13(8-11)18(19,20)21)5-6-15(10)23-16(24)9-14(22)17(25)26/h2-8,14H,9,22H2,1H3,(H,23,24)(H,25,26)/t14-/m0/s1
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n/an/a 600n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410459
PNG
(CHEMBL2113117)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(Br)ccc-23)c1)C(O)=O
Show InChI InChI=1S/C17H15BrN2O3/c18-11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)20-16(21)8-15(19)17(22)23/h1-4,6-7,15H,5,8,19H2,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410461
PNG
(CHEMBL2113126)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O3/c1-9-6-11(21-16(22)8-15(20)17(23)24)3-4-12(9)10-2-5-13(18)14(19)7-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)/t15-/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173935
PNG
(2-Amino-N-biphenyl-4-yl-succinamic acid | CHEMBL19...)
Show SMILES NC(CC(=O)Nc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H16N2O3/c17-14(16(20)21)10-15(19)18-13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14H,10,17H2,(H,18,19)(H,20,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173914
PNG
(2-Amino-N-(3'-chloro-4'-fluoro-6-methyl-biphenyl-3...)
Show SMILES Cc1ccc(NC(=O)CC(N)C(O)=O)cc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H16ClFN2O3/c1-9-2-4-11(21-16(22)8-15(20)17(23)24)7-12(9)10-3-5-14(19)13(18)6-10/h2-7,15H,8,20H2,1H3,(H,21,22)(H,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50173917
PNG
(2-Amino-N-(10-ethyl-10H-phenoxazin-2-yl)-succinami...)
Show SMILES CCN1c2ccccc2Oc2ccc(NC(=O)CC(N)C(O)=O)cc12
Show InChI InChI=1S/C18H19N3O4/c1-2-21-13-5-3-4-6-15(13)25-16-8-7-11(9-14(16)21)20-17(22)10-12(19)18(23)24/h3-9,12H,2,10,19H2,1H3,(H,20,22)(H,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410452
PNG
(CHEMBL2113125)
Show SMILES Cc1cc(NC(=O)C[C@H](N)C(O)=O)ccc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-13(20-16(21)9-15(19)17(22)23)6-7-14(10)11-2-4-12(18)5-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410448
PNG
(CHEMBL2113120)
Show SMILES N[C@@H](CC(=O)Nc1ccc2oc3cc(F)c(F)cc3c2c1)C(O)=O
Show InChI InChI=1S/C16H12F2N2O4/c17-10-4-9-8-3-7(20-15(21)6-12(19)16(22)23)1-2-13(8)24-14(9)5-11(10)18/h1-5,12H,6,19H2,(H,20,21)(H,22,23)/t12-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50410447
PNG
(CHEMBL2113130)
Show SMILES N[C@@H](CC(=O)Nc1ccc2-c3ccccc3C(=O)c2c1)C(O)=O
Show InChI InChI=1S/C17H14N2O4/c18-14(17(22)23)8-15(20)19-9-5-6-11-10-3-1-2-4-12(10)16(21)13(11)7-9/h1-7,14H,8,18H2,(H,19,20)(H,22,23)/t14-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM86714
PNG
(WAY 212922 | WAY-212922)
Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O
Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3


Citation and Details
More data for this
Ligand-Target Pair
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