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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Exportin-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Exportin-1


(Homo sapiens)
BDBM50240512
PNG
(7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | ...)
Show SMILES COc1ccc2ccc(=O)oc2c1CC=C(C)C
Show InChI InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
PDB
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Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Osaka University

Curated by ChEMBL


Assay Description
Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...


Citation and Details
More data for this
Ligand-Target Pair
Exportin-1


(Homo sapiens)
BDBM50320332
PNG
(8-(3-methylbut-2-enyl)-2H-chromen-2-one | CHEMBL10...)
Show SMILES CC(C)=CCc1cccc2ccc(=O)oc12
Show InChI InChI=1S/C14H14O2/c1-10(2)6-7-11-4-3-5-12-8-9-13(15)16-14(11)12/h3-6,8-9H,7H2,1-2H3
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Article
PubMed
n/an/a 6.40E+3n/an/an/an/an/an/a



Osaka University

Curated by ChEMBL


Assay Description
Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...


Citation and Details
More data for this
Ligand-Target Pair
Exportin-1


(Homo sapiens)
BDBM50303499
PNG
(7-(methyloxy)-2H-chromen-2-one | 7-Methoxycoumarin...)
Show SMILES COc1ccc2ccc(=O)oc2c1
Show InChI InChI=1S/C10H8O3/c1-12-8-4-2-7-3-5-10(11)13-9(7)6-8/h2-6H,1H3
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Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Osaka University

Curated by ChEMBL


Assay Description
Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...


Citation and Details
More data for this
Ligand-Target Pair
Exportin-1


(Homo sapiens)
BDBM50320333
PNG
(7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one ...)
Show SMILES COc1ccc2CCC(=O)Oc2c1CC=C(C)C
Show InChI InChI=1S/C15H18O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-5,8H,6-7,9H2,1-3H3
PDB
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CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Osaka University

Curated by ChEMBL


Assay Description
Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...


Citation and Details
More data for this
Ligand-Target Pair
Exportin-1


(Homo sapiens)
BDBM12342
PNG
(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Show SMILES O=c1ccc2ccccc2o1
Show InChI InChI=1S/C9H6O2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H
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KEGG
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PC sid
PDB
UniChem

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AffyNet 
Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Osaka University

Curated by ChEMBL


Assay Description
Inhibition of CRM1-mediated hemagglutinin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by...


Citation and Details
More data for this
Ligand-Target Pair