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Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Eye absent protein 2 Eya domain (Eya2 ED)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231626
PNG
(NCGC00249327)
Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)s1
Show InChI InChI=1S/C17H12FN3OS2/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.90E+3n/an/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231625
PNG
(MLS000544460)
Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.10E+3n/an/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231627
PNG
(MLS000585814)
Show SMILES Cc1ccccc1C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Show InChI InChI=1S/C18H15N3O2S/c1-13-6-2-3-7-15(13)18(22)21-20-12-14-9-10-17(23-14)24-16-8-4-5-11-19-16/h2-12H,1H3,(H,21,22)/b20-12+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.30E+4n/an/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya activity was measured in 50-μl reactions using black, 96-well, half-volume microtiter plates (Greiner Bio-one) with the substrate OMFP (3-O-...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231625
PNG
(MLS000544460)
Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.00E+3n/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231625
PNG
(MLS000544460)
Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 6.10E+3n/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair
Eye absent protein 2 Eya domain (Eya2 ED)


(Homo sapiens (Human))
BDBM231625
PNG
(MLS000544460)
Show SMILES Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
Show InChI InChI=1S/C17H12FN3O2S/c18-13-5-3-4-12(10-13)17(22)21-20-11-14-7-8-16(23-14)24-15-6-1-2-9-19-15/h1-11H,(H,21,22)/b20-11+
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 800n/an/an/a6.525



University of Colorado School of Medicine



Assay Description
Eya proteins were purified via S200 in isothermal titration calorimetry (ITC) buffer (50mM NaPO4 buffer, pH 6.5, 50 mM NaCl). Inhibitor solutions wer...


J Biol Chem 289: 16349-61 (2014)


Article DOI: 10.1074/jbc.M114.566729
BindingDB Entry DOI: 10.7270/Q2CC0ZJK
More data for this
Ligand-Target Pair