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Found 51 hits Enz. Inhib. hit(s) with Target = 'Farnesyltransferase, putative' AND taxid = 5664   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Farnesyltransferase, putative


(Leishmania major)
BDBM50052351
PNG
(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Show SMILES OC1(CN2CCC1CC2)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H21NO/c21-19(14-20-12-10-18(19)11-13-20)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-9,18,21H,10-14H2
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n/an/a 13n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50208574
PNG
((R)-3-((2-benzyl-6-((3R,4S)-3-hydroxy-4-methoxypyr...)
Show SMILES CO[C@H]1CN(C[C@H]1O)c1ccc(C#C[C@@]2(O)CN3CCC2CC3)c(Cc2ccccc2)n1
Show InChI InChI=1S/C26H31N3O3/c1-32-24-17-29(16-23(24)30)25-8-7-20(22(27-25)15-19-5-3-2-4-6-19)9-12-26(31)18-28-13-10-21(26)11-14-28/h2-8,21,23-24,30-31H,10-11,13-18H2,1H3/t23-,24+,26-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50208577
PNG
((R)-3-((2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl)...)
Show SMILES COCCCOc1ccc(C#C[C@@]2(O)CN3CCC2CC3)c(Cc2ccccc2)n1
Show InChI InChI=1S/C25H30N2O3/c1-29-16-5-17-30-24-9-8-21(23(26-24)18-20-6-3-2-4-7-20)10-13-25(28)19-27-14-11-22(25)12-15-27/h2-4,6-9,22,28H,5,11-12,14-19H2,1H3/t25-/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270321
PNG
(3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-ene ...)
Show SMILES C(Oc1ccc(cc1)C1=CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C20H21NO/c1-2-4-16(5-3-1)15-22-19-8-6-17(7-9-19)20-14-21-12-10-18(20)11-13-21/h1-9,14,18H,10-13,15H2
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n/an/a 100n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50208573
PNG
(3-[1'-{4'-(Ethoxycarbonyl)-phenyl}]-quinuclidine-2...)
Show SMILES CCOC(=O)c1ccc(cc1)C1=CN2CCC1CC2
Show InChI InChI=1S/C16H19NO2/c1-2-19-16(18)14-5-3-12(4-6-14)15-11-17-9-7-13(15)8-10-17/h3-6,11,13H,2,7-10H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270302
PNG
(3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene | ...)
Show SMILES COc1ccc2cc(ccc2c1)C1=CN2CCC1CC2
Show InChI InChI=1S/C18H19NO/c1-20-17-5-4-14-10-16(3-2-15(14)11-17)18-12-19-8-6-13(18)7-9-19/h2-5,10-13H,6-9H2,1H3
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n/an/a 490n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269921
PNG
(3-[1'-{2'-(4''-Ethyl ethanoatephenyl)-ethynyl]-3-q...)
Show SMILES CCOC(=O)Cc1ccc(cc1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C19H23NO3/c1-2-23-18(21)13-16-5-3-15(4-6-16)7-10-19(22)14-20-11-8-17(19)9-12-20/h3-6,17,22H,2,8-9,11-14H2,1H3
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n/an/a 970n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269926
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-(2'-p-biphenyl)-ethy...)
Show SMILES OC[C@H]1CC2CCN1C[C@@H]2C#Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H23NO/c24-16-22-14-20-12-13-23(22)15-21(20)11-8-17-6-9-19(10-7-17)18-4-2-1-3-5-18/h1-7,9-10,20-22,24H,12-16H2/t20?,21-,22+/m0/s1
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269940
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-(2'-phenyl)-ethynyl]...)
Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccccc1
Show InChI InChI=1S/C16H19NO/c18-12-16-10-14-8-9-17(16)11-15(14)7-6-13-4-2-1-3-5-13/h1-5,14-16,18H,8-12H2/t14?,15-,16-/m0/s1
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270327
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-(2'-phenyl)-ethynyl]...)
Show SMILES OC[C@H]1CC2CCN1C[C@@H]2C#Cc1ccccc1
Show InChI InChI=1S/C16H19NO/c18-12-16-10-14-8-9-17(16)11-15(14)7-6-13-4-2-1-3-5-13/h1-5,14-16,18H,8-12H2/t14?,15-,16+/m0/s1
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269918
PNG
(3-[1'-{2'-(5''-Acetylthiophenyl)}-ethynyl]-3-quinu...)
Show SMILES CC(=O)c1ccc(s1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C15H17NO2S/c1-11(17)14-3-2-13(19-14)4-7-15(18)10-16-8-5-12(15)6-9-16/h2-3,12,18H,5-6,8-10H2,1H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269919
PNG
(3-[1'-{2'-(2''-Methyl-5''-aminophenyl)}-ethynyl]-3...)
Show SMILES Cc1ccc(N)cc1C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C16H20N2O/c1-12-2-3-15(17)10-13(12)4-7-16(19)11-18-8-5-14(16)6-9-18/h2-3,10,14,19H,5-6,8-9,11,17H2,1H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269925
PNG
(3-[1'-{2'-(2''-Amino-5''-methyl methanoatephenyl)}...)
Show SMILES COC(=O)c1ccc(N)c(c1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C17H20N2O3/c1-22-16(20)13-2-3-15(18)12(10-13)4-7-17(21)11-19-8-5-14(17)6-9-19/h2-3,10,14,21H,5-6,8-9,11,18H2,1H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269924
PNG
(3-[1'-{2'-(4''-Chloro-3''-pyridinyl)}-ethynyl]-3-q...)
Show SMILES OC1(CN2CCC1CC2)C#Cc1ccc(Cl)nc1
Show InChI InChI=1S/C14H15ClN2O/c15-13-2-1-11(9-16-13)3-6-14(18)10-17-7-4-12(14)5-8-17/h1-2,9,12,18H,4-5,7-8,10H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269923
PNG
(3-[1'-{2'-(4''-Amino-3''-pyridinyl)}-ethynyl]-3-qu...)
Show SMILES Nc1ccc(cn1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C14H17N3O/c15-13-2-1-11(9-16-13)3-6-14(18)10-17-7-4-12(14)5-8-17/h1-2,9,12,18H,4-5,7-8,10H2,(H2,15,16)
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269922
PNG
(3-[1'-{2'-(1H-Indol-4''-yl)}-ethynyl]-3-quinuclidi...)
Show SMILES OC1(CN2CCC1CC2)C#Cc1ccc2cc[nH]c2c1
Show InChI InChI=1S/C17H18N2O/c20-17(12-19-9-5-15(17)6-10-19)7-3-13-1-2-14-4-8-18-16(14)11-13/h1-2,4,8,11,15,18,20H,5-6,9-10,12H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270312
PNG
(3-[1'-{2'-(3''-Pyridinyl)}-ethynyl]-3-quinuclidino...)
Show SMILES OC1(CN2CCC1CC2)C#Cc1cccnc1
Show InChI InChI=1S/C14H16N2O/c17-14(6-3-12-2-1-7-15-10-12)11-16-8-4-13(14)5-9-16/h1-2,7,10,13,17H,4-5,8-9,11H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270326
PNG
(3-[1'-{2'-(4''-Methoxyphenyl)}-ethynyl]-3-quinucli...)
Show SMILES COc1ccc(cc1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C16H19NO2/c1-19-15-4-2-13(3-5-15)6-9-16(18)12-17-10-7-14(16)8-11-17/h2-5,14,18H,7-8,10-12H2,1H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270325
PNG
(3-[1'-{2'-(4''-Hydroxyphenyl)}-ethynyl]-3-quinucli...)
Show SMILES Oc1ccc(cc1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C15H17NO2/c17-14-3-1-12(2-4-14)5-8-15(18)11-16-9-6-13(15)7-10-16/h1-4,13,17-18H,6-7,9-11H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50036183
PNG
(3-(2'-Benzothiophenyl)-quinuclidine-2-ene | 3-Benz...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2s1
Show InChI InChI=1S/C15H15NS/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50036185
PNG
(3-(2'-Benzofuranyl)-quinuclidine-2-ene | 3-Benzofu...)
Show SMILES C1CN2CCC1C(=C2)c1cc2ccccc2o1
Show InChI InChI=1S/C15H15NO/c1-2-4-14-12(3-1)9-15(17-14)13-10-16-7-5-11(13)6-8-16/h1-4,9-11H,5-8H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270323
PNG
(3-(3'-Quinolyl)-quinuclidine-2-ene | CHEMBL478340)
Show SMILES C1CN2CCC1C(=C2)c1cnc2ccccc2c1
Show InChI InChI=1S/C16H16N2/c1-2-4-16-13(3-1)9-14(10-17-16)15-11-18-7-5-12(15)6-8-18/h1-4,9-12H,5-8H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270315
PNG
(3-[1'-{4'-(tert-Butyldimethylsilyloxy)-phenyl}]-qu...)
Show SMILES CC(C)(C)[Si](C)(C)Oc1ccc(cc1)C1=CN2CCC1CC2
Show InChI InChI=1S/C19H29NOSi/c1-19(2,3)22(4,5)21-17-8-6-15(7-9-17)18-14-20-12-10-16(18)11-13-20/h6-9,14,16H,10-13H2,1-5H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270314
PNG
(3-[1'-{4'-(Isopropoxycarbonyl)-phenyl}]-quinuclidi...)
Show SMILES CC(C)OC(=O)c1ccc(cc1)C1=CN2CCC1CC2
Show InChI InChI=1S/C17H21NO2/c1-12(2)20-17(19)15-5-3-13(4-6-15)16-11-18-9-7-14(16)8-10-18/h3-6,11-12,14H,7-10H2,1-2H3
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270313
PNG
(3-(2'-Naphtylmethyl)-quinuclidine | CHEMBL506873)
Show SMILES C(C1CN2CCC1CC2)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H21N/c1-2-4-17-11-14(5-6-15(17)3-1)12-18-13-19-9-7-16(18)8-10-19/h1-6,11,16,18H,7-10,12-13H2
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Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269935
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-{2'-(4''-benzyloxyph...)
Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H25NO2/c25-16-22-14-20-12-13-24(22)15-21(20)9-6-18-7-10-23(11-8-18)26-17-19-4-2-1-3-5-19/h1-5,7-8,10-11,20-22,25H,12-17H2/t20?,21-,22-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269934
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-{2'-(4''-benzyloxyph...)
Show SMILES OC[C@H]1CC2CCN1C[C@@H]2C#Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H25NO2/c25-16-22-14-20-12-13-24(22)15-21(20)9-6-18-7-10-23(11-8-18)26-17-19-4-2-1-3-5-19/h1-5,7-8,10-11,20-22,25H,12-17H2/t20?,21-,22+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269933
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-{2'-(4''-ethoxycarbo...)
Show SMILES CCOC(=O)c1ccc(cc1)C#C[C@H]1CN2CCC1C[C@H]2CO
Show InChI InChI=1S/C19H23NO3/c1-2-23-19(22)15-6-3-14(4-7-15)5-8-17-12-20-10-9-16(17)11-18(20)13-21/h3-4,6-7,16-18,21H,2,9-13H2,1H3/t16?,17-,18-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50052357
PNG
(3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane |...)
Show SMILES C(C1CN2CCC1CC2)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H23N/c1-2-4-17(5-3-1)18-8-6-16(7-9-18)14-20-15-21-12-10-19(20)11-13-21/h1-9,19-20H,10-15H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270301
PNG
(3-benzylquinuclidine | CHEMBL478913)
Show SMILES C(C1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C14H19N/c1-2-4-12(5-3-1)10-14-11-15-8-6-13(14)7-9-15/h1-5,13-14H,6-11H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270300
PNG
((E/Z)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quin...)
Show SMILES C1COC(O1)c1ccc(\C=C2/CN3CCC2CC3)cc1
Show InChI InChI=1S/C17H21NO2/c1-3-15(17-19-9-10-20-17)4-2-13(1)11-16-12-18-7-5-14(16)6-8-18/h1-4,11,14,17H,5-10,12H2/b16-11+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270299
PNG
((E)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quinuc...)
Show SMILES C1COC(O1)c1ccc(\C=C2\CN3CCC2CC3)cc1
Show InChI InChI=1S/C17H21NO2/c1-3-15(17-19-9-10-20-17)4-2-13(1)11-16-12-18-7-5-14(16)6-8-18/h1-4,11,14,17H,5-10,12H2/b16-11-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270285
PNG
((E/Z)-3-[4'-Carbonylbenzylidene]-quinuclidine | CH...)
Show SMILES O=Cc1ccc(\C=C2/CN3CCC2CC3)cc1
Show InChI InChI=1S/C15H17NO/c17-11-13-3-1-12(2-4-13)9-15-10-16-7-5-14(15)6-8-16/h1-4,9,11,14H,5-8,10H2/b15-9+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270284
PNG
((E/Z)-3-[(Naphty-2'-yl-)-methylene]-quinuclidine |...)
Show SMILES C1CN2CCC1\C(C2)=C\c1ccc2ccccc2c1
Show InChI InChI=1S/C18H19N/c1-2-4-17-11-14(5-6-15(17)3-1)12-18-13-19-9-7-16(18)8-10-19/h1-6,11-12,16H,7-10,13H2/b18-12+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270282
PNG
((E/Z)-3-benzylidenequinuclidine | CHEMBL478358)
Show SMILES C1CN2CCC1\C(C2)=C\c1ccccc1
Show InChI InChI=1S/C14H17N/c1-2-4-12(5-3-1)10-14-11-15-8-6-13(14)7-9-15/h1-5,10,13H,6-9,11H2/b14-10+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270283
PNG
((E/Z)-3-(biphenyl-4-ylmethylene)quinuclidine | CHE...)
Show SMILES C1CN2CCC1\C(C2)=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H21N/c1-2-4-17(5-3-1)18-8-6-16(7-9-18)14-20-15-21-12-10-19(20)11-13-21/h1-9,14,19H,10-13,15H2/b20-14+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270322
PNG
(3-(2'-Naphtyl)-quinuclidine-2-ene | CHEMBL516895)
Show SMILES C1CN2CCC1C(=C2)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H17N/c1-2-4-15-11-16(6-5-13(15)3-1)17-12-18-9-7-14(17)8-10-18/h1-6,11-12,14H,7-10H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269937
PNG
(3-[1'-2'-(4''-Hydroxy-3''-benzoic acid)}-ethynyl]-...)
Show SMILES OC(=O)c1cc(ccc1O)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C16H17NO4/c18-14-2-1-11(9-13(14)15(19)20)3-6-16(21)10-17-7-4-12(16)5-8-17/h1-2,9,12,18,21H,4-5,7-8,10H2,(H,19,20)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269938
PNG
(3-[1'-2'-(2''-Pyrazinyl)}-ethynyl]-3-quinuclidinol...)
Show SMILES OC1(CN2CCC1CC2)C#Cc1cnccn1
Show InChI InChI=1S/C13H15N3O/c17-13(4-1-12-9-14-5-6-15-12)10-16-7-2-11(13)3-8-16/h5-6,9,11,17H,2-3,7-8,10H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269927
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-(2'-p-biphenyl)-ethy...)
Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H23NO/c24-16-22-14-20-12-13-23(22)15-21(20)11-8-17-6-9-19(10-7-17)18-4-2-1-3-5-18/h1-7,9-10,20-22,24H,12-16H2/t20?,21-,22-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269928
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-{2'-(2''-naphtyl)}-e...)
Show SMILES OC[C@H]1CC2CCN1C[C@@H]2C#Cc1ccc2ccccc2c1
Show InChI InChI=1S/C20H21NO/c22-14-20-12-18-9-10-21(20)13-19(18)8-6-15-5-7-16-3-1-2-4-17(16)11-15/h1-5,7,11,18-20,22H,9-10,12-14H2/t18?,19-,20+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269929
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-2'-(2''-naphtyl)}-et...)
Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccc2ccccc2c1
Show InChI InChI=1S/C20H21NO/c22-14-20-12-18-9-10-21(20)13-19(18)8-6-15-5-7-16-3-1-2-4-17(16)11-15/h1-5,7,11,18-20,22H,9-10,12-14H2/t18?,19-,20-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269930
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-2'-(2''-quinolyl)}-e...)
Show SMILES OC[C@H]1CC2CCN1C[C@@H]2C#Cc1cnc2ccccc2c1
Show InChI InChI=1S/C19H20N2O/c22-13-18-10-15-7-8-21(18)12-17(15)6-5-14-9-16-3-1-2-4-19(16)20-11-14/h1-4,9,11,15,17-18,22H,7-8,10,12-13H2/t15?,17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269941
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-2'-(2''-quinolyl)-et...)
Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1cnc2ccccc2c1
Show InChI InChI=1S/C19H20N2O/c22-13-18-10-15-7-8-21(18)12-17(15)6-5-14-9-16-3-1-2-4-19(16)20-11-14/h1-4,9,11,15,17-18,22H,7-8,10,12-13H2/t15?,17-,18-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270299
PNG
((E)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quinuc...)
Show SMILES C1COC(O1)c1ccc(\C=C2\CN3CCC2CC3)cc1
Show InChI InChI=1S/C17H21NO2/c1-3-15(17-19-9-10-20-17)4-2-13(1)11-16-12-18-7-5-14(16)6-8-18/h1-4,11,14,17H,5-10,12H2/b16-11-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269939
PNG
(3-[1'-{2'-(3'',5''-Dimethylphenyl)}-ethynyl]-3-qui...)
Show SMILES Cc1cc(C)cc(c1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C17H21NO/c1-13-9-14(2)11-15(10-13)3-6-17(19)12-18-7-4-16(17)5-8-18/h9-11,16,19H,4-5,7-8,12H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269932
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-2'-(4''-ethoxycarbon...)
Show SMILES CCOC(=O)c1ccc(cc1)C#C[C@H]1CN2CCC1C[C@@H]2CO
Show InChI InChI=1S/C19H23NO3/c1-2-23-19(22)15-6-3-14(4-7-15)5-8-17-12-20-10-9-16(17)11-18(20)13-21/h3-4,6-7,16-18,21H,2,9-13H2,1H3/t16?,17-,18+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269942
PNG
((2R,5S)-2-Hydroxymethyl-5-[1'-{2'-(4''-ethyl ethan...)
Show SMILES CCOC(=O)Cc1ccc(cc1)C#C[C@H]1CN2CCC1C[C@@H]2CO
Show InChI InChI=1S/C20H25NO3/c1-2-24-20(23)11-16-5-3-15(4-6-16)7-8-18-13-21-10-9-17(18)12-19(21)14-22/h3-6,17-19,22H,2,9-14H2,1H3/t17?,18-,19+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50269936
PNG
((2S,5S)-2-Hydroxymethyl-5-[1'-2'-(4''-ethoxycarbon...)
Show SMILES CCOC(=O)Cc1ccc(cc1)C#C[C@H]1CN2CCC1C[C@H]2CO
Show InChI InChI=1S/C20H25NO3/c1-2-24-20(23)11-16-5-3-15(4-6-16)7-8-18-13-21-10-9-17(18)12-19(21)14-22/h3-6,17-19,22H,2,9-14H2,1H3/t17?,18-,19-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Farnesyltransferase, putative


(Leishmania major)
BDBM50270311
PNG
(3-[1'-{2'-(4''-Ethylbenzoate)}-ethynyl]-3-quinucli...)
Show SMILES CCOC(=O)c1ccc(cc1)C#CC1(O)CN2CCC1CC2
Show InChI InChI=1S/C18H21NO3/c1-2-22-17(20)15-5-3-14(4-6-15)7-10-18(21)13-19-11-8-16(18)9-12-19/h3-6,16,21H,2,8-9,11-13H2,1H3
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n/an/a 4.25E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
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