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Compile Data Set for Download or QSAR

Found 13790 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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1.30n/an/an/an/an/an/an/an/a



Principia Biopharma Inc

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis method


J Med Chem 60: 6516-6527 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00360
BindingDB Entry DOI: 10.7270/Q2C53P3H
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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1.60n/an/an/an/an/an/an/an/a



Principia Biopharma Inc

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...


J Med Chem 60: 6516-6527 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00360
BindingDB Entry DOI: 10.7270/Q2C53P3H
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50504104
PNG
(CHEMBL4446835)
Show SMILES Cc1c(oc2ccc(C)cc12)-c1n(nc2c1c(N)n[nH]c2=O)-c1ccc(NC(=O)C=C)cc1
Show InChI InChI=1S/C24H20N6O3/c1-4-18(31)26-14-6-8-15(9-7-14)30-21(19-20(29-30)24(32)28-27-23(19)25)22-13(3)16-11-12(2)5-10-17(16)33-22/h4-11H,1H2,2-3H3,(H2,25,27)(H,26,31)(H,28,32)
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1.90n/an/an/an/an/an/an/an/a



Shanghai University

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins


J Med Chem 62: 7473-7488 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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2.20n/an/an/an/an/an/an/an/a



Principia Biopharma Inc

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis method


J Med Chem 60: 6516-6527 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00360
BindingDB Entry DOI: 10.7270/Q2C53P3H
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445224
PNG
(US10669235, Example 15)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)NCCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O6/c1-21-18-26-27(19-25(21)33(43)44-2)36-31(41)29(26)30(22-6-4-3-5-7-22)35-24-10-8-23(9-11-24)32(42)38-15-13-37(14-16-38)20-28(40)34-12-17-39/h3-11,18-19,35,39H,12-17,20H2,1-2H3,(H,34,40)(H,36,41)/b30-29-
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2.5n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445226
PNG
(US10669235, Example 17)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H30N4O4/c1-19-17-24-25(18-23(19)30(37)38-3)32-28(35)26(24)27(20-7-5-4-6-8-20)31-22-11-9-21(10-12-22)29(36)34-15-13-33(2)14-16-34/h4-12,17-18,31H,13-16H2,1-3H3,(H,32,35)/b27-26-
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5.31n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445223
PNG
(US10669235, Example 14 | US10669235, Example 50)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-
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5.51n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445223
PNG
(US10669235, Example 14 | US10669235, Example 50)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-
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5.51n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445209
PNG
(US10669235, Nintedanib)
Show SMILES COC(=O)c1ccc2c(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c(O)[nH]c2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3/b32-29+
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5.90n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445241
PNG
(US10669235, Example 32)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(CCO)CCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H34N4O5/c1-20-18-25-26(19-24(20)31(39)40-4)33-29(37)27(25)28(21-8-6-5-7-9-21)32-23-12-10-22(11-13-23)30(38)35(16-17-36)15-14-34(2)3/h5-13,18-19,32,36H,14-17H2,1-4H3,(H,33,37)/b28-27-
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6.65n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445247
PNG
(US10669235, Example 38)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(CO)(CN(C)C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H38N4O5/c1-22-18-27-28(19-26(22)33(42)43-4)36-31(40)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(41)38-16-14-34(21-39,15-17-38)20-37(2)3/h5-13,18-19,35,39H,14-17,20-21H2,1-4H3,(H,36,40)/b30-29-
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6.93n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445222
PNG
(US10669235, Example 13 | US10669235, Example 49)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-
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7.16n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445222
PNG
(US10669235, Example 13 | US10669235, Example 49)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-
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7.16n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445215
PNG
(US10669235, Example 6)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-
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7.35n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445242
PNG
(US10669235, Example 33)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CC[C@@H](CN(C)C)[C@H](O)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H36N4O5/c1-20-16-26-27(17-25(20)33(41)42-4)35-31(39)29(26)30(21-8-6-5-7-9-21)34-24-12-10-22(11-13-24)32(40)37-15-14-23(18-36(2)3)28(38)19-37/h5-13,16-17,23,28,34,38H,14-15,18-19H2,1-4H3,(H,35,39)/b30-29-/t23-,28+/m0/s1
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7.40n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445255
PNG
(US10669235, Example 46)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-21-19-26-27(20-25(21)32(40)41-2)34-30(38)28(26)29(22-7-4-3-5-8-22)33-24-11-9-23(10-12-24)31(39)36-14-6-13-35(15-16-36)17-18-37/h3-5,7-12,19-20,33,37H,6,13-18H2,1-2H3,(H,34,38)/b29-28-
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7.78n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445224
PNG
(US10669235, Example 15)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)NCCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O6/c1-21-18-26-27(19-25(21)33(43)44-2)36-31(41)29(26)30(22-6-4-3-5-7-22)35-24-10-8-23(9-11-24)32(42)38-15-13-37(14-16-38)20-28(40)34-12-17-39/h3-11,18-19,35,39H,12-17,20H2,1-2H3,(H,34,40)(H,36,41)/b30-29-
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7.90n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445255
PNG
(US10669235, Example 46)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-21-19-26-27(20-25(21)32(40)41-2)34-30(38)28(26)29(22-7-4-3-5-8-22)33-24-11-9-23(10-12-24)31(39)36-14-6-13-35(15-16-36)17-18-37/h3-5,7-12,19-20,33,37H,6,13-18H2,1-2H3,(H,34,38)/b29-28-
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7.92n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445213
PNG
(US10669235, Example 4)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H35N5O4/c1-21-19-26-27(20-25(21)32(40)41-3)35-31(39)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(38)33-13-14-37-17-15-36(2)16-18-37/h4-12,19-20,34H,13-18H2,1-3H3,(H,33,38)(H,35,39)/b29-28-
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8.07n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445257
PNG
(US10669235, Example 48)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)[C@H]3CN(C)C[C@@H]3O)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O5/c1-18-14-23-24(15-22(18)31(39)40-4)33-29(37)27(23)28(19-8-6-5-7-9-19)32-21-12-10-20(11-13-21)30(38)35(3)25-16-34(2)17-26(25)36/h5-15,25-26,32,36H,16-17H2,1-4H3,(H,33,37)/b28-27-/t25-,26-/m0/s1
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8.47n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445246
PNG
(US10669235, Example 37)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(O)(CN4CCCC4)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C35H38N4O5/c1-23-20-28-29(21-27(23)34(42)44-2)37-32(40)30(28)31(24-8-4-3-5-9-24)36-26-12-10-25(11-13-26)33(41)39-18-14-35(43,15-19-39)22-38-16-6-7-17-38/h3-5,8-13,20-21,36,43H,6-7,14-19,22H2,1-2H3,(H,37,40)/b31-30-
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8.56n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445241
PNG
(US10669235, Example 32)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(CCO)CCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H34N4O5/c1-20-18-25-26(19-24(20)31(39)40-4)33-29(37)27(25)28(21-8-6-5-7-9-21)32-23-12-10-22(11-13-23)30(38)35(16-17-36)15-14-34(2)3/h5-13,18-19,32,36H,14-17H2,1-4H3,(H,33,37)/b28-27-
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9.03n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445228
PNG
(US10669235, Example 19)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O5/c1-20-18-25-26(19-24(20)31(39)40-2)33-29(37)27(25)28(21-6-4-3-5-7-21)32-23-10-8-22(9-11-23)30(38)35-14-12-34(13-15-35)16-17-36/h3-11,18-19,32,36H,12-17H2,1-2H3,(H,33,37)/b28-27-
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9.04n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445250
PNG
(US10669235, Example 41)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-
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9.31n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445218
PNG
(US10669235, Example 9)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H31N5O5/c1-19-16-24-25(17-23(19)31(40)41-2)35-30(39)27(24)28(20-6-4-3-5-7-20)34-22-10-8-21(9-11-22)29(38)33-13-15-36-14-12-32-26(37)18-36/h3-11,16-17,34H,12-15,18H2,1-2H3,(H,32,37)(H,33,38)(H,35,39)/b28-27-
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9.42n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445231
PNG
(US10669235, Example 22)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26-
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9.53n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445247
PNG
(US10669235, Example 38)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(CO)(CN(C)C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H38N4O5/c1-22-18-27-28(19-26(22)33(42)43-4)36-31(40)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(41)38-16-14-34(21-39,15-17-38)20-37(2)3/h5-13,18-19,35,39H,14-17,20-21H2,1-4H3,(H,36,40)/b30-29-
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9.73n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50504106
PNG
(CHEMBL4462946)
Show SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)-n1nc2c(c1-c1oc3ccc(Cl)cc3c1C)c(N)n[nH]c2=O
Show InChI InChI=1S/C26H24ClN7O3/c1-14-18-13-15(27)6-11-19(18)37-24(14)23-21-22(26(36)31-30-25(21)28)32-34(23)17-9-7-16(8-10-17)29-20(35)5-4-12-33(2)3/h4-11,13H,12H2,1-3H3,(H2,28,30)(H,29,35)(H,31,36)/b5-4+
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10n/an/an/an/an/an/an/an/a



Shanghai University

Curated by ChEMBL


Assay Description
Irreversible inhibition of human FGFR1 using poly (Glu, Tyr)4:1 as substrate measured after 60 mins


J Med Chem 62: 7473-7488 (2019)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445214
PNG
(US10669235, Example 5)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-17-38-16-7-15-37(2)18-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29-
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10.4n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445262
PNG
(US10669235, Example 53)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCNC(=O)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H33N5O5/c1-20-18-25-26(19-24(20)32(41)42-2)36-31(40)28(25)29(21-6-4-3-5-7-21)35-23-10-8-22(9-11-23)30(39)34-14-17-37-15-12-27(38)33-13-16-37/h3-11,18-19,35H,12-17H2,1-2H3,(H,33,38)(H,34,39)(H,36,40)/b29-28-
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10.4n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445230
PNG
(US10669235, Example 21)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O4/c1-22-20-27-28(21-26(22)33(41)42-3)36-32(40)29(27)30(23-8-5-4-6-9-23)35-25-12-10-24(11-13-25)31(39)34-14-7-15-38-18-16-37(2)17-19-38/h4-6,8-13,20-21,35H,7,14-19H2,1-3H3,(H,34,39)(H,36,40)/b30-29-
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10.7n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445260
PNG
(US10669235, Example 51)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN(C)CCO)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-19-17-24-25(18-23(19)30(38)39-3)33-29(37)26(24)27(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)28(36)31-13-14-34(2)15-16-35/h4-12,17-18,32,35H,13-16H2,1-3H3,(H,31,36)(H,33,37)/b27-26-
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10.8n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445246
PNG
(US10669235, Example 37)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(O)(CN4CCCC4)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C35H38N4O5/c1-23-20-28-29(21-27(23)34(42)44-2)37-32(40)30(28)31(24-8-4-3-5-9-24)36-26-12-10-25(11-13-26)33(41)39-18-14-35(43,15-19-39)22-38-16-6-7-17-38/h3-5,8-13,20-21,36,43H,6-7,14-19,22H2,1-2H3,(H,37,40)/b31-30-
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11.2n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445257
PNG
(US10669235, Example 48)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)[C@H]3CN(C)C[C@@H]3O)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O5/c1-18-14-23-24(15-22(18)31(39)40-4)33-29(37)27(23)28(19-8-6-5-7-9-19)32-21-12-10-20(11-13-21)30(38)35(3)25-16-34(2)17-26(25)36/h5-15,25-26,32,36H,16-17H2,1-4H3,(H,33,37)/b28-27-/t25-,26-/m0/s1
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11.3n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445225
PNG
(US10669235, Example 16)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3cccc(c3)C(=O)N(C)CCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O4/c1-19-16-24-25(18-23(19)30(37)38-5)32-28(35)26(24)27(20-10-7-6-8-11-20)31-22-13-9-12-21(17-22)29(36)34(4)15-14-33(2)3/h6-13,16-18,31H,14-15H2,1-5H3,(H,32,35)/b27-26-
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11.4n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445221
PNG
(US10669235, Example 12)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(O)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)34-23-10-8-22(9-11-23)30(38)33-14-17-36-15-12-24(37)13-16-36/h3-11,18-19,24,34,37H,12-17H2,1-2H3,(H,33,38)(H,35,39)/b29-28-
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11.5n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445240
PNG
(US10669235, Example 31)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(CC3)C(=O)NCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C35H39N5O5/c1-22-20-28-29(21-27(22)35(44)45-4)38-33(42)30(28)31(23-8-6-5-7-9-23)37-26-12-10-25(11-13-26)34(43)40-17-14-24(15-18-40)32(41)36-16-19-39(2)3/h5-13,20-21,24,37H,14-19H2,1-4H3,(H,36,41)(H,38,42)/b31-30-
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12.2n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445265
PNG
(US10669235, Example 56)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCCNC(=O)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-2)36-31(40)28(25)29(21-7-4-3-5-8-21)35-23-11-9-22(10-12-23)30(39)34-14-16-37-15-6-13-33-27(38)19-37/h3-5,7-12,17-18,35H,6,13-16,19H2,1-2H3,(H,33,38)(H,34,39)(H,36,40)/b29-28-
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12.6n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445234
PNG
(US10669235, Example 25)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C28H30N4O5S/c1-18-16-23-24(17-22(18)28(34)37-4)31-27(33)25(23)26(19-8-6-5-7-9-19)30-20-10-12-21(13-11-20)38(35,36)29-14-15-32(2)3/h5-13,16-17,29-30H,14-15H2,1-4H3,(H,31,33)/b26-25-
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12.7n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445212
PNG
(US10669235, Example 3)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-
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12.9n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445228
PNG
(US10669235, Example 19)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O5/c1-20-18-25-26(19-24(20)31(39)40-2)33-29(37)27(25)28(21-6-4-3-5-7-21)32-23-10-8-22(9-11-23)30(38)35-14-12-34(13-15-35)16-17-36/h3-11,18-19,32,36H,12-17H2,1-2H3,(H,33,37)/b28-27-
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13.6n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445227
PNG
(US10669235, Example 18)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27-
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13.7n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445210
PNG
((Z)-Methyl 5-methyl-3-(((4-(N-(2-(4-methylpiperazi...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)S(=O)(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H35N5O5S/c1-21-19-26-27(20-25(21)31(38)41-3)34-30(37)28(26)29(22-7-5-4-6-8-22)33-23-9-11-24(12-10-23)42(39,40)32-13-14-36-17-15-35(2)16-18-36/h4-12,19-20,32-33H,13-18H2,1-3H3,(H,34,37)/b29-28-
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13.8n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445220
PNG
(US10669235, Example 11)
Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1
Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28-
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14.1n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM445242
PNG
(US10669235, Example 33)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CC[C@@H](CN(C)C)[C@H](O)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H36N4O5/c1-20-16-26-27(17-25(20)33(41)42-4)35-31(39)29(26)30(21-8-6-5-7-9-21)34-24-12-10-22(11-13-24)32(40)37-15-14-23(18-36(2)3)28(38)19-37/h5-13,16-17,23,28,34,38H,14-15,18-19H2,1-4H3,(H,35,39)/b30-29-/t23-,28+/m0/s1
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14.3n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445233
PNG
(US10669235, Example 24)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCN(CC3)C(C)=O)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O5/c1-21-19-27-28(20-26(21)33(42)43-3)36-32(41)29(27)30(23-7-5-4-6-8-23)35-25-11-9-24(10-12-25)31(40)34-13-14-37-15-17-38(18-16-37)22(2)39/h4-12,19-20,35H,13-18H2,1-3H3,(H,34,40)(H,36,41)/b30-29-
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14.3n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445248
PNG
(US10669235, Example 39)
Show SMILES COCCNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1
Show InChI InChI=1S/C34H37N5O6/c1-22-19-27-28(20-26(22)34(43)45-3)37-32(41)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)33(42)39-16-14-38(15-17-39)21-29(40)35-13-18-44-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,40)(H,37,41)/b31-30-
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14.7n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445211
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethyl)carbamo...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C29H30N4O4/c1-18-16-23-24(17-22(18)29(36)37-4)32-28(35)25(23)26(19-8-6-5-7-9-19)31-21-12-10-20(11-13-21)27(34)30-14-15-33(2)3/h5-13,16-17,31H,14-15H2,1-4H3,(H,30,34)(H,32,35)/b26-25-
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14.8n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445249
PNG
(US10669235, Example 40)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3(CCC3)N(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O4/c1-20-17-25-26(18-24(20)31(39)40-4)35-30(38)27(25)28(21-9-6-5-7-10-21)34-23-13-11-22(12-14-23)29(37)33-19-32(36(2)3)15-8-16-32/h5-7,9-14,17-18,34H,8,15-16,19H2,1-4H3,(H,33,37)(H,35,38)/b28-27-
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14.9n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM445219
PNG
(US10669235, Example 10)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O5/c1-21-19-26-27(20-25(21)33(42)43-3)36-32(41)29(26)30(22-7-5-4-6-8-22)35-24-11-9-23(10-12-24)31(40)34-14-13-28(39)38-17-15-37(2)16-18-38/h4-12,19-20,35H,13-18H2,1-3H3,(H,34,40)(H,36,41)/b30-29-
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15.2n/an/an/an/an/an/an/an/a



RESPIVERT LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US10669235 (2020)

More data for this
Ligand-Target Pair
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