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Compile Data Set for Download or QSAR

Found 40 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 5.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 6.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 6.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 7.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 7.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 9.20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 54n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50182212
PNG
(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Show SMILES COc1ccc(cc1)N1Cc2cnc(Nc3ccc(F)cc3)nc2N(C2CC[C@@H](O)C2)C1=O
Show InChI InChI=1S/C24H24FN5O3/c1-33-21-10-7-18(8-11-21)29-14-15-13-26-23(27-17-4-2-16(25)3-5-17)28-22(15)30(24(29)32)19-6-9-20(31)12-19/h2-5,7-8,10-11,13,19-20,31H,6,9,12,14H2,1H3,(H,26,27,28)/t19?,20-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human FGFR


Bioorg Med Chem Lett 16: 1950-3 (2006)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 1.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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n/an/a 5.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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n/an/a 6.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384727
PNG
(CHEMBL2037226)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
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n/an/a 7.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a 7.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a 7.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50181532
PNG
(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Show SMILES COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C29H33FN6O4S/c1-39-25-14-23-24(15-26(25)40-11-3-8-36-9-6-19(17-37)7-10-36)32-18-33-28(23)35-29-31-16-22(41-29)13-27(38)34-21-5-2-4-20(30)12-21/h2,4-5,12,14-16,18-19,37H,3,6-11,13,17H2,1H3,(H,34,38)(H,31,32,33,35)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR


J Med Chem 49: 955-70 (2006)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384727
PNG
(CHEMBL2037226)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
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n/an/a 9.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384720
PNG
(CHEMBL2037220)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C(O)=O)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H29F3N6O4/c1-41-7-9-42(10-8-41)26-13-19(11-21(14-26)33(34,35)36)30(43)39-23-4-2-3-22(15-23)38-24-5-6-27-28(31(44)40-29(27)17-24)16-25-12-20(18-37-25)32(45)46/h2-6,11-18,37-38H,7-10H2,1H3,(H,39,43)(H,40,44)(H,45,46)/b28-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR3 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50384720
PNG
(CHEMBL2037220)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C(O)=O)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H29F3N6O4/c1-41-7-9-42(10-8-41)26-13-19(11-21(14-26)33(34,35)36)30(43)39-23-4-2-3-22(15-23)38-24-5-6-27-28(31(44)40-29(27)17-24)16-25-12-20(18-37-25)32(45)46/h2-6,11-18,37-38H,7-10H2,1H3,(H,39,43)(H,40,44)(H,45,46)/b28-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused FGFR4 in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50162978
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-ethyl-amino)-...)
Show SMILES CCN(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C19H18N6OS/c1-2-25(11-13-6-4-3-5-7-13)18-22-17(23-19(26)24-18)21-14-8-9-15-16(10-14)27-12-20-15/h3-10,12H,2,11H2,1H3,(H2,21,22,23,24,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts


J Med Chem 48: 1717-20 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50162976
PNG
(4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-et...)
Show SMILES CC(C)(Nc1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1)c1ccccc1
Show InChI InChI=1S/C19H18N6OS/c1-19(2,12-6-4-3-5-7-12)25-17-22-16(23-18(26)24-17)21-13-8-9-14-15(10-13)27-11-20-14/h3-11H,1-2H3,(H3,21,22,23,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts


J Med Chem 48: 1717-20 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50162973
PNG
(CHEMBL177298 | N-[4-(Benzothiazol-6-ylamino)-6-(1-...)
Show SMILES CC(C)(Nc1nc(NO)nc(Nc2ccc3ncsc3c2)n1)c1ccccc1
Show InChI InChI=1S/C19H19N7OS/c1-19(2,12-6-4-3-5-7-12)25-17-22-16(23-18(24-17)26-27)21-13-8-9-14-15(10-13)28-11-20-14/h3-11,27H,1-2H3,(H3,21,22,23,24,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts


J Med Chem 48: 1717-20 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50162972
PNG
(4-(Benzothiazol-6-ylamino)-6-(benzyl-isopropyl-ami...)
Show SMILES CC(C)N(Cc1ccccc1)c1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1
Show InChI InChI=1S/C20H20N6OS/c1-13(2)26(11-14-6-4-3-5-7-14)19-23-18(24-20(27)25-19)22-15-8-9-16-17(10-15)28-12-21-16/h3-10,12-13H,11H2,1-2H3,(H2,22,23,24,25,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mouse Fibroblast growth factor receptor 1 expressed in NIH 3T3 fibroblasts


J Med Chem 48: 1717-20 (2005)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM4882
PNG
((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...)
Show SMILES Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
Show InChI InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
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n/an/a 1.00E+4n/an/an/an/an/an/a



New York University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting


Science 276: 955-60 (1997)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


J Med Chem 50: 1584-97 (2007)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 2.00E+4n/an/an/an/an/an/a



New York University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting


Science 276: 955-60 (1997)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50117319
PNG
(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCOCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C30H40N6O5/c1-22(2)41-24-7-5-23(6-8-24)33-30(37)36-12-10-35(11-13-36)29-25-19-27(38-3)28(20-26(25)31-21-32-29)40-16-4-9-34-14-17-39-18-15-34/h5-8,19-22H,4,9-18H2,1-3H3,(H,33,37)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM13535
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 3.44E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)

More data for this
Ligand-Target Pair