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Compile Data Set for Download or QSAR

Found 3591 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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89n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FGFR3 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50396071
PNG
(CHEMBL2170582)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1
Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30)
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217n/an/an/an/an/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR4


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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350n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FGFR1 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1
Show InChI InChI=1S/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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400n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of FGFR3


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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493n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR2


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FGFR4


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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1.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR3 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>1.86E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR3


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>4.74E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


Citation and Details
More data for this
Ligand-Target Pair
FGFR2


(HUMAN)
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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7.22E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
FGFR2


(HUMAN)
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161438
PNG
(US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a 0.100n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209350
PNG
(US9266883, 149)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCSCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O4S/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209374
PNG
(US9266883, 240)
Show SMILES CC(C)Sc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H26N6O3S/c1-14(2)33-20-9-21(25-11-18(20)10-24)27-23(32)29-7-5-6-16-8-17(12-28(4)15(3)31)19(13-30)26-22(16)29/h8-9,11,13-14H,5-7,12H2,1-4H3,(H,25,27,32)
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n/an/a<0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209388
PNG
(US9266883, 263)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C22H23N7O5/c1-33-7-4-24-16-10-19(25-12-15(16)11-23)27-21(31)29-5-2-3-14-9-18(17(13-30)26-20(14)29)28-6-8-34-22(28)32/h9-10,12-13H,2-8H2,1H3,(H2,24,25,27,31)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM194899
PNG
(US9206184, 80)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CN2CCNC(=O)C2)c(Cl)n2ncnc(N)c12
Show InChI InChI=1S/C21H21ClN6O2S/c1-11-5-12-7-15(31-19(12)14(6-11)30-2)17-13(8-27-4-3-24-16(29)9-27)20(22)28-18(17)21(23)25-10-26-28/h5-7,10H,3-4,8-9H2,1-2H3,(H,24,29)(H2,23,25,26)
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n/an/a 0.200n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209258
PNG
(US9266883, 16)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O4S/c1-14(2)35(33,34)19-8-4-3-7-18(19)27-20-17(24)12-25-22(28-20)29-23(32)30-11-5-6-15-9-10-16(13-31)26-21(15)30/h3-4,7-10,12-14H,5-6,11H2,1-2H3,(H2,25,27,28,29,32)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161392
PNG
(US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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n/an/a 0.200n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209340
PNG
(US9266883, 115)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4[C@@H](C)COC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1/C25H28N6O6/c1-15-13-36-25(34)31(15)11-18-7-17-5-4-6-30(23(17)28-20(18)12-32)24(33)29-22-8-21(19(9-26)10-27-22)37-16(2)14-35-3/h7-8,10,12,15-16H,4-6,11,13-14H2,1-3H3,(H,27,29,33)/t15-,16+/s2
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209277
PNG
(US9266883, 35)
Show SMILES O=Cc1ccc2CCCN(C(=O)Nc3cc(OCC4CCO4)c(cn3)C#N)c2n1
Show InChI InChI=1/C20H19N5O4/c21-9-14-10-22-18(8-17(14)29-12-16-5-7-28-16)24-20(27)25-6-1-2-13-3-4-15(11-26)23-19(13)25/h3-4,8,10-11,16H,1-2,5-7,12H2,(H,22,24,27)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209342
PNG
(US9266883, 120)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4[C@@H](C)COCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1/C25H29N7O5/c1-16-14-37-15-23(34)32(16)12-18-8-17-4-3-6-31(24(17)29-21(18)13-33)25(35)30-22-9-20(27-5-7-36-2)19(10-26)11-28-22/h8-9,11,13,16H,3-7,12,14-15H2,1-2H3,(H2,27,28,30,35)/t16-/s2
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209345
PNG
(US9266883, 141)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CO)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H26N6O5/c1-14(2)34-19-8-20(25-10-17(19)9-24)27-23(33)29-6-4-5-15-7-16(11-28(3)21(32)13-31)18(12-30)26-22(15)29/h7-8,10,12,14,31H,4-6,11,13H2,1-3H3,(H,25,27,33)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161396
PNG
(US9108973, 9)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn(C2CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C21H20N6O3/c1-4-18(28)26-10-14(11-26)27-21-19(20(22)23-12-24-21)17(25-27)6-5-13-7-15(29-2)9-16(8-13)30-3/h4,7-9,12,14H,1,10-11H2,2-3H3,(H2,22,23,24)
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n/an/a 0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM161438
PNG
(US9108973, 51)
Show SMILES COc1cc(OC)cc(c1)C#CC1=CN(C2CN(C2)C(=O)C=C)C2N=CN=C(N)C12
Show InChI InChI=1/C22H23N5O3/c1-4-19(28)26-11-16(12-26)27-10-15(20-21(23)24-13-25-22(20)27)6-5-14-7-17(29-2)9-18(8-14)30-3/h4,7-10,13,16,20,22H,1,11-12H2,2-3H3,(H2,23,24,25)
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM161453
PNG
(US9108973, 66)
Show SMILES COC(=O)[C@@H]1C[C@@H](CN1C(=O)C=C)n1cc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12
Show InChI InChI=1/C25H25N5O5/c1-5-21(31)30-13-17(10-20(30)25(32)35-4)29-12-16(22-23(26)27-14-28-24(22)29)7-6-15-8-18(33-2)11-19(9-15)34-3/h5,8-9,11-12,14,17,20H,1,10,13H2,2-4H3,(H2,26,27,28)/t17-,20-/s2
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n/an/a<0.300n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209349
PNG
(US9266883, 148)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)COC)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-30(22(33)15-36-3)13-17-9-16-5-4-7-31(23(16)28-20(17)14-32)24(34)29-21-10-19(26-6-8-35-2)18(11-25)12-27-21/h9-10,12,14H,4-8,13,15H2,1-3H3,(H2,26,27,29,34)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM130859
PNG
(US8829199, 114)
Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C27H29N7O/c1-15-4-5-16(2)33(15)14-18-6-8-22-19(10-18)11-25(32-22)26(35)21-13-29-34(27(21)28)20-7-9-23-24(12-20)31-17(3)30-23/h6-13,15-16,32H,4-5,14,28H2,1-3H3,(H,30,31)
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n/an/a 0.320n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM161426
PNG
(US9108973, 39 | US9108973, 73)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1/C23H23N5O3/c1-4-20(29)27-8-7-17(13-27)28-12-16(21-22(24)25-14-26-23(21)28)6-5-15-9-18(30-2)11-19(10-15)31-3/h4,9-12,14,17H,1,7-8,13H2,2-3H3,(H2,24,25,26)/t17-/s2
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n/an/a 0.400n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209348
PNG
(US9266883, 145)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H31N7O4/c1-16(2)36-21-10-22(27-12-19(21)11-26)29-25(35)32-8-6-7-17-9-18(20(15-33)28-24(17)32)13-31(5)23(34)14-30(3)4/h9-10,12,15-16H,6-8,13-14H2,1-5H3,(H,27,29,35)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209354
PNG
(US9266883, 188)
Show SMILES CN(Cc1cc2CCCN(C(=O)Nc3cc(NCCOC(F)(F)F)c(cn3)C#N)c2nc1C=O)C(C)=O
Show InChI InChI=1S/C23H24F3N7O4/c1-14(35)32(2)12-16-8-15-4-3-6-33(21(15)30-19(16)13-34)22(36)31-20-9-18(17(10-27)11-29-20)28-5-7-37-23(24,25)26/h8-9,11,13H,3-7,12H2,1-2H3,(H2,28,29,31,36)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209334
PNG
(US9266883, 98)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM161419
PNG
(US9108973, 32)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2C[C@@H](C#C)N(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1/C24H22N6O3/c1-5-16-11-17(13-29(16)21(31)6-2)30-24-22(23(25)26-14-27-24)20(28-30)8-7-15-9-18(32-3)12-19(10-15)33-4/h1,6,9-10,12,14,16-17H,2,11,13H2,3-4H3,(H2,25,26,27)/t16-,17+/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128502
PNG
(US8796244, 81)
Show SMILES CC(C)(CO)Nc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C24H24F3N7O2/c1-23(2,14-35)31-20-7-6-18(32-33-20)15-8-9-34-19(12-28-21(34)11-15)16-4-3-5-17(10-16)30-22(36)29-13-24(25,26)27/h3-12,35H,13-14H2,1-2H3,(H,31,33)(H2,29,30,36)
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n/an/a 0.447n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128624
PNG
(US8796244, 213)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nccc(n1)-n1ccnc1
Show InChI InChI=1S/C23H17F3N8O/c24-23(25,26)13-30-22(35)31-17-3-1-2-15(10-17)18-12-29-20-11-16(5-8-34(18)20)21-28-6-4-19(32-21)33-9-7-27-14-33/h1-12,14H,13H2,(H2,30,31,35)
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n/an/a 0.460n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128551
PNG
(US8796244, 133)
Show SMILES OC1CCCN(C1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H24F3N7O2/c26-25(27,28)15-30-24(37)31-18-4-1-3-17(11-18)21-13-29-23-12-16(8-10-35(21)23)20-6-7-22(33-32-20)34-9-2-5-19(36)14-34/h1,3-4,6-8,10-13,19,36H,2,5,9,14-15H2,(H2,30,31,37)
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n/an/a 0.484n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139913
PNG
(US8895745, 375)
Show SMILES Cn1cnc(c1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N6O/c1-28-10-16(26-12-28)13-5-6-29-17(9-24-18(29)8-13)14-3-2-4-15(7-14)27-19(30)25-11-20(21,22)23/h2-10,12H,11H2,1H3,(H2,25,27,30)
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n/an/a 0.490n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM194837
PNG
(US9206184, 18 | US9206184, 19)
Show SMILES CCOCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C24H30N6O2S/c1-4-32-13-17-18(12-29-7-5-26-6-8-29)30-22(24(25)27-14-28-30)21(17)20-11-16-9-15(2)10-19(31-3)23(16)33-20/h9-11,14,26H,4-8,12-13H2,1-3H3,(H2,25,27,28)
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n/an/a 0.5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM194900
PNG
(US9206184, 81 | US9206184, 82)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(CNCC(C)(C)O)c(Cl)n2ncnc(N)c12
Show InChI InChI=1S/C21H24ClN5O2S/c1-11-5-12-7-15(30-18(12)14(6-11)29-4)16-13(8-24-9-21(2,3)28)19(22)27-17(16)20(23)25-10-26-27/h5-7,10,24,28H,8-9H2,1-4H3,(H2,23,25,26)
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BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161392
PNG
(US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM194880
PNG
(US9206184, 61)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(-c2cnco2)c(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C24H25N7O2S/c1-14-7-15-9-19(34-23(15)17(8-14)32-2)21-20(18-10-27-13-33-18)16(11-30-5-3-26-4-6-30)31-22(21)24(25)28-12-29-31/h7-10,12-13,26H,3-6,11H2,1-2H3,(H2,25,28,29)
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BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161389
PNG
(US9108973, 2)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM161434
PNG
(US9108973, 47)
Show SMILES COc1cc(OC)cc(c1)C#Cc1cn([C@H]2CCN(C2)C(=O)C#CC(C)(C)O)c2ncnc(N)c12
Show InChI InChI=1/C26H27N5O4/c1-26(2,33)9-7-22(32)30-10-8-19(15-30)31-14-18(23-24(27)28-16-29-25(23)31)6-5-17-11-20(34-3)13-21(12-17)35-4/h11-14,16,19,33H,8,10,15H2,1-4H3,(H2,27,28,29)/t19-/s2
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128659
PNG
(US8796244, 250)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nnc(NC2CC2)s1
Show InChI InChI=1S/C21H18F3N7OS/c22-21(23,24)11-26-19(32)27-15-3-1-2-12(8-15)16-10-25-17-9-13(6-7-31(16)17)18-29-30-20(33-18)28-14-4-5-14/h1-3,6-10,14H,4-5,11H2,(H,28,30)(H2,26,27,32)
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n/an/a 0.5n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128516
PNG
(US8796244, 95)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H21F3N8O2/c25-24(26,27)14-30-23(37)31-17-3-1-2-16(10-17)19-12-29-21-11-15(6-8-35(19)21)18-4-5-20(33-32-18)34-9-7-28-22(36)13-34/h1-6,8,10-12H,7,9,13-14H2,(H,28,36)(H2,30,31,37)
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n/an/a 0.530n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128496
PNG
(US8796244, 75)
Show SMILES NC1CCN(CC1)c1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H25F3N8O/c26-25(27,28)15-31-24(37)32-19-3-1-2-17(12-19)21-14-30-23-13-16(6-11-36(21)23)20-4-5-22(34-33-20)35-9-7-18(29)8-10-35/h1-6,11-14,18H,7-10,15,29H2,(H2,31,32,37)
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n/an/a 0.535n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128668
PNG
(US8796244, 261)
Show SMILES Nc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C18H14F3N7OS/c19-18(20,21)9-24-17(29)25-12-3-1-2-10(6-12)13-8-23-14-7-11(4-5-28(13)14)15-26-27-16(22)30-15/h1-8H,9H2,(H2,22,27)(H2,24,25,29)
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n/an/a 0.540n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128468
PNG
(US8796244, 47)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1cnn(c1)C1CCOC1
Show InChI InChI=1S/C23H21F3N6O2/c24-23(25,26)14-28-22(33)30-18-3-1-2-16(8-18)20-11-27-21-9-15(4-6-31(20)21)17-10-29-32(12-17)19-5-7-34-13-19/h1-4,6,8-12,19H,5,7,13-14H2,(H2,28,30,33)
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n/an/a 0.542n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128427
PNG
(US8796244, 6)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O/c1-33-8-6-21(7-9-33)35-15-19(13-31-35)17-5-10-34-22(14-29-23(34)12-17)18-3-2-4-20(11-18)32-24(36)30-16-25(26,27)28/h2-5,10-15,21H,6-9,16H2,1H3,(H2,30,32,36)
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n/an/a 0.545n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128428
PNG
(US8796244, 7)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ccc(nn1)N1CCCCC1
Show InChI InChI=1S/C25H24F3N7O/c26-25(27,28)16-30-24(36)31-19-6-4-5-18(13-19)21-15-29-23-14-17(9-12-35(21)23)20-7-8-22(33-32-20)34-10-2-1-3-11-34/h4-9,12-15H,1-3,10-11,16H2,(H2,30,31,36)
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n/an/a 0.550n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM128561
PNG
(US8796244, 145)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C27H26F3N7O2/c1-18(38)35-9-11-36(12-10-35)24-6-5-21(15-31-24)19-7-8-37-23(16-32-25(37)14-19)20-3-2-4-22(13-20)34-26(39)33-17-27(28,29)30/h2-8,13-16H,9-12,17H2,1H3,(H2,33,34,39)
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n/an/a 0.560n/an/an/an/an/an/a



Astex Therapeutics Ltd

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2 final concentration in 1 kinase assay buffer (Table 1). Enzymes were then incubated with test compounds, ...


US Patent US8796244 (2014)

More data for this
Ligand-Target Pair
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