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Compile Data Set for Download or QSAR

Found 884 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 4 (FGFR4)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50396071
PNG
(CHEMBL2170582)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1
Show InChI InChI=1S/C21H17F3N6O4/c1-25-17(31)10-33-13-4-2-3-11(7-13)28-20-26-9-14(22)18(30-20)27-12-5-6-16-15(8-12)29-19(32)21(23,24)34-16/h2-9H,10H2,1H3,(H,25,31)(H,29,32)(H2,26,27,28,30)
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217n/an/an/an/an/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR4


J Med Chem 55: 3614-43 (2012)


Article DOI: 10.1021/jm201271b
BindingDB Entry DOI: 10.7270/Q2NZ88RC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50341519
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1
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>1.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of FGFR4


J Med Chem 54: 2341-50 (2011)


Article DOI: 10.1021/jm101499u
BindingDB Entry DOI: 10.7270/Q2KH0NPW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209374
PNG
(US9266883, 240)
Show SMILES CC(C)Sc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H26N6O3S/c1-14(2)33-20-9-21(25-11-18(20)10-24)27-23(32)29-7-5-6-16-8-17(12-28(4)15(3)31)19(13-30)26-22(16)29/h8-9,11,13-14H,5-7,12H2,1-4H3,(H,25,27,32)
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n/an/a<0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209350
PNG
(US9266883, 149)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCSCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O4S/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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n/an/a<0.200n/an/an/an/an/an/a



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209388
PNG
(US9266883, 263)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C22H23N7O5/c1-33-7-4-24-16-10-19(25-12-15(16)11-23)27-21(31)29-5-2-3-14-9-18(17(13-30)26-20(14)29)28-6-8-34-22(28)32/h9-10,12-13H,2-8H2,1H3,(H2,24,25,27,31)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209258
PNG
(US9266883, 16)
Show SMILES CC(C)S(=O)(=O)c1ccccc1Nc1nc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O4S/c1-14(2)35(33,34)19-8-4-3-7-18(19)27-20-17(24)12-25-22(28-20)29-23(32)30-11-5-6-15-9-10-16(13-31)26-21(15)30/h3-4,7-10,12-14H,5-6,11H2,1-2H3,(H2,25,27,28,29,32)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209340
PNG
(US9266883, 115)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4[C@@H](C)COC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H28N6O6/c1-15-13-36-25(34)31(15)11-18-7-17-5-4-6-30(23(17)28-20(18)12-32)24(33)29-22-8-21(19(9-26)10-27-22)37-16(2)14-35-3/h7-8,10,12,15-16H,4-6,11,13-14H2,1-3H3,(H,27,29,33)/t15-,16+/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209349
PNG
(US9266883, 148)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)COC)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H29N7O5/c1-30(22(33)15-36-3)13-17-9-16-5-4-7-31(23(16)28-20(17)14-32)24(34)29-21-10-19(26-6-8-35-2)18(11-25)12-27-21/h9-10,12,14H,4-8,13,15H2,1-3H3,(H2,26,27,29,34)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209277
PNG
(US9266883, 35)
Show SMILES O=Cc1ccc2CCCN(C(=O)Nc3cc(OCC4CCO4)c(cn3)C#N)c2n1
Show InChI InChI=1S/C20H19N5O4/c21-9-14-10-22-18(8-17(14)29-12-16-5-7-28-16)24-20(27)25-6-1-2-13-3-4-15(11-26)23-19(13)25/h3-4,8,10-11,16H,1-2,5-7,12H2,(H,22,24,27)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209345
PNG
(US9266883, 141)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CO)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H26N6O5/c1-14(2)34-19-8-20(25-10-17(19)9-24)27-23(33)29-6-4-5-15-7-16(11-28(3)21(32)13-31)18(12-30)26-22(15)29/h7-8,10,12,14,31H,4-6,11,13H2,1-3H3,(H,25,27,33)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209342
PNG
(US9266883, 120)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4[C@@H](C)COCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H29N7O5/c1-16-14-37-15-23(34)32(16)12-18-8-17-4-3-6-31(24(17)29-21(18)13-33)25(35)30-22-9-20(27-5-7-36-2)19(10-26)11-28-22/h8-9,11,13,16H,3-7,12,14-15H2,1-2H3,(H2,27,28,30,35)/t16-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209348
PNG
(US9266883, 145)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H31N7O4/c1-16(2)36-21-10-22(27-12-19(21)11-26)29-25(35)32-8-6-7-17-9-18(20(15-33)28-24(17)32)13-31(5)23(34)14-30(3)4/h9-10,12,15-16H,6-8,13-14H2,1-5H3,(H,27,29,35)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209354
PNG
(US9266883, 188)
Show SMILES CN(Cc1cc2CCCN(C(=O)Nc3cc(NCCOC(F)(F)F)c(cn3)C#N)c2nc1C=O)C(C)=O
Show InChI InChI=1S/C23H24F3N7O4/c1-14(35)32(2)12-16-8-15-4-3-6-33(21(15)30-19(16)13-34)22(36)31-20-9-18(17(10-27)11-29-20)28-5-7-37-23(24,25)26/h8-9,11,13H,3-7,12H2,1-2H3,(H2,28,29,31,36)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209334
PNG
(US9266883, 98)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM161392
PNG
(US9108973, 5)
Show SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C#C)c2ncnc(N)c12
Show InChI InChI=1S/C22H20N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h1,9-11,13,15H,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...


US Patent US9108973 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HJV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209368
PNG
(US9266883, 228)
Show SMILES COCCNc1cc(NC(=O)N2[C@@H](C)CCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C26H32N8O4/c1-17-4-5-18-10-19(14-33-8-7-32(2)15-24(33)36)22(16-35)30-25(18)34(17)26(37)31-23-11-21(28-6-9-38-3)20(12-27)13-29-23/h10-11,13,16-17H,4-9,14-15H2,1-3H3,(H2,28,29,31,37)/t17-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209341
PNG
(US9266883, 118)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4[C@H](C)COCC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H29N7O5/c1-16-14-37-15-23(34)32(16)12-18-8-17-4-3-6-31(24(17)29-21(18)13-33)25(35)30-22-9-20(27-5-7-36-2)19(10-26)11-28-22/h8-9,11,13,16H,3-7,12,14-15H2,1-2H3,(H2,27,28,30,35)/t16-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209361
PNG
(US9266883, 205)
Show SMILES COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C26H31N7O5/c1-17(16-37-3)38-22-10-23(28-12-20(22)11-27)30-26(36)33-6-4-5-18-9-19(21(15-34)29-25(18)33)13-32-8-7-31(2)14-24(32)35/h9-10,12,15,17H,4-8,13-14,16H2,1-3H3,(H,28,30,36)/t17-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209275
PNG
(US9266883, 33)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C19H19N5O3/c1-12(2)27-16-8-17(21-10-14(16)9-20)23-19(26)24-7-3-4-13-5-6-15(11-25)22-18(13)24/h5-6,8,10-12H,3-4,7H2,1-2H3,(H,21,23,26)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209367
PNG
(US9266883, 227)
Show SMILES CC(C)Oc1cc(NC(=O)N2[C@@H](C)CCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C26H31N7O4/c1-16(2)37-22-10-23(28-12-20(22)11-27)30-26(36)33-17(3)5-6-18-9-19(21(15-34)29-25(18)33)13-32-8-7-31(4)14-24(32)35/h9-10,12,15-17H,5-8,13-14H2,1-4H3,(H,28,30,36)/t17-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209332
PNG
(US9266883, 92)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H29N7O4/c1-16(2)36-21-10-22(27-12-19(21)11-26)29-25(35)32-6-4-5-17-9-18(20(15-33)28-24(17)32)13-31-8-7-30(3)14-23(31)34/h9-10,12,15-16H,4-8,13-14H2,1-3H3,(H,27,29,35)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209282
PNG
(US9266883, 40)
Show SMILES O=Cc1ccc2CCCN(C(=O)Nc3cc(OC4CCOC4)c(cn3)C#N)c2n1
Show InChI InChI=1S/C20H19N5O4/c21-9-14-10-22-18(8-17(14)29-16-5-7-28-12-16)24-20(27)25-6-1-2-13-3-4-15(11-26)23-19(13)25/h3-4,8,10-11,16H,1-2,5-7,12H2,(H,22,24,27)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209333
PNG
(US9266883, 95)
Show SMILES CC(C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H30N8O3/c1-16(2)28-20-10-22(27-12-19(20)11-26)30-25(36)33-6-4-5-17-9-18(21(15-34)29-24(17)33)13-32-8-7-31(3)14-23(32)35/h9-10,12,15-16H,4-8,13-14H2,1-3H3,(H2,27,28,30,36)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209302
PNG
(US9266883, 60)
Show SMILES OCc1cc2CCCN(C(=O)Nc3cc(OCC(O)CCCl)c(cn3)C#N)c2nc1C=O
Show InChI InChI=1S/C21H22ClN5O5/c22-4-3-16(30)12-32-18-7-19(24-9-15(18)8-23)26-21(31)27-5-1-2-13-6-14(10-28)17(11-29)25-20(13)27/h6-7,9,11,16,28,30H,1-5,10,12H2,(H,24,26,31)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209307
PNG
(US9266883, 65)
Show SMILES OC[C@H]1[C@@H]2CC[C@@H](C2)[C@H]1Nc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C25H28N6O4/c26-9-18-10-27-22(8-20(18)28-23-15-4-3-14(6-15)19(23)12-33)30-25(35)31-5-1-2-16-7-17(11-32)21(13-34)29-24(16)31/h7-8,10,13-15,19,23,32-33H,1-6,11-12H2,(H2,27,28,30,35)/t14-,15+,19+,23-/m1/s1
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209337
PNG
(US9266883, 105)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](O)C4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O5/c1-36-8-5-26-18-10-21(27-12-17(18)11-25)29-24(35)31-6-2-3-15-9-16(19(14-32)28-22(15)31)13-30-7-4-20(33)23(30)34/h9-10,12,14,20,33H,2-8,13H2,1H3,(H2,26,27,29,35)/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209335
PNG
(US9266883, 100)
Show SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](O)C4=O)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C24H27N7O5/c1-36-8-5-26-18-10-21(27-12-17(18)11-25)29-24(35)31-6-2-3-15-9-16(19(14-32)28-22(15)31)13-30-7-4-20(33)23(30)34/h9-10,12,14,20,33H,2-8,13H2,1H3,(H2,26,27,29,35)/t20-/m0/s1
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249446
PNG
(US9434697, 167)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249447
PNG
(US9434697, 168)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)


(Homo sapiens (Human))
BDBM209389
PNG
(US9266883, 264)
Show SMILES CC(C)Oc1cc(NC(=O)N2CCCc3cc(C4CCOC4)c(C=O)nc23)ncc1C#N
Show InChI InChI=1S/C23H25N5O4/c1-14(2)32-20-9-21(25-11-17(20)10-24)27-23(30)28-6-3-4-15-8-18(16-5-7-31-13-16)19(12-29)26-22(15)28/h8-9,11-12,14,16H,3-7,13H2,1-2H3,(H,25,27,30)
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Novartis AG

US Patent


Assay Description
Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...


US Patent US9266883 (2016)


BindingDB Entry DOI: 10.7270/Q2CC0ZGP
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249391
PNG
(US9434697, 100)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249395
PNG
(US9434697, 107)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US9434697, 108)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249398
PNG
(US9434697, 111)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

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Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249399
PNG
(US9434697, 112)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl
Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249400
PNG
(US9434697, 113)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249401
PNG
(US9434697, 114)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl
Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249403
PNG
(US9434697, 120)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN(C)C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O4/c1-6-23(37)33-18-11-8-7-10-17(18)32-21-15-22(31-16-30-21)36(13-9-12-35(2)3)27(38)34-26-24(28)19(39-4)14-20(40-5)25(26)29/h6-8,10-11,14-16H,1,9,12-13H2,2-5H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249404
PNG
(US9434697, 121)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(CCCN2CCN(C)CC2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-5-26(41)36-21-10-7-6-9-20(21)35-24-18-25(34-19-33-24)40(12-8-11-39-15-13-38(2)14-16-39)30(42)37-29-27(31)22(43-3)17-23(44-4)28(29)32/h5-7,9-10,17-19H,1,8,11-16H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249405
PNG
(US9434697, 122)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCNCC3)ncn2)c1Cl
Show InChI InChI=1S/C28H31Cl2N7O4/c1-5-24(38)35-19-12-17(16-8-10-31-11-9-16)6-7-18(19)34-22-14-23(33-15-32-22)37(2)28(39)36-27-25(29)20(40-3)13-21(41-4)26(27)30/h5-7,12-16,31H,1,8-11H2,2-4H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249406
PNG
(US9434697, 123)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)ncn2)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O5/c1-5-23(37)33-18-12-16(36-8-10-41-11-9-36)6-7-17(18)32-21-14-22(31-15-30-21)35(2)27(38)34-26-24(28)19(39-3)13-20(40-4)25(26)29/h5-7,12-15H,1,8-11H2,2-4H3,(H,33,37)(H,34,38)(H,30,31,32)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249407
PNG
(US9434697, 124)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3C[C@H](C)N[C@H](C)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H34Cl2N8O4/c1-7-25(40)36-20-10-18(39-13-16(2)34-17(3)14-39)8-9-19(20)35-23-12-24(33-15-32-23)38(4)29(41)37-28-26(30)21(42-5)11-22(43-6)27(28)31/h7-12,15-17,34H,1,13-14H2,2-6H3,(H,36,40)(H,37,41)(H,32,33,35)/t16-,17+
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249408
PNG
(US9434697, 125)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)S(C)(=O)=O)ncn2)c1Cl
Show InChI InChI=1S/C28H32Cl2N8O6S/c1-6-24(39)34-19-13-17(37-9-11-38(12-10-37)45(5,41)42)7-8-18(19)33-22-15-23(32-16-31-22)36(2)28(40)35-27-25(29)20(43-3)14-21(44-4)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249409
PNG
(US9434697, 126)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H33Cl2N7O4/c1-7-24(38)34-19-13-17(9-8-12-36(2)3)10-11-18(19)33-22-15-23(32-16-31-22)37(4)28(39)35-27-25(29)20(40-5)14-21(41-6)26(27)30/h7,10-11,13-16H,1,8-9,12H2,2-6H3,(H,34,38)(H,35,39)(H,31,32,33)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249410
PNG
(US9434697, 127)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C27H31Cl2N7O5/c1-7-23(37)33-18-12-16(41-11-10-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249414
PNG
(US9434697, 131)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccccn2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-11-6-5-10-18(19)34-22-14-23(33-16-32-22)37(15-17-9-7-8-12-31-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249415
PNG
(US9434697, 132)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccncc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl
Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-8-6-5-7-18(19)34-22-14-23(33-16-32-22)37(15-17-9-11-31-12-10-17)28(39)36-27-25(29)20(40-2)13-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)
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US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249417
PNG
(US9434697, 135)
Show SMILES CCN1CCN(Cc2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C30H36Cl2N8O4/c1-6-26(41)36-21-14-19(17-40-12-10-39(7-2)11-13-40)8-9-20(21)35-24-16-25(34-18-33-24)38(3)30(42)37-29-27(31)22(43-4)15-23(44-5)28(29)32/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,36,41)(H,37,42)(H,33,34,35)
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EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
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