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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Follicle stimulating hormone receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Follicle stimulating hormone receptor


(Rattus norvegicus)
BDBM50162936
PNG
(Biphenyl-4-carboxylic acid (1-acetyl-2,2,4-trimeth...)
Show SMILES CC(=O)N1c2ccc(NC(=O)c3ccc(cc3)-c3ccccc3)cc2C(C)(CC1(C)C)c1ccccc1
Show InChI InChI=1S/C33H32N2O2/c1-23(36)35-30-20-19-28(21-29(30)33(4,22-32(35,2)3)27-13-9-6-10-14-27)34-31(37)26-17-15-25(16-18-26)24-11-7-5-8-12-24/h5-21H,22H2,1-4H3,(H,34,37)
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Article
PubMed
n/an/a 540n/an/an/an/an/an/a



Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line


Citation and Details
More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Rattus norvegicus)
BDBM50405781
PNG
(CHEMBL2369814)
Show SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C53H71N13O9/c1-4-57-51(74)45-16-10-22-66(45)52(75)40(15-9-21-58-53(55)56)61-47(70)41(23-30(2)3)62-49(72)43(26-33-28-60-39-14-8-6-12-36(33)39)64-48(71)42(24-31-17-19-34(68)20-18-31)63-50(73)44(29-67)65-46(69)37(54)25-32-27-59-38-13-7-5-11-35(32)38/h5-8,11-14,17-20,27-28,30,37,40-45,59-60,67-68H,4,9-10,15-16,21-26,29,54H2,1-3H3,(H,57,74)(H,61,70)(H,62,72)(H,63,73)(H,64,71)(H,65,69)(H4,55,56,58)/t37-,40-,41-,42-,43+,44-,45-/m0/s1
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n/an/an/a 57.5n/an/an/an/an/a



Abbott Laboratory

Curated by ChEMBL


Assay Description
Luteinising hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)


J Med Chem 32: 2340-4 (1989)

More data for this
Ligand-Target Pair
Follicle stimulating hormone receptor


(Rattus norvegicus)
BDBM50452577
PNG
(CHEMBL2369794)
Show SMILES CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C48H72N12O9/c1-6-52-46(68)40-14-10-20-60(40)47(69)35(13-9-19-53-48(50)51)55-42(64)36(21-27(2)3)56-43(65)37(22-28(4)5)57-44(66)38(23-29-15-17-31(62)18-16-29)58-45(67)39(26-61)59-41(63)33(49)24-30-25-54-34-12-8-7-11-32(30)34/h7-8,11-12,15-18,25,27-28,33,35-40,54,61-62H,6,9-10,13-14,19-24,26,49H2,1-5H3,(H,52,68)(H,55,64)(H,56,65)(H,57,66)(H,58,67)(H,59,63)(H4,50,51,53)/t33-,35-,36-,37+,38-,39-,40-/m0/s1
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n/an/an/a 871n/an/an/an/an/a



Abbott Laboratory

Curated by ChEMBL


Assay Description
Luteinising hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)


J Med Chem 32: 2340-4 (1989)

More data for this
Ligand-Target Pair