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Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with Target = 'Fructose-1,6-bisphosphatase' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 340n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50095256
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-4-fluor...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(c3)C#C)c2cc1OC
Show InChI InChI=1S/C18H14FN3O2/c1-4-11-7-12(5-6-14(11)19)22-18-13-8-16(23-2)17(24-3)9-15(13)20-10-21-18/h1,5-10H,2-3H3,(H,20,21,22)
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n/an/a 770n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50004952
PNG
(3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carbo...)
Show SMILES OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C12H9Cl2NO4/c13-5-3-7(14)10-6(1-2-9(16)17)11(12(18)19)15-8(10)4-5/h3-4,15H,1-2H2,(H,16,17)(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Fructose-1,6-bisphosphatase (F16BPase) in porcine kidney


Bioorg Med Chem Lett 13: 2055-8 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293592
PNG
(4-(2-Aminothiazol-4-yl)phenol | 4-(2-amino-1,3-thi...)
Show SMILES Nc1nc(cs1)-c1ccc(O)cc1
Show InChI InChI=1S/C9H8N2OS/c10-9-11-8(5-13-9)6-1-3-7(12)4-2-6/h1-5,12H,(H2,10,11)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM18137
PNG
(AMP | CHEMBL752 | [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM18137
PNG
(AMP | CHEMBL752 | [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50316378
PNG
(1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bi...)
Show SMILES CC(C)CC(=O)c1c(O)cc2oc3c(C(=O)CC(C)C)c(O)cc(O)c3c2c1O
Show InChI InChI=1S/C22H24O7/c1-9(2)5-11(23)17-15(27)8-16-20(21(17)28)19-14(26)7-13(25)18(22(19)29-16)12(24)6-10(3)4/h7-10,25-28H,5-6H2,1-4H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50316378
PNG
(1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bi...)
Show SMILES CC(C)CC(=O)c1c(O)cc2oc3c(C(=O)CC(C)C)c(O)cc(O)c3c2c1O
Show InChI InChI=1S/C22H24O7/c1-9(2)5-11(23)17-15(27)8-16-20(21(17)28)19-14(26)7-13(25)18(22(19)29-16)12(24)6-10(3)4/h7-10,25-28H,5-6H2,1-4H3
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US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



TRUSTEES OF BOSTON COLLEGE

US Patent


Assay Description
FBPase activity was measured spectrophotometrically by employing the coupling enzymes phosphoglucose isomerase and glucose-6-phosphate dehydrogenase....


US Patent US9273021 (2016)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50095259
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(3-ethynyl-phenyl)...)
Show SMILES COc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OC
Show InChI InChI=1S/C18H15N3O2/c1-4-12-6-5-7-13(8-12)21-18-14-9-16(22-2)17(23-3)10-15(14)19-11-20-18/h1,5-11H,2-3H3,(H,19,20,21)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50095266
PNG
((3-Chloro-4-fluoro-phenyl)-(6,7-diethoxy-quinazoli...)
Show SMILES CCOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCC
Show InChI InChI=1S/C18H17ClFN3O2/c1-3-24-16-8-12-15(9-17(16)25-4-2)21-10-22-18(12)23-11-5-6-14(20)13(19)7-11/h5-10H,3-4H2,1-2H3,(H,21,22,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50095261
PNG
((3-Chloro-phenyl)-(6,7-diethoxy-quinazolin-4-yl)-a...)
Show SMILES CCOc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OCC
Show InChI InChI=1S/C18H18ClN3O2/c1-3-23-16-9-14-15(10-17(16)24-4-2)20-11-21-18(14)22-13-7-5-6-12(19)8-13/h5-11H,3-4H2,1-2H3,(H,20,21,22)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50316379
PNG
(1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bi...)
Show SMILES CCC(C)C(=O)c1c(O)cc2oc3c(C(=O)C(C)CC)c(O)cc(O)c3c2c1O
Show InChI InChI=1S/C22H24O7/c1-5-9(3)19(26)16-13(25)8-14-18(21(16)28)15-11(23)7-12(24)17(22(15)29-14)20(27)10(4)6-2/h7-10,23-25,28H,5-6H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50316379
PNG
(1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bi...)
Show SMILES CCC(C)C(=O)c1c(O)cc2oc3c(C(=O)C(C)CC)c(O)cc(O)c3c2c1O
Show InChI InChI=1S/C22H24O7/c1-5-9(3)19(26)16-13(25)8-14-18(21(16)28)15-11(23)7-12(24)17(22(15)29-14)20(27)10(4)6-2/h7-10,23-25,28H,5-6H2,1-4H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



TRUSTEES OF BOSTON COLLEGE

US Patent


Assay Description
FBPase activity was measured spectrophotometrically by employing the coupling enzymes phosphoglucose isomerase and glucose-6-phosphate dehydrogenase....


US Patent US9273021 (2016)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293581
PNG
(4-(2-(3-Hydroxyphenylamino)thiazol-4-yl)benzene-1,...)
Show SMILES Oc1cccc(Nc2nc(cs2)-c2ccc(O)cc2O)c1
Show InChI InChI=1S/C15H12N2O3S/c18-10-3-1-2-9(6-10)16-15-17-13(8-21-15)12-5-4-11(19)7-14(12)20/h1-8,18-20H,(H,16,17)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM3532
PNG
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM3556
PNG
(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Show SMILES CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC
Show InChI InChI=1S/C18H18BrN3O2/c1-3-23-16-9-14-15(10-17(16)24-4-2)20-11-21-18(14)22-13-7-5-6-12(19)8-13/h5-11H,3-4H2,1-2H3,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM3032
PNG
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPase


Bioorg Med Chem Lett 11: 17-21 (2001)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293578
PNG
(4-(2-(4-Hydroxyphenylamino)thiazol-4-yl)benzene-1,...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2ccc(O)cc2O)cc1
Show InChI InChI=1S/C15H12N2O3S/c18-10-3-1-9(2-4-10)16-15-17-13(8-21-15)12-6-5-11(19)7-14(12)20/h1-8,18-20H,(H,16,17)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293580
PNG
(3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol | C...)
Show SMILES Oc1ccc(cc1)-c1csc(Nc2cccc(O)c2)n1
Show InChI InChI=1S/C15H12N2O2S/c18-12-6-4-10(5-7-12)14-9-20-15(17-14)16-11-2-1-3-13(19)8-11/h1-9,18-19H,(H,16,17)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293583
PNG
(2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol | C...)
Show SMILES Oc1ccc(cc1)-c1csc(Nc2ccccc2O)n1
Show InChI InChI=1S/C15H12N2O2S/c18-11-7-5-10(6-8-11)13-9-20-15(17-13)16-12-3-1-2-4-14(12)19/h1-9,18-19H,(H,16,17)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293584
PNG
(4-(2-(2-Hydroxyphenylamino)thiazol-4-yl)benzene-1,...)
Show SMILES Oc1ccc(-c2csc(Nc3ccccc3O)n2)c(O)c1
Show InChI InChI=1S/C15H12N2O3S/c18-9-5-6-10(14(20)7-9)12-8-21-15(17-12)16-11-3-1-2-4-13(11)19/h1-8,18-20H,(H,16,17)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293596
PNG
(CHEMBL563935 | methyl 4-ethyl-5-methyl-2-(3-(pyrid...)
Show SMILES CCc1c(C)sc(NC(=S)NCc2ccccn2)c1C(=O)OC
Show InChI InChI=1S/C16H19N3O2S2/c1-4-12-10(2)23-14(13(12)15(20)21-3)19-16(22)18-9-11-7-5-6-8-17-11/h5-8H,4,9H2,1-3H3,(H2,18,19,22)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293572
PNG
(4-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)benzenesul...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(cs2)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H13N3O3S2/c16-23(20,21)13-7-3-11(4-8-13)17-15-18-14(9-22-15)10-1-5-12(19)6-2-10/h1-9,19H,(H,17,18)(H2,16,20,21)
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n/an/a 3.16E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293572
PNG
(4-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)benzenesul...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(cs2)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H13N3O3S2/c16-23(20,21)13-7-3-11(4-8-13)17-15-18-14(9-22-15)10-1-5-12(19)6-2-10/h1-9,19H,(H,17,18)(H2,16,20,21)
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n/an/a 3.16E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293579
PNG
(3-(4-Phenylthiazol-2-ylamino)phenol | CHEMBL554135)
Show SMILES Oc1cccc(Nc2nc(cs2)-c2ccccc2)c1
Show InChI InChI=1S/C15H12N2OS/c18-13-8-4-7-12(9-13)16-15-17-14(10-19-15)11-5-2-1-3-6-11/h1-10,18H,(H,16,17)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293586
PNG
(4-(2-(3-Nitrophenylamino)thiazol-4-yl)phenol | CHE...)
Show SMILES Oc1ccc(cc1)-c1csc(Nc2cccc(c2)[N+]([O-])=O)n1
Show InChI InChI=1S/C15H11N3O3S/c19-13-6-4-10(5-7-13)14-9-22-15(17-14)16-11-2-1-3-12(8-11)18(20)21/h1-9,19H,(H,16,17)
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n/an/a 4.80E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293577
PNG
(4-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol | C...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2ccc(O)cc2)cc1
Show InChI InChI=1S/C15H12N2O2S/c18-12-5-1-10(2-6-12)14-9-20-15(17-14)16-11-3-7-13(19)8-4-11/h1-9,18-19H,(H,16,17)
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n/an/a 4.80E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293591
PNG
(3-(4-(4-hydroxyphenyl)thiazol-2-ylamino)benzoic ac...)
Show SMILES OC(=O)c1cccc(Nc2nc(cs2)-c2ccc(O)cc2)c1
Show InChI InChI=1S/C16H12N2O3S/c19-13-6-4-10(5-7-13)14-9-22-16(18-14)17-12-3-1-2-11(8-12)15(20)21/h1-9,19H,(H,17,18)(H,20,21)
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n/an/a 4.80E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293575
PNG
(3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)benzenesul...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nc(cs2)-c2ccc(O)cc2)c1
Show InChI InChI=1S/C15H13N3O3S2/c16-23(20,21)13-3-1-2-11(8-13)17-15-18-14(9-22-15)10-4-6-12(19)7-5-10/h1-9,19H,(H,17,18)(H2,16,20,21)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293573
PNG
(4-(4-(2,4-dihydroxyphenyl)thiazol-2-ylamino)benzen...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(cs2)-c2ccc(O)cc2O)cc1
Show InChI InChI=1S/C15H13N3O4S2/c16-24(21,22)11-4-1-9(2-5-11)17-15-18-13(8-23-15)12-6-3-10(19)7-14(12)20/h1-8,19-20H,(H,17,18)(H2,16,21,22)
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n/an/a 5.50E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293593
PNG
(4-(2-aminothiazol-4-yl)benzene-1,3-diol | CHEMBL54...)
Show SMILES Nc1nc(cs1)-c1ccc(O)cc1O
Show InChI InChI=1S/C9H8N2O2S/c10-9-11-7(4-14-9)6-2-1-5(12)3-8(6)13/h1-4,12-13H,(H2,10,11)
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n/an/a 9.30E+4n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293574
PNG
(3-(4-Phenylthiazol-2-ylamino)benzenesulfonamide | ...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nc(cs2)-c2ccccc2)c1
Show InChI InChI=1S/C15H13N3O2S2/c16-22(19,20)13-8-4-7-12(9-13)17-15-18-14(10-21-15)11-5-2-1-3-6-11/h1-10H,(H,17,18)(H2,16,19,20)
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n/an/a 1.04E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293589
PNG
(2-(2-(Phenylamino)thiazol-4-yl)phenol | CHEMBL5628...)
Show SMILES Oc1ccccc1-c1csc(Nc2ccccc2)n1
Show InChI InChI=1S/C15H12N2OS/c18-14-9-5-4-8-12(14)13-10-19-15(17-13)16-11-6-2-1-3-7-11/h1-10,18H,(H,16,17)
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n/an/a 1.19E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293576
PNG
(4-(4-phenylthiazol-2-ylamino)phenol | 4131JH0380 |...)
Show SMILES Oc1ccc(Nc2nc(cs2)-c2ccccc2)cc1
Show InChI InChI=1S/C15H12N2OS/c18-13-8-6-12(7-9-13)16-15-17-14(10-19-15)11-4-2-1-3-5-11/h1-10,18H,(H,16,17)
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n/an/a 1.24E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293571
PNG
(4-(4-Phenyl-thiazol-2-ylamino)-benzenesulfonamide ...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(cs2)-c2ccccc2)cc1
Show InChI InChI=1S/C15H13N3O2S2/c16-22(19,20)13-8-6-12(7-9-13)17-15-18-14(10-21-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)(H2,16,19,20)
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n/an/a 1.45E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293585
PNG
(4-(2-(4-Nitrophenylamino)thiazol-4-yl)phenol | CHE...)
Show SMILES Oc1ccc(cc1)-c1csc(Nc2ccc(cc2)[N+]([O-])=O)n1
Show InChI InChI=1S/C15H11N3O3S/c19-13-7-1-10(2-8-13)14-9-22-15(17-14)16-11-3-5-12(6-4-11)18(20)21/h1-9,19H,(H,16,17)
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n/an/a 2.46E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293582
PNG
(2-(4-Phenylthiazol-2-ylamino)phenol | CHEMBL555896)
Show SMILES Oc1ccccc1Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C15H12N2OS/c18-14-9-5-4-8-12(14)16-15-17-13(10-19-15)11-6-2-1-3-7-11/h1-10,18H,(H,16,17)
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n/an/a 2.70E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293587
PNG
(4-(2-(phenylamino)thiazol-4-yl)phenol | CHEMBL5536...)
Show SMILES Oc1ccc(cc1)-c1csc(Nc2ccccc2)n1
Show InChI InChI=1S/C15H12N2OS/c18-13-8-6-11(7-9-13)14-10-19-15(17-14)16-12-4-2-1-3-5-12/h1-10,18H,(H,16,17)
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n/an/a 3.18E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293588
PNG
(4-(2-(Phenylamino)thiazol-4-yl)benzene-1,3-diol | ...)
Show SMILES Oc1ccc(-c2csc(Nc3ccccc3)n2)c(O)c1
Show InChI InChI=1S/C15H12N2O2S/c18-11-6-7-12(14(19)8-11)13-9-20-15(17-13)16-10-4-2-1-3-5-10/h1-9,18-19H,(H,16,17)
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n/an/a 3.43E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293590
PNG
(3-(4-phenylthiazol-2-ylamino)benzoic acid | CHEMBL...)
Show SMILES OC(=O)c1cccc(Nc2nc(cs2)-c2ccccc2)c1
Show InChI InChI=1S/C16H12N2O2S/c19-15(20)12-7-4-8-13(9-12)17-16-18-14(10-21-16)11-5-2-1-3-6-11/h1-10H,(H,17,18)(H,19,20)
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n/an/a 5.71E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293597
PNG
(4,4'-sulfonyldibenzoic acid | 4-[(4-carboxybenzene...)
Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C14H10O6S/c15-13(16)9-1-5-11(6-2-9)21(19,20)12-7-3-10(4-8-12)14(17)18/h1-8H,(H,15,16)(H,17,18)
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n/an/a 7.50E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50202829
PNG
((+)-USNIC ACID | (+)-Usnic acid | 2,6-diacetyl-3,7...)
Show SMILES CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)[C@@]2(C)C1=O
Show InChI InChI=1S/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,11,22-23H,1-4H3
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n/an/a 9.30E+5n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphogluco...


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM209638
PNG
(US9273021, Usnic Acid)
Show SMILES CC(=O)C1=C(O)C=C2Oc3c(c(O)c(C)c(O)c3C(C)=O)C2(C)C1=O
Show InChI InChI=1/C18H16O7/c1-6-14(22)12(8(3)20)16-13(15(6)23)18(4)10(25-16)5-9(21)11(7(2)19)17(18)24/h5,21-23H,1-4H3
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US Patent
n/an/a 9.30E+5n/an/an/an/an/an/a



TRUSTEES OF BOSTON COLLEGE

US Patent


Assay Description
FBPase activity was measured spectrophotometrically by employing the coupling enzymes phosphoglucose isomerase and glucose-6-phosphate dehydrogenase....


US Patent US9273021 (2016)

More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM31190
PNG
(thiazol-2-amine, 1)
Show SMILES Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C9H8N2S/c10-9-11-8(6-12-9)7-4-2-1-3-5-7/h1-6H,(H2,10,11)
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n/an/a 1.39E+6n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50264074
PNG
(CHEMBL510166 | N,4-Diphenylthiazol-2-amine)
Show SMILES N(c1nc(cs1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2S/c1-3-7-12(8-4-1)14-11-18-15(17-14)16-13-9-5-2-6-10-13/h1-11H,(H,16,17)
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n/an/a 2.50E+6n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Sus scrofa (Pig))
BDBM50293595
PNG
(1-(3,5-dimethyl-1H-pyrazol-1-yl)-3-(naphthalen-2-y...)
Show SMILES Cc1cc(C)n(CC(O)COc2ccc3ccccc3c2)n1
Show InChI InChI=1S/C18H20N2O2/c1-13-9-14(2)20(19-13)11-17(21)12-22-18-8-7-15-5-3-4-6-16(15)10-18/h3-10,17,21H,11-12H2,1-2H3
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n/an/a 3.00E+6n/an/an/an/an/an/a



Boston College

Curated by ChEMBL


Assay Description
Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry


Citation and Details
More data for this
Ligand-Target Pair