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Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'Fucosyltransferase 5' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fucosyltransferase 5


(Homo sapiens)
BDBM50366926
PNG
(CHEMBL609638)
Show SMILES CC1CC(OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c2nc(N)[nH]c3=O)C(O)C(O)C1O
Show InChI InChI=1S/C17H27N5O14P2/c1-5-2-6(10(24)12(26)9(5)23)35-38(31,32)36-37(29,30)33-3-7-11(25)13(27)16(34-7)22-4-19-8-14(22)20-17(18)21-15(8)28/h4-7,9-13,16,23-27H,2-3H2,1H3,(H,29,30)(H,31,32)(H3,18,20,21,28)/t5?,6?,7-,9?,10?,11-,12?,13-,16?/m1/s1
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6.71E+4n/an/an/an/an/an/an/an/a



David Geffen School of Medicine at University of California

Curated by ChEMBL


Assay Description
Inhibition of Fucosyltransferase 5 by the compound was evaluated; Competitive inhibition


Bioorg Med Chem Lett 14: 571-3 (2004)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM50366925
PNG
(CHEMBL610712)
Show SMILES CC1OC(CP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c2nc(N)[nH]c3=O)C(O)C(O)C1O
Show InChI InChI=1S/C17H27N5O14P2/c1-5-9(23)12(26)11(25)7(34-5)3-37(29,30)36-38(31,32)33-2-6-10(24)13(27)16(35-6)22-4-19-8-14(22)20-17(18)21-15(8)28/h4-7,9-13,16,23-27H,2-3H2,1H3,(H,29,30)(H,31,32)(H3,18,20,21,28)/t5?,6-,7?,9?,10-,11?,12?,13-,16?/m1/s1
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8.89E+5n/an/an/an/an/an/an/an/a



David Geffen School of Medicine at University of California

Curated by ChEMBL


Assay Description
Inhibition of Fucosyltransferase 5 by the compound was evaluated; Weak competitive inhibition


Bioorg Med Chem Lett 14: 571-3 (2004)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM50101904
PNG
(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of 1 mM fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM92459
PNG
(CHEMBL384759 | GDP | Guanosine Diphosphate)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
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n/an/a 6.70E+4n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM50101904
PNG
(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
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n/an/a 8.20E+4n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of 10 mM fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM50101907
PNG
(({[(2R,3S,4R,5R)-5-(2-azaniumyl-6-hydroxy-9H-purin...)
Show SMILES CP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C11H17N5O10P2/c1-27(20,21)26-28(22,23)24-2-4-6(17)7(18)10(25-4)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H,20,21)(H,22,23)(H3,12,14,15,19)/p-1/t4-,6-,7-,10-/m1/s1
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n/an/a>5.00E+5n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)

More data for this
Ligand-Target Pair
Fucosyltransferase 5


(Homo sapiens)
BDBM50101906
PNG
(CHEMBL53188 | GDP-Azasugar analogue)
Show SMILES [NH3+]CCOP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C12H20N6O11P2/c13-1-2-26-30(22,23)29-31(24,25)27-3-5-7(19)8(20)11(28-5)18-4-15-6-9(18)16-12(14)17-10(6)21/h4-5,7-8,11,19-20H,1-3,13H2,(H,22,23)(H,24,25)(H3,14,16,17,21)/t5-,7-,8-,11-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamine


Bioorg Med Chem Lett 11: 1809-11 (2001)

More data for this
Ligand-Target Pair