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Compile Data Set for Download or QSAR

Found 135 hits Enz. Inhib. hit(s) with Target = 'G protein-activated inward rectifier potassium channel 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437954
PNG
(CHEMBL2409269)
Show SMILES Fc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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n/an/a 450n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497399
PNG
(CHEMBL3339105)
Show SMILES Cc1cc(NC(=O)Nc2cc(nn2-c2ccccc2)C2(CC2)C(F)(F)F)ccc1F
Show InChI InChI=1S/C21H18F4N4O/c1-13-11-14(7-8-16(13)22)26-19(30)27-18-12-17(20(9-10-20)21(23,24)25)28-29(18)15-5-3-2-4-6-15/h2-8,11-12H,9-10H2,1H3,(H2,26,27,30)
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n/an/a 480n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437955
PNG
(CHEMBL2409135)
Show SMILES Cc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c1-15-6-5-7-17(12-15)22-21(26)23-20-14-18(13-16-10-11-16)24-25(20)19-8-3-2-4-9-19/h2-9,12,14,16H,10-11,13H2,1H3,(H2,22,23,26)
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n/an/a 520n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437953
PNG
(CHEMBL2409098)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-5-4-6-16(12-15)25-20(29)26-19-13-17(11-14-9-10-14)27-28(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,25,26,29)
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n/an/a 540n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437988
PNG
(CHEMBL2409101)
Show SMILES Clc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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n/an/a 630n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437990
PNG
(CHEMBL2409099)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1
Show InChI InChI=1S/C20H19FN4O/c21-15-8-10-16(11-9-15)22-20(26)23-19-13-17(12-14-6-7-14)24-25(19)18-4-2-1-3-5-18/h1-5,8-11,13-14H,6-7,12H2,(H2,22,23,26)
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n/an/a 640n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497381
PNG
(CHEMBL3339113)
Show SMILES CC1(CC1)c1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H18F2N4O/c1-20(9-10-20)17-12-18(26(25-17)14-5-3-2-4-6-14)24-19(27)23-13-7-8-15(21)16(22)11-13/h2-8,11-12H,9-10H2,1H3,(H2,23,24,27)
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n/an/a 740n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437989
PNG
(CHEMBL2409100)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-17-11-14(8-9-18(17)22)23-20(27)24-19-12-15(10-13-6-7-13)25-26(19)16-4-2-1-3-5-16/h1-5,8-9,11-13H,6-7,10H2,(H2,23,24,27)
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n/an/a 810n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497417
PNG
(CHEMBL3339101)
Show SMILES Cc1cc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2(F)F)ccc1F
Show InChI InChI=1S/C20H17F3N4O/c1-12-9-13(7-8-16(12)21)24-19(28)25-18-10-17(15-11-20(15,22)23)26-27(18)14-5-3-2-4-6-14/h2-10,15H,11H2,1H3,(H2,24,25,28)
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n/an/a 830n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437962
PNG
(CHEMBL2409119)
Show SMILES Cc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H20N4O/c1-14-6-5-7-16(12-14)21-20(25)22-19-13-18(15-10-11-15)23-24(19)17-8-3-2-4-9-17/h2-9,12-13,15H,10-11H2,1H3,(H2,21,22,25)
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n/an/a 850n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437960
PNG
(CHEMBL2409122)
Show SMILES CSc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H20N4OS/c1-26-17-9-5-6-15(12-17)21-20(25)22-19-13-18(14-10-11-14)23-24(19)16-7-3-2-4-8-16/h2-9,12-14H,10-11H2,1H3,(H2,21,22,25)
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n/an/a 950n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497370
PNG
(CHEMBL3339114)
Show SMILES Cc1cc(NC(=O)Nc2cc(nn2-c2ccccc2)C2(C)CC2)ccc1F
Show InChI InChI=1S/C21H21FN4O/c1-14-12-15(8-9-17(14)22)23-20(27)24-19-13-18(21(2)10-11-21)25-26(19)16-6-4-3-5-7-16/h3-9,12-13H,10-11H2,1-2H3,(H2,23,24,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497407
PNG
(CHEMBL3339102)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2(F)F)cc1
Show InChI InChI=1S/C20H15F5N4O/c21-19(22)11-15(19)16-10-17(29(28-16)14-4-2-1-3-5-14)27-18(30)26-13-8-6-12(7-9-13)20(23,24)25/h1-10,15H,11H2,(H2,26,27,30)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437961
PNG
(CHEMBL2409121)
Show SMILES Fc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C19H17FN4O/c20-14-5-4-6-15(11-14)21-19(25)22-18-12-17(13-9-10-13)23-24(18)16-7-2-1-3-8-16/h1-8,11-13H,9-10H2,(H2,21,22,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437986
PNG
(CHEMBL2409103)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-8-5-9-16(12-15)25-20(29)26-19-13-18(14-6-4-7-14)27-28(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,25,26,29)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437987
PNG
(CHEMBL2409102)
Show SMILES Clc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497371
PNG
(CHEMBL3339099)
Show SMILES Cc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2(F)F)cc1
Show InChI InChI=1S/C20H18F2N4O/c1-13-7-9-14(10-8-13)23-19(27)24-18-11-17(16-12-20(16,21)22)25-26(18)15-5-3-2-4-6-15/h2-11,16H,12H2,1H3,(H2,23,24,27)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497373
PNG
(CHEMBL3339115)
Show SMILES CC1(CC1)c1cc(NC(=O)Nc2cccc(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H19FN4O/c1-20(10-11-20)17-13-18(25(24-17)16-8-3-2-4-9-16)23-19(26)22-15-7-5-6-14(21)12-15/h2-9,12-13H,10-11H2,1H3,(H2,22,23,26)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497409
PNG
(CHEMBL3339116)
Show SMILES Cc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2(C)CC2)cc1
Show InChI InChI=1S/C21H22N4O/c1-15-8-10-16(11-9-15)22-20(26)23-19-14-18(21(2)12-13-21)24-25(19)17-6-4-3-5-7-17/h3-11,14H,12-13H2,1-2H3,(H2,22,23,26)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437984
PNG
(CHEMBL2409105)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-16-11-14(9-10-17(16)22)23-20(27)24-19-12-18(13-5-4-6-13)25-26(19)15-7-2-1-3-8-15/h1-3,7-13H,4-6H2,(H2,23,24,27)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497404
PNG
(CHEMBL3339117)
Show SMILES Cc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2(C)CC2)c1
Show InChI InChI=1S/C21H22N4O/c1-15-7-6-8-16(13-15)22-20(26)23-19-14-18(21(2)11-12-21)24-25(19)17-9-4-3-5-10-17/h3-10,13-14H,11-12H2,1-2H3,(H2,22,23,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437985
PNG
(CHEMBL2409104)
Show SMILES Brc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19BrN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437966
PNG
(CHEMBL2409114)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H18F2N4O/c1-12(2)17-11-18(25(24-17)14-6-4-3-5-7-14)23-19(26)22-13-8-9-15(20)16(21)10-13/h3-12H,1-2H3,(H2,22,23,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497410
PNG
(CHEMBL3339119)
Show SMILES CC1(CC1)c1cc(NC(=O)Nc2ccc(Br)cc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H19BrN4O/c1-20(11-12-20)17-13-18(25(24-17)16-5-3-2-4-6-16)23-19(26)22-15-9-7-14(21)8-10-15/h2-10,13H,11-12H2,1H3,(H2,22,23,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497415
PNG
(CHEMBL3339104)
Show SMILES COc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)cc1
Show InChI InChI=1S/C20H20N4O2/c1-26-17-11-9-15(10-12-17)21-20(25)22-19-13-18(14-7-8-14)23-24(19)16-5-3-2-4-6-16/h2-6,9-14H,7-8H2,1H3,(H2,21,22,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497398
PNG
(CHEMBL3339103)
Show SMILES Cc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)cc1
Show InChI InChI=1S/C20H20N4O/c1-14-7-11-16(12-8-14)21-20(25)22-19-13-18(15-9-10-15)23-24(19)17-5-3-2-4-6-17/h2-8,11-13,15H,9-10H2,1H3,(H2,21,22,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437958
PNG
(CHEMBL2409124)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H19FN4O/c1-13(2)17-12-18(24(23-17)16-9-4-3-5-10-16)22-19(25)21-15-8-6-7-14(20)11-15/h3-13H,1-2H3,(H2,21,22,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437959
PNG
(CHEMBL2409123)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H19F3N4O/c1-13(2)17-12-18(27(26-17)16-9-4-3-5-10-16)25-19(28)24-15-8-6-7-14(11-15)20(21,22)23/h3-13H,1-2H3,(H2,24,25,28)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497406
PNG
(CHEMBL3339100)
Show SMILES COc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2(F)F)cc1
Show InChI InChI=1S/C20H18F2N4O2/c1-28-15-9-7-13(8-10-15)23-19(27)24-18-11-17(16-12-20(16,21)22)25-26(18)14-5-3-2-4-6-14/h2-11,16H,12H2,1H3,(H2,23,24,27)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437957
PNG
(CHEMBL2409125)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(C)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-10-5-4-6-11-17)22-20(25)21-16-9-7-8-15(3)12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497405
PNG
(CHEMBL3339095)
Show SMILES Fc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)c1
Show InChI InChI=1S/C21H21FN4O/c22-16-9-6-10-17(13-16)23-21(27)24-20-14-19(15-7-4-5-8-15)25-26(20)18-11-2-1-3-12-18/h1-3,6,9-15H,4-5,7-8H2,(H2,23,24,27)
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n/an/a 3.60E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497400
PNG
(CHEMBL3339106)
Show SMILES FC(F)(F)C1(CC1)c1cc(NC(=O)Nc2ccccc2Cl)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H16ClF3N4O/c21-14-8-4-5-9-15(14)25-18(29)26-17-12-16(19(10-11-19)20(22,23)24)27-28(17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H2,25,26,29)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497372
PNG
(CHEMBL3339107)
Show SMILES FC(F)(F)C1(CC1)c1cc(NC(=O)Nc2ccccc2Br)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H16BrF3N4O/c21-14-8-4-5-9-15(14)25-18(29)26-17-12-16(19(10-11-19)20(22,23)24)27-28(17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H2,25,26,29)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437956
PNG
(CHEMBL2409126)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(C)cc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-7-5-4-6-8-17)22-20(25)21-16-11-9-15(3)10-12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497401
PNG
(CHEMBL3339108)
Show SMILES FC(F)(F)C1(CC1)c1cc(NC(=O)Nc2cc(Cl)cc(Cl)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H15Cl2F3N4O/c21-12-8-13(22)10-14(9-12)26-18(30)27-17-11-16(19(6-7-19)20(23,24)25)28-29(17)15-4-2-1-3-5-15/h1-5,8-11H,6-7H2,(H2,26,27,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497396
PNG
(CHEMBL3339096)
Show SMILES COc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1
Show InChI InChI=1S/C22H24N4O2/c1-28-19-13-11-17(12-14-19)23-22(27)24-21-15-20(16-7-5-6-8-16)25-26(21)18-9-3-2-4-10-18/h2-4,9-16H,5-8H2,1H3,(H2,23,24,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497395
PNG
(CHEMBL3339094)
Show SMILES Brc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1
Show InChI InChI=1S/C21H21BrN4O/c22-16-10-12-17(13-11-16)23-21(27)24-20-14-19(15-6-4-5-7-15)25-26(20)18-8-2-1-3-9-18/h1-3,8-15H,4-7H2,(H2,23,24,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497397
PNG
(CHEMBL3339097)
Show SMILES Cc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1
Show InChI InChI=1S/C22H24N4O/c1-16-11-13-18(14-12-16)23-22(27)24-21-15-20(17-7-5-6-8-17)25-26(21)19-9-3-2-4-10-19/h2-4,9-15,17H,5-8H2,1H3,(H2,23,24,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437964
PNG
(CHEMBL2409116)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1F
Show InChI InChI=1S/C21H20F2N4O/c22-17-11-10-15(12-18(17)23)24-21(28)25-20-13-19(14-6-4-5-7-14)26-27(20)16-8-2-1-3-9-16/h1-3,8-14H,4-7H2,(H2,24,25,28)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497408
PNG
(CHEMBL3339109)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2(CC2)C(F)(F)F)c1
Show InChI InChI=1S/C21H16F6N4O/c22-20(23,24)13-5-4-6-14(11-13)28-18(32)29-17-12-16(19(9-10-19)21(25,26)27)30-31(17)15-7-2-1-3-8-15/h1-8,11-12H,9-10H2,(H2,28,29,32)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497416
PNG
(CHEMBL3339118)
Show SMILES CC1(CC1)c1cc(NC(=O)Nc2ccc(cc2)C(F)(F)F)n(n1)-c1ccccc1
Show InChI InChI=1S/C21H19F3N4O/c1-20(11-12-20)17-13-18(28(27-17)16-5-3-2-4-6-16)26-19(29)25-15-9-7-14(8-10-15)21(22,23)24/h2-10,13H,11-12H2,1H3,(H2,25,26,29)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497402
PNG
(CHEMBL3339110)
Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1cc(nn1-c1ccccc1)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C21H16F6N4O/c22-20(23,24)14-8-4-5-9-15(14)28-18(32)29-17-12-16(19(10-11-19)21(25,26)27)30-31(17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H2,28,29,32)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497369
PNG
(CHEMBL3339098)
Show SMILES Clc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1
Show InChI InChI=1S/C21H21ClN4O/c22-16-10-12-17(13-11-16)23-21(27)24-20-14-19(15-6-4-5-7-15)25-26(20)18-8-2-1-3-9-18/h1-3,8-15H,4-7H2,(H2,23,24,27)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497403
PNG
(CHEMBL3339111)
Show SMILES FC(F)(F)C1(CC1)c1cc(NC(=O)Nc2cccc(Br)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H16BrF3N4O/c21-13-5-4-6-14(11-13)25-18(29)26-17-12-16(19(9-10-19)20(22,23)24)27-28(17)15-7-2-1-3-8-15/h1-8,11-12H,9-10H2,(H2,25,26,29)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497418
PNG
(CHEMBL3339112)
Show SMILES COc1ccccc1NC(=O)Nc1cc(nn1-c1ccccc1)C1(CC1)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O2/c1-30-16-10-6-5-9-15(16)25-19(29)26-18-13-17(20(11-12-20)21(22,23)24)27-28(18)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H2,25,26,29)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437967
PNG
(CHEMBL2409112)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)-c2ccccc2)cc1F
Show InChI InChI=1S/C22H16F2N4O/c23-18-12-11-16(13-19(18)24)25-22(29)26-21-14-20(15-7-3-1-4-8-15)27-28(21)17-9-5-2-6-10-17/h1-14H,(H2,25,26,29)
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Article
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437965
PNG
(CHEMBL2409115)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)cc1F
Show InChI InChI=1S/C20H18F2N4O/c21-16-10-9-14(11-17(16)22)23-20(27)24-19-12-18(13-5-4-6-13)25-26(19)15-7-2-1-3-8-15/h1-3,7-13H,4-6H2,(H2,23,24,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437963
PNG
(CHEMBL2409117)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C(F)(F)F)cc1F
Show InChI InChI=1S/C17H11F5N4O/c18-12-7-6-10(8-13(12)19)23-16(27)24-15-9-14(17(20,21)22)25-26(15)11-4-2-1-3-5-11/h1-9H,(H2,23,24,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture & Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Rattus norvegicus)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/an/an/a 0.0614n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q21G0JR7
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Rattus norvegicus)
BDBM50004233
PNG
(5,11-dimethyl-2H-pyrido[4,3-b]carbazole | CHEMBL12...)
Show SMILES Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12
Show InChI InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
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n/an/an/an/a 1.49n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q21G0JR7
More data for this
Ligand-Target Pair
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