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Found 69 hits Enz. Inhib. hit(s) with Target = 'G protein-activated inward rectifier potassium channel 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437954
PNG
(CHEMBL2409269)
Show SMILES Fc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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n/an/a 450n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437955
PNG
(CHEMBL2409135)
Show SMILES Cc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c1-15-6-5-7-17(12-15)22-21(26)23-20-14-18(13-16-10-11-16)24-25(20)19-8-3-2-4-9-19/h2-9,12,14,16H,10-11,13H2,1H3,(H2,22,23,26)
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n/an/a 520n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437953
PNG
(CHEMBL2409098)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-5-4-6-16(12-15)25-20(29)26-19-13-17(11-14-9-10-14)27-28(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,25,26,29)
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n/an/a 540n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437988
PNG
(CHEMBL2409101)
Show SMILES Clc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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n/an/a 630n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437990
PNG
(CHEMBL2409099)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1
Show InChI InChI=1S/C20H19FN4O/c21-15-8-10-16(11-9-15)22-20(26)23-19-13-17(12-14-6-7-14)24-25(19)18-4-2-1-3-5-18/h1-5,8-11,13-14H,6-7,12H2,(H2,22,23,26)
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n/an/a 640n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437989
PNG
(CHEMBL2409100)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-17-11-14(8-9-18(17)22)23-20(27)24-19-12-15(10-13-6-7-13)25-26(19)16-4-2-1-3-5-16/h1-5,8-9,11-13H,6-7,10H2,(H2,23,24,27)
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n/an/a 810n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437962
PNG
(CHEMBL2409119)
Show SMILES Cc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H20N4O/c1-14-6-5-7-16(12-14)21-20(25)22-19-13-18(15-10-11-15)23-24(19)17-8-3-2-4-9-17/h2-9,12-13,15H,10-11H2,1H3,(H2,21,22,25)
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n/an/a 850n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437960
PNG
(CHEMBL2409122)
Show SMILES CSc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H20N4OS/c1-26-17-9-5-6-15(12-17)21-20(25)22-19-13-18(14-10-11-14)23-24(19)16-7-3-2-4-8-16/h2-9,12-14H,10-11H2,1H3,(H2,21,22,25)
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n/an/a 950n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437961
PNG
(CHEMBL2409121)
Show SMILES Fc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)c1
Show InChI InChI=1S/C19H17FN4O/c20-14-5-4-6-15(11-14)21-19(25)22-18-12-17(13-9-10-13)23-24(18)16-7-2-1-3-8-16/h1-8,11-13H,9-10H2,(H2,21,22,25)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437986
PNG
(CHEMBL2409103)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-8-5-9-16(12-15)25-20(29)26-19-13-18(14-6-4-7-14)27-28(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,25,26,29)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437987
PNG
(CHEMBL2409102)
Show SMILES Clc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437984
PNG
(CHEMBL2409105)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-16-11-14(9-10-17(16)22)23-20(27)24-19-12-18(13-5-4-6-13)25-26(19)15-7-2-1-3-8-15/h1-3,7-13H,4-6H2,(H2,23,24,27)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437985
PNG
(CHEMBL2409104)
Show SMILES Brc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19BrN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437966
PNG
(CHEMBL2409114)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H18F2N4O/c1-12(2)17-11-18(25(24-17)14-6-4-3-5-7-14)23-19(26)22-13-8-9-15(20)16(21)10-13/h3-12H,1-2H3,(H2,22,23,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437958
PNG
(CHEMBL2409124)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H19FN4O/c1-13(2)17-12-18(24(23-17)16-9-4-3-5-10-16)22-19(25)21-15-8-6-7-14(20)11-15/h3-13H,1-2H3,(H2,21,22,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437959
PNG
(CHEMBL2409123)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H19F3N4O/c1-13(2)17-12-18(27(26-17)16-9-4-3-5-10-16)25-19(28)24-15-8-6-7-14(11-15)20(21,22)23/h3-13H,1-2H3,(H2,24,25,28)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437957
PNG
(CHEMBL2409125)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(C)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-10-5-4-6-11-17)22-20(25)21-16-9-7-8-15(3)12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437956
PNG
(CHEMBL2409126)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(C)cc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-7-5-4-6-8-17)22-20(25)21-16-11-9-15(3)10-12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437964
PNG
(CHEMBL2409116)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1F
Show InChI InChI=1S/C21H20F2N4O/c22-17-11-10-15(12-18(17)23)24-21(28)25-20-13-19(14-6-4-5-7-14)26-27(20)16-8-2-1-3-9-16/h1-3,8-14H,4-7H2,(H2,24,25,28)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437965
PNG
(CHEMBL2409115)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)cc1F
Show InChI InChI=1S/C20H18F2N4O/c21-16-10-9-14(11-17(16)22)23-20(27)24-19-12-18(13-5-4-6-13)25-26(19)15-7-2-1-3-8-15/h1-3,7-13H,4-6H2,(H2,23,24,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437967
PNG
(CHEMBL2409112)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)-c2ccccc2)cc1F
Show InChI InChI=1S/C22H16F2N4O/c23-18-12-11-16(13-19(18)24)25-22(29)26-21-14-20(15-7-3-1-4-8-15)27-28(21)17-9-5-2-6-10-17/h1-14H,(H2,25,26,29)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437963
PNG
(CHEMBL2409117)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C(F)(F)F)cc1F
Show InChI InChI=1S/C17H11F5N4O/c18-12-7-6-10(8-13(12)19)23-16(27)24-15-9-14(17(20,21)22)25-26(15)11-4-2-1-3-5-11/h1-9H,(H2,23,24,27)
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n/an/a 3.00E+4n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439407
PNG
(CHEMBL2420535)
Show SMILES FC(F)(F)c1ccc(NC(=O)Cc2ccccc2Cl)cc1
Show InChI InChI=1S/C15H11ClF3NO/c16-13-4-2-1-3-10(13)9-14(21)20-12-7-5-11(6-8-12)15(17,18)19/h1-8H,9H2,(H,20,21)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439408
PNG
(CHEMBL2420534)
Show SMILES Clc1cccc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C14H11Cl2NO/c15-11-5-3-6-12(9-11)17-14(18)8-10-4-1-2-7-13(10)16/h1-7,9H,8H2,(H,17,18)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439409
PNG
(CHEMBL2420533)
Show SMILES Clc1ccc(NC(=O)Cc2ccccc2Cl)cc1
Show InChI InChI=1S/C14H11Cl2NO/c15-11-5-7-12(8-6-11)17-14(18)9-10-3-1-2-4-13(10)16/h1-8H,9H2,(H,17,18)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439410
PNG
(CHEMBL2420532)
Show SMILES FC(F)(F)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Cl
Show InChI InChI=1S/C15H10Cl2F3NO/c16-12-4-2-1-3-9(12)7-14(22)21-10-5-6-13(17)11(8-10)15(18,19)20/h1-6,8H,7H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439411
PNG
(CHEMBL2420531)
Show SMILES FC(F)(F)c1cc(Cl)cc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C15H10Cl2F3NO/c16-11-6-10(15(18,19)20)7-12(8-11)21-14(22)5-9-3-1-2-4-13(9)17/h1-4,6-8H,5H2,(H,21,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439412
PNG
(CHEMBL2420530)
Show SMILES FC(F)Oc1cccc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C15H12ClF2NO2/c16-13-7-2-1-4-10(13)8-14(20)19-11-5-3-6-12(9-11)21-15(17)18/h1-7,9,15H,8H2,(H,19,20)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439413
PNG
(CHEMBL2420529)
Show SMILES CC(C)(C)c1cccc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C18H20ClNO/c1-18(2,3)14-8-6-9-15(12-14)20-17(21)11-13-7-4-5-10-16(13)19/h4-10,12H,11H2,1-3H3,(H,20,21)
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n/an/an/an/a 5.90E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439414
PNG
(CHEMBL2420550)
Show SMILES CS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1F
Show InChI InChI=1S/C15H13ClFNO3S/c1-22(20,21)14-9-11(6-7-13(14)17)18-15(19)8-10-4-2-3-5-12(10)16/h2-7,9H,8H2,1H3,(H,18,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439415
PNG
(CHEMBL2420549)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2cccc(c2)C#N)ccc1C
Show InChI InChI=1S/C17H18N4O3S/c1-12-7-8-15(10-16(12)25(23,24)21(2)3)20-17(22)19-14-6-4-5-13(9-14)11-18/h4-10H,1-3H3,(H2,19,20,22)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439416
PNG
(CHEMBL2420548)
Show SMILES COc1ccc(OC)c(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)N(C)C)c1
Show InChI InChI=1S/C18H23N3O5S/c1-12-6-7-13(10-17(12)27(23,24)21(2)3)19-18(22)20-15-11-14(25-4)8-9-16(15)26-5/h6-11H,1-5H3,(H2,19,20,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439417
PNG
(CHEMBL2420547)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(cc2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C17H18F3N3O3S/c1-11-4-7-14(10-15(11)27(25,26)23(2)3)22-16(24)21-13-8-5-12(6-9-13)17(18,19)20/h4-10H,1-3H3,(H2,21,22,24)
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n/an/an/an/a 1.50E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439418
PNG
(CHEMBL2420546)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2Cl)ccc1C
Show InChI InChI=1S/C16H18ClN3O3S/c1-11-8-9-12(10-15(11)24(22,23)20(2)3)18-16(21)19-14-7-5-4-6-13(14)17/h4-10H,1-3H3,(H2,18,19,21)
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n/an/an/an/a 2.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439419
PNG
(CHEMBL2420545)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2cccc(F)c2)ccc1C
Show InChI InChI=1S/C16H18FN3O3S/c1-11-7-8-14(10-15(11)24(22,23)20(2)3)19-16(21)18-13-6-4-5-12(17)9-13/h4-10H,1-3H3,(H2,18,19,21)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439420
PNG
(CHEMBL2420544)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2F)ccc1C
Show InChI InChI=1S/C16H18FN3O3S/c1-11-8-9-12(10-15(11)24(22,23)20(2)3)18-16(21)19-14-7-5-4-6-13(14)17/h4-10H,1-3H3,(H2,18,19,21)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439421
PNG
(CHEMBL2420543)
Show SMILES COc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)N(C)C)cc1
Show InChI InChI=1S/C17H21N3O4S/c1-12-5-6-14(11-16(12)25(22,23)20(2)3)19-17(21)18-13-7-9-15(24-4)10-8-13/h5-11H,1-4H3,(H2,18,19,21)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439422
PNG
(CHEMBL2420542)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(C)c(Cl)c2)ccc1C
Show InChI InChI=1S/C17H20ClN3O3S/c1-11-5-7-13(9-15(11)18)19-17(22)20-14-8-6-12(2)16(10-14)25(23,24)21(3)4/h5-10H,1-4H3,(H2,19,20,22)
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n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439423
PNG
(CHEMBL2420541)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(Cl)cc2)ccc1C
Show InChI InChI=1S/C16H18ClN3O3S/c1-11-4-7-14(10-15(11)24(22,23)20(2)3)19-16(21)18-13-8-5-12(17)6-9-13/h4-10H,1-3H3,(H2,18,19,21)
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n/an/an/an/a 3.30E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50439424
PNG
(CHEMBL2420540)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)ccc1C
Show InChI InChI=1S/C16H19N3O3S/c1-12-9-10-14(11-15(12)23(21,22)19(2)3)18-16(20)17-13-7-5-4-6-8-13/h4-11H,1-3H3,(H2,17,18,20)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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n/an/an/an/a 160n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50115223
PNG
(1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-ure...)
Show SMILES Cc1cc(NC(=O)Nc2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H16N4O/c1-13-12-16(21(20-13)15-10-6-3-7-11-15)19-17(22)18-14-8-4-2-5-9-14/h2-12H,1H3,(H2,18,19,22)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437968
PNG
(CHEMBL2409134)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)n(Cc2ccccc2)n1
Show InChI InChI=1S/C21H21F3N4O/c1-14(2)18-12-19(28(27-18)13-15-7-4-3-5-8-15)26-20(29)25-17-10-6-9-16(11-17)21(22,23)24/h3-12,14H,13H2,1-2H3,(H2,25,26,29)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437969
PNG
(CHEMBL2409133)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(Cl)c2)n(Cc2ccccc2)n1
Show InChI InChI=1S/C20H21ClN4O/c1-14(2)18-12-19(25(24-18)13-15-7-4-3-5-8-15)23-20(26)22-17-10-6-9-16(21)11-17/h3-12,14H,13H2,1-2H3,(H2,22,23,26)
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n/an/an/an/a 470n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437970
PNG
(CHEMBL2409132)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-16-10-15(8-9-17(16)22)23-20(27)24-19-11-18(14-6-7-14)25-26(19)12-13-4-2-1-3-5-13/h1-5,8-11,14H,6-7,12H2,(H2,23,24,27)
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n/an/an/an/a 210n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437971
PNG
(CHEMBL2409131)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1
Show InChI InChI=1S/C20H19FN4O/c21-16-8-10-17(11-9-16)22-20(26)23-19-12-18(15-6-7-15)24-25(19)13-14-4-2-1-3-5-14/h1-5,8-12,15H,6-7,13H2,(H2,22,23,26)
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n/an/an/an/a 350n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437972
PNG
(CHEMBL2409130)
Show SMILES Cc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1
Show InChI InChI=1S/C21H22N4O/c1-15-7-11-18(12-8-15)22-21(26)23-20-13-19(17-9-10-17)24-25(20)14-16-5-3-2-4-6-16/h2-8,11-13,17H,9-10,14H2,1H3,(H2,22,23,26)
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n/an/an/an/a 570n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437973
PNG
(CHEMBL2409129)
Show SMILES Brc1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H19BrN4O/c21-16-7-4-8-17(11-16)22-20(26)23-19-12-18(15-9-10-15)24-25(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,22,23,26)
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n/an/an/an/a 380n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437974
PNG
(CHEMBL2409128)
Show SMILES Fc1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H19FN4O/c21-16-7-4-8-17(11-16)22-20(26)23-19-12-18(15-9-10-15)24-25(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,22,23,26)
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n/an/an/an/a 530n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens)
BDBM50437975
PNG
(CHEMBL2409127)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)16-7-4-8-17(11-16)25-20(29)26-19-12-18(15-9-10-15)27-28(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,25,26,29)
PDB
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n/an/an/an/a 340n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
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