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Compile Data Set for Download or QSAR

Found 27 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor family C group 6 member A' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133685
PNG
(CHEMBL3633663)
Show SMILES O=C(CN1CCCC(C1)C(=O)N1CCOCC1)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1/C26H29N3O3/c30-23(18-28-12-6-9-20(17-28)26(31)29-13-15-32-16-14-29)24-21-10-4-5-11-22(21)27-25(24)19-7-2-1-3-8-19/h1-5,7-8,10-11,20,27H,6,9,12-18H2
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133685
PNG
(CHEMBL3633663)
Show SMILES O=C(CN1CCCC(C1)C(=O)N1CCOCC1)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1/C26H29N3O3/c30-23(18-28-12-6-9-20(17-28)26(31)29-13-15-32-16-14-29)24-21-10-4-5-11-22(21)27-25(24)19-7-2-1-3-8-19/h1-5,7-8,10-11,20,27H,6,9,12-18H2
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133679
PNG
(CHEMBL3633665)
Show SMILES CN(CCN1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H27N3O2/c1-25(11-12-26-13-15-28-16-14-26)17-21(27)22-19-9-5-6-10-20(19)24-23(22)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 6.17E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133679
PNG
(CHEMBL3633665)
Show SMILES CN(CCN1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H27N3O2/c1-25(11-12-26-13-15-28-16-14-26)17-21(27)22-19-9-5-6-10-20(19)24-23(22)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 6.17E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133682
PNG
(CHEMBL3633656)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1C(=O)CN(C)CC(=O)N1CCOCC1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-11-13-31-14-12-27)15-21(28)23-19-5-3-4-6-20(19)25-24(23)17-7-9-18(30-2)10-8-17/h3-10,25H,11-16H2,1-2H3
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n/an/a 9.33E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133682
PNG
(CHEMBL3633656)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1C(=O)CN(C)CC(=O)N1CCOCC1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-11-13-31-14-12-27)15-21(28)23-19-5-3-4-6-20(19)25-24(23)17-7-9-18(30-2)10-8-17/h3-10,25H,11-16H2,1-2H3
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n/an/a 9.33E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133681
PNG
(CHEMBL3633655)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24FN3O3/c1-26(15-21(29)27-10-12-30-13-11-27)14-20(28)22-18-4-2-3-5-19(18)25-23(22)16-6-8-17(24)9-7-16/h2-9,25H,10-15H2,1H3
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n/an/a 2.13E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133681
PNG
(CHEMBL3633655)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C23H24FN3O3/c1-26(15-21(29)27-10-12-30-13-11-27)14-20(28)22-18-4-2-3-5-19(18)25-23(22)16-6-8-17(24)9-7-16/h2-9,25H,10-15H2,1H3
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n/an/a 2.14E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133676
PNG
(CHEMBL3633650)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,24H,11-16H2,1H3
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n/an/a 2.19E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133676
PNG
(CHEMBL3633650)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,24H,11-16H2,1H3
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n/an/a 2.19E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133677
PNG
(CHEMBL3633651)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccc(F)cc12)-c1ccccc1
Show InChI InChI=1S/C23H24FN3O3/c1-26(15-21(29)27-9-11-30-12-10-27)14-20(28)22-18-13-17(24)7-8-19(18)25-23(22)16-5-3-2-4-6-16/h2-8,13,25H,9-12,14-15H2,1H3
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n/an/a 3.98E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133677
PNG
(CHEMBL3633651)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccc(F)cc12)-c1ccccc1
Show InChI InChI=1S/C23H24FN3O3/c1-26(15-21(29)27-9-11-30-12-10-27)14-20(28)22-18-13-17(24)7-8-19(18)25-23(22)16-5-3-2-4-6-16/h2-8,13,25H,9-12,14-15H2,1H3
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n/an/a 3.98E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133686
PNG
(CHEMBL3633664)
Show SMILES CN(CC(=O)N1CCCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O2/c1-25(16-21(28)26-13-7-8-14-26)15-20(27)22-18-11-5-6-12-19(18)24-23(22)17-9-3-2-4-10-17/h2-6,9-12,24H,7-8,13-16H2,1H3
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n/an/a 5.73E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133686
PNG
(CHEMBL3633664)
Show SMILES CN(CC(=O)N1CCCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O2/c1-25(16-21(28)26-13-7-8-14-26)15-20(27)22-18-11-5-6-12-19(18)24-23(22)17-9-3-2-4-10-17/h2-6,9-12,24H,7-8,13-16H2,1H3
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n/an/a 5.75E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133680
PNG
(CHEMBL3633654)
Show SMILES COc1ccc2[nH]c(c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1)-c1ccccc1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-10-12-31-13-11-27)15-21(28)23-19-14-18(30-2)8-9-20(19)25-24(23)17-6-4-3-5-7-17/h3-9,14,25H,10-13,15-16H2,1-2H3
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n/an/a 6.61E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133680
PNG
(CHEMBL3633654)
Show SMILES COc1ccc2[nH]c(c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1)-c1ccccc1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-10-12-31-13-11-27)15-21(28)23-19-14-18(30-2)8-9-20(19)25-24(23)17-6-4-3-5-7-17/h3-9,14,25H,10-13,15-16H2,1-2H3
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n/an/a 6.61E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133678
PNG
(CHEMBL3633653)
Show SMILES CN(CCc1c([nH]c2ccccc12)-c1ccccc1)CC(=O)N1CCOCC1
Show InChI InChI=1S/C23H27N3O2/c1-25(17-22(27)26-13-15-28-16-14-26)12-11-20-19-9-5-6-10-21(19)24-23(20)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 1.32E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133678
PNG
(CHEMBL3633653)
Show SMILES CN(CCc1c([nH]c2ccccc12)-c1ccccc1)CC(=O)N1CCOCC1
Show InChI InChI=1S/C23H27N3O2/c1-25(17-22(27)26-13-15-28-16-14-26)12-11-20-19-9-5-6-10-21(19)24-23(20)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 1.32E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133683
PNG
(CHEMBL3633657)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccco1
Show InChI InChI=1S/C21H23N3O4/c1-23(14-19(26)24-8-11-27-12-9-24)13-17(25)20-15-5-2-3-6-16(15)22-21(20)18-7-4-10-28-18/h2-7,10,22H,8-9,11-14H2,1H3
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n/an/a 2.45E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133683
PNG
(CHEMBL3633657)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccco1
Show InChI InChI=1S/C21H23N3O4/c1-23(14-19(26)24-8-11-27-12-9-24)13-17(25)20-15-5-2-3-6-16(15)22-21(20)18-7-4-10-28-18/h2-7,10,22H,8-9,11-14H2,1H3
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n/an/a 2.48E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133684
PNG
(CHEMBL3633662)
Show SMILES O=C(CNCC(=O)c1c([nH]c2ccccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C22H23N3O3/c26-19(14-23-15-20(27)25-10-12-28-13-11-25)21-17-8-4-5-9-18(17)24-22(21)16-6-2-1-3-7-16/h1-9,23-24H,10-15H2
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n/an/a 2.56E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133684
PNG
(CHEMBL3633662)
Show SMILES O=C(CNCC(=O)c1c([nH]c2ccccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C22H23N3O3/c26-19(14-23-15-20(27)25-10-12-28-13-11-25)21-17-8-4-5-9-18(17)24-22(21)16-6-2-1-3-7-16/h1-9,23-24H,10-15H2
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n/an/a 2.57E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133688
PNG
(CHEMBL3633658)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccc(CC(=O)N(C)C)cc12)-c1ccccc1
Show InChI InChI=1S/C27H32N4O4/c1-29(2)24(33)16-19-9-10-22-21(15-19)26(27(28-22)20-7-5-4-6-8-20)23(32)17-30(3)18-25(34)31-11-13-35-14-12-31/h4-10,15,28H,11-14,16-18H2,1-3H3
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n/an/a>4.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133689
PNG
(CHEMBL3633659)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c(CO)[nH]c2ccccc12
Show InChI InChI=1S/C18H23N3O4/c1-20(11-17(24)21-6-8-25-9-7-21)10-16(23)18-13-4-2-3-5-14(13)19-15(18)12-22/h2-5,19,22H,6-12H2,1H3
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University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133690
PNG
(CHEMBL3633660)
Show SMILES CN(CC(O)c1c([nH]c2ccccc12)-c1ccccc1)CC(=O)N1CCOCC1
Show InChI InChI=1/C23H27N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,20,24,27H,11-16H2,1H3
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University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133691
PNG
(CHEMBL3633661)
Show SMILES CN(CC(=O)N1CCOCC1)C(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-24(15-19(26)25-11-13-28-14-12-25)22(27)20-17-9-5-6-10-18(17)23-21(20)16-7-3-2-4-8-16/h2-10,23H,11-15H2,1H3
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n/an/a>4.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
G-protein coupled receptor family C group 6 member A


(Mus musculus)
BDBM50133687
PNG
(CHEMBL3633652)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C17H21N3O3/c1-19(12-17(22)20-6-8-23-9-7-20)11-16(21)14-10-18-15-5-3-2-4-13(14)15/h2-5,10,18H,6-9,11-12H2,1H3
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n/an/a>4.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GPRC6A receptor expressed in HEK293 cells assessed as inhibition of L-ornithine-induced inositol monophosphate accumulat...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair