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Compile Data Set for Download or QSAR

Found 117 hits Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor kinase 2' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50049820
PNG
(4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2...)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2ncnc(N)c12
Show InChI InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16)/t5-,7-,8-,12-/m1/s1
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6.70E+4n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of beta-adrenergic receptor kinase(unknown origin)


J Biol Chem 282: 15271-83 (2007)


Article DOI: 10.1074/jbc.M701362200
BindingDB Entry DOI: 10.7270/Q2XD11FR
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258598
PNG
(US9493490, Example 10 | US9493490, G)
Show SMILES C[C@@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m1/s1
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n/an/a 13.9n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258594
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2)c(F)c1
Show InChI InChI=1S/C15H15BFNO3/c1-9(18)10-3-5-15(14(17)6-10)21-12-4-2-11-8-20-16(19)13(11)7-12/h2-7,9,19H,8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258595
PNG
(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-13(5-3-11-8-20-16(19)15(9)11)21-14-4-2-10(7-18)6-12(14)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258596
PNG
(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)
Show SMILES CC(N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258597
PNG
(US9493490, Example 9 | US9493490, F)
Show SMILES C[C@H](N)c1ccc(Oc2ccc3COB(O)c3c2C)c(F)c1
Show InChI InChI=1S/C16H17BFNO3/c1-9-14(5-4-12-8-21-17(20)16(9)12)22-15-6-3-11(10(2)19)7-13(15)18/h3-7,10,20H,8,19H2,1-2H3/t10-/m0/s1
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n/an/a>20n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258599
PNG
(US9493490, Example 11 | US9493490, L | US9493490, ...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CNC(=O)OC(C)(C)C)c1F
Show InChI InChI=1S/C20H23BFNO5/c1-12-15(9-8-14-11-26-21(25)17(12)14)27-16-7-5-6-13(18(16)22)10-23-19(24)28-20(2,3)4/h5-9,25H,10-11H2,1-4H3,(H,23,24)
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n/an/a>30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM258600
PNG
(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)
Show SMILES Cc1c2B(O)OCc2ccc1Oc1cccc(CN)c1F
Show InChI InChI=1S/C15H15BFNO3/c1-9-12(6-5-11-8-20-16(19)14(9)11)21-13-4-2-3-10(7-18)15(13)17/h2-6,19H,7-8,18H2,1H3
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n/an/a>30n/an/an/an/an/an/a



Anacor Pharmaceuticals, Inc.

US Patent


Assay Description
Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...


US Patent US9493490 (2016)


BindingDB Entry DOI: 10.7270/Q2R2109J
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of GRK2-mediated bovine tubulin phosphorylation by scintillation counting


J Med Chem 53: 1867-70 (2010)


Article DOI: 10.1021/jm9017515
BindingDB Entry DOI: 10.7270/Q2P26Z8Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50441685
PNG
(CHEMBL2435840)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(O)=O
Show InChI InChI=1S/C41H74N16O10/c1-7-23(6)32(39(66)67)57-38(65)30(19-58)56-37(64)29(16-24-18-47-20-50-24)55-34(61)26(11-9-13-49-41(45)46)52-33(60)25(10-8-12-48-40(43)44)53-36(63)28(15-22(4)5)54-35(62)27(14-21(2)3)51-31(59)17-42/h18,20-23,25-30,32,58H,7-17,19,42H2,1-6H3,(H,47,50)(H,51,59)(H,52,60)(H,53,63)(H,54,62)(H,55,61)(H,56,64)(H,57,65)(H,66,67)(H4,43,44,48)(H4,45,46,49)/t23-,25-,26+,27-,28-,29-,30-,32-/m0/s1
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n/an/a 340n/an/an/an/an/an/a



Federico II" University of Naples

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin)-mediated phosphorylation of rhodopsin in bovine-rod outer segment membranes incubated under white light conditio...


Eur J Med Chem 69: 384-92 (2013)


Article DOI: 10.1016/j.ejmech.2013.08.039
BindingDB Entry DOI: 10.7270/Q27W6DNH
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444090
PNG
(CHEMBL3093151)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)N1CCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O/c25-23-20(24-29-21-4-3-19(12-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
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n/an/a 460n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50134187
PNG
(CHEMBL3735506)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C23H26F2N4O2/c1-31-12-11-29-9-7-15(8-10-29)14-26-23(30)22-18-13-16(5-6-20(18)27-28-22)17-3-2-4-19(24)21(17)25/h2-6,13,15H,7-12,14H2,1H3,(H,26,30)(H,27,28)
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n/an/a 530n/an/an/an/an/an/a



Angelini S.p.A.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GRK2 by LANCE assay


J Med Chem 58: 8920-37 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01208
BindingDB Entry DOI: 10.7270/Q2416ZX5
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444108
PNG
(CHEMBL3093243)
Show SMILES COc1ccc(cc1)N(C(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1ccccc1
Show InChI InChI=1S/C34H32N8O3/c1-44-28-10-8-27(9-11-28)42(26-5-3-2-4-6-26)34(43)39-24-7-12-30-31(18-24)45-33(40-30)29-17-22(19-37-32(29)35)23-20-38-41(21-23)25-13-15-36-16-14-25/h2-12,17-21,25,36H,13-16H2,1H3,(H2,35,37)(H,39,43)
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n/an/a 660n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444137
PNG
(CHEMBL3093258)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)N1CCCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H29N7O/c26-24-21(12-17(14-28-24)18-15-29-32(16-18)19-6-8-27-9-7-19)25-30-22-13-20(4-5-23(22)33-25)31-10-2-1-3-11-31/h4-5,12-16,19,27H,1-3,6-11H2,(H2,26,28)
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n/an/a 850n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444104
PNG
(CHEMBL3093247)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)c3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H24FN7O2/c28-19-3-1-16(2-4-19)26(36)33-20-5-6-23-24(12-20)37-27(34-23)22-11-17(13-31-25(22)29)18-14-32-35(15-18)21-7-9-30-10-8-21/h1-6,11-15,21,30H,7-10H2,(H2,29,31)(H,33,36)
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n/an/a 960n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444135
PNG
(CHEMBL3093260)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)N1CCCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O/c25-23-20(24-29-21-12-19(3-4-22(21)32-24)30-9-1-2-10-30)11-16(13-27-23)17-14-28-31(15-17)18-5-7-26-8-6-18/h3-4,11-15,18,26H,1-2,5-10H2,(H2,25,27)
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n/an/a 1.65E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444107
PNG
(CHEMBL3093244)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H25FN8O2/c28-18-1-3-19(4-2-18)33-27(37)34-20-5-6-23-24(12-20)38-26(35-23)22-11-16(13-31-25(22)29)17-14-32-36(15-17)21-7-9-30-10-8-21/h1-6,11-15,21,30H,7-10H2,(H2,29,31)(H2,33,34,37)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384025
PNG
(CHEMBL2032279 | CHEMBL2079395)
Show SMILES Cc1cc2nc(oc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-6-17-19(8-18(12)28)29-21(26-17)16-7-13(9-24-20(16)22)14-10-25-27(11-14)15-2-4-23-5-3-15/h6-11,15,23,28H,2-5H2,1H3,(H2,22,24)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444121
PNG
(CHEMBL3093155)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3cc(F)cc(F)c3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H23F2N7O/c27-17-8-18(28)10-20(9-17)33-19-1-2-23-24(11-19)36-26(34-23)22-7-15(12-31-25(22)29)16-13-32-35(14-16)21-3-5-30-6-4-21/h1-2,7-14,21,30,33H,3-6H2,(H2,29,31)
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n/an/a 2.26E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384018
PNG
(CHEMBL2032286)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)Nc3ccccc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H26N8O2/c28-25-22(12-17(14-30-25)18-15-31-35(16-18)21-8-10-29-11-9-21)26-34-23-7-6-20(13-24(23)37-26)33-27(36)32-19-4-2-1-3-5-19/h1-7,12-16,21,29H,8-11H2,(H2,28,30)(H2,32,33,36)
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n/an/a 2.63E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444101
PNG
(CHEMBL3093250)
Show SMILES COc1ccc(cc1)-c1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H26N6O2/c1-34-22-5-2-17(3-6-22)18-4-7-24-25(13-18)35-27(32-24)23-12-19(14-30-26(23)28)20-15-31-33(16-20)21-8-10-29-11-9-21/h2-7,12-16,21,29H,8-11H2,1H3,(H2,28,30)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384034
PNG
(CHEMBL2032159 | CHEMBL2032299)
Show SMILES CC(=O)Nc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H23N7O2/c1-13(30)27-16-2-3-20-19(9-16)28-22(31-20)18-8-14(10-25-21(18)23)15-11-26-29(12-15)17-4-6-24-7-5-17/h2-3,8-12,17,24H,4-7H2,1H3,(H2,23,25)(H,27,30)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444106
PNG
(CHEMBL3093245)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)c3ccccc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H25N7O2/c28-25-22(12-18(14-30-25)19-15-31-34(16-19)21-8-10-29-11-9-21)27-33-23-7-6-20(13-24(23)36-27)32-26(35)17-4-2-1-3-5-17/h1-7,12-16,21,29H,8-11H2,(H2,28,30)(H,32,35)
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n/an/a 3.19E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444128
PNG
(CHEMBL3093147)
Show SMILES CCCNc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C23H27N7O/c1-2-7-26-17-3-4-21-20(11-17)29-23(31-21)19-10-15(12-27-22(19)24)16-13-28-30(14-16)18-5-8-25-9-6-18/h3-4,10-14,18,25-26H,2,5-9H2,1H3,(H2,24,27)
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n/an/a 3.19E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444105
PNG
(CHEMBL3093246)
Show SMILES Nc1ncc(cc1-c1nc2ccc(NC(=O)c3ccc(cc3)C(F)(F)F)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H24F3N7O2/c29-28(30,31)19-3-1-16(2-4-19)26(39)36-20-5-6-23-24(12-20)40-27(37-23)22-11-17(13-34-25(22)32)18-14-35-38(15-18)21-7-9-33-10-8-21/h1-6,11-15,21,33H,7-10H2,(H2,32,34)(H,36,39)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444111
PNG
(CHEMBL3093164)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3ccc(nn3)-c3ccccc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C30H26N8O2/c31-29-24(14-20(16-33-29)21-17-34-38(18-21)22-10-12-32-13-11-22)30-35-26-7-6-23(15-27(26)40-30)39-28-9-8-25(36-37-28)19-4-2-1-3-5-19/h1-9,14-18,22,32H,10-13H2,(H2,31,33)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444103
PNG
(CHEMBL3093248)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H27N7O3/c1-37-22-5-2-17(3-6-22)27(36)33-20-4-7-24-25(13-20)38-28(34-24)23-12-18(14-31-26(23)29)19-15-32-35(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H,33,36)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444116
PNG
(CHEMBL3093159)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)-c1ccc2[nH]ncc2c1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H24N8O/c28-26-22(10-18(12-30-26)20-14-32-35(15-20)21-5-7-29-8-6-21)27-33-24-4-2-17(11-25(24)36-27)16-1-3-23-19(9-16)13-31-34-23/h1-4,9-15,21,29H,5-8H2,(H2,28,30)(H,31,34)
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n/an/a 4.05E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384020
PNG
(CHEMBL2032284 | CHEMBL2079522)
Show SMILES Nc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c21-14-1-2-18-17(8-14)26-20(28-18)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6,21H2,(H2,22,24)
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n/an/a 4.22E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444132
PNG
(CHEMBL3093144)
Show SMILES Nc1ncc(cc1-c1nc2cc(Nc3ccccc3)ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H25N7O/c27-25-22(12-17(14-29-25)18-15-30-33(16-18)21-8-10-28-11-9-21)26-32-23-13-20(6-7-24(23)34-26)31-19-4-2-1-3-5-19/h1-7,12-16,21,28,31H,8-11H2,(H2,27,29)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444125
PNG
(CHEMBL3093150)
Show SMILES Nc1ncc(cc1-c1nc2ccc(cc2o1)N1CCOCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O2/c25-23-20(11-16(13-27-23)17-14-28-31(15-17)18-3-5-26-6-4-18)24-29-21-2-1-19(12-22(21)33-24)30-7-9-32-10-8-30/h1-2,11-15,18,26H,3-10H2,(H2,25,27)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444130
PNG
(CHEMBL3093145)
Show SMILES CCCCNc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H29N7O/c1-2-3-8-27-18-4-5-22-21(12-18)30-24(32-22)20-11-16(13-28-23(20)25)17-14-29-31(15-17)19-6-9-26-10-7-19/h4-5,11-15,19,26-27H,2-3,6-10H2,1H3,(H2,25,28)
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n/an/a 5.52E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444123
PNG
(CHEMBL3093153)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H23F6N7O/c29-27(30,31)17-8-18(28(32,33)34)10-20(9-17)39-19-1-2-23-24(11-19)42-26(40-23)22-7-15(12-37-25(22)35)16-13-38-41(14-16)21-3-5-36-6-4-21/h1-2,7-14,21,36,39H,3-6H2,(H2,35,37)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444109
PNG
(CHEMBL3093242)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccccn3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H24N8O/c26-24-20(11-16(13-29-24)17-14-30-33(15-17)19-6-9-27-10-7-19)25-32-21-5-4-18(12-22(21)34-25)31-23-3-1-2-8-28-23/h1-5,8,11-15,19,27H,6-7,9-10H2,(H2,26,29)(H,28,31)
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n/an/a 6.05E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384019
PNG
(CHEMBL2032285 | CHEMBL2079397)
Show SMILES Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H21N7O/c21-14-1-2-17-18(8-14)28-20(26-17)16-7-12(9-24-19(16)22)13-10-25-27(11-13)15-3-5-23-6-4-15/h1-2,7-11,15,23H,3-6,21H2,(H2,22,24)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384035
PNG
(CHEMBL2032158 | CHEMBL2078645)
Show SMILES CNc1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H23N7O/c1-23-15-2-3-19-18(9-15)27-21(29-19)17-8-13(10-25-20(17)22)14-11-26-28(12-14)16-4-6-24-7-5-16/h2-3,8-12,16,23-24H,4-7H2,1H3,(H2,22,25)
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n/an/a 6.32E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444136
PNG
(CHEMBL3093259)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)N1CCOCC1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O2/c25-23-20(11-16(13-27-23)17-14-28-31(15-17)18-3-5-26-6-4-18)24-29-21-12-19(1-2-22(21)33-24)30-7-9-32-10-8-30/h1-2,11-15,18,26H,3-10H2,(H2,25,27)
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n/an/a 6.43E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444097
PNG
(CHEMBL3093254)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3ccc4cn[nH]c4c3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C27H24N8O2/c28-26-20(9-17(11-30-26)18-13-32-35(14-18)19-5-7-29-8-6-19)27-33-21-3-4-23(36)24(25(21)37-27)15-1-2-16-12-31-34-22(16)10-15/h1-4,9-14,19,29,36H,5-8H2,(H2,28,30)(H,31,34)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444112
PNG
(CHEMBL3093163)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3cc(ccn3)C#N)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H22N8O2/c27-12-16-3-8-30-24(9-16)35-20-1-2-22-23(11-20)36-26(33-22)21-10-17(13-31-25(21)28)18-14-32-34(15-18)19-4-6-29-7-5-19/h1-3,8-11,13-15,19,29H,4-7H2,(H2,28,31)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444129
PNG
(CHEMBL3093146)
Show SMILES CN(C)c1ccc2oc(nc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H25N7O/c1-28(2)17-3-4-20-19(10-17)27-22(30-20)18-9-14(11-25-21(18)23)15-12-26-29(13-15)16-5-7-24-8-6-16/h3-4,9-13,16,24H,5-8H2,1-2H3,(H2,23,25)
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n/an/a 8.27E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384014
PNG
(CHEMBL2032290)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H28N8O4S/c1-17-2-5-22(6-3-17)41(38,39)35-28(37)33-20-4-7-24-25(13-20)40-27(34-24)23-12-18(14-31-26(23)29)19-15-32-36(16-19)21-8-10-30-11-9-21/h2-7,12-16,21,30H,8-11H2,1H3,(H2,29,31)(H2,33,35,37)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444091
PNG
(CHEMBL3093257)
Show SMILES COc1ccc2nc(oc2c1-c1ccc2cn[nH]c2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C28H26N8O2/c1-37-24-5-4-22-26(25(24)16-2-3-17-13-32-35-23(17)11-16)38-28(34-22)21-10-18(12-31-27(21)29)19-14-33-36(15-19)20-6-8-30-9-7-20/h2-5,10-15,20,30H,6-9H2,1H3,(H2,29,31)(H,32,35)
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n/an/a 9.16E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384015
PNG
(CHEMBL2032289)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Nc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24FN7O/c27-18-1-3-19(4-2-18)32-20-5-6-23-24(12-20)35-26(33-23)22-11-16(13-30-25(22)28)17-14-31-34(15-17)21-7-9-29-10-8-21/h1-6,11-15,21,29,32H,7-10H2,(H2,28,30)
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n/an/a 9.30E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384021
PNG
(CHEMBL2032283 | CHEMBL2079205)
Show SMILES Nc1ncc(cc1-c1nc2ccc(O)c(-c3ccccc3)c2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24N6O2/c27-25-20(12-17(13-29-25)18-14-30-32(15-18)19-8-10-28-11-9-19)26-31-21-6-7-22(33)23(24(21)34-26)16-4-2-1-3-5-16/h1-7,12-15,19,28,33H,8-11H2,(H2,27,29)
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n/an/a 9.70E+3n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444100
PNG
(CHEMBL3093251)
Show SMILES CC(C)NC(=O)c1cc2nc(oc2cc1O)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H27N7O3/c1-13(2)29-23(33)17-8-19-21(9-20(17)32)34-24(30-19)18-7-14(10-27-22(18)25)15-11-28-31(12-15)16-3-5-26-6-4-16/h7-13,16,26,32H,3-6H2,1-2H3,(H2,25,27)(H,29,33)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444102
PNG
(CHEMBL3093249)
Show SMILES CS(=O)(=O)Oc1ccc2nc(oc2c1)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O4S/c1-32(28,29)31-16-2-3-18-19(9-16)30-21(26-18)17-8-13(10-24-20(17)22)14-11-25-27(12-14)15-4-6-23-7-5-15/h2-3,8-12,15,23H,4-7H2,1H3,(H2,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444127
PNG
(CHEMBL3093148)
Show SMILES Nc1ncc(cc1-c1nc2cc(ccc2o1)-c1ccccc1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H24N6O/c27-25-22(12-19(14-29-25)20-15-30-32(16-20)21-8-10-28-11-9-21)26-31-23-13-18(6-7-24(23)33-26)17-4-2-1-3-5-17/h1-7,12-16,21,28H,8-11H2,(H2,27,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50384030
PNG
(CHEMBL2032272 | CHEMBL2079392)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3ncccn3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H22N8O2/c25-22-19(10-15(12-29-22)16-13-30-32(14-16)17-4-8-26-9-5-17)23-31-20-3-2-18(11-21(20)34-23)33-24-27-6-1-7-28-24/h1-3,6-7,10-14,17,26H,4-5,8-9H2,(H2,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50208911
PNG
(CHEMBL3884319)
Show SMILES CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12
Show InChI InChI=1S/C23H22N4O2/c1-23(2)17-13-24-22(25-14-7-4-3-5-8-14)26-20(17)27(21(23)29)18-12-11-16-15(18)9-6-10-19(16)28/h3-10,13,18,28H,11-12H2,1-2H3,(H,24,25,26)/t18-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length His-tagged ADRBK1 expressed in baculovirus expression system


Bioorg Med Chem Lett 27: 114-120 (2017)


Article DOI: 10.1016/j.bmcl.2016.08.068
BindingDB Entry DOI: 10.7270/Q2N018JC
More data for this
Ligand-Target Pair
G-protein coupled receptor kinase 2


(Homo sapiens (Human))
BDBM50444114
PNG
(CHEMBL3093161)
Show SMILES Nc1ncc(cc1-c1nc2ccc(Oc3ccc(F)cc3)cc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C26H23FN6O2/c27-18-1-3-20(4-2-18)34-21-5-6-23-24(12-21)35-26(32-23)22-11-16(13-30-25(22)28)17-14-31-33(15-17)19-7-9-29-10-8-19/h1-6,11-15,19,29H,7-10H2,(H2,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of GRK-2 (unknown origin) preincubated with enzyme for 10 mins before adding peptide substrate and ATP measured after 1 hr by LANCE-TR-FRE...


Bioorg Med Chem Lett 23: 6711-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.10.036
BindingDB Entry DOI: 10.7270/Q2SX6FPP
More data for this
Ligand-Target Pair
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