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Found 131 hits Enz. Inhib. hit(s) with Target = 'GABA A receptor alpha-2/beta-2/gamma-2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50142567
PNG
(9-(4-Methyl-thiazol-2-yl)-11-phenyl-6,7-dihydro-5H...)
Show SMILES Cc1csc(n1)-c1cc(-c2ccccc2)c2-c3cnccc3CCCn2c1=O
Show InChI InChI=1S/C23H19N3OS/c1-15-14-28-22(25-15)19-12-18(16-6-3-2-4-7-16)21-20-13-24-10-9-17(20)8-5-11-26(21)23(19)27/h2-4,6-7,9-10,12-14H,5,8,11H2,1H3
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Article
PubMed
0.300n/an/an/an/an/an/an/an/a



The Neuroscience Research Centre

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro-15-1788 from human GABA-A receptor alpha2 subunit expressed in L(tk) cells


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50142570
PNG
(9-(4-Methyl-thiazol-2-yl)-11-pyridin-4-yl-6,7-dihy...)
Show SMILES Cc1csc(n1)-c1cc(-c2ccncc2)c2-c3cnccc3CCCn2c1=O
Show InChI InChI=1S/C22H18N4OS/c1-14-13-28-21(25-14)18-11-17(16-4-7-23-8-5-16)20-19-12-24-9-6-15(19)3-2-10-26(20)22(18)27/h4-9,11-13H,2-3,10H2,1H3
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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GABAA alpha2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50179998
PNG
(7-tert-butyl-3-(2,5-difluorophenyl)-6-((2-methyl-2...)
Show SMILES Cn1ncnc1COc1nn2c(nnc2cc1C(C)(C)C)-c1cc(F)ccc1F
Show InChI InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3
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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GABAA alpha2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50156083
PNG
(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Show SMILES Cc1cc(no1)-c1nncc2c(c(OCc3ncnn3C)nn12)C(C)(C)C
Show InChI InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GABAA alpha2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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1n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50001765
PNG
(8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]tri...)
Show SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12
Show InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
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1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50017320
PNG
(8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-tria...)
Show SMILES CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21
Show InChI InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3
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1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50019213
PNG
(1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1
Show InChI InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
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1.70n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144227
PNG
(US8952008, 4)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C22H21FN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3
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<2.47n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50243981
PNG
(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Show SMILES COC(=O)c1cc2c(cn1)[nH]c1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,15H,1H3
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2.90n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50017309
PNG
(7-Chloro-3-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-5-m...)
Show SMILES CC(C)c1nc(no1)-c1ncn-2c1CN(C)C(=O)c1c(Cl)cccc-21
Show InChI InChI=1S/C17H16ClN5O2/c1-9(2)16-20-15(21-25-16)14-12-7-22(3)17(24)13-10(18)5-4-6-11(13)23(12)8-19-14/h4-6,8-9H,7H2,1-3H3
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3.70n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50244033
PNG
(Abecarnil | CHEMBL454095 | isopropyl 6-(benzyloxy)...)
Show SMILES COCc1c(ncc2[nH]c3ccc(OCc4ccccc4)cc3c12)C(=O)OC(C)C
Show InChI InChI=1S/C24H24N2O4/c1-15(2)30-24(27)23-19(14-28-3)22-18-11-17(29-13-16-7-5-4-6-8-16)9-10-20(18)26-21(22)12-25-23/h4-12,15,26H,13-14H2,1-3H3
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4.40n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144226
PNG
(US8952008, 3)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C19H16FN5O2S/c1-2-25-11-22-18-16(10-23-24-19(18)25)13-5-8-17(20)15(9-13)12-3-6-14(7-4-12)28(21,26)27/h3-11H,2H2,1H3,(H2,21,26,27)
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US Patent
5.08n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM25878
PNG
(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)
Show SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O
Show InChI InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
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5.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144239
PNG
(US8952008, 32)
Show SMILES CC(C)n1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C20H18FN5O2S/c1-12(2)26-11-23-19-17(10-24-25-20(19)26)14-5-8-18(21)16(9-14)13-3-6-15(7-4-13)29(22,27)28/h3-12H,1-2H3,(H2,22,27,28)
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US Patent
5.82n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50243981
PNG
(Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 ...)
Show SMILES COC(=O)c1cc2c(cn1)[nH]c1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,15H,1H3
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6.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144252
PNG
(US8952008, 8)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C20H18FN5O2S/c1-3-26-12-23-19-17(11-24-25-20(19)26)14-6-9-18(21)16(10-14)13-4-7-15(8-5-13)29(27,28)22-2/h4-12,22H,3H2,1-2H3
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7.45n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144256
PNG
(US8952008, 12)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(C)(=O)=O
Show InChI InChI=1S/C21H19FN4O3S/c1-4-26-12-23-20-17(11-24-25-21(20)26)13-5-8-18(22)16(9-13)15-7-6-14(30(3,27)28)10-19(15)29-2/h5-12H,4H2,1-3H3
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7.48n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144270
PNG
(US8952008, 38)
Show SMILES COc1cc(ccc1-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C)S(C)(=O)=O
Show InChI InChI=1S/C22H21FN4O3S/c1-13(2)27-12-24-21-18(11-25-26-22(21)27)14-5-8-19(23)17(9-14)16-7-6-15(31(4,28)29)10-20(16)30-3/h5-13H,1-4H3
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8.56n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50000687
PNG
(2-(3-Carboxy-propyl)-6-(4-methoxy-phenyl)-2H-pyrid...)
Show SMILES COc1ccc(cc1)-c1ccc(=[NH2+])n(CCCC(O)=O)n1
Show InChI InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)/p+1
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8.91n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM23183
PNG
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)
Show SMILES NCc1cc(=O)[nH]o1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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8.91n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM23183
PNG
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)
Show SMILES NCc1cc(=O)[nH]o1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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9.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144229
PNG
(US8952008, 6)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)C1CCC1
Show InChI InChI=1S/C24H23FN4O3S/c1-3-29-14-26-23-20(13-27-28-24(23)29)15-7-10-21(25)19(11-15)18-9-8-17(12-22(18)32-2)33(30,31)16-5-4-6-16/h7-14,16H,3-6H2,1-2H3
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US Patent
9.51n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144230
PNG
(US8952008, 7)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)C1CC1
Show InChI InChI=1S/C23H21FN4O3S/c1-3-28-13-25-22-19(12-26-27-23(22)28)14-4-9-20(24)18(10-14)17-8-7-16(11-21(17)31-2)32(29,30)15-5-6-15/h4,7-13,15H,3,5-6H2,1-2H3
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9.71n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM26267
PNG
(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=[N+]=[N-]
Show InChI InChI=1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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10.4n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144225
PNG
(US8952008, 2)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C20H16F2N4O2S/c1-3-26-11-23-19-16(10-24-25-20(19)26)12-4-7-17(21)15(8-12)14-6-5-13(9-18(14)22)29(2,27)28/h4-11H,3H2,1-2H3
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10.9n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144257
PNG
(US8952008, 13)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)C(C)C
Show InChI InChI=1S/C23H23FN4O3S/c1-5-28-13-25-22-19(12-26-27-23(22)28)15-6-9-20(24)18(10-15)17-8-7-16(11-21(17)31-4)32(29,30)14(2)3/h6-14H,5H2,1-4H3
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11.7n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144272
PNG
(US8952008, 40)
Show SMILES CCS(=O)(=O)c1ccc(c(OC)c1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C23H23FN4O3S/c1-5-32(29,30)16-7-8-17(21(11-16)31-4)18-10-15(6-9-20(18)24)19-12-26-27-23-22(19)25-13-28(23)14(2)3/h6-14H,5H2,1-4H3
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14n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM81951
PNG
(CAS_104999 | DMCM | NSC_104999)
Show SMILES CCc1c(ncc2[nH]c3cc(OC)c(OC)cc3c12)C(=O)OC
Show InChI InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3
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14.4n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144271
PNG
(US8952008, 39)
Show SMILES CCS(=O)(=O)c1ccc(c(Cl)c1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C22H20ClFN4O2S/c1-4-31(29,30)15-6-7-16(19(23)10-15)17-9-14(5-8-20(17)24)18-11-26-27-22-21(18)25-12-28(22)13(2)3/h5-13H,4H2,1-3H3
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14.4n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144240
PNG
(US8952008, 33)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C21H20FN5O2S/c1-13(2)27-12-24-20-18(11-25-26-21(20)27)15-6-9-19(22)17(10-15)14-4-7-16(8-5-14)30(28,29)23-3/h4-13,23H,1-3H3
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16.4n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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16.9n/an/an/an/an/an/an/an/a



Universität Heidelberg

Curated by PDSP Ki Database




Science 245: 1389-92 (1989)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144253
PNG
(US8952008, 9)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H17FN4O2S/c1-3-25-12-22-19-17(11-23-24-20(19)25)14-6-9-18(21)16(10-14)13-4-7-15(8-5-13)28(2,26)27/h4-12H,3H2,1-2H3
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17.7n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144259
PNG
(US8952008, 15)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1F)S(=O)(=O)CC
Show InChI InChI=1S/C21H18F2N4O2S/c1-3-27-12-24-20-17(11-25-26-21(20)27)13-5-8-18(22)16(9-13)15-7-6-14(10-19(15)23)30(28,29)4-2/h5-12H,3-4H2,1-2H3
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18.2n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144262
PNG
(US8952008, 20)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C1CC1
Show InChI InChI=1S/C21H18FN5O2S/c1-23-30(28,29)16-7-2-13(3-8-16)17-10-14(4-9-19(17)22)18-11-25-26-21-20(18)24-12-27(21)15-5-6-15/h2-4,7-12,15,23H,5-6H2,1H3
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19n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144269
PNG
(US8952008, 37)
Show SMILES COc1cc(ccc1-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H25FN4O3S/c1-14(2)29-13-26-23-20(12-27-28-24(23)29)16-6-9-21(25)19(10-16)18-8-7-17(11-22(18)32-5)33(30,31)15(3)4/h6-15H,1-5H3
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19.1n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50244262
PNG
(CHEMBL471978 | ethyl 7-ethynyl-4-methyl-5-oxo-4,5-...)
Show SMILES CCOC(=O)c1ncn2c1n(C)c(=O)c1cc(ccc21)C#C
Show InChI InChI=1S/C16H13N3O3/c1-4-10-6-7-12-11(8-10)15(20)18(3)14-13(16(21)22-5-2)17-9-19(12)14/h1,6-9H,5H2,2-3H3
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21.4n/an/an/an/an/an/an/an/a



Moltech Corporation

Curated by ChEMBL


Assay Description
Binding affinity to GABAA alpha-2-beta-3-gamma-2 receptor


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144250
PNG
(US8952008, 49)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(=O)(=O)CC
Show InChI InChI=1S/C21H19FN4O2S/c1-3-26-13-23-20-18(12-24-25-21(20)26)15-7-10-19(22)17(11-15)14-5-8-16(9-6-14)29(27,28)4-2/h5-13H,3-4H2,1-2H3
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21.7n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A Alpha2Beta1Gamma2


(Homo sapiens (Human))
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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22.9n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144238
PNG
(US8952008, 31)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C22H21FN4O2S/c1-4-30(28,29)17-8-5-15(6-9-17)18-11-16(7-10-20(18)23)19-12-25-26-22-21(19)24-13-27(22)14(2)3/h5-14H,4H2,1-3H3
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23.9n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50049736
PNG
(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Show SMILES CN1Cc2c(ncn2-c2ccc(cc2C1=O)C#C)C(=O)OC(C)(C)C
Show InChI InChI=1S/C19H19N3O3/c1-6-12-7-8-14-13(9-12)17(23)21(5)10-15-16(20-11-22(14)15)18(24)25-19(2,3)4/h1,7-9,11H,10H2,2-5H3
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26.3n/an/an/an/an/an/an/an/a



Moltech Corporation

Curated by ChEMBL


Assay Description
Binding affinity to GABAA alpha-2-beta-3-gamma-2 receptor


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50067424
PNG
((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Show SMILES CCOC(=O)c1ncn-2c1[C@@H]1CCCN1C(=O)c1cc(OC)ccc-21
Show InChI InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
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27n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of GABAA alpha2 (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144273
PNG
(US8952008, 41)
Show SMILES CCS(=O)(=O)c1ccc(c(c1)C#N)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C23H20FN5O2S/c1-4-32(30,31)17-6-7-18(16(9-17)11-25)19-10-15(5-8-21(19)24)20-12-27-28-23-22(20)26-13-29(23)14(2)3/h5-10,12-14H,4H2,1-3H3
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29.1n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144246
PNG
(US8952008, 45)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(Cl)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC
Show InChI InChI=1S/C22H21ClN4O3S/c1-4-27-13-24-21-18(12-25-26-22(21)27)14-6-9-19(23)17(10-14)16-8-7-15(11-20(16)30-3)31(28,29)5-2/h6-13H,4-5H2,1-3H3
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29.7n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144224
PNG
(US8952008, 1)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1)S(=O)(=O)C(C)C
Show InChI InChI=1S/C22H21FN4O2S/c1-4-27-13-24-21-19(12-25-26-22(21)27)16-7-10-20(23)18(11-16)15-5-8-17(9-6-15)30(28,29)14(2)3/h5-14H,4H2,1-3H3
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US Patent
31.1n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144232
PNG
(US8952008, 19)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C1CC1
Show InChI InChI=1S/C22H19FN4O2S/c1-2-30(28,29)17-8-3-14(4-9-17)18-11-15(5-10-20(18)23)19-12-25-26-22-21(19)24-13-27(22)16-6-7-16/h3-5,8-13,16H,2,6-7H2,1H3
KEGG

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US Patent
31.1n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144241
PNG
(US8952008, 34)
Show SMILES CCS(=O)(=O)c1ccc(c(F)c1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C(C)C
Show InChI InChI=1S/C22H20F2N4O2S/c1-4-31(29,30)15-6-7-16(20(24)10-15)17-9-14(5-8-19(17)23)18-11-26-27-22-21(18)25-12-28(22)13(2)3/h5-13H,4H2,1-3H3
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US Patent
34.5n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144234
PNG
(US8952008, 27)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1cc(ccc1F)-c1cnnc2n(cnc12)C1(C)CC1
Show InChI InChI=1S/C23H21FN4O2S/c1-3-31(29,30)17-7-4-15(5-8-17)18-12-16(6-9-20(18)24)19-13-26-27-22-21(19)25-14-28(22)23(2)10-11-23/h4-9,12-14H,3,10-11H2,1-2H3
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US Patent
34.8n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM144258
PNG
(US8952008, 14)
Show SMILES CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1C(F)F)S(=O)(=O)CC
Show InChI InChI=1S/C22H19F3N4O2S/c1-3-29-12-26-20-18(11-27-28-22(20)29)13-5-8-19(23)16(9-13)15-7-6-14(32(30,31)4-2)10-17(15)21(24)25/h5-12,21H,3-4H2,1-2H3
KEGG

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US Patent
35.4n/an/an/an/an/an/an/an/a



Pfizer Limited

US Patent


Assay Description
The affinity of the test compounds was determined by radioligand competition binding assay, using the known compound [3H]Ro-15-1788 (Flumazenil) (Per...


US Patent US8952008 (2015)

More data for this
Ligand-Target Pair
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