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Found 11 hits Enz. Inhib. hit(s) with Target = 'GABA receptor alpha-1/beta-1/gamma-2 subunit' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50229594
PNG
(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Show SMILES COc1ccccc1CN(C(C)=O)c1cnccc1Oc1ccccc1
Show InChI InChI=1S/C21H20N2O3/c1-16(24)23(15-17-8-6-7-11-20(17)25-2)19-14-22-13-12-21(19)26-18-9-4-3-5-10-18/h3-14H,15H2,1-2H3
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>1n/an/an/an/an/an/an/an/a



National Institute of Mental Health

Curated by ChEMBL


Assay Description
Binding affinity to GABA alpha-1-beta-1-gamma-2 receptor


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064420
PNG
((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Show SMILES CC(C)c1cc(cc(C(C)C)c1O)C(=O)c1ccccc1
Show InChI InChI=1S/C19H22O2/c1-12(2)16-10-15(11-17(13(3)4)19(16)21)18(20)14-8-6-5-7-9-14/h5-13,21H,1-4H3
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PubMed
n/an/an/an/a 9.00E+3n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064419
PNG
(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Show SMILES CC(C)c1cc(Cl)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17ClO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 3.80E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064417
PNG
(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Show SMILES CC(C)c1cc(Br)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17BrO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 3.80E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50058046
PNG
(CHEMBL526 | PROPOFOL | propofol)
Show SMILES CC(C)c1cccc(C(C)C)c1O
Show InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
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n/an/an/an/a 4.40E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064419
PNG
(4-Chloro-2,6-diisopropyl-phenol | CHEMBL292402)
Show SMILES CC(C)c1cc(Cl)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17ClO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 1.00E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064424
PNG
(4-Iodo-2,6-diisopropyl-phenol | 4-Iodo-2,6-diisopr...)
Show SMILES CC(C)c1cc(I)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17IO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 1.20E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50058046
PNG
(CHEMBL526 | PROPOFOL | propofol)
Show SMILES CC(C)c1cccc(C(C)C)c1O
Show InChI InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
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n/an/an/an/a 8.00E+3n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064417
PNG
(4-Bromo-2,6-diisopropyl-phenol | CHEMBL54497)
Show SMILES CC(C)c1cc(Br)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17BrO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 1.20E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064424
PNG
(4-Iodo-2,6-diisopropyl-phenol | 4-Iodo-2,6-diisopr...)
Show SMILES CC(C)c1cc(I)cc(C(C)C)c1O
Show InChI InChI=1S/C12H17IO/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8,14H,1-4H3
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n/an/an/an/a 5.10E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-1/beta-1/gamma-2 subunit


(Homo sapiens (Human))
BDBM50064420
PNG
((4-Hydroxy-3,5-diisopropyl-phenyl)-phenyl-methanon...)
Show SMILES CC(C)c1cc(cc(C(C)C)c1O)C(=O)c1ccccc1
Show InChI InChI=1S/C19H22O2/c1-12(2)16-10-15(11-17(13(3)4)19(16)21)18(20)14-8-6-5-7-9-14/h5-13,21H,1-4H3
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n/an/an/an/a 4.70E+4n/an/an/an/a



Università degli Studi di Bari

Curated by ChEMBL


Assay Description
Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1beta1-gamma2 GABA-A receptor subunits


Citation and Details
More data for this
Ligand-Target Pair