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Found 42 hits Enz. Inhib. hit(s) with Target = 'GABA receptor alpha-6/beta-2/gamma-2 subunit' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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2.10n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50001478
PNG
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)
Show SMILES COC(=O)c1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3
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6n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50035527
PNG
(3-Methyl-9H-beta-carboline | CHEMBL344859)
Show SMILES Cc1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3
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8n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50001478
PNG
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)
Show SMILES COC(=O)c1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3
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8n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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9n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50001478
PNG
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)
Show SMILES COC(=O)c1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3
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10n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50035527
PNG
(3-Methyl-9H-beta-carboline | CHEMBL344859)
Show SMILES Cc1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3
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11n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50040717
PNG
((R)-1-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-10,11,1...)
Show SMILES O=C1CCC2N1c1ccccc1-n1cnc(-c3noc(n3)C3CC3)c21
Show InChI InChI=1S/C18H15N5O2/c24-14-8-7-13-16-15(17-20-18(25-21-17)10-5-6-10)19-9-22(16)11-3-1-2-4-12(11)23(13)14/h1-4,9-10,13H,5-8H2
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13.2n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50048855
PNG
(3-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4H-imidazo...)
Show SMILES CN(C)C(=O)N1Cc2c(ncn2-c2ccccc12)-c1noc(n1)C1CC1
Show InChI InChI=1S/C18H18N6O2/c1-22(2)18(25)23-9-14-15(16-20-17(26-21-16)11-7-8-11)19-10-24(14)13-6-4-3-5-12(13)23/h3-6,10-11H,7-9H2,1-2H3
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13.2n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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17n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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17n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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20n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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33n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50035527
PNG
(3-Methyl-9H-beta-carboline | CHEMBL344859)
Show SMILES Cc1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3
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39n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50035527
PNG
(3-Methyl-9H-beta-carboline | CHEMBL344859)
Show SMILES Cc1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3
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45n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26263
PNG
(Anexate | CHEMBL407 | FLUMAZENIL | Ro15-1788 | Rom...)
Show SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21
Show InChI InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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90n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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98n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50001478
PNG
(9H-beta-Carboline-3-carboxylic acid methyl ester |...)
Show SMILES COC(=O)c1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C13H10N2O2/c1-17-13(16)11-6-9-8-4-2-3-5-10(8)15-12(9)7-14-11/h2-7,14H,1H3
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190n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054654
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-6-oxo-5,6-...)
Show SMILES CC(C)(C)OC(=O)N1CC(=O)N2Cc3c(ncn3-c3cccc1c23)-c1noc(n1)C1CC1
Show InChI InChI=1S/C22H22N6O4/c1-22(2,3)31-21(30)26-10-16(29)27-9-15-17(19-24-20(32-25-19)12-7-8-12)23-11-28(15)14-6-4-5-13(26)18(14)27/h4-6,11-12H,7-10H2,1-3H3
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054655
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4-phenyl-4...)
Show SMILES O=C1CC(c2ccccc2)c2cccc-3c2N1Cc1c(ncn-31)-c1noc(n1)C1CC1
Show InChI InChI=1S/C24H19N5O2/c30-20-11-17(14-5-2-1-3-6-14)16-7-4-8-18-22(16)28(20)12-19-21(25-13-29(18)19)23-26-24(31-27-23)15-9-10-15/h1-8,13,15,17H,9-12H2
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054661
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4...)
Show SMILES CN1Cc2cccc-3c2N(Cc2c(ncn-32)-c2noc(n2)C2CC2)C1=O
Show InChI InChI=1S/C18H16N6O2/c1-22-7-11-3-2-4-12-15(11)23(18(22)25)8-13-14(19-9-24(12)13)16-20-17(26-21-16)10-5-6-10/h2-4,9-10H,5-8H2,1H3
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054657
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4,5-dihydr...)
Show SMILES O=C1CNc2cccc-3c2N1Cc1c(ncn-31)-c1noc(n1)C1CC1
Show InChI InChI=1S/C17H14N6O2/c24-13-6-18-10-2-1-3-11-15(10)22(13)7-12-14(19-8-23(11)12)16-20-17(25-21-16)9-4-5-9/h1-3,8-9,18H,4-7H2
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054662
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4,4-dimeth...)
Show SMILES CC1(C)CC(=O)N2Cc3c(ncn3-c3cccc1c23)-c1noc(n1)C1CC1
Show InChI InChI=1S/C20H19N5O2/c1-20(2)8-15(26)24-9-14-16(18-22-19(27-23-18)11-6-7-11)21-10-25(14)13-5-3-4-12(20)17(13)24/h3-5,10-11H,6-9H2,1-2H3
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054663
PNG
(7-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4-methoxy-...)
Show SMILES COn1c2cccc3-n4cnc(-c5noc(n5)C5CC5)c4Cn(c23)c1=O
Show InChI InChI=1S/C17H14N6O3/c1-25-23-11-4-2-3-10-14(11)21(17(23)24)7-12-13(18-8-22(10)12)15-19-16(26-20-15)9-5-6-9/h2-4,8-9H,5-7H2,1H3
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054660
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4,5-dihydr...)
Show SMILES O=C1CCc2cccc-3c2N1Cc1c(ncn-31)-c1noc(n1)C1CC1
Show InChI InChI=1S/C18H15N5O2/c24-14-7-6-10-2-1-3-12-16(10)22(14)8-13-15(19-9-23(12)13)17-20-18(25-21-17)11-4-5-11/h1-3,9,11H,4-8H2
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054656
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-5-isopropy...)
Show SMILES CC(C)N1Cc2cccc-3c2N(Cc2c(ncn-32)-c2noc(n2)C2CC2)C1=O
Show InChI InChI=1S/C20H20N6O2/c1-11(2)24-8-13-4-3-5-14-17(13)25(20(24)27)9-15-16(21-10-26(14)15)18-22-19(28-23-18)12-6-7-12/h3-5,10-12H,6-9H2,1-2H3
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50054659
PNG
(8-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-4H,7H-5-ox...)
Show SMILES O=C1OCc2cccc-3c2N1Cc1c(ncn-31)-c1noc(n1)C1CC1
Show InChI InChI=1S/C17H13N5O3/c23-17-21-6-12-13(15-19-16(25-20-15)9-4-5-9)18-8-22(12)11-3-1-2-10(7-24-17)14(11)21/h1-3,8-9H,4-7H2
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>589n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50048837
PNG
(3-(5-Cyclopropyl-[1,2,4]oxadiazol-3-yl)-5-isopropy...)
Show SMILES CC(C)n1c2ccccc2n2cnc(-c3noc(n3)C3CC3)c2c1=O
Show InChI InChI=1S/C18H17N5O2/c1-10(2)23-13-6-4-3-5-12(13)22-9-19-14(15(22)18(23)24)16-20-17(25-21-16)11-7-8-11/h3-6,9-11H,7-8H2,1-2H3
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603n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50026756
PNG
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Show SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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620n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50026756
PNG
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Show SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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780n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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980n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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1.40E+3n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50035527
PNG
(3-Methyl-9H-beta-carboline | CHEMBL344859)
Show SMILES Cc1cc2c(c[nH]1)nc1ccccc21
Show InChI InChI=1S/C12H10N2/c1-8-6-10-9-4-2-3-5-11(9)14-12(10)7-13-8/h2-7,13H,1H3
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2.05E+3n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50026756
PNG
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Show SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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4.30E+3n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50026756
PNG
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Show SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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6.00E+3n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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>7.00E+3n/an/an/an/an/an/an/an/a



Upjohn Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro- 15-4513 from alpha6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes


Citation and Details
More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr)beta2gama2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for mutant rat GABA-A receptor alpha-6-(his)-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM50026756
PNG
(3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triaz...)
Show SMILES Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair
GABA receptor alpha-6/beta-2/gamma-2 subunit


(RAT-Rattus norvegicus)
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Heidelberg

Curated by ChEMBL


Assay Description
Binding affinity for rat GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in HEK293 cells


J Med Chem 37: 4576-80 (1995)

More data for this
Ligand-Target Pair