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Compile Data Set for Download or QSAR

Found 86 hits Enz. Inhib. hit(s) with Target = 'GABA-C receptor' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA-C receptor


(Homo sapiens)
BDBM50211642
PNG
(CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium...)
Show SMILES CP(O)(=O)C1=CCNCC1
Show InChI InChI=1S/C6H12NO2P/c1-10(8,9)6-2-4-7-5-3-6/h2,7H,3-5H2,1H3,(H,8,9)
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n/an/a 2.22E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at GABAC rho1 receptor (unknown origin)


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50211642
PNG
(CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium...)
Show SMILES CP(O)(=O)C1=CCNCC1
Show InChI InChI=1S/C6H12NO2P/c1-10(8,9)6-2-4-7-5-3-6/h2,7H,3-5H2,1H3,(H,8,9)
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n/an/a 2.22E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM24189
PNG
(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Show SMILES CP(O)(O)CC(=O)CN
Show InChI InChI=1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h7-9H,2-3,5H2,1H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method


Bioorg Med Chem Lett 18: 402-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.019
BindingDB Entry DOI: 10.7270/Q2TT4RTQ
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50032973
PNG
(((Z)-3-Amino-propenyl)-methyl-phosphinic acid | 3-...)
Show SMILES CP(O)(=O)CCC=N
Show InChI InChI=1S/C4H10NO2P/c1-8(6,7)4-2-3-5/h3,5H,2,4H2,1H3,(H,6,7)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428278
PNG
(CHEMBL446306)
Show SMILES CCCCP(O)(=O)C1=C[C@@H](N)CC1
Show InChI InChI=1S/C9H18NO2P/c1-2-3-6-13(11,12)9-5-4-8(10)7-9/h7-8H,2-6,10H2,1H3,(H,11,12)/t8-/m0/s1
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n/an/a 9.76E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50240386
PNG
(5-amino-4-oxopentanoic acid | 5-aminolevulinic aci...)
Show SMILES NCC(=O)CCC(O)=O
Show InChI InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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n/an/a 1.29E+4n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50374650
PNG
(CHEMBL257443)
Show SMILES C[C@H](CCN)C(O)=O
Show InChI InChI=1S/C5H11NO2/c1-4(2-3-6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method


Bioorg Med Chem Lett 18: 402-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.019
BindingDB Entry DOI: 10.7270/Q2TT4RTQ
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM24189
PNG
(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Show SMILES CP(O)(O)CC(=O)CN
Show InChI InChI=1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h7-9H,2-3,5H2,1H3
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n/an/a 1.71E+4n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method


Bioorg Med Chem Lett 18: 402-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.019
BindingDB Entry DOI: 10.7270/Q2TT4RTQ
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50336851
PNG
(3-(aminomethyl)-1-oxo-1-hydroxy-phospholane | CHEM...)
Show SMILES NCC1CCP(O)(O)=C1
Show InChI InChI=1S/C5H12NO2P/c6-3-5-1-2-9(7,8)4-5/h4-5,7-8H,1-3,6H2
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n/an/a 1.99E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA receptor rho-2 subunit


(Homo sapiens)
BDBM50211642
PNG
(CHEMBL397209 | Methyl(1,2,3,6-tetrahydropyridinium...)
Show SMILES CP(O)(=O)C1=CCNCC1
Show InChI InChI=1S/C6H12NO2P/c1-10(8,9)6-2-4-7-5-3-6/h2,7H,3-5H2,1H3,(H,8,9)
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n/an/a 2.21E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50336850
PNG
(3-(guanido)-1-oxo-1-hydroxy-phospholane | CHEMBL16...)
Show SMILES NC(N)=NC1CCP(O)(O)=C1
Show InChI InChI=1S/C5H12N3O2P/c6-5(7)8-4-1-2-11(9,10)3-4/h3-4,9-10H,1-2H2,(H4,6,7,8)
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n/an/a 2.97E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA receptor rho-2 subunit


(Homo sapiens)
BDBM50336850
PNG
(3-(guanido)-1-oxo-1-hydroxy-phospholane | CHEMBL16...)
Show SMILES NC(N)=NC1CCP(O)(O)=C1
Show InChI InChI=1S/C5H12N3O2P/c6-5(7)8-4-1-2-11(9,10)3-4/h3-4,9-10H,1-2H2,(H4,6,7,8)
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n/an/a 5.13E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA receptor rho-2 subunit


(Homo sapiens)
BDBM50336851
PNG
(3-(aminomethyl)-1-oxo-1-hydroxy-phospholane | CHEM...)
Show SMILES NCC1CCP(O)(O)=C1
Show InChI InChI=1S/C5H12NO2P/c6-3-5-1-2-9(7,8)4-5/h4-5,7-8H,1-3,6H2
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n/an/a 5.71E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-2 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428276
PNG
(CHEMBL2337487)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNC(=O)CCC1=C2C(C)=CC(C)=[N+]2[B-](F)(F)n2c(C)cc(C)c12
Show InChI InChI=1S/C31H46BF2N4O4P/c1-6-7-17-43(41,42)26-13-12-25(20-26)36-29(40)11-9-8-10-16-35-28(39)15-14-27-30-21(2)18-23(4)37(30)32(33,34)38-24(5)19-22(3)31(27)38/h18-20,25H,6-17H2,1-5H3,(H,35,39)(H,36,40)(H,41,42)/t25-/m0/s1
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n/an/a 5.86E+4n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50032982
PNG
((3-Amino-propyl)-butyl-phosphinic acid | 3-aminopr...)
Show SMILES CCCCP(O)(=O)CCCN
Show InChI InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
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n/an/a 6.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...


ACS Med Chem Lett 2: 11-16 (2011)


Article DOI: 10.1021/ml1001344
BindingDB Entry DOI: 10.7270/Q2FX79QR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50032982
PNG
((3-Amino-propyl)-butyl-phosphinic acid | 3-aminopr...)
Show SMILES CCCCP(O)(=O)CCCN
Show InChI InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
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n/an/a 6.20E+4n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428275
PNG
(CHEMBL2337889)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C25H43N4O5PS/c1-2-3-15-35(33,34)19-13-12-18(16-19)27-23(31)11-5-4-8-14-26-22(30)10-7-6-9-21-24-20(17-36-21)28-25(32)29-24/h16,18,20-21,24H,2-15,17H2,1H3,(H,26,30)(H,27,31)(H,33,34)(H2,28,29,32)/t18-,20-,21-,24-/m0/s1
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n/an/a 7.65E+4n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50243876
PNG
(CHEMBL447036 | trans-3-Amino-cyclobutyl(methyl)pho...)
Show SMILES CP(O)(O)C1=C[C@H](N)C1
Show InChI InChI=1S/C5H12NO2P/c1-9(7,8)5-2-4(6)3-5/h2,4,7-9H,3,6H2,1H3/t4-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50243875
PNG
(CHEMBL451118 | cis-3-Amino-cyclobutyl(methyl)phosp...)
Show SMILES CP(O)(O)C1=C[C@@H](N)C1
Show InChI InChI=1S/C5H12NO2P/c1-9(7,8)5-2-4(6)3-5/h2,4,7-9H,3,6H2,1H3/t4-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428276
PNG
(CHEMBL2337487)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNC(=O)CCC1=C2C(C)=CC(C)=[N+]2[B-](F)(F)n2c(C)cc(C)c12
Show InChI InChI=1S/C31H46BF2N4O4P/c1-6-7-17-43(41,42)26-13-12-25(20-26)36-29(40)11-9-8-10-16-35-28(39)15-14-27-30-21(2)18-23(4)37(30)32(33,34)38-24(5)19-22(3)31(27)38/h18-20,25H,6-17H2,1-5H3,(H,35,39)(H,36,40)(H,41,42)/t25-/m0/s1
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n/an/a 1.03E+5n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428275
PNG
(CHEMBL2337889)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
Show InChI InChI=1S/C25H43N4O5PS/c1-2-3-15-35(33,34)19-13-12-18(16-19)27-23(31)11-5-4-8-14-26-22(30)10-7-6-9-21-24-20(17-36-21)28-25(32)29-24/h16,18,20-21,24H,2-15,17H2,1H3,(H,26,30)(H,27,31)(H,33,34)(H2,28,29,32)/t18-,20-,21-,24-/m0/s1
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n/an/a 1.48E+5n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428277
PNG
(CHEMBL2337486)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNc1ccc([N+]([O-])=O)c2nonc12
Show InChI InChI=1S/C21H30N5O6P/c1-2-3-13-33(30,31)16-9-8-15(14-16)23-19(27)7-5-4-6-12-22-17-10-11-18(26(28)29)21-20(17)24-32-25-21/h10-11,14-15,22H,2-9,12-13H2,1H3,(H,23,27)(H,30,31)/t15-/m0/s1
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n/an/a 1.93E+5n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50428277
PNG
(CHEMBL2337486)
Show SMILES CCCCP(O)(=O)C1=C[C@H](CC1)NC(=O)CCCCCNc1ccc([N+]([O-])=O)c2nonc12
Show InChI InChI=1S/C21H30N5O6P/c1-2-3-13-33(30,31)16-9-8-15(14-16)23-19(27)7-5-4-6-12-22-17-10-11-18(26(28)29)21-20(17)24-32-25-21/h10-11,14-15,22H,2-9,12-13H2,1H3,(H,23,27)(H,30,31)/t15-/m0/s1
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n/an/a 2.81E+5n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...


Citation and Details

Article DOI: 10.1021/ml300476v
BindingDB Entry DOI: 10.7270/Q27H1KXG
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50241194
PNG
((1S,2R)-2-(aminomethyl)cyclopropanecarboxylic acid...)
Show SMILES NC[C@@H]1C[C@@H]1C(O)=O
Show InChI InChI=1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1
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n/an/a>8.00E+5n/an/an/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50374649
PNG
(CHEMBL257442)
Show SMILES N[C@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C4H7NO2/c5-3-1-2(3)4(6)7/h2-3H,1,5H2,(H,6,7)/t2-,3+/m1/s1
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n/an/a 8.90E+5n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method


Bioorg Med Chem Lett 18: 402-4 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.019
BindingDB Entry DOI: 10.7270/Q2TT4RTQ
More data for this
Ligand-Target Pair
GABA receptor rho-2 subunit


(Homo sapiens)
BDBM50087269
PNG
((cis)-2-Aminomethyl-cyclopropanecarboxylic acid | ...)
Show SMILES NCC1CC1C(O)=O
Show InChI InChI=1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.75E+4n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Partial agonist activity with low efficacy against rho-2 subunit GABA-C receptor expressed in Xenopus oocytes


J Med Chem 43: 1427-47 (2000)


Article DOI: 10.1021/jm9904349
BindingDB Entry DOI: 10.7270/Q2PZ59HT
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50087271
PNG
((E)-4-Amino-but-2-enoic acid (TACA) | 4-Amino-but-...)
Show SMILES NC\C=C\C(O)=O
Show InChI InChI=1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+
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n/an/an/an/a 440n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Partial agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytes


J Med Chem 43: 1427-47 (2000)


Article DOI: 10.1021/jm9904349
BindingDB Entry DOI: 10.7270/Q2PZ59HT
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50087269
PNG
((cis)-2-Aminomethyl-cyclopropanecarboxylic acid | ...)
Show SMILES NCC1CC1C(O)=O
Show InChI InChI=1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 6.80E+4n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Full agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytes


J Med Chem 43: 1427-47 (2000)


Article DOI: 10.1021/jm9904349
BindingDB Entry DOI: 10.7270/Q2PZ59HT
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 270n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 700n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50032955
PNG
(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...)
Show SMILES OC(=O)C1=CCNCC1
Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
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n/an/an/an/a 3.90E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052794
PNG
(CHEMBL3322871)
Show SMILES CCc1nc(N)ccc1C(O)=O
Show InChI InChI=1S/C8H10N2O2/c1-2-6-5(8(11)12)3-4-7(9)10-6/h3-4H,2H2,1H3,(H2,9,10)(H,11,12)
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052795
PNG
(CHEMBL3322872)
Show SMILES CCCCc1nc(N)ccc1C(O)=O
Show InChI InChI=1S/C10H14N2O2/c1-2-3-4-8-7(10(13)14)5-6-9(11)12-8/h5-6H,2-4H2,1H3,(H2,11,12)(H,13,14)
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052797
PNG
(CHEMBL3322876)
Show SMILES CCc1cc(N)ncc1C(O)=O
Show InChI InChI=1S/C8H10N2O2/c1-2-5-3-7(9)10-4-6(5)8(11)12/h3-4H,2H2,1H3,(H2,9,10)(H,11,12)
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052798
PNG
(CHEMBL3322877)
Show SMILES CCCCc1cc(N)ncc1C(O)=O
Show InChI InChI=1S/C10H14N2O2/c1-2-3-4-7-5-9(11)12-6-8(7)10(13)14/h5-6H,2-4H2,1H3,(H2,11,12)(H,13,14)
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 2.30E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052801
PNG
(CHEMBL3322886)
Show SMILES NC1=NCC(CN1)C(O)=O
Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)
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n/an/an/an/a 8.10E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 269n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 692n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50032955
PNG
(1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,...)
Show SMILES OC(=O)C1=CCNCC1
Show InChI InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
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n/an/an/an/a 3.89E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052794
PNG
(CHEMBL3322871)
Show SMILES CCc1nc(N)ccc1C(O)=O
Show InChI InChI=1S/C8H10N2O2/c1-2-6-5(8(11)12)3-4-7(9)10-6/h3-4H,2H2,1H3,(H2,9,10)(H,11,12)
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n/an/an/an/a<1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052795
PNG
(CHEMBL3322872)
Show SMILES CCCCc1nc(N)ccc1C(O)=O
Show InChI InChI=1S/C10H14N2O2/c1-2-3-4-8-7(10(13)14)5-6-9(11)12-8/h5-6H,2-4H2,1H3,(H2,11,12)(H,13,14)
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n/an/an/an/a<1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052797
PNG
(CHEMBL3322876)
Show SMILES CCc1cc(N)ncc1C(O)=O
Show InChI InChI=1S/C8H10N2O2/c1-2-5-3-7(9)10-4-6(5)8(11)12/h3-4H,2H2,1H3,(H2,9,10)(H,11,12)
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n/an/an/an/a<1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052798
PNG
(CHEMBL3322877)
Show SMILES CCCCc1cc(N)ncc1C(O)=O
Show InChI InChI=1S/C10H14N2O2/c1-2-3-4-7-5-9(11)12-6-8(7)10(13)14/h5-6H,2-4H2,1H3,(H2,11,12)(H,13,14)
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n/an/an/an/a<1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 1.23E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50052801
PNG
(CHEMBL3322886)
Show SMILES NC1=NCC(CN1)C(O)=O
Show InChI InChI=1S/C5H9N3O2/c6-5-7-1-3(2-8-5)4(9)10/h3H,1-2H2,(H,9,10)(H3,6,7,8)
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n/an/an/an/a 1.59E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50243877
PNG
((1R,2S)-2-(aminomethyl)cyclopropanecarboxylic acid...)
Show SMILES NC[C@H]1C[C@H]1C(O)=O
Show InChI InChI=1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m1/s1
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n/an/an/an/a 4.00E+4n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50087271
PNG
((E)-4-Amino-but-2-enoic acid (TACA) | 4-Amino-but-...)
Show SMILES NC\C=C\C(O)=O
Show InChI InChI=1S/C4H7NO2/c5-3-1-2-4(6)7/h1-2H,3,5H2,(H,6,7)/b2-1+
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n/an/an/an/a 400n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM23183
PNG
(5-(aminomethyl)-1,2-oxazol-3-ol | Agarin | CHEMBL2...)
Show SMILES NCc1cc(=O)[nH]o1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 1.40E+3n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
GABA-C receptor


(Homo sapiens)
BDBM50243927
PNG
((1S,2S)-2-(aminomethyl)cyclopropanecarboxylic acid...)
Show SMILES NC[C@H]1C[C@@H]1C(O)=O
Show InChI InChI=1S/C5H9NO2/c6-2-3-1-4(3)5(7)8/h3-4H,1-2,6H2,(H,7,8)/t3-,4+/m1/s1
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n/an/an/an/a 5.90E+4n/an/an/an/a



University of Sydney

Curated by ChEMBL


Assay Description
Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...


J Med Chem 51: 3825-40 (2008)


Article DOI: 10.1021/jm7015842
BindingDB Entry DOI: 10.7270/Q27M07RR
More data for this
Ligand-Target Pair
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