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Found 70 hits Enz. Inhib. hit(s) with Target = 'GST-Lysine Specific Demethylase-1 (LSD1)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM50155773
PNG
(CHEMBL3781751 | US9469597, 5)
Show SMILES N[C@H]1CC[C@@H](CC1)N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12-,13-,14-,15+/m0/s1
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50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254603
PNG
(US9469597, 4 | US9670136, 3 (trans)-N1-((1S,2R)-2-...)
Show SMILES NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m0/s1
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50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254553
PNG
(US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...)
Show SMILES NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N3O/c23-22(24,25)16-3-1-2-14(10-16)19-9-6-15(12-27-19)18-11-20(18)28-17-7-4-13(5-8-17)21(26)29/h1-3,6,9-10,12-13,17-18,20,28H,4-5,7-8,11H2,(H2,26,29)/t13?,17?,18-,20+/m1/s1
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50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254546
PNG
(US9469597, 1 | US9670136, 5 (trans)-N1-((1R,2S)-2-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254556
PNG
(US9469597, 15 | US9670136, 15 (R)-1-(4-(((trans)-2...)
Show SMILES N[C@@H]1CCN(C1)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C19H29N3/c20-15-10-11-22(13-15)17-8-6-16(7-9-17)21-19-12-18(19)14-4-2-1-3-5-14/h1-5,15-19,21H,6-13,20H2/t15-,16?,17?,18-,19+/m1/s1
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50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254555
PNG
(US9469597, 14 | US9670136, 14 N-(4-(((trans)-2-(6-...)
Show SMILES CS(=O)(=O)NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H26F3N3O2S/c1-31(29,30)28-18-8-6-17(7-9-18)27-21-12-19(21)15-5-10-20(26-13-15)14-3-2-4-16(11-14)22(23,24)25/h2-5,10-11,13,17-19,21,27-28H,6-9,12H2,1H3/t17?,18?,19-,21+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254554
PNG
(US9469597, 13 | US9670136, 13 N-(4-(((trans)-2-(6-...)
Show SMILES CC(=O)NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H26F3N3O/c1-14(30)28-18-6-8-19(9-7-18)29-22-12-20(22)16-5-10-21(27-13-16)15-3-2-4-17(11-15)23(24,25)26/h2-5,10-11,13,18-20,22,29H,6-9,12H2,1H3,(H,28,30)/t18?,19?,20-,22+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254552
PNG
(US9469597, 11 | US9670136, 11 4-(((trans)-2-(6-(3-...)
Show SMILES OC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N2O/c22-21(23,24)15-3-1-2-13(10-15)19-9-4-14(12-25-19)18-11-20(18)26-16-5-7-17(27)8-6-16/h1-4,9-10,12,16-18,20,26-27H,5-8,11H2/t16?,17?,18-,20+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254602
PNG
(US9469597, 3)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254601
PNG
(US9469597, 2)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254549
PNG
(US9469597, 8 | US9670136, 8 N1-((trans)-2-(6-(3-(t...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N3/c22-21(23,24)15-3-1-2-13(10-15)19-9-4-14(12-26-19)18-11-20(18)27-17-7-5-16(25)6-8-17/h1-4,9-10,12,16-18,20,27H,5-8,11,25H2/t16?,17?,18-,20+/m1/s1
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550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254598
PNG
(US9469597, 57 | US9670136, 57 N1-((trans)-2-(4-((2...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2ccccc2F)cc1
Show InChI InChI=1S/C22H27FN2O/c23-21-4-2-1-3-16(21)14-26-19-11-5-15(6-12-19)20-13-22(20)25-18-9-7-17(24)8-10-18/h1-6,11-12,17-18,20,22,25H,7-10,13-14,24H2/t17?,18?,20-,22+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM50155773
PNG
(CHEMBL3781751 | US9469597, 5)
Show SMILES N[C@H]1CC[C@@H](CC1)N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12-,13-,14-,15+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254546
PNG
(US9469597, 1 | US9670136, 5 (trans)-N1-((1R,2S)-2-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254593
PNG
(US9469597, 52)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)N2CCNCC2)c1
Show InChI InChI=1S/C25H35N5O2S/c26-21-8-10-22(11-9-21)28-25-17-24(25)19-6-4-18(5-7-19)20-2-1-3-23(16-20)29-33(31,32)30-14-12-27-13-15-30/h1-7,16,21-22,24-25,27-29H,8-15,17,26H2/t21?,22?,24-,25+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254574
PNG
(US9469597, 33 | US9670136, 33 N1-(2-(naphthalen-2-...)
Show SMILES NC1CCC(CC1)NC1CC1c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2/c20-16-7-9-17(10-8-16)21-19-12-18(19)15-6-5-13-3-1-2-4-14(13)11-15/h1-6,11,16-19,21H,7-10,12,20H2
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n/an/a 21n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254584
PNG
(US9469597, 43 | US9670136, 43 N1-((trans)-2-(4-(1H...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1ccn[nH]1
Show InChI InChI=1S/C18H24N4/c19-14-5-7-15(8-6-14)21-18-11-16(18)12-1-3-13(4-2-12)17-9-10-20-22-17/h1-4,9-10,14-16,18,21H,5-8,11,19H2,(H,20,22)/t14?,15?,16-,18+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254583
PNG
(US9469597, 42 | US9670136, 42 N1-((trans)-2-(4-(1H...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C22H26N4/c23-18-7-9-19(10-8-18)25-22-12-20(22)15-3-1-14(2-4-15)16-5-6-17-13-24-26-21(17)11-16/h1-6,11,13,18-20,22,25H,7-10,12,23H2,(H,24,26)/t18?,19?,20-,22+/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254568
PNG
(US9469597, 27 | US9670136, 27 N1-(2-(o-tolyl)cyclo...)
Show SMILES Cc1ccccc1C1CC1NC1CCC(N)CC1
Show InChI InChI=1S/C16H24N2/c1-11-4-2-3-5-14(11)15-10-16(15)18-13-8-6-12(17)7-9-13/h2-5,12-13,15-16,18H,6-10,17H2,1H3
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n/an/a 27n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254589
PNG
(US9469597, 48 | US9670136, 48 N-(4′-((trans)...)
Show SMILES COc1ccc(NS(C)(=O)=O)cc1-c1ccc(cc1)[C@H]1C[C@@H]1NC1CCC(N)CC1
Show InChI InChI=1S/C23H31N3O3S/c1-29-23-12-11-19(26-30(2,27)28)13-21(23)16-5-3-15(4-6-16)20-14-22(20)25-18-9-7-17(24)8-10-18/h3-6,11-13,17-18,20,22,25-26H,7-10,14,24H2,1-2H3/t17?,18?,20-,22+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254592
PNG
(US9469597, 51)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)c2ccc(N)nc2)c1
Show InChI InChI=1S/C26H31N5O2S/c27-20-8-10-21(11-9-20)30-25-15-24(25)18-6-4-17(5-7-18)19-2-1-3-22(14-19)31-34(32,33)23-12-13-26(28)29-16-23/h1-7,12-14,16,20-21,24-25,30-31H,8-11,15,27H2,(H2,28,29)/t20?,21?,24-,25+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254586
PNG
(US9469597, 45 | US9670136, 45 3-(5-((trans)-2-((4-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C18H23N3OS/c19-12-4-6-13(7-5-12)21-16-9-15(16)17-10-20-18(23-17)11-2-1-3-14(22)8-11/h1-3,8,10,12-13,15-16,21-22H,4-7,9,19H2/t12?,13?,15-,16-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254603
PNG
(US9469597, 4 | US9670136, 3 (trans)-N1-((1S,2R)-2-...)
Show SMILES NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254596
PNG
(US9469597, 55 | US9670136, 55 N1-((trans)-2-(4-((3...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2cccc(c2)N2CCNCC2)cc1
Show InChI InChI=1S/C26H36N4O/c27-21-6-8-22(9-7-21)29-26-17-25(26)20-4-10-24(11-5-20)31-18-19-2-1-3-23(16-19)30-14-12-28-13-15-30/h1-5,10-11,16,21-22,25-26,28-29H,6-9,12-15,17-18,27H2/t21?,22?,25-,26+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254547
PNG
(US9469597, 6 | US9670136, 6 N1-((trans)-2-(thiazol...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1cncs1
Show InChI InChI=1S/C12H19N3S/c13-8-1-3-9(4-2-8)15-11-5-10(11)12-6-14-7-16-12/h6-11,15H,1-5,13H2/t8?,9?,10-,11-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254581
PNG
(US9469597, 40 | US9670136, 40 N1-((trans)-2-(4-cyc...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)C1CC1
Show InChI InChI=1S/C18H26N2/c19-15-7-9-16(10-8-15)20-18-11-17(18)14-5-3-13(4-6-14)12-1-2-12/h3-6,12,15-18,20H,1-2,7-11,19H2/t15?,16?,17-,18+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254561
PNG
(US9469597, 20 | US9670136, 20 N1-((trans)-2-phenyl...)
Show SMILES NC1CC(N[C@H]2C[C@@H]2c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H20N2/c19-16-11-18(14-9-5-4-8-13(14)16)20-17-10-15(17)12-6-2-1-3-7-12/h1-9,15-18,20H,10-11,19H2/t15-,16?,17+,18?/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254572
PNG
(US9469597, 31 | US9670136, 31 N1-(2-(2-fluoropheny...)
Show SMILES NC1CCC(CC1)NC1CC1c1ccccc1F
Show InChI InChI=1S/C15H21FN2/c16-14-4-2-1-3-12(14)13-9-15(13)18-11-7-5-10(17)6-8-11/h1-4,10-11,13,15,18H,5-9,17H2
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254570
PNG
(US9469597, 29 | US9670136, 29 N1-(2-(4-methoxyphen...)
Show SMILES COc1ccc(cc1)C1CC1NC1CCC(N)CC1
Show InChI InChI=1S/C16H24N2O/c1-19-14-8-2-11(3-9-14)15-10-16(15)18-13-6-4-12(17)5-7-13/h2-3,8-9,12-13,15-16,18H,4-7,10,17H2,1H3
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254569
PNG
(US9469597, 28 | US9670136, 28 N1-(2-(4-(trifluorom...)
Show SMILES NC1CCC(CC1)NC1CC1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H21F3N2/c17-16(18,19)11-3-1-10(2-4-11)14-9-15(14)21-13-7-5-12(20)6-8-13/h1-4,12-15,21H,5-9,20H2
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254573
PNG
(US9469597, 32 | US9670136, 32 N1-(2-(3,4-difluorop...)
Show SMILES NC1CCC(CC1)NC1CC1c1ccc(F)c(F)c1
Show InChI InChI=1S/C15H20F2N2/c16-13-6-1-9(7-14(13)17)12-8-15(12)19-11-4-2-10(18)3-5-11/h1,6-7,10-12,15,19H,2-5,8,18H2
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254551
PNG
(US9469597, 10 | US9670136, 10 N1-((trans)-2-(4-(be...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H28N2O/c23-18-8-10-19(11-9-18)24-22-14-21(22)17-6-12-20(13-7-17)25-15-16-4-2-1-3-5-16/h1-7,12-13,18-19,21-22,24H,8-11,14-15,23H2/t18?,19?,21-,22+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254585
PNG
(US9469597, 44 | US9670136, 44 3-(5-((trans)-2-((4-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C19H24N2OS/c20-13-4-6-14(7-5-13)21-17-11-16(17)19-9-8-18(23-19)12-2-1-3-15(22)10-12/h1-3,8-10,13-14,16-17,21-22H,4-7,11,20H2/t13?,14?,16-,17-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254599
PNG
(US9469597, 58 | US9670136, 58 N1-((trans)-2-(6-((3...)
Show SMILES Cc1cccc(CNc2ccc(cn2)[C@H]2C[C@@H]2NC2CCC(N)CC2)c1
Show InChI InChI=1S/C22H30N4/c1-15-3-2-4-16(11-15)13-24-22-10-5-17(14-25-22)20-12-21(20)26-19-8-6-18(23)7-9-19/h2-5,10-11,14,18-21,26H,6-9,12-13,23H2,1H3,(H,24,25)/t18?,19?,20-,21+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254559
PNG
(US9469597, 18 | US9670136, 18 N1-((trans)-2-phenyl...)
Show SMILES NC1CCCC(C1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-7-4-8-13(9-12)17-15-10-14(15)11-5-2-1-3-6-11/h1-3,5-6,12-15,17H,4,7-10,16H2/t12?,13?,14-,15+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254594
PNG
(US9469597, 53 | US9670136, 53 N1-((trans)-2-fluoro...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@]1(F)c1ccccc1
Show InChI InChI=1S/C15H21FN2/c16-15(11-4-2-1-3-5-11)10-14(15)18-13-8-6-12(17)7-9-13/h1-5,12-14,18H,6-10,17H2/t12?,13?,14-,15-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254575
PNG
(US9469597, 34 | US9670136, 34 N1-(2-methyl-2-pheny...)
Show SMILES CC1(CC1NC1CCC(N)CC1)c1ccccc1
Show InChI InChI=1S/C16H24N2/c1-16(12-5-3-2-4-6-12)11-15(16)18-14-9-7-13(17)8-10-14/h2-6,13-15,18H,7-11,17H2,1H3
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254582
PNG
(US9469597, 41 | US9670136, 41 N1-((trans)-2-(4-(py...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C20H25N3/c21-17-7-9-18(10-8-17)23-20-12-19(20)15-5-3-14(4-6-15)16-2-1-11-22-13-16/h1-6,11,13,17-20,23H,7-10,12,21H2/t17?,18?,19-,20+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254550
PNG
(US9469597, 9 | US9670136, 9 N1-((trans)-2-(3′...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N2/c23-22(24,25)17-3-1-2-16(12-17)14-4-6-15(7-5-14)20-13-21(20)27-19-10-8-18(26)9-11-19/h1-7,12,18-21,27H,8-11,13,26H2/t18?,19?,20-,21+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254567
PNG
(US9469597, 26 | US9670136, 26 N1-((trans)-2-(4-bro...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C15H21BrN2/c16-11-3-1-10(2-4-11)14-9-15(14)18-13-7-5-12(17)6-8-13/h1-4,12-15,18H,5-9,17H2/t12?,13?,14-,15+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254562
PNG
(US9469597, 21 | US9670136, 21 N1-((cis)-2-phenylcy...)
Show SMILES NC1CCC(CC1)N[C@@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15-/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254579
PNG
(US9469597, 38 | US9670136, 38 (Cis)-N1-((1R,2S)-2-...)
Show SMILES N[C@H]1CC[C@H](CC1)N[C@@H]1C[C@H]1c1ccc(cc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H25F3N2/c23-22(24,25)17-3-1-2-16(12-17)14-4-6-15(7-5-14)20-13-21(20)27-19-10-8-18(26)9-11-19/h1-7,12,18-21,27H,8-11,13,26H2/t18-,19+,20-,21+/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254600
PNG
(US9469597, 59 | US9670136, 59 3-((5-((trans)-2-((4...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(Nc2cccc(c2)C#N)nc1
Show InChI InChI=1S/C21H25N5/c22-12-14-2-1-3-18(10-14)26-21-9-4-15(13-24-21)19-11-20(19)25-17-7-5-16(23)6-8-17/h1-4,9-10,13,16-17,19-20,25H,5-8,11,23H2,(H,24,26)/t16?,17?,19-,20+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254591
PNG
(US9469597, 50)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)c2ccccc2C#N)c1
Show InChI InChI=1S/C28H30N4O2S/c29-18-22-4-1-2-7-28(22)35(33,34)32-25-6-3-5-21(16-25)19-8-10-20(11-9-19)26-17-27(26)31-24-14-12-23(30)13-15-24/h1-11,16,23-24,26-27,31-32H,12-15,17,30H2/t23?,24?,26-,27+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254558
PNG
(US9469597, 17 | US9670136, 17 4-(aminomethyl)-N-((...)
Show SMILES NCC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C16H24N2/c17-11-12-6-8-14(9-7-12)18-16-10-15(16)13-4-2-1-3-5-13/h1-5,12,14-16,18H,6-11,17H2/t12?,14?,15-,16+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254563
PNG
(US9469597, 22 | US9670136, 22 N1-methyl-N4-((trans...)
Show SMILES CNC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C16H24N2/c1-17-13-7-9-14(10-8-13)18-16-11-15(16)12-5-3-2-4-6-12/h2-6,13-18H,7-11H2,1H3/t13?,14?,15-,16+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254560
PNG
(US9469597, 19 | US9670136, 19 N1-((trans)-2-phenyl...)
Show SMILES NC1CC(C1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C13H18N2/c14-10-6-11(7-10)15-13-8-12(13)9-4-2-1-3-5-9/h1-5,10-13,15H,6-8,14H2/t10?,11?,12-,13+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254548
PNG
(US9469597, 7 | US9670136, 7 N1-((trans)-2-(pyridin...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1cccnc1
Show InChI InChI=1S/C14H21N3/c15-11-3-5-12(6-4-11)17-14-8-13(14)10-2-1-7-16-9-10/h1-2,7,9,11-14,17H,3-6,8,15H2/t11?,12?,13-,14+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254590
PNG
(US9469597, 49 | US9670136, 49 N-(3-(5-((trans)-2-(...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(NS(=O)(=O)c2ccccc2C#N)c1
Show InChI InChI=1S/C25H27N5O2S2/c26-14-17-4-1-2-7-24(17)34(31,32)30-20-6-3-5-16(12-20)25-28-15-23(33-25)21-13-22(21)29-19-10-8-18(27)9-11-19/h1-7,12,15,18-19,21-22,29-30H,8-11,13,27H2/t18?,19?,21-,22-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
GST-Lysine Specific Demethylase-1 (LSD1)


(Homo sapiens (Human))
BDBM254556
PNG
(US9469597, 15 | US9670136, 15 (R)-1-(4-(((trans)-2...)
Show SMILES N[C@@H]1CCN(C1)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C19H29N3/c20-15-10-11-22(13-15)17-8-6-16(7-9-17)21-19-12-18(19)14-4-2-1-3-5-14/h1-5,15-19,21H,6-13,20H2/t15-,16?,17?,18-,19+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9469597 (2016)


BindingDB Entry DOI: 10.7270/Q2ZW1JVG
More data for this
Ligand-Target Pair
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