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Found 178 hits Enz. Inhib. hit(s) with Target = 'GST-Lysine-specific histone demethylase 1A (LSD1)' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256461
PNG
(US9487512, 6)
Show SMILES C(CC1CCNCC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C16H24N2/c1-2-4-14(5-3-1)15-12-16(15)18-11-8-13-6-9-17-10-7-13/h1-5,13,15-18H,6-12H2/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt
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PC sid
UniChem
US Patent
50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256457
PNG
(US9487512, 1)
Show SMILES C1C(NC2CCNCC2)[C@H]1c1ccccc1
Show InChI InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14?/m1/s1
PDB

UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256459
PNG
(US9487512, 3)
Show SMILES C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
Show InChI InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
PDB

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UniChem
US Patent
50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256460
PNG
(US9487512, 4)
Show SMILES C(Oc1ccc(cc1)[C@@H]1C[C@H]1NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-2-4-16(5-3-1)15-24-19-8-6-17(7-9-19)20-14-21(20)23-18-10-12-22-13-11-18/h1-9,18,20-23H,10-15H2/t20-,21+/m0/s1
PDB

UniProtKB/SwissProt
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PC cid
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UniChem
US Patent
50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM50142189
PNG
(CHEMBL3759239 | US9487512, 5)
Show SMILES C(N[C@H]1C[C@@H]1c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C15H22N2/c1-2-4-13(5-3-1)14-10-15(14)17-11-12-6-8-16-9-7-12/h1-5,12,14-17H,6-11H2/t14-,15+/m1/s1
PDB

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US Patent
50n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256458
PNG
(US9487512, 2)
Show SMILES C1[C@H](NC2CCNCC2)[C@H]1c1ccccc1
Show InChI InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m1/s1
PDB

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UniChem
US Patent
550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256462
PNG
(US9487512, 7)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1NC1CCOCC1
Show InChI InChI=1S/C20H21F3N2O/c21-20(22,23)15-3-1-2-13(10-15)18-5-4-14(12-24-18)17-11-19(17)25-16-6-8-26-9-7-16/h1-5,10,12,16-17,19,25H,6-9,11H2/t17-,19+/m1/s1
PDB

UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256464
PNG
(US9487512, 9)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)[C@H]1C[C@@H]1NCCC1CCOCC1
Show InChI InChI=1S/C22H26ClNO/c23-20-7-5-18(6-8-20)17-1-3-19(4-2-17)21-15-22(21)24-12-9-16-10-13-25-14-11-16/h1-8,16,21-22,24H,9-15H2/t21-,22+/m1/s1
PDB

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US Patent
550n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256463
PNG
(US9487512, 8)
Show SMILES C(CC1CCOCC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C16H23NO/c1-2-4-14(5-3-1)15-12-16(15)17-9-6-13-7-10-18-11-8-13/h1-5,13,15-17H,6-12H2/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt
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PC sid
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US Patent
5.50E+3n/an/an/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256482
PNG
(US9487512, 27)
Show SMILES Fc1ccccc1COc1ccc(cc1)[C@H]1C[C@@H]1NCC1CCNCC1
Show InChI InChI=1S/C22H27FN2O/c23-21-4-2-1-3-18(21)15-26-19-7-5-17(6-8-19)20-13-22(20)25-14-16-9-11-24-12-10-16/h1-8,16,20,22,24-25H,9-15H2/t20-,22+/m1/s1
PDB

UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a 8n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256460
PNG
(US9487512, 4)
Show SMILES C(Oc1ccc(cc1)[C@@H]1C[C@H]1NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C21H26N2O/c1-2-4-16(5-3-1)15-24-19-8-6-17(7-9-19)20-14-21(20)23-18-10-12-22-13-11-18/h1-9,18,20-23H,10-15H2/t20-,21+/m0/s1
PDB

UniProtKB/SwissProt
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DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM50142189
PNG
(CHEMBL3759239 | US9487512, 5)
Show SMILES C(N[C@H]1C[C@@H]1c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C15H22N2/c1-2-4-13(5-3-1)14-10-15(14)17-11-12-6-8-16-9-7-12/h1-5,12,14-17H,6-11H2/t14-,15+/m1/s1
PDB

UniProtKB/SwissProt
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US Patent
n/an/a 22n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256484
PNG
(US9487512, 29)
Show SMILES COc1ccc(NS(C)(=O)=O)cc1-c1ccc(cc1)[C@H]1C[C@@H]1NC1CCNCC1
Show InChI InChI=1S/C22H29N3O3S/c1-28-22-8-7-18(25-29(2,26)27)13-20(22)16-5-3-15(4-6-16)19-14-21(19)24-17-9-11-23-12-10-17/h3-8,13,17,19,21,23-25H,9-12,14H2,1-2H3/t19-,21+/m1/s1
PDB

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n/an/a 23n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256498
PNG
(US9487512, 43)
Show SMILES C(N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccnc1)C1CCNCC1
Show InChI InChI=1S/C20H25N3/c1-2-18(14-22-9-1)16-3-5-17(6-4-16)19-12-20(19)23-13-15-7-10-21-11-8-15/h1-6,9,14-15,19-21,23H,7-8,10-13H2/t19-,20+/m1/s1
PDB

UniProtKB/SwissProt
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PC sid
UniChem
US Patent
n/an/a 32n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256481
PNG
(US9487512, 26)
Show SMILES C(N[C@H]1C[C@@H]1c1ccccc1)C1CCNC1
Show InChI InChI=1S/C14H20N2/c1-2-4-12(5-3-1)13-8-14(13)16-10-11-6-7-15-9-11/h1-5,11,13-16H,6-10H2/t11?,13-,14+/m1/s1
PDB

UniProtKB/SwissProt
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PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256497
PNG
(US9487512, 42)
Show SMILES C(N[C@H]1C[C@@H]1c1ccc(cc1)C1CC1)C1CCNCC1
Show InChI InChI=1S/C18H26N2/c1-2-14(1)15-3-5-16(6-4-15)17-11-18(17)20-12-13-7-9-19-10-8-13/h3-6,13-14,17-20H,1-2,7-12H2/t17-,18+/m1/s1
PDB

UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256461
PNG
(US9487512, 6)
Show SMILES C(CC1CCNCC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C16H24N2/c1-2-4-14(5-3-1)15-12-16(15)18-11-8-13-6-9-17-10-7-13/h1-5,13,15-18H,6-12H2/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256475
PNG
(US9487512, 20)
Show SMILES Fc1ccccc1C1CC1NC1CCNCC1
Show InChI InChI=1S/C14H19FN2/c15-13-4-2-1-3-11(13)12-9-14(12)17-10-5-7-16-8-6-10/h1-4,10,12,14,16-17H,5-9H2
PDB

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n/an/a 38n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256486
PNG
(US9487512, 31)
Show SMILES C(N[C@H]1C[C@@H]1c1ccccc1)C1CNC1
Show InChI InChI=1S/C13H18N2/c1-2-4-11(5-3-1)12-6-13(12)15-9-10-7-14-8-10/h1-5,10,12-15H,6-9H2/t12-,13+/m1/s1
PDB

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n/an/a 42n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256459
PNG
(US9487512, 3)
Show SMILES C1[C@@H](NC2CCNCC2)[C@@H]1c1ccccc1
Show InChI InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1
PDB

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US Patent
n/an/a 42n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256479
PNG
(US9487512, 24)
Show SMILES C1C(NC2CCNCC2)C1c1ccc2ccccc2c1
Show InChI InChI=1S/C18H22N2/c1-2-4-14-11-15(6-5-13(14)3-1)17-12-18(17)20-16-7-9-19-10-8-16/h1-6,11,16-20H,7-10,12H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 47n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256470
PNG
(US9487512, 15)
Show SMILES C1[C@H](NC2CC3(C2)CCNCC3)[C@H]1c1ccccc1
Show InChI InChI=1S/C17H24N2/c1-2-4-13(5-3-1)15-10-16(15)19-14-11-17(12-14)6-8-18-9-7-17/h1-5,14-16,18-19H,6-12H2/t15-,16+/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 48n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256457
PNG
(US9487512, 1)
Show SMILES C1C(NC2CCNCC2)[C@H]1c1ccccc1
Show InChI InChI=1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14?/m1/s1
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n/an/a 56n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256491
PNG
(US9487512, 36)
Show SMILES CC1(C)CC(CC(C)(C)N1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C18H28N2/c1-17(2)11-14(12-18(3,4)20-17)19-16-10-15(16)13-8-6-5-7-9-13/h5-9,14-16,19-20H,10-12H2,1-4H3/t15-,16+/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256468
PNG
(US9487512, 13)
Show SMILES C1[C@H](NC2CC3CCC(C2)N3)[C@H]1c1ccccc1
Show InChI InChI=1S/C16H22N2/c1-2-4-11(5-3-1)15-10-16(15)18-14-8-12-6-7-13(9-14)17-12/h1-5,12-18H,6-10H2/t12?,13?,14?,15-,16+/m1/s1
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n/an/a 69n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256469
PNG
(US9487512, 14)
Show SMILES C1[C@H](NC2CCC3(CCNCC3)CC2)[C@H]1c1ccccc1
Show InChI InChI=1S/C19H28N2/c1-2-4-15(5-3-1)17-14-18(17)21-16-6-8-19(9-7-16)10-12-20-13-11-19/h1-5,16-18,20-21H,6-14H2/t17-,18+/m1/s1
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n/an/a 71n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256499
PNG
(US9487512, 44)
Show SMILES C(N[C@H]1C[C@@H]1c1ccc(cc1)-c1ccn[nH]1)C1CCNCC1
Show InChI InChI=1S/C18H24N4/c1-3-15(17-7-10-21-22-17)4-2-14(1)16-11-18(16)20-12-13-5-8-19-9-6-13/h1-4,7,10,13,16,18-20H,5-6,8-9,11-12H2,(H,21,22)/t16-,18+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256473
PNG
(US9487512, 18)
Show SMILES C1[C@H](NC2CCNCC2)[C@H]1c1cncs1
Show InChI InChI=1S/C11H17N3S/c1-3-12-4-2-8(1)14-10-5-9(10)11-6-13-7-15-11/h6-10,12,14H,1-5H2/t9-,10-/m0/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256483
PNG
(US9487512, 28)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)[C@H]1C[C@@H]1NCC1CCNCC1
Show InChI InChI=1S/C22H25F3N2/c23-22(24,25)19-3-1-2-18(12-19)16-4-6-17(7-5-16)20-13-21(20)27-14-15-8-10-26-11-9-15/h1-7,12,15,20-21,26-27H,8-11,13-14H2/t20-,21+/m1/s1
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Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256480
PNG
(US9487512, 25)
Show SMILES CC1(CC1NC1CCNCC1)c1ccccc1
Show InChI InChI=1S/C15H22N2/c1-15(12-5-3-2-4-6-12)11-14(15)17-13-7-9-16-10-8-13/h2-6,13-14,16-17H,7-11H2,1H3
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n/an/a 97n/an/an/an/an/an/a



Oryzon Genomics S.A.

US Patent


Assay Description
The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...


US Patent US9487512 (2016)


BindingDB Entry DOI: 10.7270/Q2765D89
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256633
PNG
(US10053456, 12 | US9487511, 12 | US9718814, 12)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1cc2CCOc2c(c1)C1CC1NCC1CCOCC1
Show InChI InChI=1S/C24H32F2N2O3/c25-24(26)6-1-18(2-7-24)28-23(29)17-11-16-5-10-31-22(16)20(12-17)19-13-21(19)27-14-15-3-8-30-9-4-15/h11-12,15,18-19,21,27H,1-10,13-14H2,(H,28,29)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256637
PNG
(US10053456, 16 | US9487511, 16 | US9718814, 16)
Show SMILES Cc1nnc(NC(=O)c2cc(cc3ccccc23)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C23H26N4O2S/c1-14-26-27-23(30-14)25-22(28)20-11-17(10-16-4-2-3-5-18(16)20)19-12-21(19)24-13-15-6-8-29-9-7-15/h2-5,10-11,15,19,21,24H,6-9,12-13H2,1H3,(H,25,27,28)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256641
PNG
(US10053456, 20 | US9487511, 20 | US9718814, 20)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3NCC3CCOCC3)c(C)s2)s1
Show InChI InChI=1S/C18H24N4O2S2/c1-10-13(14-7-15(14)19-9-12-3-5-24-6-4-12)8-16(25-10)17(23)20-18-22-21-11(2)26-18/h8,12,14-15,19H,3-7,9H2,1-2H3,(H,20,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256644
PNG
(US10053456, 23 | US9487511, 23 | US9718814, 23)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NCC2CC2)s1
Show InChI InChI=1S/C15H18N4OS2/c1-8-18-19-15(22-8)17-14(20)10-4-13(21-7-10)11-5-12(11)16-6-9-2-3-9/h4,7,9,11-12,16H,2-3,5-6H2,1H3,(H,17,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256645
PNG
(US10053456, 24 | US9487511, 24 | US9718814, 24)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1csc(c1)C1CC1NCC1CCOCC1
Show InChI InChI=1S/C20H28F2N2O2S/c21-20(22)5-1-15(2-6-20)24-19(25)14-9-18(27-12-14)16-10-17(16)23-11-13-3-7-26-8-4-13/h9,12-13,15-17,23H,1-8,10-11H2,(H,24,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256649
PNG
(US10053456, 28 | US9487511, 28 | US9718814, 28)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1cc(cs1)C1CC1NCC1CC1
Show InChI InChI=1S/C18H24F2N2OS/c19-18(20)5-3-13(4-6-18)22-17(23)16-7-12(10-24-16)14-8-15(14)21-9-11-1-2-11/h7,10-11,13-15,21H,1-6,8-9H2,(H,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256651
PNG
(US10053456, 30 | US9487511, 30 | US9718814, 30)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1csc(c1)C1CC1NCC1CC1
Show InChI InChI=1S/C18H24F2N2OS/c19-18(20)5-3-13(4-6-18)22-17(23)12-7-16(24-10-12)14-8-15(14)21-9-11-1-2-11/h7,10-11,13-15,21H,1-6,8-9H2,(H,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256652
PNG
(US10053456, 31 | US9487511, 31 | US9718814, 31)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1csc(c1)C1CC1NC1CCOCC1
Show InChI InChI=1S/C19H26F2N2O2S/c20-19(21)5-1-13(2-6-19)23-18(24)12-9-17(26-11-12)15-10-16(15)22-14-3-7-25-8-4-14/h9,11,13-16,22H,1-8,10H2,(H,23,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256653
PNG
(US10053456, 32 | US9487511, 32 | US9718814, 32)
Show SMILES O=C(NC1CCOCC1)c1csc(c1)C1CC1NCC1CC1
Show InChI InChI=1S/C17H24N2O2S/c20-17(19-13-3-5-21-6-4-13)12-7-16(22-10-12)14-8-15(14)18-9-11-1-2-11/h7,10-11,13-15,18H,1-6,8-9H2,(H,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256654
PNG
(US10053456, 33 | US9487511, 33 | US9718814, 33)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NC2CCC2)s1
Show InChI InChI=1S/C15H18N4OS2/c1-8-18-19-15(22-8)17-14(20)9-5-13(21-7-9)11-6-12(11)16-10-3-2-4-10/h5,7,10-12,16H,2-4,6H2,1H3,(H,17,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256655
PNG
(US10053456, 34 | US9487511, 34 | US9718814, 34)
Show SMILES Cn1cc(NC(=O)c2csc(c2)C2CC2NC2CCC2)cn1
Show InChI InChI=1S/C16H20N4OS/c1-20-8-12(7-17-20)19-16(21)10-5-15(22-9-10)13-6-14(13)18-11-3-2-4-11/h5,7-9,11,13-14,18H,2-4,6H2,1H3,(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256659
PNG
(US9487511, 38)
Show SMILES O=C(NC1CCCC1)c1csc(c1)[C@H]1C[C@H]1NC1CCOCC1
Show InChI InChI=1S/C18H26N2O2S/c21-18(20-13-3-1-2-4-13)12-9-17(23-11-12)15-10-16(15)19-14-5-7-22-8-6-14/h9,11,13-16,19H,1-8,10H2,(H,20,21)/t15-,16+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256660
PNG
(US9487511, 39)
Show SMILES O=C(NC1CCCC1)c1csc(c1)[C@@H]1C[C@@H]1NC1CCOCC1
Show InChI InChI=1S/C18H26N2O2S/c21-18(20-13-3-1-2-4-13)12-9-17(23-11-12)15-10-16(15)19-14-5-7-22-8-6-14/h9,11,13-16,19H,1-8,10H2,(H,20,21)/t15-,16+/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256661
PNG
(BDBM256662 | US10053456, 41 | US9487511, 40 | US97...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C17H22N4O2S2/c1-10-20-21-17(25-10)19-16(22)12-6-15(24-9-12)13-7-14(13)18-8-11-2-4-23-5-3-11/h6,9,11,13-14,18H,2-5,7-8H2,1H3,(H,19,21,22)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256661
PNG
(BDBM256662 | US10053456, 41 | US9487511, 40 | US97...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C17H22N4O2S2/c1-10-20-21-17(25-10)19-16(22)12-6-15(24-9-12)13-7-14(13)18-8-11-2-4-23-5-3-11/h6,9,11,13-14,18H,2-5,7-8H2,1H3,(H,19,21,22)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256663
PNG
(US9487511, 42)
Show SMILES O=C(NC1CCOCC1)c1csc(c1)[C@H]1C[C@H]1NC1CCC1
Show InChI InChI=1S/C17H24N2O2S/c20-17(19-13-4-6-21-7-5-13)11-8-16(22-10-11)14-9-15(14)18-12-2-1-3-12/h8,10,12-15,18H,1-7,9H2,(H,19,20)/t14-,15+/m0/s1
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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256665
PNG
(US9487511, 44)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1csc(c1)[C@H]1C[C@H]1NC1CCOCC1
Show InChI InChI=1S/C19H26F2N2O2S/c20-19(21)5-1-13(2-6-19)23-18(24)12-9-17(26-11-12)15-10-16(15)22-14-3-7-25-8-4-14/h9,11,13-16,22H,1-8,10H2,(H,23,24)/t15-,16+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256666
PNG
(BDBM256667 | US9487511, 45)
Show SMILES NC1CCC(CC1)N[C@@H]1C[C@@H]1c1cc(cs1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C20H29F2N3OS/c21-20(22)7-5-15(6-8-20)25-19(26)12-9-18(27-11-12)16-10-17(16)24-14-3-1-13(23)2-4-14/h9,11,13-17,24H,1-8,10,23H2,(H,25,26)/t13?,14?,16-,17+/m0/s1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256666
PNG
(BDBM256667 | US9487511, 45)
Show SMILES NC1CCC(CC1)N[C@@H]1C[C@@H]1c1cc(cs1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C20H29F2N3OS/c21-20(22)7-5-15(6-8-20)25-19(26)12-9-18(27-11-12)16-10-17(16)24-14-3-1-13(23)2-4-14/h9,11,13-17,24H,1-8,10,23H2,(H,25,26)/t13?,14?,16-,17+/m0/s1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
GST-Lysine-specific histone demethylase 1A (LSD1)


(Homo sapiens (Human))
BDBM256668
PNG
(US9487511, 47)
Show SMILES FC1(F)CCC(CC1)N[C@@H]1C[C@@H]1c1cc(cs1)C(=O)NC1CCOCC1
Show InChI InChI=1S/C19H26F2N2O2S/c20-19(21)5-1-13(2-6-19)22-16-10-15(16)17-9-12(11-26-17)18(24)23-14-3-7-25-8-4-14/h9,11,13-16,22H,1-8,10H2,(H,23,24)/t15-,16+/m0/s1
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
A test compound dissolved in DMSO was added by to a reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing LSD1 enzyme, and the m...


US Patent US9487511 (2016)


BindingDB Entry DOI: 10.7270/Q2V123Q4
More data for this
Ligand-Target Pair
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