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Compile Data Set for Download or QSAR

Found 134 hits Enz. Inhib. hit(s) with Target = 'Gastric inhibitory polypeptide receptor' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360599
PNG
(CHEMBL1933365)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)20-9-11-22(12-10-20)33-16-21(15-31-33)32-24(17-3-1-2-4-17)18-5-7-19(8-6-18)25(36)30-14-13-23(34)35/h5-12,15-17,24,32H,1-4,13-14H2,(H,30,36)(H,34,35)
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927n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360599
PNG
(CHEMBL1933365)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)C1CCCC1
Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)20-9-11-22(12-10-20)33-16-21(15-31-33)32-24(17-3-1-2-4-17)18-5-7-19(8-6-18)25(36)30-14-13-23(34)35/h5-12,15-17,24,32H,1-4,13-14H2,(H,30,36)(H,34,35)
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927n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360597
PNG
(CHEMBL1933363)
Show SMILES CCCC(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H25F3N4O3/c1-2-3-21(16-4-6-17(7-5-16)23(34)28-13-12-22(32)33)30-19-14-29-31(15-19)20-10-8-18(9-11-20)24(25,26)27/h4-11,14-15,21,30H,2-3,12-13H2,1H3,(H,28,34)(H,32,33)
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1.95E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360598
PNG
(CHEMBL1933364)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(CCC(F)(F)F)Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H22F6N4O3/c25-23(26,27)11-9-20(15-1-3-16(4-2-15)22(37)31-12-10-21(35)36)33-18-13-32-34(14-18)19-7-5-17(6-8-19)24(28,29)30/h1-8,13-14,20,33H,9-12H2,(H,31,37)(H,35,36)
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3.84E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360598
PNG
(CHEMBL1933364)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(CCC(F)(F)F)Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H22F6N4O3/c25-23(26,27)11-9-20(15-1-3-16(4-2-15)22(37)31-12-10-21(35)36)33-18-13-32-34(14-18)19-7-5-17(6-8-19)24(28,29)30/h1-8,13-14,20,33H,9-12H2,(H,31,37)(H,35,36)
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3.84E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360594
PNG
(CHEMBL1933360)
Show SMILES CCCC(Oc1cnn(c1)-c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24F3N3O4/c1-2-3-21(16-4-6-17(7-5-16)23(33)28-13-12-22(31)32)34-20-14-29-30(15-20)19-10-8-18(9-11-19)24(25,26)27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,28,33)(H,31,32)
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4.08E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50360594
PNG
(CHEMBL1933360)
Show SMILES CCCC(Oc1cnn(c1)-c1ccc(cc1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C24H24F3N3O4/c1-2-3-21(16-4-6-17(7-5-16)23(33)28-13-12-22(31)32)34-20-14-29-30(15-20)19-10-8-18(9-11-19)24(25,26)27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,28,33)(H,31,32)
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4.08E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]GIP from human GIPR


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245060
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(4-trifluoromet...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(SC(F)(F)F)cc2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C31H32F3N3O5S/c32-31(33,34)43-26-16-12-24(13-17-26)36-30(42)37(25-14-10-22(11-15-25)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)28(39)35-18-27(38)29(40)41/h6-17,21,27,38H,1-5,18-19H2,(H,35,39)(H,36,42)(H,40,41)/t27-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50171817
PNG
(3-(4-((1-(4-tert-butylcyclohexyl)-3-(4-(trifluorom...)
Show SMILES CC(C)(C)C1CCC(CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H36F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-7,10-11,14-15,21,23H,8-9,12-13,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 28n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50202060
PNG
(3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluoromethoxy...)
Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3N3O5/c1-28(2,3)21-8-12-23(13-9-21)35(27(39)34-22-10-14-24(15-11-22)40-29(30,31)32)18-19-4-6-20(7-5-19)26(38)33-17-16-25(36)37/h4-15H,16-18H2,1-3H3,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 38n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50334486
PNG
(CHEMBL1643951 | trans-4-((1-(4-tert-butylcyclohexy...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C27H32F3N7O3/c1-26(2,3)19-8-12-21(13-9-19)37(25(39)31-20-10-14-22(15-11-20)40-27(28,29)30)16-17-4-6-18(7-5-17)23(38)32-24-33-35-36-34-24/h4-7,10-11,14-15,19,21H,8-9,12-13,16H2,1-3H3,(H,31,39)(H2,32,33,34,35,36,38)/t19-,21-
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50202031
PNG
(3-(4-((1-(4-cyclohexenylphenyl)-3-(3,5-dichlorophe...)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1
Show InChI InChI=1S/C30H29Cl2N3O4/c31-24-16-25(32)18-26(17-24)34-30(39)35(27-12-10-22(11-13-27)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(38)33-15-14-28(36)37/h4,6-13,16-18H,1-3,5,14-15,19H2,(H,33,38)(H,34,39)(H,36,37)
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n/an/a 64n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245062
PNG
((R)-3-{4-[3-(3-tert-Butylphenyl)-1-(4-cyclohexylph...)
Show SMILES CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1
Show InChI InChI=1S/C34H41N3O5/c1-34(2,3)27-10-7-11-28(20-27)36-33(42)37(29-18-16-25(17-19-29)24-8-5-4-6-9-24)22-23-12-14-26(15-13-23)31(39)35-21-30(38)32(40)41/h7,10-20,24,30,38H,4-6,8-9,21-22H2,1-3H3,(H,35,39)(H,36,42)(H,40,41)/t30-/m1/s1
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n/an/a 74n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245099
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(2,2,4,4-t...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc3OC(F)(F)OC(F)(F)c3c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C32H29F4N3O7/c33-31(34)25-16-23(12-15-27(25)45-32(35,36)46-31)38-30(44)39(24-13-10-21(11-14-24)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(41)37-17-26(40)29(42)43/h4,6-16,26,40H,1-3,5,17-18H2,(H,37,41)(H,38,44)(H,42,43)/t26-/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244457
PNG
((R)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m1/s1
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n/an/a 87n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245098
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3,5-dichloroph...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C30H31Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h6-16,20,27,36H,1-5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1
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n/an/a 93n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50202041
PNG
(CHEMBL375167 | trans-3-{4-[3-(3,5-Bis(trifluoromet...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H35F6N3O4/c1-28(2,3)20-8-10-24(11-9-20)39(17-18-4-6-19(7-5-18)26(42)37-13-12-25(40)41)27(43)38-23-15-21(29(31,32)33)14-22(16-23)30(34,35)36/h4-7,14-16,20,24H,8-13,17H2,1-3H3,(H,37,42)(H,38,43)(H,40,41)/t20-,24-
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n/an/a 93n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245057
PNG
((R)-trans-3-{4-[1-(4-tert-Butyl-cyclohexyl)-3-(3-m...)
Show SMILES Cc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C30H38F3N3O5/c1-18-13-22(30(31,32)33)15-23(14-18)35-28(41)36(24-11-9-21(10-12-24)29(2,3)4)17-19-5-7-20(8-6-19)26(38)34-16-25(37)27(39)40/h5-8,13-15,21,24-25,37H,9-12,16-17H2,1-4H3,(H,34,38)(H,35,41)(H,39,40)/t21-,24-,25-/m1/s1
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n/an/a 98n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199497
PNG
(1-(7-((2H-tetrazol-5-yl)carbamoyl)-3,4-dihydro-2H-...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H34F3N7O4/c1-28(2,3)18-5-9-20(10-6-18)39(27(41)33-19-7-11-21(12-8-19)43-29(30,31)32)23-14-15-42-24-16-17(4-13-22(23)24)25(40)34-26-35-37-38-36-26/h4,7-8,11-13,16,18,20,23H,5-6,9-10,14-15H2,1-3H3,(H,33,41)(H2,34,35,36,37,38,40)/t18-,20-,23?
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n/an/a 117n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199493
PNG
(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(triflu...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H35F3N6O3/c1-29(2,3)21-8-10-22(11-9-21)39(26(40)16-18-4-12-23(13-5-18)42-30(31,32)33)25-15-7-19-17-20(6-14-24(19)25)27(41)34-28-35-37-38-36-28/h4-6,12-14,17,21-22,25H,7-11,15-16H2,1-3H3,(H2,34,35,36,37,38,41)/t21-,22-,25?
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n/an/a 118n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199498
PNG
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26?
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n/an/a 132n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244509
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methoxy-5-tr...)
Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C32H34F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h7-17,21,28,39H,2-6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1
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n/an/a 145n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199488
PNG
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H40F3N3O5/c1-31(2,3)22-8-12-24(13-9-22)38(30(42)37-23-10-14-25(15-11-23)43-32(33,34)35)27-6-4-5-20-19-21(7-16-26(20)27)29(41)36-18-17-28(39)40/h7,10-11,14-16,19,22,24,27H,4-6,8-9,12-13,17-18H2,1-3H3,(H,36,41)(H,37,42)(H,39,40)/t22-,24-,27?
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n/an/a 171n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199491
PNG
(1-(6-((2H-tetrazol-5-yl)carbamoyl)-1,2,3,4-tetrahy...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C30H36F3N7O3/c1-29(2,3)20-8-12-22(13-9-20)40(28(42)34-21-10-14-23(15-11-21)43-30(31,32)33)25-6-4-5-18-17-19(7-16-24(18)25)26(41)35-27-36-38-39-37-27/h7,10-11,14-17,20,22,25H,4-6,8-9,12-13H2,1-3H3,(H,34,42)(H2,35,36,37,38,39,41)/t20-,22-,25?
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n/an/a 178n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245061
PNG
((R)-3-{4-[3-(4-Cyano-3-trifluoromethylphenyl)-1-(4...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C32H31F3N4O5/c33-32(34,35)27-16-25(13-10-24(27)17-36)38-31(44)39(26-14-11-22(12-15-26)21-4-2-1-3-5-21)19-20-6-8-23(9-7-20)29(41)37-18-28(40)30(42)43/h6-16,21,28,40H,1-5,18-19H2,(H,37,41)(H,38,44)(H,42,43)/t28-/m1/s1
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n/an/a 198n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29106
PNG
(aminothiazole, 3)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc(cc2)C2=CCCCC2)cc1
Show InChI InChI=1S/C33H30F3N3O4S/c34-33(35,36)43-28-16-12-25(13-17-28)29-21-44-32(38-29)39(27-14-10-24(11-15-27)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41)
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n/an/a 207n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244506
PNG
((R)-3-{4-[3-(3-Bromophenyl)-1-(4-cyclohexylphenyl)...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(cc2)C2CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C30H32BrN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4,7-17,21,27,35H,1-3,5-6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1
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n/an/a 216n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199489
PNG
(3-(4-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCOc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H38F3N3O6/c1-30(2,3)20-5-9-22(10-6-20)37(29(41)36-21-7-11-23(12-8-21)43-31(32,33)34)25-15-17-42-26-18-19(4-13-24(25)26)28(40)35-16-14-27(38)39/h4,7-8,11-13,18,20,22,25H,5-6,9-10,14-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t20-,22-,25?
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n/an/a 217n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244505
PNG
((R)-trans-3-{4-[1-(4-tert-Butylcyclohexyl)-3-(3,5-...)
Show SMILES Cc1cc(C)cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)[C@H]2CC[C@@H](CC2)C(C)(C)C)c1
Show InChI InChI=1S/C30H41N3O5/c1-19-14-20(2)16-24(15-19)32-29(38)33(25-12-10-23(11-13-25)30(3,4)5)18-21-6-8-22(9-7-21)27(35)31-17-26(34)28(36)37/h6-9,14-16,23,25-26,34H,10-13,17-18H2,1-5H3,(H,31,35)(H,32,38)(H,36,37)/t23-,25-,26-/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245100
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-fluoro-...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(F)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C31H29F4N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1
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n/an/a 277n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244508
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3-methoxy...)
Show SMILES COc1cc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2=CCCCC2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C32H32F3N3O6/c1-44-27-16-24(32(33,34)35)15-25(17-27)37-31(43)38(26-13-11-22(12-14-26)21-5-3-2-4-6-21)19-20-7-9-23(10-8-20)29(40)36-18-28(39)30(41)42/h5,7-17,28,39H,2-4,6,18-19H2,1H3,(H,36,40)(H,37,43)(H,41,42)/t28-/m1/s1
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n/an/a 279n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199486
PNG
(3-(1-(N-((1r,4r)-4-tert-butylcyclohexyl)-2-(4-(tri...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C32H39F3N2O5/c1-31(2,3)23-8-10-24(11-9-23)37(28(38)18-20-4-12-25(13-5-20)42-32(33,34)35)27-15-7-21-19-22(6-14-26(21)27)30(41)36-17-16-29(39)40/h4-6,12-14,19,23-24,27H,7-11,15-18H2,1-3H3,(H,36,41)(H,39,40)/t23-,24-,27?
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n/an/a 286n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50358373
PNG
(CHEMBL1922839)
Show SMILES CCCOc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(cc3)C(C)(C)C)n(C)c12)C(F)(F)F
Show InChI InChI=1S/C31H33F3N8O2/c1-6-15-44-25-17-22(31(32,33)34)16-24-26(25)41(5)29(35-23-13-11-21(12-14-23)30(2,3)4)42(24)18-19-7-9-20(10-8-19)27(43)36-28-37-39-40-38-28/h7-14,16-17H,6,15,18H2,1-5H3,(H2,36,37,38,39,40,43)
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n/an/a 290n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GIP receptor by cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50199492
PNG
(1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H34F3N7O3/c1-28(2,3)19-6-10-21(11-7-19)39(27(41)33-20-8-12-22(13-9-20)42-29(30,31)32)24-15-5-17-16-18(4-14-23(17)24)25(40)34-26-35-37-38-36-26/h4,8-9,12-14,16,19,21,24H,5-7,10-11,15H2,1-3H3,(H,33,41)(H2,34,35,36,37,38,40)/t19-,21-,24?
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n/an/a 296n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50393781
PNG
(CHEMBL2159337)
Show SMILES C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(cc1-c1ccc2cc(OC(F)(F)F)ccc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H24Cl2F3N3O4/c1-18(19-2-4-20(5-3-19)31(43)38-11-10-30(41)42)40-29(17-28(39-40)24-13-25(33)16-26(34)14-24)23-7-6-22-15-27(44-32(35,36)37)9-8-21(22)12-23/h2-9,12-18H,10-11H2,1H3,(H,38,43)(H,41,42)/t18-/m0/s1
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n/an/a 307n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245056
PNG
((R/S)-3-{4-[1-(4-tert-Butylphenyl)-3-(4-trifluorom...)
Show SMILES CC(C)(C)c1ccc(cc1)N(Cc1ccc(cc1)C(=O)NCC(O)C(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3N3O6/c1-28(2,3)20-8-12-22(13-9-20)35(27(40)34-21-10-14-23(15-11-21)41-29(30,31)32)17-18-4-6-19(7-5-18)25(37)33-16-24(36)26(38)39/h4-15,24,36H,16-17H2,1-3H3,(H,33,37)(H,34,40)(H,38,39)
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n/an/a 315n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29132
PNG
(thiazole, 29)
Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C28H22ClF3N2O4S/c29-21-9-5-19(6-10-21)24-16-39-27(34-24)23(18-7-11-22(12-8-18)38-28(30,31)32)15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36)
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n/an/a 316n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244455
PNG
((R)-3-{4-[1-(4-Cyclohex-1-enylphenyl)-3-(3,5-dichl...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C30H29Cl2N3O5/c31-23-14-24(32)16-25(15-23)34-30(40)35(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(37)33-17-27(36)29(38)39/h4,6-16,27,36H,1-3,5,17-18H2,(H,33,37)(H,34,40)(H,38,39)/t27-/m1/s1
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n/an/a 359n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29107
PNG
(aminothiazole, 4)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1
Show InChI InChI=1S/C33H30F3N3O3S/c34-33(35,36)27-14-10-25(11-15-27)29-21-43-32(38-29)39(28-16-12-24(13-17-28)23-4-2-1-3-5-23)20-22-6-8-26(9-7-22)31(42)37-19-18-30(40)41/h4,6-17,21H,1-3,5,18-20H2,(H,37,42)(H,40,41)
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n/an/a 368n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50358368
PNG
(CHEMBL1922834)
Show SMILES CCCOc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F
Show InChI InChI=1S/C28H24F6N8O3/c1-3-12-44-22-14-18(27(29,30)31)13-21-23(22)41(2)26(35-19-8-10-20(11-9-19)45-28(32,33)34)42(21)15-16-4-6-17(7-5-16)24(43)36-25-37-39-40-38-25/h4-11,13-14H,3,12,15H2,1-2H3,(H2,36,37,38,39,40,43)
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n/an/a 370n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human GIP receptor by cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244458
PNG
((S)-trans-3-{4-[3-(3,5-Bis(trifluoromethyl)phenyl)...)
Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NC[C@H](O)C(O)=O)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C30H35F6N3O5/c1-28(2,3)19-8-10-23(11-9-19)39(16-17-4-6-18(7-5-17)25(41)37-15-24(40)26(42)43)27(44)38-22-13-20(29(31,32)33)12-21(14-22)30(34,35)36/h4-7,12-14,19,23-24,40H,8-11,15-16H2,1-3H3,(H,37,41)(H,38,44)(H,42,43)/t19-,23-,24-/m0/s1
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n/an/a 373n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50393783
PNG
(CHEMBL2159339)
Show SMILES C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1nc(cc1-c1ccc2cc(ccc2c1)C(F)(F)F)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C32H24Cl2F3N3O3/c1-18(19-2-4-20(5-3-19)31(43)38-11-10-30(41)42)40-29(17-28(39-40)24-14-26(33)16-27(34)15-24)23-7-6-22-13-25(32(35,36)37)9-8-21(22)12-23/h2-9,12-18H,10-11H2,1H3,(H,38,43)(H,41,42)/t18-/m0/s1
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n/an/a 378n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50244507
PNG
((R)-3-{4-[3-(3-Bromo-5-trifluoromethylphenyl)-1-(4...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cc(Br)cc(c2)C(F)(F)F)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C31H29BrF3N3O5/c32-24-14-23(31(33,34)35)15-25(16-24)37-30(43)38(26-12-10-21(11-13-26)20-4-2-1-3-5-20)18-19-6-8-22(9-7-19)28(40)36-17-27(39)29(41)42/h4,6-16,27,39H,1-3,5,17-18H2,(H,36,40)(H,37,43)(H,41,42)/t27-/m1/s1
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n/an/a 380n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29130
PNG
(thiazole, 27)
Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(cc2)C(F)(F)F)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H22ClF3N2O3S/c29-22-11-7-18(8-12-22)23(15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36)27-34-24(16-38-27)19-5-9-21(10-6-19)28(30,31)32/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36)
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n/an/a 381n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29104
PNG
(aminothiazole, 1)
Show SMILES OC(=O)CCNC(=O)c1ccc(CN(c2nc(cs2)-c2ccccc2)c2ccc(cc2)C2=CCCCC2)cc1
Show InChI InChI=1S/C32H31N3O3S/c36-30(37)19-20-33-31(38)27-13-11-23(12-14-27)21-35(32-34-29(22-39-32)26-9-5-2-6-10-26)28-17-15-25(16-18-28)24-7-3-1-4-8-24/h2,5-7,9-18,22H,1,3-4,8,19-21H2,(H,33,38)(H,36,37)
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n/an/a 389n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245059
PNG
((R)-3-{4-[3-(3-Chlorophenyl)-1-(4-cyclohex-1-enylp...)
Show SMILES O[C@H](CNC(=O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(cc2)C2=CCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C30H30ClN3O5/c31-24-7-4-8-25(17-24)33-30(39)34(26-15-13-22(14-16-26)21-5-2-1-3-6-21)19-20-9-11-23(12-10-20)28(36)32-18-27(35)29(37)38/h4-5,7-17,27,35H,1-3,6,18-19H2,(H,32,36)(H,33,39)(H,37,38)/t27-/m1/s1
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n/an/a 406n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50245101
PNG
((R)-3-{4-[1-(4-Cyclohexylphenyl)-3-(3-methylthio)p...)
Show SMILES CSc1cccc(NC(=O)N(Cc2ccc(cc2)C(=O)NC[C@@H](O)C(O)=O)c2ccc(cc2)C2CCCCC2)c1
Show InChI InChI=1S/C31H35N3O5S/c1-40-27-9-5-8-25(18-27)33-31(39)34(26-16-14-23(15-17-26)22-6-3-2-4-7-22)20-21-10-12-24(13-11-21)29(36)32-19-28(35)30(37)38/h5,8-18,22,28,35H,2-4,6-7,19-20H2,1H3,(H,32,36)(H,33,39)(H,37,38)/t28-/m1/s1
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n/an/a 411n/an/an/an/an/an/a



Novo Nordisk A/S

Curated by ChEMBL


Assay Description
Binding affinity to human cloned GIPR expressed in BHK cells


Citation and Details
More data for this
Ligand-Target Pair
Gastric Inhibitory Polypeptide Receptor (GIPR)


(Homo sapiens)
BDBM29131
PNG
(thiazole, 28)
Show SMILES OC(=O)CCNC(=O)c1ccc(CC(c2nc(cs2)-c2ccc(OC(F)(F)F)cc2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C28H22ClF3N2O4S/c29-21-9-5-18(6-10-21)23(15-17-1-3-20(4-2-17)26(37)33-14-13-25(35)36)27-34-24(16-39-27)19-7-11-22(12-8-19)38-28(30,31)32/h1-12,16,23H,13-15H2,(H,33,37)(H,35,36)
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n/an/a 429n/an/an/an/a7.522



Novo Nordisk A/S



Assay Description
Wheat Germ Agglutinin derivatized SPA beads containing a scintillant (WGA beads) (Amersham) bound the membranes of BHK cells transfected with the hum...


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50171819
PNG
(4-[9-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl...)
Show SMILES CC(C)(C)C1CCC2(CC1)CCN(C(=O)N2Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H34F3N7O3/c1-27(2,3)21-12-14-28(15-13-21)16-17-38(22-8-10-23(11-9-22)42-29(30,31)32)26(41)39(28)18-19-4-6-20(7-5-19)24(40)33-25-34-36-37-35-25/h4-11,21H,12-18H2,1-3H3,(H2,33,34,35,36,37,40)
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n/an/a 430n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human gastric inhibitory polypeptide receptor (hGIP) mediated cAMP accumulation


Citation and Details
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens)
BDBM50393786
PNG
(CHEMBL2159342)
Show SMILES CC(C)c1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C34H31Cl2N3O3/c1-20(2)24-8-9-26-15-27(11-10-25(26)14-24)32-19-31(28-16-29(35)18-30(36)17-28)38-39(32)21(3)22-4-6-23(7-5-22)34(42)37-13-12-33(40)41/h4-11,14-21H,12-13H2,1-3H3,(H,37,42)(H,40,41)/t21-/m0/s1
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n/an/a 431n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIPR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...


Citation and Details
More data for this
Ligand-Target Pair
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